Exercise, Nutrition, Cardiometabolic Health in Cancer: From Molecular Mechanisms to Precision Interventions

Dear Colleagues,

Cancer and its treatments can substantially affect cardiac tissue, vascular, metabolic, and musculoskeletal health long-term, increasing cardiometabolic risk and reducing physical function. Exercise and nutrition have emerged as key non-pharmacological strategies to mitigate these adverse effects through mechanisms that decrease inflammation, oxidative stress, and improve metabolic regulation, immune function, body composition, and vascular health. Particular attention will be given to exercise oncology, including moderate-intensity continuous (MICT), resistance (RT), high-intensity interval (HIIT), and concurrent training (CT). Studies examining arterial stiffness, endothelial and microvascular function, blood pressure, cardiorespiratory fitness, skeletal muscle health, body composition, metabolic syndrome, insulin resistance, lipid metabolism, and treatment-related cardiotoxicity are particularly encouraged. A central theme is the progression toward precision exercise and personalized nutritional interventions. We invite research addressing interindividual variability, dose–response relationships, and patient- or treatment-specific phenotypes. We welcome original studies, clinical trials, acute and chronic interventions, mechanistic and methodological studies, systematic reviews, and meta-analyses. By integrating exercise physiology, nutrition, oncology, cardiovascular, metabolism, and rehabilitation sciences, this Special Issue aims to advance precision lifestyle strategies that preserve cardiometabolic health, improve physical function, reduce treatment-related toxicity, and enhance long-term health and quality of life in people living with and beyond cancer.

Dr. Cristian Álvarez
Guest Editor

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