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10 Results Found

  • Article
  • Open Access
2 Citations
2,311 Views
16 Pages

Do Microplastics Affect the Photodegradation of Duloxetine and Its Phototoxicity to Protozoan Spirostomum ambiguum (Müller, 1786) Ehrenberg, 1835?

  • Justyna Chojnacka,
  • Joanna Giebułtowicz,
  • Natalia Choińska,
  • Agata Drobniewska and
  • Grzegorz Nałęcz-Jawecki

8 November 2023

As contaminants are often present in aquatic environments as mixtures, they may interact with each other and affect living organisms differently than when tested individually. Emerging pollutants such as pharmaceuticals and microplastics can be influ...

  • Article
  • Open Access
5 Citations
1,800 Views
18 Pages

The Microbial Assay for Risk Assessment (MARA) in the Assessment of the Antimicrobial Activity of Ofloxacin and Its Photoproducts

  • Grzegorz Nałęcz-Jawecki,
  • Jakub Mielniczek,
  • Milena Wawryniuk,
  • Joanna Giebułtowicz and
  • Agata Drobniewska

Ofloxacin is one of the most commonly used antibacterial substances in the world. Like most medicines, it ends up in the environment through municipal sewage and undergoes various transformations, e.g., photodegradation. The aim of this study was an...

(This article belongs to the Section Molecular Microbiology)
  • Article
  • Open Access
4 Citations
3,062 Views
16 Pages

The Mutual Effect of Microparticles and Antidepressants on the Protozoan Spirostomum ambiguum (Müller, 1786) Ehrenberg, 1835

  • Justyna Chojnacka,
  • Agata Drobniewska,
  • Wioletta Lenga,
  • Joanna Misztal and ,
  • Milena Wawryniuk and
  • Grzegorz Nałęcz-Jawecki
  • + 1 author+ 0 author

31 January 2023

Antidepressants, especially selective serotonin re-uptake inhibitors, which are among the most commonly used pharmaceuticals, are ubiquitous in effluents and freshwaters. Microparticles, including microplastics, show sorption properties to different...

(This article belongs to the Section Water Quality and Contamination)
  • Article
  • Open Access
9 Citations
5,618 Views
19 Pages

New Approaches to Determining the D/H Ratio in Aqueous Media Based on Diffuse Laser Light Scattering for Promising Application in Deuterium-Depleted Water Analysis in Antitumor Therapy

  • Anton V. Syroeshkin,
  • Elena V. Uspenskaya,
  • Olga V. Levitskaya,
  • Ekaterina S. Kuzmina and ,
  • Ilaha V. Kazimova,
  • Hoang Thi Ngoc Quynh and
  • Tatiana V. Pleteneva
  • + 2 authors+ 0 author

2 December 2024

The development of affordable and reliable methods for quantitative determination of stable atomic nuclei in aqueous solutions and adjuvant agents used in tumor chemotherapy is an important task in modern pharmaceutical chemistry. This work quantifie...

  • Article
  • Open Access
1 Citations
6,337 Views
20 Pages

31 December 2024

Peptides occupy a significant share of the pharmaceutical market and are among the top-200 selling drugs in the group of non-insulin drugs with analgesic, antibacterial and cardiovascular effects. The aim of this work is to develop a comprehensive an...

  • Article
  • Open Access
27 Citations
4,742 Views
18 Pages

Influence of Selected Antidepressants on the Ciliated Protozoan Spirostomum ambiguum: Toxicity, Bioaccumulation, and Biotransformation Products

  • Grzegorz Nałęcz-Jawecki,
  • Milena Wawryniuk,
  • Joanna Giebułtowicz,
  • Adam Olkowski and
  • Agata Drobniewska

25 March 2020

The present study aimed to evaluate the effect of the most common antidepressants on aquatic protozoa. Spirostomum ambiguum was used as the model protozoan. The biological activity of four antidepressants, namely fluoxetine, sertraline, paroxetine, a...

(This article belongs to the Special Issue Pharmaceutical Residues in the Environment)
  • Article
  • Open Access
1 Citations
2,092 Views
19 Pages

Influence of Mechanical Loading on the Process of Tribochemical Action on Physicochemical and Biopharmaceutical Properties of Substances, Using Lacosamide as an Example: From Micronisation to Mechanical Activation

  • Elena V. Uspenskaya,
  • Ekaterina Kuzmina,
  • Hoang Thi Ngoc Quynh,
  • Maria A. Komkova and ,
  • Ilaha V. Kazimova and
  • Aleksey A. Timofeev
  • + 1 author+ 0 author

Many physical and chemical properties of solids, such as strength, plasticity, dispersibility, solubility and dissolution are determined by defects in the crystal structure. The aim of this work is to study in situ dynamic, dispersion, chemical, biol...

(This article belongs to the Special Issue Novel Dry Powder Formulation and Delivery Systems)
  • Article
  • Open Access
20 Citations
6,598 Views
17 Pages

Chelation of Zinc with Biogenic Amino Acids: Description of Properties Using Balaban Index, Assessment of Biological Activity on Spirostomum Ambiguum Cellular Biosensor, Influence on Biofilms and Direct Antibacterial Action

  • Alla V. Marukhlenko,
  • Mariya A. Morozova,
  • Arsène M. J. Mbarga,
  • Nadezhda V. Antipova and ,
  • Anton V. Syroeshkin,
  • Irina V. Podoprigora and
  • Tatiana V. Maksimova
  • + 2 authors+ 0 author

9 August 2022

The complexation of biogenic molecules with metals is the widespread strategy in screening for new pharmaceuticals with improved therapeutic and physicochemical properties. This paper demonstrates the possibility of using simple QSAR modeling based o...

(This article belongs to the Special Issue Structure and Ligand Based Drug Design)
  • Feature Paper
  • Article
  • Open Access
15 Citations
4,558 Views
14 Pages

12 August 2019

Silicated hydroxyapatite powders enriched with small amounts of manganese (Mn2+) cations were synthesized via two different methods: precipitation in aqueous solution and the solid-state method. The source of Mn2+ ions was manganese acetate, while si...

(This article belongs to the Special Issue Novel Biomaterials for Orthopaedic/Musculoskeletal Tissue Engineering)
  • Article
  • Open Access
4 Citations
3,726 Views
20 Pages

Exploring the Effects of Cramped-Impact-Type Mechanical Action on Active Pharmaceutical Ingredient (Levofloxacin)—Prospects for Pharmaceutical Applications

  • Elena Uspenskaya,
  • Anastasia Simutina,
  • Ekaterina Kuzmina,
  • Vasilisa Sukhanova and ,
  • Timur Garaev,
  • Tatiana Pleteneva,
  • Alena Koldina,
  • Ekaterina Kolyabina,
  • Gleb Petrov and
  • Anton Syroeshkin
  • + 5 authors+ 0 author

9 June 2023

Mechanochemistry is one of the ten great discoveries of green chemistry methods for synthesizing new substances. A drug substance from the fluoroquinolone group was exposed to high-intensity mechanical impacts using a laboratory knife mill for 21 min...

(This article belongs to the Special Issue Particle Technologies)