Pain Management: Novel Biomarkers and Therapeutic Targets
A special issue of Pharmaceuticals (ISSN 1424-8247). This special issue belongs to the section "Pharmacology".
Deadline for manuscript submissions: 30 September 2026 | Viewed by 7
Special Issue Editors
Interests: pain; chronic pain; antioxidants; immune system
2. Department of Human Sciences and Quality of Life Promotion, San Raffaele University, 00166 Rome, Italy
Interests: acute pain; chronic pain; oxidative stress; biomarker
Special Issues, Collections and Topics in MDPI journals
Special Issue Information
Dear Colleagues,
Pain represents a major global health, social, and economic challenge worldwide. Chronic pain, in particular, is a complex and multifactorial condition characterized by persistent symptoms and limited therapeutic options.
The identification and validation of reliable pain biomarkers are crucial for improving diagnosis, patient stratification, prognosis, and treatment monitoring in chronic pain conditions. Advances in molecular, biochemical, and translational research are opening new perspectives for understanding pain mechanisms and developing personalized therapeutic strategies.
This Special Issue aims to gather high-quality original research and review articles addressing novel biomarkers of chronic pain, including—but not limited to—molecular, genetic, inflammatory, immune, and neurobiological markers, as well as their clinical relevance and translational potential.
Particular attention will be given to studies exploring innovative pain management strategies, including the role of antioxidants and bioactive compounds in modulating pain pathways, inflammation, and oxidative stress. In addition, we welcome contributions on the role of sirtuin during inflammatory pain.
Special emphasis will be placed on pharmacological interventions targeting immune activation, specifically NK, B, and T cell signaling, and the therapeutic modulation of neuroimmune axes for the management of chronic pain. Pharmaceuticals invites both original research articles and reviews that shed light on the current challenges and emerging opportunities in pain management research.
Dr. Lucia Carmela Passacatini
Dr. Sara Ilari
Guest Editors
Manuscript Submission Information
Manuscripts should be submitted online at www.mdpi.com by registering and logging in to this website. Once you are registered, click here to go to the submission form. Manuscripts can be submitted until the deadline. All submissions that pass pre-check are peer-reviewed. Accepted papers will be published continuously in the journal (as soon as accepted) and will be listed together on the special issue website. Research articles, review articles as well as short communications are invited. For planned papers, a title and short abstract (about 250 words) can be sent to the Editorial Office for assessment.
Submitted manuscripts should not have been published previously, nor be under consideration for publication elsewhere (except conference proceedings papers). All manuscripts are thoroughly refereed through a single-blind peer-review process. A guide for authors and other relevant information for submission of manuscripts is available on the Instructions for Authors page. Pharmaceuticals is an international peer-reviewed open access monthly journal published by MDPI.
Please visit the Instructions for Authors page before submitting a manuscript. The Article Processing Charge (APC) for publication in this open access journal is 2900 CHF (Swiss Francs). Submitted papers should be well formatted and use good English. Authors may use MDPI's English editing service prior to publication or during author revisions.
Keywords
- chronic pain
- inflammation
- oxidative stress
- NK cells
- immune activation
- epigenetic regulation
- sirtuins
- antioxidants
- chronic pain management
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