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25 Results Found

  • Article
  • Open Access
4 Citations
2,601 Views
10 Pages

Linac-Based Ultrahypofractionated Partial Breast Irradiation (APBI) in Low-Risk Breast Cancer: First Results of a Monoinstitutional Observational Analysis

  • Roland Merten,
  • Mirko Fischer,
  • Gennadii Kopytsia,
  • Jörn Wichmann,
  • Tim Lange,
  • Anne Caroline Knöchelmann,
  • Jan-Niklas Becker,
  • Rüdiger Klapdor,
  • Jan Hinrichs and
  • Michael Bremer

10 February 2023

Purpose: For adjuvant radiotherapy of low-risk breast cancer after breast-conserving surgery, there have been many trials of hypofractionation and partial breast irradiation (PBI) over the years, with proven mild long-term toxicity. The aim of this s...

  • Article
  • Open Access
3 Citations
1,175 Views
13 Pages

Long-Term Results of a Prospective Multicenter Trial of APBI with Photon IORT

  • Laura García-Cabrera,
  • Beatriz Pinar-Sedeño,
  • María Auxiliadora Cabezón-Pons,
  • Nieves Rodriguez-Ibarria,
  • Alba Dominguez-Dominguez,
  • Daniel Aguiar-Santana,
  • Paula Martín-Barrientos,
  • Irene Rey-López,
  • Pedro C. Lara and
  • Marta Lloret-Saez-Bravo

23 May 2025

Purpose: The aim of the present study is to analyze, for the first time, the results of a large prospective academic multicenter trial of partial breast irradiation (PBI) with exclusive photon intraoperative radiation therapy (ph-IORT) in early breas...

  • Article
  • Open Access
4 Citations
4,997 Views
10 Pages

Proton Partial Breast Irradiation: Detailed Description of Acute Clinico-Radiologic Effects

  • Valentina Ovalle,
  • Eric A. Strom,
  • Simona Shaitelman,
  • Karen Hoffman,
  • Richard Amos,
  • George Perkins,
  • Welela Tereffe,
  • Benjamin D. Smith,
  • Michael Stauder and
  • Wendy Woodward

7 April 2018

Introduction: Accelerated partial breast irradiation (APBI) with protons results in a very different acute effect profile than standard whole breast irradiation. We reviewed our initial experience with proton APBI and felt that a detailed description...

  • Article
  • Open Access
6 Citations
2,561 Views
14 Pages

Pathologic Response to Neoadjuvant Sequential Chemoradiation Therapy in Locally Advanced Breast Cancer: Preliminary, Translational Results from the French Neo-APBI-01 Trial

  • Nhu Hanh To,
  • Isabelle Gabelle-Flandin,
  • Thi My Hanh Luong,
  • Gokoulakrichenane Loganadane,
  • Nabila Ouidir,
  • Chahrazed Boukhobza,
  • Noémie Grellier,
  • Camille Verry,
  • Allan Thiolat and
  • Yazid Belkacemi
  • + 2 authors

29 March 2023

Background: Radiation therapy (RT), a novel approach to boost the anticancer immune response, has been progressively evaluated in the neoadjuvant setting in breast cancer (BC). Purpose: We aimed to evaluate immunity-related indicators of response to...

  • Proceeding Paper
  • Open Access
22 Citations
3,061 Views
5 Pages

Towards Manufacture Stable Lead Perovskite APbI3 (A = Cs, MA, FA) Based Solar Cells with Low-Cost Techniques

  • Amal Bouich,
  • Julia Marí-Guaita,
  • Asmaa Bouich,
  • Inmaculada Guaita Pradas and
  • Bernabé Marí

12 January 2022

Herein, we examine the impact of cations on the structural, morphological, optical properties and degradation of lead perovskite APbI3 (where A = MA, FA, Cs). Its structure, surface morphology and optical properties have been investigated by X-ray di...

