Drug Therapy for Autoimmune and Inflammatory Skin Conditions

A special issue of Pharmaceuticals (ISSN 1424-8247). This special issue belongs to the section "Pharmacology".

Deadline for manuscript submissions: 25 September 2026 | Viewed by 873

Editors


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Guest Editor
Division of Rheumatology, Zucker School of Medicine, Hofstra/NSU/LIJ Northwell Health, Manhasset, New York, NY, USA
Interests: neuro rheumatology; reproductive rheumatology; cardio rheumatology; women’s health in rheumatology

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Guest Editor
Division of Rheumatology, Zucker School of Medicine, Hofstra/NSU/LIJ Northwell Health, Manhasset, New York, NY, USA
Interests: Inflammatory muscle disorders; systemic vasculitis; systemic lupus erythematosus

Special Issue Information

Dear Colleagues,

Autoimmune and inflammatory skin conditions represent a heterogenous group of disorders driven by the dysregulated innate and adaptive immune system affecting the largest organ in human body. These conditions can be a skin-limited condition or occur as part of broader manifestation of systemic autoimmune process. Their spectrum ranges from rare monogenic autoinflammatory disorders to common polygenic autoimmune disease. Over the past decade, major advances in understanding immunopathogenesis have led to the development of targeted immunotherapies that have transformed treatment strategies in autoimmune and inflammatory skin conditions. Biologic agents and small-molecule-based immunotherapies have demonstrated significant improvement in disease control and patient quality of life. This Special Issue aims to highlight current and emerging drug therapies for autoimmune and inflammatory skin conditions. We welcome original research articles, real-world outcomes, clinical trials, translational studies, mechanistic investigations, case reports, or case series exploring novel therapeutic strategies for the treatment of autoimmune and inflammatory skin conditions.

Dr. Sumatha Channapatna Suresh
Dr. Galina Marder
Guest Editors

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Keywords

  • autoimmune skin disease
  • psoriasis
  • immunotherapy
  • cutaneous lupus
  • dermatitis
  • biologic therapies
  • dermatomyositis
  • translational therapeutics

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Published Papers (1 paper)

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25 pages, 1038 KB  
Systematic Review
The Latest Advances in Rosacea Treatment: A Systematic Review
by Anastazja Andrusiewicz, Sofiia Khimuk, Jakub Niżnik, Dmytro Sirko, Daniel Mijas and Danuta Nowicka
Pharmaceuticals 2026, 19(7), 982; https://doi.org/10.3390/ph19070982 (registering DOI) - 24 Jun 2026
Abstract
Background: Rosacea is a chronic inflammatory dermatosis characterized by vascular dysregulation, immune dysfunction, neurovascular alterations, and microbial involvement. Recent advances in understanding its pathophysiology have led to the development of targeted therapeutic strategies addressing multiple disease mechanisms. This systematic review aimed to evaluate [...] Read more.
Background: Rosacea is a chronic inflammatory dermatosis characterized by vascular dysregulation, immune dysfunction, neurovascular alterations, and microbial involvement. Recent advances in understanding its pathophysiology have led to the development of targeted therapeutic strategies addressing multiple disease mechanisms. This systematic review aimed to evaluate contemporary evidence regarding emerging and established treatment approaches for rosacea. Methods: A systematic review was conducted in accordance with the Preferred Reporting Items for Systematic Reviews and Meta-Analyses (PRISMA) guidelines. PubMed, Scopus, and Web of Science were searched for studies published between 2016 and 2025. Original human studies evaluating therapeutic interventions for rosacea were included. Study selection, data extraction, and risk-of-bias assessment were performed independently by two reviewers. Methodological quality was assessed using Joanna Briggs Institute (JBI) critical appraisal tools appropriate for each study design. Results: Fifteen studies involving 537 patients with rosacea and 77 controls (614 participants in total) met the eligibility criteria. Evaluated interventions included vascular-targeted therapies, topical anti-inflammatory agents, systemic and immunomodulatory treatments, and microbiome-oriented approaches. Oxymetazoline, pulsed-dye laser, platelet-rich plasma, ivermectin, azelaic acid, dapsone, sulfur preparations, and metronidazole demonstrated clinical benefits in reducing erythema, inflammatory lesions, or overall disease severity. Emerging therapies, including tofacitinib and oral ivermectin, showed promising results in refractory disease. Microbiome-related interventions, particularly Demodex-targeted therapies and Helicobacter pylori eradication, were also associated with clinical improvement. Risk-of-bias assessment identified two studies with low risk of bias, twelve with moderate risk of bias, and one study with high risk of bias. Conclusions: Current evidence supports a multimodal and mechanism-based approach to rosacea management, integrating vascular, inflammatory, immunological, and microbiological targets. However, the available evidence remains limited by small sample sizes, heterogeneous methodologies, short follow-up periods, and a predominance of non-randomized study designs. Large, well-designed randomized controlled trials are needed to establish optimal evidence-based treatment strategies and define the long-term efficacy and safety of emerging therapies. Full article
(This article belongs to the Special Issue Drug Therapy for Autoimmune and Inflammatory Skin Conditions)
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