Special Issues

Pharmaceuticals publishes Special Issues to create collections of papers on specific topics, with the aim of building a community of authors and readers to discuss the latest research and develop new ideas and research directions. Special Issues are led by Guest Editors, who are experts on the topic and all Special Issue submissions follow MDPI's standard editorial process. The journal’s Editor-in-Chief and/or designated Editorial Board Member will oversee Guest Editor appointments and Special Issue proposals, checking their content for relevance and ensuring the suitability of the material for the journal. The papers published in a Special Issue will be collected and displayed on a dedicated page of the journal’s website. Further information on MDPI's Special Issue policies and Guest Editor responsibilities can be found here. For any inquiries related to a Special Issue, please contact the Editorial Office.

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Medicinal Chemistry of Thiazine and Oxazine Derivatives: Trends and Future Directions as Therapeutic Drugs submission deadline 10 Sep 2026 | 1 articles | Viewed by 2976 | Submission Open
Keywords: thiazine; oxazine; morpholine; thiomorpholine; benzothiazine; phenothiazine; synthesis; drug; anti-inflammatory; anticancer
(This special issue belongs to the Section Medicinal Chemistry)
Pharmacogenomics and Pediatric Pharmacotherapy submission deadline 10 Sep 2026 | 1 articles | Viewed by 1190 | Submission Open
Keywords: pharmacokinetics; pediatric formulations; pharmacodynamics; drug metabolism; pharmacogenetics; drug transport; ontogeny developmental pattern; modeling; drug safety; simulation; off-label drug use
(This special issue belongs to the Section Pharmacology)
Biomarkers in the Treatment of Cardiovascular Diseases
edited by
submission deadline 10 Sep 2026 | Viewed by 352 | Submission Open
Keywords: biomarkers; precision medicine; pharmacogenomics; heart failure phenotyping; molecular cardiology
(This special issue belongs to the Section Medicinal Chemistry)
Pharmaceutical Formulation Characterization Design, 2nd Edition submission deadline 15 Sep 2026 | 3 articles | Viewed by 3280 | Submission Open
Keywords: Quality by Design; factorial design; design space; solid dosage forms; risk assessment; critical process parameters; quality target product profile
(This special issue belongs to the Section Pharmaceutical Technology)
Structural Insights into Protein Kinases-Targeted Therapies: Overcoming Resistance and Advancing Precision Oncology
edited by David Hecht
submission deadline 20 Sep 2026 | 4 articles | Viewed by 7583 | Submission Open
Keywords: protein kinases inhibitor resistance; structural biology of of protein kinases; computational modeling; drug design; preclinical and clinical studies; precision oncology; ALK resistance for personalized medicine
(This special issue belongs to the Section Medicinal Chemistry)
Natural Antioxidants from Medicinal Plants: Extraction and Bioactivity submission deadline 20 Sep 2026 | 2 articles | Viewed by 2132 | Submission Open
Keywords: natural antioxidants; medicinal plants; extraction methods; bioactivity; phenolic compounds; free radical scavenging; pharmacological potential; in silico and in vitro correlation; molecular modeling
(This special issue belongs to the Section Natural Products)
Computation-Driven Discovery of Modern Small-Molecule Therapeutics: From Enzyme Inhibition to Targeted Protein Degradation submission deadline 20 Sep 2026 | 1 articles | Viewed by 891 | Submission Open
Keywords: computer-aided drug design; small-molecule drugs; enzyme inhibition; PROTACs; molecular docking; molecular dynamics simulation; artificial intelligence in drug design; virtual screening
(This special issue belongs to the Section AI in Drug Development)
Multiomics Perspective in Pharmacogenomics
edited by
submission deadline 20 Sep 2026 | Viewed by 348 | Submission Open
Keywords: clinical pharmacogenomics; epigenomics in pharmacogenomics; transcriptomics in pharmacogenomics; proteomics and metabolomics in pharmacogenomics; microbiome in pharmacogenomics; multiomics in pharmacogenomics; AI and computational tools in pharmacogenomics; genome profiling in pharmacogenomics; metadata in pharmacogenomics
(This special issue belongs to the Section Pharmacology)
