Special Issue "Neuropsychiatric Diseases in Children and Nutrition"

A special issue of Nutrients (ISSN 2072-6643). This special issue belongs to the section "Clinical Nutrition".

Deadline for manuscript submissions: 30 April 2021.

Special Issue Editors

Dr. Pierangelo Veggiotti
Guest Editor
V. Buzzi Children Hospital, University of Milan, Milan
Interests: drug-resistant epilepsy; rare diseases; pediatric neurology; ketogenic dietary therapies
Dr. Ludovica Pasca

Guest Editor
University of Pavia
Interests: : drug-resistant epilepsy; focal epilepsy; neuroimaging of epilepsy; ketogenic dietary therapies

Special Issue Information

Dear Colleagues,

This Special Issue will focus on the new advances and future challenges of dietary therapies for childhood-onset neuropsychiatric disorders.

Neuropsychiatric and neurodevelopmental disorders are often characterized by a multifactorial etiology that contributes to the complexity of clinical manifestation, which are presented as an overlap of neurological and psychiatric symptoms. While traditional drug therapies are frequently effective, a personalized nutritional approach and dietary therapies might strengthen or replace traditional drug treatments in refractory cases. Moreover, both patients and their families and clinicians are now searching for new and individualized treatments.

Ketogenic dietary treatments have been effectively used in some cases of drug-resistant epilepsies and in chronic metabolic diseases, in addition to being assessed in a variety of other neurological conditions in both animal models and human trials. A ketogenic diet (KD) has been demonstrated to result in an improvement of both cognitive and motor functioning in animal models in the study of brain injury as well as in animal models of multiple sclerosis, showing an effect on memory impairment and inflammation. Comorbidities and overlapping manifestations between epilepsy and other neuropsychiatric disorders might suggest some common underlying physiopathological features and thus imply the application of ketogenic dietary therapies.

However, the specific KD mechanism of action in neurological and psychiatric diseases is still poorly understood, therefore representing a stimulating and challenging research field.

The aim of this Special Issue is to outline the potential role of dietary therapies in child neuropsychiatric disorders other than seizure control, and even in terms of cognitive and behavioral improvement. The focus will be placed on the role of the ketogenic diet and nutritional therapeutic functions on both neurological (e.g., developing brain, epilepsy of different etiologies, headache, brain tumors) and psychiatric (e.g., ADHD and autism) diseases.

Addressing the link between brain function and nutrition would allow for a better definition of the pathological mechanism and specific therapeutic target for use in clinical practice.

Dr. Pierangelo Veggiotti
Dr. Ludovica Pasca
Guest Editors

Manuscript Submission Information

Manuscripts should be submitted online at www.mdpi.com by registering and logging in to this website. Once you are registered, click here to go to the submission form. Manuscripts can be submitted until the deadline. All papers will be peer-reviewed. Accepted papers will be published continuously in the journal (as soon as accepted) and will be listed together on the special issue website. Research articles, review articles as well as short communications are invited. For planned papers, a title and short abstract (about 100 words) can be sent to the Editorial Office for announcement on this website.

Submitted manuscripts should not have been published previously, nor be under consideration for publication elsewhere (except conference proceedings papers). All manuscripts are thoroughly refereed through a single-blind peer-review process. A guide for authors and other relevant information for submission of manuscripts is available on the Instructions for Authors page. Nutrients is an international peer-reviewed open access monthly journal published by MDPI.

Please visit the Instructions for Authors page before submitting a manuscript. The Article Processing Charge (APC) for publication in this open access journal is 2400 CHF (Swiss Francs). Submitted papers should be well formatted and use good English. Authors may use MDPI's English editing service prior to publication or during author revisions.


  • Neuropsychiatric disorders
  • Brain development
  • Mental health
  • Epilepsy
  • Autism
  • Attention deficit hyperactivity disorder
  • Headache
  • Multiple sclerosis
  • Brain cancer
  • Epigenetics
  • Intestinal microbiota
  • Ketogenic dietary therapies
  • Supplementation
  • Target therapy
  • Quality of life
  • Personalized nutrition

Published Papers

This special issue is now open for submission, see below for planned papers.

Planned Papers

The below list represents only planned manuscripts. Some of these manuscripts have not been received by the Editorial Office yet. Papers submitted to MDPI journals are subject to peer-review.

Title: Kd and child psychiatric diseases
Authors: Emmanuelle Bostock
Affiliation: University of Tasmania

Title: Use of ketogenic diet in status epilepticus
Authors: Marisa Armeno; Roberto Caraballo
Affiliation: Fundacion Hospital de Pediatria Professor Dr. Juan P. Garrahan

Title: The effect of nutritional supplements on children and adults with autism in the US
Authors: James B. Adams
Affiliation: Arizona State University

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