  • Review
  • Open Access
17 Citations
8,138 Views
19 Pages

The Role of Interstitial Brachytherapy for Breast Cancer Treatment: An Overview of Indications, Applications, and Technical Notes

  • Salvatore Cozzi,
  • Matteo Augugliaro,
  • Patrizia Ciammella,
  • Andrea Botti,
  • Valeria Trojani,
  • Masoumeh Najafi,
  • Gladys Blandino,
  • Maria Paola Ruggieri,
  • Lucia Giaccherini and
  • Lilia Bardoscia
  • + 7 authors

23 May 2022

Breast cancer represents the second leading cause of cancer-related death in the female population, despite continuing advances in treatment options that have significantly accelerated in recent years. Conservative treatments have radically changed t...

  • Review
  • Open Access
8 Citations
4,671 Views
12 Pages

Radiation in Early-Stage Breast Cancer: Moving beyond an All or Nothing Approach

  • Juhi M. Purswani,
  • Camille Hardy-Abeloos,
  • Carmen A. Perez,
  • Maryann J. Kwa,
  • Manjeet Chadha and
  • Naamit K. Gerber

23 December 2022

Radiotherapy omission is increasingly considered for selected patients with early-stage breast cancer. However, with emerging data on the safety and efficacy of radiotherapy de-escalation with partial breast irradiation and accelerated treatment regi...

  • Article
  • Open Access
6 Citations
2,826 Views
10 Pages

External Beam Accelerated Partial Breast Irradiation in Early Breast Cancer and the Risk for Radiogenic Pneumonitis

  • Oliver J. Ott,
  • Wilhelm Stillkrieg,
  • Ulrike Lambrecht,
  • Tim-Oliver Sauer,
  • Claudia Schweizer,
  • Allison Lamrani,
  • Vratislav Strnad,
  • Carolin C. Hack,
  • Matthias W. Beckmann and
  • Luitpold Distel
  • + 2 authors

20 July 2022

In order to evaluate the risk for radiation-associated symptomatic pneumonitis in a prospective external beam accelerated partial breast irradiation (APBI) trial, between 2011 and 2021, 170 patients with early stage breast cancer were enclosed in the...

  • Article
  • Open Access
5 Citations
3,167 Views
13 Pages

External-Beam-Accelerated Partial-Breast Irradiation Reduces Organ-at-Risk Doses Compared to Whole-Breast Irradiation after Breast-Conserving Surgery

  • Oliver J. Ott,
  • Wilhelm Stillkrieg,
  • Ulrike Lambrecht,
  • Claudia Schweizer,
  • Allison Lamrani,
  • Tim-Oliver Sauer,
  • Vratislav Strnad,
  • Christoph Bert,
  • Carolin C. Hack and
  • Rainer Fietkau
  • + 1 author

9 June 2023

In order to evaluate organ-at-risk (OAR) doses in external-beam-accelerated partial-breast irradiation (APBI) compared to standard whole-breast irradiation (WBI) after breast-conserving surgery. Between 2011 and 2021, 170 patients with early breast c...

  • Review
  • Open Access
17 Citations
9,520 Views
13 Pages

Different Re-Irradiation Techniques after Breast-Conserving Surgery for Recurrent or New Primary Breast Cancer

  • Camille Hardy Abeloos,
  • Juhi M. Purswani,
  • Paulina Galavis,
  • Allison McCarthy,
  • Christine Hitchen,
  • J. Isabelle Choi and
  • Naamit K. Gerber

13 January 2023

Breast re-irradiation (reRT) after breast-conserving surgery (BCS) using external beam radiation is an increasingly used salvage approach for women presenting with recurrent or new primary breast cancer. However, radiation technique, dose and fractio...

  • Article
  • Open Access
2 Citations
2,832 Views
14 Pages

4 November 2022

Higher power conversion efficiencies for photovoltaic devices can be achieved through simple and low production cost processing of APbI3(A=CH3NH3,CHN2H4,…) perovskites. Due to their limited long-term stability, however, there is an urgent need...