Medicinal Plants: Exploring Plant-Based Bioactive Compounds for Cancer and Metabolic Diseases Prevention and Intervention submission deadline 25 Sep 2026 | 9 articles | Viewed by 26934 | Submission Open
Keywords: cancer; metastasis; tumor growth; tumor spread; bioactive compounds; phytochemicals; medicinal plants; phytochemistry; cancer prevention; cancer intervention; metabolic diseases; metabolism; diabetes; MAFLD; dyslipidemia
(This special issue belongs to the Section Natural Products)
Advances in Prostate Cancer Therapeutics
edited by
submission deadline 25 Sep 2026 | 5 articles | Viewed by 15631 | Submission Open
Keywords: prostate cancer; androgen deprivation therapy (ADT); castration-resistant prostate cancer (CRPC); androgen receptor signaling inhibitors; PARP inhibitors; ionizing radiation therapy; radiopharmaceuticals; immunotherapy; biomarkers; personalized medicine; therapeutic resistance; targeted therapy; combination therapy; hormone-sensitive prostate cancer (HSPC); next-generation therapeutics; translational oncology
(This special issue belongs to the Section Pharmacology)
Heterocyclic Compounds in Medicinal Chemistry, 2nd Edition submission deadline 25 Sep 2026 | 5 articles | Viewed by 14668 | Submission Open
Keywords: heterocycles; drug design; drug discovery; bioactive compounds; structure-based drug design; structure–activity relationship; in silico studies; ADMET properties; multicomponent reactions; phytochemicals
(This special issue belongs to the Section Medicinal Chemistry)
Advances in Topical and Mucosal Drug Delivery Systems submission deadline 25 Sep 2026 | 5 articles | Viewed by 11624 | Submission Open
Keywords: topical drug delivery; mucosal drug delivery; transdermal drug delivery; controlled release; bioavailability enhancement; formulation development
(This special issue belongs to the Section Pharmaceutical Technology)
Cutting-Edge Biotechnologies and Applications of Natural Products in Drug R&D and Disease Treatment
edited by
submission deadline 25 Sep 2026 | 4 articles | Viewed by 10982 | Submission Open
Keywords: natural products; bioactive compounds; natural product drug discovery and drug design; natural drug formulation; metabolic engineering for bioactive compounds; natural therapeutic agents; nanoformulations of natural compounds; synthetic biology for natural product biosynthesis; genome editing and creation of novel bioactive compounds
(This special issue belongs to the Section Natural Products)
Natural Products with Anticancer Activity
edited by
submission deadline 25 Sep 2026 | 5 articles | Viewed by 10000 | Submission Open
Keywords: natural products; extracts; anticancer activities; phytochemicals; molecular mechanisms
(This special issue belongs to the Section Medicinal Chemistry)
Natural Products and Bioactive Compounds for the Prevention and Treatment of Non-Communicable Chronic Diseases
edited by
submission deadline 25 Sep 2026 | 4 articles | Viewed by 4997 | Submission Open
Keywords: natural products; phytochemicals; chronic diseases; functional foods; herbal medicine; non-communicable diseases; ethnopharmacology; bioactivity
(This special issue belongs to the Section Natural Products)
Targeting Enzymes in Drug Design and Discovery
edited by
submission deadline 25 Sep 2026 | 3 articles | Viewed by 4140 | Submission Open
Keywords: drug design; computer-aided drug design (CADD); molecular docking; molecular dynamics; QSAR; druggable proteins; synthesis; in vitro and in vivo activity evaluations; ADMET predictions and evaluations
(This special issue belongs to the Section Biopharmaceuticals)
Drug Therapy for Autoimmune and Inflammatory Skin Conditions
edited by Sumatha Channapatna Suresh and Galina Marder
submission deadline 25 Sep 2026 | 2 articles | Viewed by 3815 | Submission Open
Keywords: autoimmune skin disease; psoriasis; immunotherapy; cutaneous lupus; dermatitis; biologic therapies; dermatomyositis; translational therapeutics
(This special issue belongs to the Section Pharmacology)
Advances in the Medicinal Synthesis of Bioactive Compounds submission deadline 25 Sep 2026 | 2 articles | Viewed by 2855 | Submission Open
Keywords: medicinal chemistry; bioactive compounds; synthetic methodologies; structure–activity relationship (SAR); drug discovery; pharmacokinetics; therapeutic agents; green chemistry; computational modeling; interdisciplinary research
