Linac-Based Ultrahypofractionated Partial Breast Irradiation (APBI) in Low-Risk Breast Cancer: First Results of a Monoinstitutional Observational Analysis
Abstract
:Simple Summary
Abstract
1. Introduction
2. Materials and Methods
3. Results
3.1. Quantitative Dose-Volume Analysis of PTV
3.2. Organs at Risk
3.3. Analysis of Acute Clinical Toxicity
4. Discussion
5. Conclusions
Supplementary Materials
Author Contributions
Funding
Institutional Review Board Statement
Informed Consent Statement
Data Availability Statement
Conflicts of Interest
References
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T-Stage | ||||
T i.s. n = 8 | T1 n = 43 | T2 n = 10 | T3 n = 0 | T4 n = 0 |
Location quadrant of the breast | ||||
Upper outer quadrant n = 34 | Upper inner quadrant n = 14 | Lower outer quadrant n = 5 | Lower inner quadrant n = 5 | Central n = 3 |
All | 3D-Planned | VMAT | ||
---|---|---|---|---|
Lung ipsilateral | V5Gy | 7.5% | 5.2% | 7.9% |
V10Gy | 1.8% | 1.5% | 1.8% | |
V15Gy | 0.6% | 0.7% | 0.6% | |
V20Gy | 0.2% | 0.4% | 0.1% | |
Breast contralateral | Dmean | 0.32 Gy | 0.11 Gy | 0.36 Gy |
D2% | 1.06 Gy | 0.29 Gy | 1.19 Gy |
Right Breast Irradiated | Left Breast Irradiated | |
---|---|---|
3D planning (n = 8) | 0.13 (0.07–0.19) | 0.44 (0.21–0.65) |
VMAT planning (n = 53) | 0.57 (0.14–1.65) | 0.67 (0.15–2.1) |
All | 0.51 (0.07–1.65) | 0.63 (0.07–2.1) |
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Merten, R.; Fischer, M.; Kopytsia, G.; Wichmann, J.; Lange, T.; Knöchelmann, A.C.; Becker, J.-N.; Klapdor, R.; Hinrichs, J.; Bremer, M. Linac-Based Ultrahypofractionated Partial Breast Irradiation (APBI) in Low-Risk Breast Cancer: First Results of a Monoinstitutional Observational Analysis. Cancers 2023, 15, 1138. https://doi.org/10.3390/cancers15041138
Merten R, Fischer M, Kopytsia G, Wichmann J, Lange T, Knöchelmann AC, Becker J-N, Klapdor R, Hinrichs J, Bremer M. Linac-Based Ultrahypofractionated Partial Breast Irradiation (APBI) in Low-Risk Breast Cancer: First Results of a Monoinstitutional Observational Analysis. Cancers. 2023; 15(4):1138. https://doi.org/10.3390/cancers15041138
Chicago/Turabian StyleMerten, Roland, Mirko Fischer, Gennadii Kopytsia, Jörn Wichmann, Tim Lange, Anne Caroline Knöchelmann, Jan-Niklas Becker, Rüdiger Klapdor, Jan Hinrichs, and Michael Bremer. 2023. "Linac-Based Ultrahypofractionated Partial Breast Irradiation (APBI) in Low-Risk Breast Cancer: First Results of a Monoinstitutional Observational Analysis" Cancers 15, no. 4: 1138. https://doi.org/10.3390/cancers15041138