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Toxins 2010, 2(1), 54-68;

Reciprocal Interactions between Lactoferrin and Bacterial Endotoxins and Their Role in the Regulation of the Immune Response

Department of Cell Biology and Neurosciences, Istituto Superiore di Sanità, Viale Regina Elena 299, Rome, Italy
Department of Public Health Sciences, Sapienza, University of Rome, Italy
Author to whom correspondence should be addressed.
Received: 1 December 2009 / Revised: 23 December 2009 / Accepted: 25 December 2009 / Published: 8 January 2010
(This article belongs to the Collection Toxicity and Therapeutic Interventions in the Immune System)
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Lactoferrin (Lf), an iron-binding glycoprotein expressed in most biological fluids, represents a major component of the mammalian innate immune system. Lf’s multiple activities rely not only on its capacity to bind iron, but also to interact with molecular and cellular components of both host and pathogens. Lf can bind and sequester lipopolysaccharide (LPS), thus preventing pro-inflammatory pathway activation, sepsis and tissue damage. However, Lf-bound LPS may retain the capacity to induce cell activation via Toll-like receptor 4-dependent and -independent mechanisms. This review discusses the complex interplay between Lf and LPS and its relevance in the regulation of the immune response. View Full-Text
Keywords: lactoferrin; lipopolysaccharide; inflammation; immune response lactoferrin; lipopolysaccharide; inflammation; immune response

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This is an open access article distributed under the Creative Commons Attribution License (CC BY 3.0).

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Latorre, D.; Puddu, P.; Valenti, P.; Gessani, S. Reciprocal Interactions between Lactoferrin and Bacterial Endotoxins and Their Role in the Regulation of the Immune Response. Toxins 2010, 2, 54-68.

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