(This special issue belongs to the Section Medicinal Chemistry)
Therapies for Autoimmune Diseases submission deadline 25 Sep 2026 | Viewed by 2851 | Submission Open
Keywords: autoimmune diseases; immunotherapy; immunomodulation; biologic therapies; small molecule drugs; therapeutic vaccines; tolerogenic strategies; monoclonal antibodies; personalized medicine; targeted drug delivery
(This special issue belongs to the Section Medicinal Chemistry)
Biological Properties of Nanostructures Incorporated in Polymeric Matrices submission deadline 25 Sep 2026 | 2 articles | Viewed by 2574 | Submission Open
Keywords: antimicrobial resistance; cancer; diseases; nanotechnology; polimer
(This special issue belongs to the Section Pharmaceutical Technology)
Novel Anti-Obesity Pharmacotherapies submission deadline 25 Sep 2026 | 1 articles | Viewed by 2455 | Submission Open
Keywords: obesity; anti-obesity pharmacotherapy; weight management; combination therapy; incretin-based polyagonists; amylin analogs; melanocortin receptor modulators; fibroblast growth factor mimetics; mitochondrial uncoupler; clinical efficacy; obesity-induced diseases
(This special issue belongs to the Section Pharmacology)
Drug Delivery Strategies for Brain Targeting and Drug Repurposing: Exploring Alternative Routes and Novel Pharmacological Targets
edited by Paraskevi Papakyriakopoulou and
submission deadline 25 Sep 2026 | 1 articles | Viewed by 2036 | Submission Open
Keywords: drug repurposing; brain drug delivery; delivery-driven repurposing; brain pharmacokinetics; brain pharmacodynamics; CNS-targeted drug delivery
(This special issue belongs to the Section Pharmaceutical Technology)
Nanocarriers in Cancer Therapy: From Drug Delivery to Radiotherapy submission deadline 25 Sep 2026 | 2 articles | Viewed by 1773 | Submission Open
Keywords: cancer nanomedicine; lipid nanoparticles; drug delivery; radiotherapy enhancement; nanocarriers; tumor microenvironment; nano-immunotherapy; cancer vaccines; stimuli-responsive systems
(This special issue belongs to the Section Pharmaceutical Technology)
Recent Advancements in the Development of Antiprotozoal Agents: 2nd Edition
edited by Francesco Saccoliti and Alessandro Giraudo
submission deadline 25 Sep 2026 | 2 articles | Viewed by 1739 | Submission Open
Keywords: antiprotozoal; drug discovery; chemotherapy; parasite; protozoa; mechanism of antiprotozoal agents
(This special issue belongs to the Section Medicinal Chemistry)
Fluoroquinolones, 2nd Edition
edited by and
submission deadline 25 Sep 2026 | 1 articles | Viewed by 1450 | Submission Open
Keywords: fluoroquinolones; fluoroquinolone-associated disability; antibiotic safety; fluoroquinolone toxicity; antibiotic stewardship
(This special issue belongs to the Section Pharmacology)
Gut Microbiota Modulation: Probiotics, Postbiotics and Other Bioactive Compounds—2nd Edition submission deadline 25 Sep 2026 | 1 articles | Viewed by 1240 | Submission Open
Keywords: gut microbiota; bioactive compounds; immune system; nutrition respiratory health
Pharmacokinetics and Pharmacometrics Driving Innovation submission deadline 25 Sep 2026 | 1 articles | Viewed by 1070 | Submission Open
Keywords: pharmacokinetics; drug development; ADME; bioanalytical methods; bioequivalence; bioavailability; IVIVC; PBBM; PBBK; biopharmacy
(This special issue belongs to the Section Pharmacology)
Ophthalmic Drugs and Pharmacology
edited by Christin Henein and Sahar Awwad
submission deadline 25 Sep 2026 | 1 articles | Viewed by 1052 | Submission Open
Keywords: ophthalmic diseases; optic neuropathies; eye diseases; glaucoma; corneal disorders; retinal degeneration; ocular surface disease
(This special issue belongs to the Section Pharmacology)
New Paradigms and Multidimensional Explorations in Drug Development Driven by Chemoinformatics submission deadline 25 Sep 2026 | Viewed by 849 | Submission Open
Keywords: chemoinformatics; drug discovery and development; artificial intelligence in chemistry; chemical space exploration; multidimensional data integration; molecular design; predictive modeling
(This special issue belongs to the Section AI in Drug Development)
Design and Development of PLGA and Polysaccharide Microparticles submission deadline 25 Sep 2026 | 1 articles | Viewed by 732 | Submission Open
