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Life publishes Special Issues to create collections of papers on specific topics, with the aim of building a community of authors and readers to discuss the latest research and develop new ideas and research directions. Special Issues are led by Guest Editors, who are experts on the topic and all Special Issue submissions follow MDPI's standard editorial process. The journal’s Editor-in-Chief and/or designated Editorial Board Member will oversee Guest Editor appointments and Special Issue proposals, checking their content for relevance and ensuring the suitability of the material for the journal. The papers published in a Special Issue will be collected and displayed on a dedicated page of the journal’s website. Further information on MDPI's Special Issue policies and Guest Editor responsibilities can be found here. For any inquiries related to a Special Issue, please contact the Editorial Office.

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Physiological Responses and Adaptation Mechanisms of Plants to Stress

edited by

Jie Luo

and Bassam T. Yasseen

submission deadline 31 Oct 2025 | Viewed by 59 | Submission Open

Keywords: biotechnology; chemical composition; growth processes; heavy metals; hormonal balance; improving growth variables; mechanisms of osmotic stress; pollution; photosynthesis; stomatal behaviors

(This special issue belongs to the Section Plant Science)

Management of Ischemia and Heart Failure—3rd Edition

edited by

Cristian Mornoş

submission deadline 31 Oct 2025 | Viewed by 58 | Submission Open

Keywords: heart failure; myocardial ischemia; left ventricular remodeling; prognosis

(This special issue belongs to the Section Medical Research)

Therapeutic Approaches of Natural Products in Health and Disease

edited by

Mina Mihaylova Todorova

and

Stoyanka Atanasova

submission deadline 31 Oct 2025 | Viewed by 48 | Submission Open

Keywords: natural products; bioactive compounds; isolation; analysis; metabolism; in vitro and in vivo experiments; pharmacological activity

(This special issue belongs to the Section Pharmaceutical Science)

Cross-Species Studies of Cognitive Behaviors: Aspects of Physiological Mechanisms

edited by Nobuo Masataka

submission deadline 31 Oct 2025 | Viewed by 44 | Submission Open

Keywords: cognitive neuroscience; species-specificity; neural network; brain imaging; communication; social brain; phylogeny

(This special issue belongs to the Section Animal Science)

Urologic Cancer: From Pathophysiology to Therapeutics

edited by

Gianluca Spena

and Roberto Contieri

submission deadline 31 Oct 2025 | Viewed by 41 | Submission Open

Keywords: urologic oncology; robotic surgery; prostate cancer; kidney cancer; bladder cancer; minimally invasive surgery; molecular biomarkers

(This special issue belongs to the Section Medical Research)

Reconstruction of Bone Defects

edited by

Jörg Eschweiler

and

Philipp Kobbe

submission deadline 1 Nov 2025 | 5 articles | Viewed by 3336 | Submission Open

Keywords: bone and fracture biomechanics; bone healing; critical size bone defects; fracture non-union; inflammation; joint arthroplasty and fracture osteosynthesis; implant designs; materials proprieties; patient selection; primary and revision settings

(This special issue belongs to the Section Medical Research)

Breaking the Code: How Genome Sequencing Is Revolutionizing the Diagnosis of Rare Diseases

edited by

Massimiliano Chetta

and

Nenad Bukvic

submission deadline 6 Nov 2025 | Viewed by 156 | Submission Open

Keywords: genomics; bioinformatics; genetics; cytogenetics

(This special issue belongs to the Section Genetics and Genomics)

Advancing Plant Resilience: Genetics and Agronomy

edited by Meng Jiang, Ruiqing Li and Ning Xu

submission deadline 14 Nov 2025 | Viewed by 45 | Submission Open

Keywords: plant stress; genetic mechanisms; signaling networks; agronomic practices; sustainable agriculture; crop improvement; stress mitigation

(This special issue belongs to the Section Plant Science)

Plant-Derived Natural Products and Their Biomedical Properties: 2nd Edition

edited by

Efstathia Papada

and

Charalampia Amerikanou

submission deadline 15 Nov 2025 | Viewed by 99 | Submission Open

Keywords: plant-derived natural products; phytochemicals; antioxidants; inflammation; therapeutic agent

(This special issue belongs to the Section Pharmaceutical Science)

Placental Spectrum Disorders and Gynecological Oncology

edited by Gianluca Raffaello Damiani

submission deadline 15 Nov 2025 | Viewed by 39 | Submission Open

Keywords: placenta; trophoblastic tumor; mola; tumors; bleeding

(This special issue belongs to the Section Medical Research)

Telomere Length as a Marker of Biological Age and Age-Related Diseases

edited by Stella Baliou

submission deadline 20 Nov 2025 | Viewed by 118 | Submission Open

Keywords: telomeres; biological aging; diseases; mechanisms

(This special issue belongs to the Section Medical Research)

