Promising Natural Products with Anti-Inflammatory and Antioxidant Bioactivities: Extraction, Identification, and Biological Evaluation
A special issue of Pharmaceuticals (ISSN 1424-8247). This special issue belongs to the section "Natural Products".
Deadline for manuscript submissions: 31 January 2026 | Viewed by 5
Special Issue Editors
Interests: plant extracts; extraction techniques; chemical compounds; skin; inflammation; inflammatory molecules; signaling pathways; macrophages; fibroblasts; keratinocytes
Interests: natural bioactive compounds; medicinal chemistry; bioactivity and toxicology; functional applications
Special Issues, Collections and Topics in MDPI journals
Special Issue Information
Dear Colleagues,
Nature has long served as a rich and innovative source of inspiration for pharmaceutical discovery. A wide range of natural sources—including plants, animals, fungi, and microorganisms—have provided structurally diverse and biologically active compounds. The continuous interest in these sources reflects their potential to drive the development of novel therapeutic agents. Notably, bioactive compounds derived from natural matrices are often associated with favorable safety profiles and therapeutic efficacy, offering promising alternatives to restore physiological homeostasis and enhance overall well-being.
Naturally derived bioactive compounds often exhibit potent anti-inflammatory and antioxidant properties. These molecules interact with various cellular targets, modulating key biological processes such as the production of pro-inflammatory mediators and the regulation of antioxidant defense systems. These mechanisms are closely associated with the prevention and management of numerous chronic conditions, including immune-mediated disorders, dermatological diseases, and metabolic syndromes.
Given the growing global interest in natural therapeutics, there is a pressing need to explore novel bioresources, develop innovative and sustainable extraction methodologies, identify and characterize bioactive constituents, and comprehensively evaluate their biological activities. These efforts are essential for fully harnessing the medicinal potential of natural products and supporting the development of safer, more effective, and sustainable therapeutic strategies.
This Special Issue aims to compile cutting-edge research and comprehensive reviews on innovative and sustainable extraction techniques, advanced analytical methodologies, and the biological validation of natural compounds with anti-inflammatory and/or antioxidant activity, using relevant in vitro and in vivo models. Contributions focusing on natural products derived from plants, mushrooms, marine organisms, bee products, and related by-products are especially welcome.
We hope this Special Issue will contribute to the development of safe, effective, and sustainable therapeutic or preventive strategies, while providing a valuable platform to advance scientific knowledge on natural compounds and promote interdisciplinary collaborations across natural products development, chemistry, cell and molecular biology, and pharmacology.
Dr. Sara Vieira
Dr. Lillian Barros
Guest Editors
Manuscript Submission Information
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Keywords
- bioactive compounds
- extraction techniques
- anti-inflammatory activity
- antioxidant activity
- inflammation
- inflammatory molecules
- signaling pathways
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