Keywords: drug delivery systems; polymeric systems; nanotechnology; controlled release
(This special issue belongs to the Section Medicinal Chemistry)
Low-Dose Naltrexone for Chronic and Cancer Pain
edited by
submission deadline 25 Sep 2026 | Viewed by 386 | Submission Open
Keywords: low-dose naltrexone; LDN; chronic pain; cancer pain; analgesia; neuroinflammation; endocannabinoid system; pain management
(This special issue belongs to the Section Pharmacology)
Progress of Hydrogel Applications in Novel Drug Delivery Platforms, 2nd Edition submission deadline 25 Sep 2026 | Viewed by 335 | Submission Open
Keywords: hydrogels; targeted drug delivery; drug release; drug delivery; smart hydrogels; stimuli-responsive hydrogels; controlled release; hydrogel-based drug delivery; drug carriers
(This special issue belongs to the Section Pharmaceutical Technology)
Drug Treatment for Ophthalmic Diseases
edited by Doina Gherghel and Stephanie Mroczkowska
submission deadline 25 Sep 2026 | Viewed by 281 | Submission Open
Keywords: novel ocular therapies; drug delivery systems; increased compliance; improved bioavailability; reduced side effects; nanotechnology; gene therapy; artificial intelligence
(This special issue belongs to the Section Pharmacology)
Research Progress in New Drug Discovery Driven by Computational and Experimental Approaches
edited by Sankalp Jain
submission deadline 25 Sep 2026 | Viewed by 267 | Submission Open
Keywords: AI-driven drug discovery; machine learning in drug discovery; computational drug design; virtual screening and experimental validation; integrative computational-experimental approaches
(This special issue belongs to the Section AI in Drug Development)
Research, Development, and Application of Bioactive Compounds from Marine and Terrestrial Fungi
edited by Qun Zhou
submission deadline 25 Sep 2026 | Viewed by 258 | Submission Open
Keywords: marine fungi; terrestrial fungi; bioactive compounds; secondary metabolites; natural product drug discovery; biosynthesis; pharmacological activity; genome mining
(This special issue belongs to the Section Natural Products)
Impact of Drug Transporter Gene Variation on Pharmacokinetics and Clinical Outcomes in Chronic Disease Therapy submission deadline 28 Sep 2026 | Viewed by 471 | Submission Open
Keywords: drug transporter gene variants; chronic diseases; pharmacokinetics; clinical therapeutic effects; individualized medication; ABCB1; SLC22A family; SLCO1B1
(This special issue belongs to the Section Pharmacology)
Therapeutic Potential of Silver Nanoparticles (AgNPs), 2nd Edition
edited by
submission deadline 30 Sep 2026 | 9 articles | Viewed by 23075 | Submission Open
Keywords: metallic nanostructures; plasmonic nanomaterials; photothermal therapy; photodynamic therapy; antimicrobial; antioxidant; anticancer
(This special issue belongs to the Section Medicinal Chemistry)
Multi-Targeted Natural Products as Therapeutics, 2nd Edition submission deadline 30 Sep 2026 | 6 articles | Viewed by 9060 | Submission Open
Keywords: natural products; medicinal herbs; marine products; animal products; bioactive compounds; multifactorial diseases; multi-targeting phytochemicals
(This special issue belongs to the Section Natural Products)
Neuropharmacology of Plant Extracts and Their Active Compounds (Second Edition) submission deadline 30 Sep 2026 | 5 articles | Viewed by 5405 | Submission Open
Keywords: medicinal plant; mental disorder; preclinical; clinical
(This special issue belongs to the Section Natural Products)
Promising Natural Products with Anti-Inflammatory and Antioxidant Bioactivities: Extraction, Identification, and Biological Evaluation
edited by Sara Vieira and
submission deadline 30 Sep 2026 | 3 articles | Viewed by 5360 | Submission Open
Keywords: bioactive compounds; extraction techniques; anti-inflammatory activity; antioxidant activity; inflammation; inflammatory molecules; signaling pathways
(This special issue belongs to the Section Natural Products)
Pleiotropic Agents and Their Therapeutic Potential in Gastroenterology, Angiology, and Musculoskeletal Disorders
edited by , Mario Starešinić, and Alenka Boban Blagaic
submission deadline 30 Sep 2026 | 1 articles | Viewed by 4093 | Submission Open