Explore Innovative Exercise-Based Interventions for Chronic Diseases

edited by

Hee-Tae Roh

submission deadline 20 Nov 2025 | Viewed by 38 | Submission Open

Keywords: physical activity; acute exercise; exercise training; inflammation; oxidative stress; antioxidant; chronic disease; environmental stress; brain health; aging

Current and Future Perspectives of Artificial Intelligence in Medicine

edited by Giuseppe Consorti, Lisa Catarzi and

Guido Gabriele

submission deadline 21 Nov 2025 | 3 articles | Viewed by 2845 | Submission Open

Keywords: artificial intelligence; machine learning; deep learning; medical practices; artificial neural network; computational health informatics; predictive analytics in healthcare; ethics in AI for medical applications

(This special issue belongs to the Section Medical Research)

Lipid Metabolism Pathways: From Life to Disease

edited by

Anna Eiring

submission deadline 21 Nov 2025 | 1 articles | Viewed by 1419 | Submission Open

Keywords: lipid metabolism; lipid signaling; apoptosis; ferroptosis; autophagy; membrane dynamics; fatty acid oxidation; obesity

(This special issue belongs to the Section Cell Biology and Tissue Engineering)

Agri-Food Waste Extracts: Structural and Functional Characterization

edited by

Stefania Lamponi

submission deadline 21 Nov 2025 | Viewed by 228 | Submission Open

Keywords: agri-food waste; extracts; extraction techniques; chemical characterization; bioactivity; cytotoxicity and cytocompatibility; isolation of bioactive molecules

(This special issue belongs to the Section Plant Science)

Advances in Ubiquitous Connective Tissue Architecture: Fascia, Dynamic movements and Perception in Living Structures

edited by

Jean Claude Guimberteau

submission deadline 25 Nov 2025 | 1 articles | Viewed by 1061 | Submission Open

Keywords: fascia; connective tissue; fibrillar network; microvolumes; collagen; cell microenvironment; force absorption system

(This special issue belongs to the Section Cell Biology and Tissue Engineering)

From Prediction to Experimental Assays of More Selective and Cleaner Bioactive Synthetics: A Systemic View

edited by

Gabriela Fiss

and Petrônio Filgueiras de Athayde-Filho

submission deadline 25 Nov 2025 | Viewed by 288 | Submission Open

Keywords: antimicrobial activity; artemia salina; bioinformatics; drug research; green chemistry; lipophilicity; medicinal chemistry

(This special issue belongs to the Section Pharmaceutical Science)

Photodynamic Therapy for Medical Applications: From Infections to Tissue Regeneration

edited by Rafał Wiench and

Zhiwei Hu

submission deadline 25 Nov 2025 | Viewed by 83 | Submission Open

Keywords: photodynamic therapy (PDT); photosensitizers; reactive oxygen species (ROS); infections and antimicrobial PDT (aPDT); tissue regeneration and wound healing; oral potentially malignant disorders (OPMDs); oncology and cancer treatment; dermatology and skin disorders

(This special issue belongs to the Section Medical Research)

Sialic Acid and Sialic Acid Derivatives in Biomedicine

edited by

Paola Rota

and

Marco Piccoli

submission deadline 26 Nov 2025 | 1 articles | Viewed by 1191 | Submission Open

Keywords: sialic acid; drug development; sialidase inhibitors; sialylation; sialidase; biomarker

(This special issue belongs to the Section Physiology and Pathology)

Advances in Medical Imaging of Animal Models for Human Diseases

edited by

Yihsiu Chung

and Tsai-Hsien Hung

submission deadline 26 Nov 2025 | Viewed by 242 | Submission Open

Keywords: medical imaging; animal models; preclinical research; human disease; oncology

(This special issue belongs to the Section Medical Research)

Advances in Geriatric Medicine: Risk Assessment, Biomarkers, and Management Strategies

edited by

Nadya Kagansky

and Yochai Levy

submission deadline 26 Nov 2025 | Viewed by 86 | Submission Open

Keywords: geriatric risk assessment; biomarkers in aging; personalized geriatric care

(This special issue belongs to the Section Medical Research)

Advances in Regenerative Medicine in Disease Treatment: Harnessing Potential and Bridging Challenges

edited by Edward H. Ntege and

Adrian Neagu

submission deadline 26 Nov 2025 | Viewed by 75 | Submission Open

Keywords: regenerative medicine; tissue engineering; stem cells; molecular therapy; personalized medicine; targeted delivery; immunomodulation

(This special issue belongs to the Section Physiology and Pathology)