  • Review
  • Open Access
3 Citations
3,033 Views
17 Pages

Special Techniques of Adjuvant Breast Carcinoma Radiotherapy

  • Iveta Kolářová,
  • Bohuslav Melichar,
  • Jaroslav Vaňásek,
  • Igor Sirák,
  • Jiří Petera,
  • Kateřina Horáčková,
  • Denisa Pohanková,
  • Zuzana Šinkorová,
  • Oldřich Hošek and
  • Milan Vošmik

31 December 2022

Modern radiotherapy techniques are designed to permit reduced irradiation of healthy tissue, resulting in a diminished risk of adverse effects and shortened recovery times. Several randomized studies have demonstrated the benefits of increased dosage...

  • Article
  • Open Access
39 Citations
6,079 Views
12 Pages

5 March 2020

In the current work, a series of black polyimide (PI) films with excellent thermal and dimensional stability at elevated temperatures were successfully developed. For this purpose, two aromatic diamines including 4,4′-iminodianline (NDA) and 2-...

  • Article
  • Open Access
1 Citations
1,969 Views
10 Pages

Ten-Year Results of Accelerated Partial-Breast Irradiation with Interstitial Multicatheter Brachytherapy after Breast-Conserving Surgery for Low-Risk Early Breast Cancer

  • Nieves G. Rodríguez-Ibarria,
  • Beatriz Pinar,
  • Laura García,
  • Auxiliadora Cabezón,
  • Dolores Rey-Baltar,
  • Juan Ignacio Rodríguez-Melcón,
  • Marta Lloret and
  • Pedro C. Lara

13 March 2024

Patients with an early carcinoma of the breast are commonly treated by breast-conserving surgery (BCS) and postoperative radiotherapy. Partial-breast irradiation has gained acceptance in the last few years. Between December 2008 and December 2017, 18...

  • Article
  • Open Access
7 Citations
5,432 Views
9 Pages

24 November 2019

The crystal structures of three new hybrid organic-inorganic lead halide compounds [IqH]PbI3, [4MiH]PbI3, and [BzH]PbI3 ([IqH+] = isoquinolinium, [4MiH+] = 4-methylimidazolium, [BzH+] = benzotriazolium) have been determined by single crystal x-ray di...

  • Article
  • Open Access
11 Citations
4,288 Views
13 Pages

Psychrotrophic bacteria, commonly called spoilage bacteria, can produce highly toxic hydrogen sulfide (H2S) in meat products. Thus, monitoring the presence of hydrogen sulfide in meat samples is crucial for food safety and storage. Here, we report a...

  • Article
  • Open Access
15 Citations
2,883 Views
13 Pages

Cell-In-Cell Structures in Early Breast Cancer Are Prognostically Valuable

  • Mareike F. Bauer,
  • Laura S. Hildebrand,
  • Marie-Charlotte Rosahl,
  • Ramona Erber,
  • Sören Schnellhardt,
  • Maike Büttner-Herold,
  • Florian Putz,
  • Oliver J. Ott,
  • Carolin C. Hack and
  • Luitpold Distel
  • + 1 author

24 December 2022

Cell-in-cell (CIC) structures in breast cancer have so far been studied in a small inhomogeneous patient population, suggesting the prognostic importance of CIC. In the present study, we focused on CIC in early hormone-sensitive breast cancer. With i...

  • Article
  • Open Access
1 Citations
490 Views
30 Pages

14 November 2025

Hybrid halide perovskites are promising materials for optoelectronics and space applications due to their excellent light absorption, high efficiency, and light weight. However, their stability under radiation exposure remains a key challenge, especi...

  • Article
  • Open Access
1 Citations
1,221 Views
23 Pages

Prognostic Significance of Macrophage Phenotypes in Peri-Tumoral Normal Tissue of Early-Stage Breast Cancer

  • Marcel Hirschmann,
  • Sören Schnellhardt,
  • Matthias Rübner,
  • Sarah Segelhorst,
  • Oliver Ott,
  • Ramona Erber,
  • Christoph Daniel,
  • Maike Büttner-Herold,
  • Paul Gass and
  • Luitpold Distel
  • + 1 author

3 June 2025

In recent years, tumor-infiltrating inflammatory cells within the tumor microenvironment have been extensively studied. However, much less is known about inflammatory cells in the normal tissue surrounding tumors. In this study, we assess the prognos...

