Special Issue "Novel Biomaterials for Orthopaedic/Musculoskeletal Tissue Engineering"

A special issue of Materials (ISSN 1996-1944). This special issue belongs to the section "Biomaterials".

Deadline for manuscript submissions: 31 January 2020.

Special Issue Editor

Guest Editor
Dr. Joanna Kolmas Website E-Mail
Department of Analytical Chemistry and Biomaterials, Analytical GroupFaculty of Pharmacy and Laboratory Medicine Division, Medical University of Warsaw
Interests: bone and dental biomaterials, bioceramics, calcium phosphates, physicochemical methods, spectroscopy, materials characterization

Special Issue Information

Dear Colleagues,

Bone tissue engineering, developed as an alternative to autografts and allografts, represents one of the most investigated biomedical areas. Numerous biomaterials based on synthetic and natural polymers, bioceramics, and metals have been investigated in order to replace and repair the damaged native tissues. Recent advances are also focused on 3D porous scaffold templates providing structural support for bone cells. Moreover, the addition of various growth factors, cytokines, or selected drugs (i.e., antiresorptive, anticancer, or antimicrobial drugs) may significantly improve the bone healing process.

This Special Issue focuses on the new developments in biomaterials for orthopaedic/musculoskeletal tissue engineering. Particularly, it will cover a selection of recent research topics and review articles in the field of synthesis, the physicochemical properties of new biomaterials and their composites, as well as cell-biomaterial interactions. Biomaterials for growth factors and drug delivery are also of interest.

Dr. Joanna Kolmas
Guest Editor

Manuscript Submission Information

Manuscripts should be submitted online at www.mdpi.com by registering and logging in to this website. Once you are registered, click here to go to the submission form. Manuscripts can be submitted until the deadline. All papers will be peer-reviewed. Accepted papers will be published continuously in the journal (as soon as accepted) and will be listed together on the special issue website. Research articles, review articles as well as short communications are invited. For planned papers, a title and short abstract (about 100 words) can be sent to the Editorial Office for announcement on this website.

Submitted manuscripts should not have been published previously, nor be under consideration for publication elsewhere (except conference proceedings papers). All manuscripts are thoroughly refereed through a single-blind peer-review process. A guide for authors and other relevant information for submission of manuscripts is available on the Instructions for Authors page. Materials is an international peer-reviewed open access semimonthly journal published by MDPI.

Please visit the Instructions for Authors page before submitting a manuscript. The Article Processing Charge (APC) for publication in this open access journal is 1800 CHF (Swiss Francs). Submitted papers should be well formatted and use good English. Authors may use MDPI's English editing service prior to publication or during author revisions.

Keywords

  • Biomaterials
  • Orthopaedic/musculoskeletal tissue engineering
  • Biomaterial–cell interaction
  • Physicochemical properties
  • Composites
  • Scaffolds
  • Tissue regeneration
  • Multifunctional biomaterials.

Published Papers (2 papers)

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Research

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Open AccessFeature PaperArticle
Dual Doping of Silicon and Manganese in Hydroxyapatites: Physicochemical Properties and Preliminary Biological Studies
Materials 2019, 12(16), 2566; https://doi.org/10.3390/ma12162566 - 12 Aug 2019
Abstract
Silicated hydroxyapatite powders enriched with small amounts of manganese (Mn2+) cations were synthesized via two different methods: precipitation in aqueous solution and the solid-state method. The source of Mn2+ ions was manganese acetate, while silicon was incorporated using two different [...] Read more.
Silicated hydroxyapatite powders enriched with small amounts of manganese (Mn2+) cations were synthesized via two different methods: precipitation in aqueous solution and the solid-state method. The source of Mn2+ ions was manganese acetate, while silicon was incorporated using two different reagents: silicon acetate and sodium metasilicate. Powder X-ray diffraction (PXRD) analysis showed that the powders obtained via the precipitation method consisted of single-phase nanocrystalline hydroxyapatite. In contrast, samples obtained via the solid-state method were heterogenous and contaminated with other phases, (i.e., calcium oxide, calcium hydroxide, and silicocarnotite) arising during thermal treatment. The transmission electron microscope (TEM) images showed powders obtained via the precipitation method were nanosized and elongated, while solid-state synthesis produced spherical microcrystals. The phase identification was complemented by Fourier transform infrared spectroscopy (FTIR). An in-depth analysis via solid-state nuclear magnetic resonance (ssNMR) was carried out, using phosphorus 31P single-pulse Bloch decay (BD) (31P BD) and cross-polarization (CP) experiments from protons to silicon-29 nuclei (1H → 29Si CP). The elemental measurements carried out using wavelength-dispersive X-ray fluorescence (WD-XRF) showed that the efficiency of introducing manganese and silicon ions was between 45% and 95%, depending on the synthesis method and the reagents. Preliminary biological tests on the bacteria Allivibrio fisheri (Microtox®) and the protozoan Spirostomum ambiguum (Spirotox) showed no toxic effect in any of the samples. The obtained materials may find potential application in regenerative medicine, bone implantology, and orthopedics as bone substitutes or implant coatings. Full article
(This article belongs to the Special Issue Novel Biomaterials for Orthopaedic/Musculoskeletal Tissue Engineering)
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Review

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Open AccessReview
Hydroxyapatite and Fluorapatite in Conservative Dentistry and Oral Implantology—A Review
Materials 2019, 12(17), 2683; https://doi.org/10.3390/ma12172683 - 22 Aug 2019
Abstract
Calcium phosphate, due to its similarity to the inorganic fraction of mineralized tissues, has played a key role in many areas of medicine, in particular, regenerative medicine and orthopedics. It has also found application in conservative dentistry and dental surgery, in particular, as [...] Read more.
Calcium phosphate, due to its similarity to the inorganic fraction of mineralized tissues, has played a key role in many areas of medicine, in particular, regenerative medicine and orthopedics. It has also found application in conservative dentistry and dental surgery, in particular, as components of toothpaste and mouth rinse, coatings of dental implants, cements, and bone substitute materials for the restoration of cavities in maxillofacial surgery. In dental applications, the most important role is played by hydroxyapatite and fluorapatite, i.e., calcium phosphates characterized by the highest chemical stability and very low solubility. This paper presents the role of both apatites in dentistry and a review of recent achievements in the field of the application of these materials. Full article
(This article belongs to the Special Issue Novel Biomaterials for Orthopaedic/Musculoskeletal Tissue Engineering)
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