Musculoskeletal Medicine in Rheumatic Diseases

edited by

Florentin Ananu Vreju

and Emilio Filippucci

submission deadline 28 Nov 2025 | 3 articles | Viewed by 5121 | Submission Open

Keywords: rheumatic disease; rheumatoid arthritis; spondylarthritis; microcrystal arthritis; musculoskeletal ultrasonography; biologic treatment; disease-modifying antirheumatic drugs; imagining techniques

(This special issue belongs to the Section Medical Research)

Space Medicine Ophthalmology: Insights from Molecular Observations to the Clinical Management of Ocular Risks in Microgravity

edited by Joshua Ong

submission deadline 28 Nov 2025 | 3 articles | Viewed by 2959 | Submission Open

Keywords: spaceflight; space medicine; ophthalmology; space medicine; microgravity; cornea; retina; ocular surface

(This special issue belongs to the Section Astrobiology)

Muscle Wasting, Aging, and Cancer: The Effects of Physical Exercise

edited by

Paula Tavares

submission deadline 28 Nov 2025 | 1 articles | Viewed by 786 | Submission Open

Keywords: sarcopenia; aging; cancer; muscle wasting; physical exercise; resistance training; satellite cells; inflammation; metabolic health; quality of life

(This special issue belongs to the Section Physiology and Pathology)

Artificial Intelligence and Computational Models in Understanding Human Diseases

edited by Sergey K. Aityan

submission deadline 28 Nov 2025 | Viewed by 123 | Submission Open

Keywords: artificial intelligence; AI; diagnostics; computational medicine; medical modeling; medical simulation; medical data analysis

(This special issue belongs to the Section Biochemistry, Biophysics and Computational Biology)

Effects of Environmental Factors on Challenges of Plant Breeding: 2nd Edition

edited by

Katalin Magyar-Tábori

and

Nóra Mendler-Drienyovszki

submission deadline 28 Nov 2025 | Viewed by 103 | Submission Open

Keywords: plant breeding; winter hardiness; sowing time; adaptation to cold/frost; physiology of cold/frost tolerance; snow cover

(This special issue belongs to the Section Plant Science)

Helicobacter pylori: 2nd Edition

edited by

Ovidiu Pop

and

Simona Gurzu

submission deadline 28 Nov 2025 | Viewed by 82 | Submission Open

Keywords: H. pylori; cancers; antioxidative process; diagnostic methods

(This special issue belongs to the Section Microbiology)

Epigenetics, Microbiota, and Food—Shaping Immune Health and Longevity

edited by

Berit Hippe

submission deadline 28 Nov 2025 | Viewed by 80 | Submission Open

Keywords: epigenetics; nutrigenomics; aging; microRNA; DNA methylation; diet; nutrients; microbiota; longevity; natural components

(This special issue belongs to the Section Physiology and Pathology)

Trends in Microbiology 2025

edited by

Pabulo Rampelotto

and

Milan Kolar

submission deadline 30 Nov 2025 | 10 articles | Viewed by 14517 | Submission Open

Keywords: agricultural microbiology; clinical microbiology; environmental microbiology; food microbiology; industrial microbiology; marine microbiology; microbial biochemistry; microbial biofuel and bioenergy; microbial ecology; microbial evolution; microbial genetics; microbial metabolism; microbial pathogenesis; microbial physiology

(This special issue belongs to the Section Microbiology)

Noninvasive Skin Imaging: The Present and the Future in General Dermatology

edited by

Bijan Safai

and

Banu Farabi

submission deadline 30 Nov 2025 | 4 articles | Viewed by 6911 | Submission Open

Keywords: skin imaging; dermatoscopy; dermatology imaging; dermatosurgery; clinical dermatology

(This special issue belongs to the Section Medical Research)

Plant Functional Genomics and Breeding

edited by

Yifeng Wang

submission deadline 30 Nov 2025 | 7 articles | Viewed by 6806 | Submission Open

Keywords: functional genomics; biological breeding; gene cloning; molecular network; genetic improvement

(This special issue belongs to the Section Plant Science)

Traumatic Brain Injury (TBI)

edited by

Seyed Ahmad Naseri Alavi

and Andrew J. Kobets

submission deadline 30 Nov 2025 | 3 articles | Viewed by 5623 | Submission Open

Keywords: neurosurgery; neuroscience; Traumatic Brain Injury; TBI; head injury; imaging; prognosis; labaratory findings; quality of life

(This special issue belongs to the Section Medical Research)

Pathophysiology, Diagnosis, and Treatments of Intestinal Diseases

edited by Amosy Ephreim M’Koma

submission deadline 30 Nov 2025 | 4 articles | Viewed by 4952 | Submission Open

Keywords: gastrointestinal disease/disorders; pathophysiology; diagnostics and treatment

(This special issue belongs to the Section Physiology and Pathology)