  • Article
  • Open Access
9 Citations
4,122 Views
11 Pages

1 June 2019

Protection of intrinsically brittle quartz chromatographic columns (CCs) from breakage or property deterioration in gas chromatography (GC) analysis has become an important research topic regarding high-temperature GC techniques. Polyimide (PI) has p...

  • Article
  • Open Access
16 Citations
4,132 Views
14 Pages

Accelerated Partial Breast Irradiation: Macrophage Polarisation Shift Classification Identifies High-Risk Tumours in Early Hormone Receptor-Positive Breast Cancer

  • Sören Schnellhardt,
  • Ramona Erber,
  • Maike Büttner-Herold,
  • Marie-Charlotte Rosahl,
  • Oliver J. Ott,
  • Vratislav Strnad,
  • Matthias W. Beckmann,
  • Lillian King,
  • Arndt Hartmann and
  • Luitpold Distel
  • + 1 author

14 February 2020

Studies have demonstrated correlations between accumulations of tumour-associated macrophages (TAMs), especially of M2-like phenotype, and increased mortality in advanced breast cancer. We investigated the prognostic potential of both main macrophage...

  • Article
  • Open Access
18 Citations
3,227 Views
17 Pages

Tumour-Infiltrating Inflammatory Cells in Early Breast Cancer: An Underrated Prognostic and Predictive Factor?

  • Sören Schnellhardt,
  • Ramona Erber,
  • Maike Büttner-Herold,
  • Marie-Charlotte Rosahl,
  • Oliver J. Ott,
  • Vratislav Strnad,
  • Matthias W. Beckmann,
  • Lillian King,
  • Arndt Hartmann and
  • Luitpold Distel
  • + 1 author

3 November 2020

The role of tumour-infiltrating inflammatory cells (TIICs) in the disease progression of hormone-receptor-positive breast cancer (HR+ BC) is largely unclear since it is generally regarded as the least immunogenic BC subtype. This study investigated t...

  • Article
  • Open Access
6 Citations
2,925 Views
18 Pages

Redox Chemistry of the Subphases of α-CsPbI2Br and β-CsPbI2Br: Theory Reveals New Potential for Photostability

  • Lavrenty Gennady Gutsev,
  • Sean Nations,
  • Bala Ramu Ramachandran,
  • Gennady Lavrenty Gutsev,
  • Shengnian Wang,
  • Sergei Aldoshin and
  • Yuhua Duan

9 January 2023

The logic in the design of a halide-mixed APb(I1−xBrx)3 perovskite is quite straightforward: to combine the superior photovoltaic qualities of iodine-based perovskites with the increased stability of bromine-based perovskites. However, even sma...

  • Article
  • Open Access
29 Citations
3,728 Views
19 Pages

Investigation of the Surface Coating, Humidity Degradation, and Recovery of Perovskite Film Phase for Solar-Cell Applications

  • Amal Bouich,
  • Julia Marí-Guaita,
  • Faisal Baig,
  • Yousaf Hameed Khattak,
  • Bernabé Marí Soucase and
  • Pablo Palacios

31 August 2022

Presently, we inquire about the organic/inorganic cation effect on different properties based on structure, morphology, and steadiness in preparing a one-step solution of APbI3 thin films, where A = MA, FA, Cs, using spin coating. This study was cond...

  • Article
  • Open Access
10 Citations
2,239 Views
17 Pages

Tumor-Associated Neutrophils Are a Negative Prognostic Factor in Early Luminal Breast Cancers Lacking Immunosuppressive Macrophage Recruitment

  • Eva Schmidt,
  • Luitpold Distel,
  • Ramona Erber,
  • Maike Büttner-Herold,
  • Marie-Charlotte Rosahl,
  • Oliver J. Ott,
  • Vratislav Strnad,
  • Carolin C. Hack,
  • Arndt Hartmann and
  • Sören Schnellhardt
  • + 2 authors

15 September 2024

Background: Tumor-associated neutrophils (TANs) are important modulators of the tumor microenvironment with opposing functions that can promote and inhibit tumor progression. The prognostic role of TANs in early luminal breast cancer is unclear. Meth...