Keywords: pleiotropic agents; therapeutic potential; tissue repair; angiogenesis; gastroenterology; musculoskeletal disorders
(This special issue belongs to the Section Biopharmaceuticals)
Targeting Epigenetic Regulation for Cancer Therapy submission deadline 30 Sep 2026 | 2 articles | Viewed by 3257 | Submission Open
Keywords: epigenetics; chromatin remodeling; histone modifications; non-coding RNAs; gene regulation; cancer therapy; epigenetic biomarkers; therapeutic targets
(This special issue belongs to the Section Pharmacology)
Application of 2D and 3D-QSAR Models in Drug Design: 2nd Edition
edited by
submission deadline 30 Sep 2026 | 2 articles | Viewed by 2174 | Submission Open
Keywords: quantitative structure–activity relationship (QSAR); structure–activity relationship (SAR); 3D-QSAR; molecular descriptors; pharmacophore modeling; molecular docking; molecular dynamics; computer-aided drug design (CADD); machine learning in drug discovery; AI-driven drug design
(This special issue belongs to the Section Medicinal Chemistry)
Integrated In Silico, In Cellulo, In Vitro and In Vivo Approaches in Modern Drug Discovery submission deadline 30 Sep 2026 | 1 articles | Viewed by 2015 | Submission Open
Keywords: integrated drug discovery; in silico/in vitro/in cellulo/in vivo studies; multilevel experimental validation; molecular docking; molecular dynamics simulations; QSAR modeling; ADMET prediction; structure–activity relationships (SAR); structure-based drug design; medicinal chemistry; translational pharmacology
(This special issue belongs to the Section Medicinal Chemistry)
Pain Management: Novel Biomarkers and Therapeutic Targets
edited by Lucia Carmela Passacatini and Sara Ilari
submission deadline 30 Sep 2026 | 2 articles | Viewed by 1812 | Submission Open
Keywords: chronic pain; inflammation; oxidative stress; NK cells; immune activation; epigenetic regulation; sirtuins; antioxidants; chronic pain management
(This special issue belongs to the Section Pharmacology)
Advances in Small-Molecule Therapeutics Targeting Signaling Pathways
edited by
submission deadline 30 Sep 2026 | 2 articles | Viewed by 1589 | Submission Open
Keywords: small molecules; natural compounds; synthetic compounds; signaling pathways; drug design; drug development; HTS; computational tools; biological evaluations; QSAR; bioavailability; pharmacokinetics
(This special issue belongs to the Section Medicinal Chemistry)
Integrating Precision Nutrition with Pharmacological Therapies: Mechanisms, Clinical Outcomes, and Therapeutic Efficiency
edited by
submission deadline 30 Sep 2026 | 1 articles | Viewed by 1303 | Submission Open
Keywords: precision nutrition; Foods for Special Medical Purposes (FSMPs); nutritional support; drug–nutrient interactions; pharmacokinetics; pharmacodynamics; personalized medicine; pharmacological therapies; cost-effectiveness; integrated care
(This special issue belongs to the Section Pharmacology)
Pre-Formulation Strategies: Drug-Excipient Compatibility and Stability Assessment
edited by Paul Albu
submission deadline 30 Sep 2026 | 1 articles | Viewed by 1141 | Submission Open
Keywords: preformulation; drug-excipient compatibility; forced degradation; stability testing; polymorphism; cocrystallisation; DSC; FTIR
(This special issue belongs to the Section Pharmaceutical Technology)
Nanoplatforms for Enhanced Cancer Therapy
edited by Sang Bong Lee
submission deadline 30 Sep 2026 | 1 articles | Viewed by 1070 | Submission Open
Keywords: nanoplatforms; cancer therapy; cell tracking; molecular imaging; multimodal imaging; radiation therapy; radionuclide therapy; radiotheranostics targeted drug delivery; nanomedicine; tumor targeting; radiosensitization; radioisotope delivery; theranostics; precision oncology
(This special issue belongs to the Section Pharmaceutical Technology)
Natural Compounds as Potential Antibacterial Agents: From Molecular Discovery to Smart Applications
edited by , Altevir Rossato Viana and
submission deadline 30 Sep 2026 | Viewed by 866 | Submission Open
Keywords: natural products; WHO priority pathogens; antimicrobial resistance (AMR); antimicrobial photodynamic inactivation; bioactive compounds; biofilms; smart materials; phytochemicals; drug delivery systems
(This special issue belongs to the Section Natural Products)
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