Pharmacokinetics and Pharmacometrics Driving Innovation
A special issue of Pharmaceuticals (ISSN 1424-8247). This special issue belongs to the section "Pharmacology".
Deadline for manuscript submissions: 12 March 2026 | Viewed by 51
Special Issue Editors
Interests: pharmacokinetics; drug development; ADME; bioanalytical method development and validation
Interests: bioequivalence; bioavailability; pharmacokinetics; IVIVC; dissolution; PBBM; PBBK; biopharmacy
Special Issues, Collections and Topics in MDPI journals
Special Issue Information
Dear Colleagues,
Pharmacokinetics (PK) and pharmacometrics (PMx) have long been central in elucidating drug disposition and guiding pharmacotherapy. Their role has expanded from determining concentration–time profiles to shaping drug development, regulatory science, and clinical practice. By quantifying drug disposition and exposure–response relationships, PK and PMx provide critical insights that can be utilized to improve the safety, efficacy, and individualization of therapy.
For this Special Issue of Pharmaceuticals, “Pharmacokinetics and Pharmacometrics Driving Innovation”, we welcome contributions demonstrating how PK and PMx generate new therapeutic opportunities or optimize existing ones.
Submission topics may include, but are not limited to, the following:
- Regulatory applications with PBPK/PBBM, IVIVC/IVIVR, exposure–response analyses, and case studies on DDIs or food effects;
- Early in silico, animal, and translational studies, including microdosing, microtracers, and sparse or opportunistic sampling;
- Dose optimization and individualization through clinical PK, TDM, Bayesian forecasting, pharmacogenomics, and real-world data;
- Studies in special populations such as pediatrics, pregnancy, obesity, hepatic/renal impairment, and ICU patients, with formulation or delivery implications;
- Advances in formulation and drug delivery, bioequivalence, BCS/BDDCS tools, predictive dissolution, and bioperformance;
- Developments in bioanalytical sciences, including LC-MS/MS validation, miniaturization, and analyte stabilization;
- Exploratory and proof-of-concept studies identifying therapeutic alternatives, optimizing therapies, or proposing translational strategies;
- Innovative modeling approaches such as PBPK, PK/PD, QSP, and AI/ML when mechanistically anchored.
This Special Issue will highlight the diversity of PK and PMx applications and their impact on innovation in pharmacotherapy.
Dr. Michel L Campos
Dr. Marcelo Gomes Davanço
Dr. Mariana Millan Fachi
Guest Editors
Manuscript Submission Information
Manuscripts should be submitted online at www.mdpi.com by registering and logging in to this website. Once you are registered, click here to go to the submission form. Manuscripts can be submitted until the deadline. All submissions that pass pre-check are peer-reviewed. Accepted papers will be published continuously in the journal (as soon as accepted) and will be listed together on the special issue website. Research articles, review articles as well as short communications are invited. For planned papers, a title and short abstract (about 100 words) can be sent to the Editorial Office for announcement on this website.
Submitted manuscripts should not have been published previously, nor be under consideration for publication elsewhere (except conference proceedings papers). All manuscripts are thoroughly refereed through a single-blind peer-review process. A guide for authors and other relevant information for submission of manuscripts is available on the Instructions for Authors page. Pharmaceuticals is an international peer-reviewed open access monthly journal published by MDPI.
Please visit the Instructions for Authors page before submitting a manuscript. The Article Processing Charge (APC) for publication in this open access journal is 2900 CHF (Swiss Francs). Submitted papers should be well formatted and use good English. Authors may use MDPI's English editing service prior to publication or during author revisions.
Keywords
- pharmacokinetics
- drug development
- ADME
- bioanalytical methods
- bioequivalence
- bioavailability
- IVIVC
- PBBM
- PBBK
- biopharmacy
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