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19 Results Found

  • Article
  • Open Access
2 Citations
3,245 Views
11 Pages

M860, a Monoclonal Antibody against Human Lactoferrin, Enhances Tumoricidal Activity of Low Dosage Lactoferrin via Granzyme B Induction

  • Ya Li,
  • Jie Li,
  • Zheng Gong,
  • Xiao-Hua Pan,
  • Zi-Han Ma,
  • Shu-Yan Ma,
  • Hong-Min Wang,
  • Hong-Liang Dong,
  • Fang-Yuan Gong and
  • Xiao-Ming Gao

9 October 2019

Lactoferrin (LF) is a soluble glycoprotein of the transferring family found in most biological fluids, functioning as a major first line defense molecule against infection in mammals. It also shows certain anti-tumor activity, but its clinical applic...

  • Communication
  • Open Access
5 Citations
2,554 Views
8 Pages

Influence of Deliverable Form of Dietary Vitamin D3 on the Immune Response in Late-Lactating Dairy Goats

  • Adela Mora-Gutierrez,
  • Maryuri T. Núñez de González,
  • Selamawit Woldesenbet,
  • Rahmat Attaie and
  • Yoonsung Jung

22 May 2024

Mastitis-causing bacteria can establish persistent infections in the mammary glands of commercially important dairy animals despite the presence of strong specific humoral and cellular immune mechanisms. We investigated the effect of vitamin D3 in th...

  • Review
  • Open Access
44 Citations
9,033 Views
30 Pages

Time to Kill and Time to Heal: The Multifaceted Role of Lactoferrin and Lactoferricin in Host Defense

  • Anna Ohradanova-Repic,
  • Romana Praženicová,
  • Laura Gebetsberger,
  • Tetiana Moskalets,
  • Rostislav Skrabana,
  • Ondrej Cehlar,
  • Gabor Tajti,
  • Hannes Stockinger and
  • Vladimir Leksa

Lactoferrin is an iron-binding glycoprotein present in most human exocrine fluids, particularly breast milk. Lactoferrin is also released from neutrophil granules, and its concentration increases rapidly at the site of inflammation. Immune cells of b...

  • Review
  • Open Access
40 Citations
5,992 Views
16 Pages

Nutraceuticals in Viral Infections: An Overview of the Immunomodulating Properties

  • Giorgio Costagliola,
  • Giulia Nuzzi,
  • Erika Spada,
  • Pasquale Comberiati,
  • Elvira Verduci and
  • Diego G. Peroni

14 July 2021

Nutraceuticals, including vitamin D, vitamin A, zinc, lactoferrin, polyphenols coenzyme Q, magnesium, and selenium, are implicated in the modulation of the complex molecular pathways involved in the immune response against viral pathogens. A common e...

  • Review
  • Open Access
59 Citations
14,268 Views
15 Pages

8 January 2010

Lactoferrin (Lf), an iron-binding glycoprotein expressed in most biological fluids, represents a major component of the mammalian innate immune system. Lf’s multiple activities rely not only on its capacity to bind iron, but also to interact with mol...

  • Review
  • Open Access
141 Citations
17,494 Views
22 Pages

Benefits of Lactoferrin, Osteopontin and Milk Fat Globule Membranes for Infants

  • Hans Demmelmair,
  • Christine Prell,
  • Niklas Timby and
  • Bo Lönnerdal

28 July 2017

The provision of essential and non-essential amino acids for breast-fed infants is the major function of milk proteins. In addition, breast-fed infants might benefit from bioactivities of milk proteins, which are exhibited in the intestine during the...

  • Article
  • Open Access
3 Citations
3,331 Views
16 Pages

Host Defense Peptides LL-37 and Lactoferrin Trigger ET Release from Blood-Derived Circulating Monocytes

  • Frederic V. Schwäbe,
  • Lotta Happonen,
  • Sofie Ekestubbe and
  • Ariane Neumann

Neutrophils are commonly regarded as the first line of immune response during infection or in tissue injury-induced inflammation. The rapid influx of these cells results in the release of host defense proteins (HDPs) or formation of neutrophil extrac...

  • Review
  • Open Access
39 Citations
9,591 Views
28 Pages

Antimicrobial Properties of Colostrum and Milk

  • Furkan Eker,
  • Emir Akdaşçi,
  • Hatice Duman,
  • Yalçın Mert Yalçıntaş,
  • Ahmet Alperen Canbolat,
  • Arda Erkan Kalkan,
  • Sercan Karav and
  • Dunja Šamec

The growing number of antibiotic resistance genes is putting a strain on the ecosystem and harming human health. In addition, consumers have developed a cautious attitude towards chemical preservatives. Colostrum and milk are excellent sources of ant...

  • Review
  • Open Access
47 Citations
7,466 Views
21 Pages

Viral Hepatitis and Iron Dysregulation: Molecular Pathways and the Role of Lactoferrin

  • Romina Mancinelli,
  • Luigi Rosa,
  • Antimo Cutone,
  • Maria Stefania Lepanto,
  • Antonio Franchitto,
  • Paolo Onori,
  • Eugenio Gaudio and
  • Piera Valenti

24 April 2020

The liver is a frontline immune site specifically designed to check and detect potential pathogens from the bloodstream to maintain a general state of immune hyporesponsiveness. One of the main functions of the liver is the regulation of iron homeost...

  • Article
  • Open Access
3 Citations
2,745 Views
15 Pages

27 November 2024

Background/Objectives: Lactoferrin (Lf) is an iron-binding glycoprotein with multiple bioactivities, including promotion of cell proliferation and differentiation, immunomodulation, and antimicrobial activity. Lf, a basic glycoprotein, can bind to &a...

  • Article
  • Open Access
2 Citations
3,824 Views
17 Pages

Effect of Milk Protein–Polyphenol Conjugate on the Regulation of GLP-1 Hormone

  • Huda Abdulrahim Wazzan,
  • Amanda N. Abraham,
  • Noshin Saiara,
  • Sushil Anand,
  • Harsharn Gill and
  • Ravi Shukla

19 June 2024

Modern functional foods are designed to provide health benefits beyond basic nutrition. They are enriched with bioactive ingredients like probiotics, vitamins, minerals, and antioxidants. These foods support overall health, enhance immune function, a...

  • Review
  • Open Access
1 Citations
2,206 Views
21 Pages

Selected Protective Mechanisms of Human Milk Against Intestinal Protozoal Infections in Infants

  • Joanna Wróblewska,
  • Anna Długosz,
  • Marcin Wróblewski,
  • Jarosław Nuszkiewicz,
  • Paweł Sutkowy and
  • Alina Woźniak

Human milk, especially colostrum, is a biologically complex fluid with potent protective properties against gastrointestinal disturbances in infants. Among intestinal protozoa transmitted via the fecal–oral route, this review focuses on Giardia...

  • Review
  • Open Access
40 Citations
12,669 Views
29 Pages

17 December 2021

Women’s intimate health depends on several factors, such as age, diet, coexisting metabolic disorders, hormonal equilibrium, sexual activity, drug intake, contraception, surgery, and personal hygiene. These factors may affect the homeostasis of...

  • Review
  • Open Access
22 Citations
5,382 Views
27 Pages

Extracellular Vesicles from Animal Milk: Great Potentialities and Critical Issues

  • Samanta Mecocci,
  • Massimo Trabalza-Marinucci and
  • Katia Cappelli

22 November 2022

Other than representing the main source of nutrition for newborn mammals, milk delivers a sophisticated signaling system from mother to child that promotes postnatal health. The bioactive components transferred through the milk intake are important f...

  • Article
  • Open Access
6 Citations
2,805 Views
12 Pages

Enzyme-Linked Aptamer Kits for Rapid, Visual, and Sensitive Determination of Lactoferrin in Dairy Products

  • Fan Zhang,
  • Hongxia Du,
  • Linsen Li,
  • Tengfei Li,
  • Jing Wang,
  • Zilei Chen,
  • Mengmeng Yan,
  • Chao Zhu and
  • Feng Qu

22 November 2022

Lactoferrin (Lf), as a popular nutritional fortification in dairy products, has the ability regulate the body’s immune system and function as a broad-spectrum antibacterial, which is of great significance to the growth and development of infant...

  • Article
  • Open Access
9 Citations
3,950 Views
24 Pages

An In-Silico Investigation to Design a Multi-Epitopes Vaccine against Multi-Drug Resistant Hafnia alvei

  • Fahad M. Alshabrmi,
  • Faris Alrumaihi,
  • Sahar Falah Alrasheedi,
  • Wafa Abdullah I. Al-Megrin,
  • Ahmad Almatroudi and
  • Khaled S. Allemailem

15 July 2022

Antimicrobial resistance has become a significant health issue because of the misuse of antibiotics in our daily lives, resulting in high rates of morbidity and mortality. Hafnia alvei is a rod-shaped, Gram-negative and facultative anaerobic bacteria...

  • Systematic Review
  • Open Access
8 Citations
4,655 Views
19 Pages

The Clinical Utility of Soluble Serum Biomarkers in Autoimmune Pancreatitis: A Systematic Review

  • Ana Dugic,
  • Cristina Verdejo Gil,
  • Claudia Mellenthin,
  • Miroslav Vujasinovic,
  • J.-Matthias Löhr and
  • Steffen Mühldorfer

Autoimmune pancreatitis (AIP) is a rare etiological type of chronic pancreatitis. The clinical and radiological presentation of AIP often resembles that of pancreatic cancer. Identifying non-invasive markers for their early distinction is of utmost i...

  • Article
  • Open Access
2 Citations
2,605 Views
12 Pages

Temporal Dynamics of T Helper Populations in the Proximal Small Intestine after Oral Bovine Lactoferrin Administration in BALB/c Mice

  • Mario Ynga-Durand,
  • Gabriela Tapia-Pastrana,
  • Xóchitl Abril Rebollar-Ruíz,
  • Mariazell Yépez-Ortega,
  • Oscar Nieto-Yañez,
  • Ivonne Maciel Arciniega-Martínez and
  • Aldo Arturo Reséndiz-Albor

19 August 2021

Bovine lactoferrin (bLf), a component of milk and a dietary supplement, modulates intestinal immunity at effector and inductor sites. Considering the regional difference in intestinal compartments and the dynamics of local cytokine-producing cells in...

  • Article
  • Open Access
16 Citations
2,956 Views
20 Pages

Computational Design of a Chimeric Vaccine against Plesiomonas shigelloides Using Pan-Genome and Reverse Vaccinology

  • Mahnoor Mushtaq,
  • Saifullah Khan,
  • Muhammad Hassan,
  • Alhanouf I. Al-Harbi,
  • Alaa R. Hameed,
  • Khadeeja Khan,
  • Saba Ismail,
  • Muhammad Irfan and
  • Sajjad Ahmad

8 November 2022

The swift emergence of antibiotic resistance (AR) in bacterial pathogens to make themselves adaptable to changing environments has become an alarming health issue. To prevent AR infection, many ways can be accomplished such as by decreasing the misus...