Clinical Research in Male Reproduction

edited by Andrea Crafa,

Aldo E. Calogero

and Richard Quinton

submission deadline 30 Nov 2025 | 3 articles | Viewed by 4816 | Submission Open

Keywords: male infertility; male fertility; male sub-fertility; idiopathic male infertility; male reproduction

(This special issue belongs to the Section Medical Research)

Synthesis and Evaluation of Novel Anticancer and Anti-Inflammatory Agents

edited by Po-Jen Chen,

Yu-Chia Chang

and Shun-Hua Chen

submission deadline 30 Nov 2025 | 3 articles | Viewed by 3216 | Submission Open

Keywords: anticancer agents; anti-inflammatory agents; pharmacology; molecular and cell biology; drug design; medicinal chemistry; pharmacodynamics; pharmacokinetics; structure– activity relationship (SAR)

(This special issue belongs to the Section Pharmaceutical Science)

New Insights into Parkinson’s Disease: From Molecular Basis to Therapy

edited by

Kallirhoe Kalinderi

submission deadline 30 Nov 2025 | 2 articles | Viewed by 2558 | Submission Open

Keywords: Parkinson’ s disease; neurodegeneration; genes; GWAs; polygenic risk score; therapy; precision medicine; pathways; pharmacogenetics; surgicogenomics

(This special issue belongs to the Section Medical Research)

Pharmacokinetic and Pharmacogenetic Approaches in Personalized Medicine

edited by

Silvia De Francia

and Giuliana Abbadessa

submission deadline 30 Nov 2025 | 1 articles | Viewed by 1085 | Submission Open

Keywords: pharmacogenetics; pharmacokinetics; sex; gender; drugs; personalization

(This special issue belongs to the Section Pharmaceutical Science)

Novel Therapeutic Strategies for Targeting Glioblastoma Stem Cells

edited by

Tsung-I Hsu

and

Chih Jie Shen

submission deadline 30 Nov 2025 | Viewed by 431 | Submission Open

Keywords: glioblastoma; chemotherapeutic resistance; glioblastoma stem cells; immunosuppression; brain– blood barrier

(This special issue belongs to the Section Physiology and Pathology)

Prostate Cancer: 4th Edition

edited by

Paula Oliveira

and

Ana Faustino

submission deadline 30 Nov 2025 | 1 articles | Viewed by 352 | Submission Open

Keywords: incidence; mortality; diagnosis; histopathology; imaging; treatment; prognosis; case report; animals; humans; modeling

(This special issue belongs to the Section Medical Research)

Gender Medicine: Current Knowledge and Future Perspectives

edited by

Laura Franza

submission deadline 30 Nov 2025 | Viewed by 282 | Submission Open

Keywords: gender; gender medicine; LGBTQ + health; health equity in gender medicine; intersectionality; pharmacology; reproductive health; chronic diseases; transgender healthcare; sex-specific healthcare

(This special issue belongs to the Section Medical Research)

Advances in the Glyoxalase Pathway: Implications for Oxidative Stress Management in Cancer Therapy and in Age-related Disease

edited by

Laura Cianfruglia

and

Salvatore Vaiasicca

submission deadline 30 Nov 2025 | 1 articles | Viewed by 233 | Submission Open

Keywords: glyoxalase system; methylglyoxal; advanced glycation end-products; dicarbonyl stress; oxidative stress; age-related disease; cancer

(This special issue belongs to the Section Physiology and Pathology)

Total Joint Arthroplasty and Joint Replacement

edited by

Corrado Ciatti

Luca Andriollo

Francesco Benazzo

and

Stefano Marco Paolo Rossi

submission deadline 30 Nov 2025 | 1 articles | Viewed by 187 | Submission Open

Keywords: robotic and technology-assisted joint replacement; periprosthetic joint infection— prevention; diagnosis; and therapeutics; biomaterials and implant design; tissue engineering; muscle strengthening and conditioning; implant designs; edema and pain

(This special issue belongs to the Section Medical Research)

New Horizons: Autoimmune-Related Thrombosis

edited by

Jean Amiral

and

Osamu Kumano

submission deadline 30 Nov 2025 | Viewed by 126 | Submission Open

Keywords: chronic or transient autoantibodies; autoimmune thrombosis; lupus anticoagulant (LA); thrombotic thrombocytopenic Purpura (TTP); anti-phospholipid syndrome (APS); heparin induced thrombocytopenia/and thrombosis (HIT/HITT); vaccine induced thrombotic thrombocytopenia (VITT)

(This special issue belongs to the Section Medical Research)

Advanced Research in Exercise Medicine

edited by

Ai-Lun Yang

submission deadline 30 Nov 2025 | Viewed by 121 | Submission Open

Keywords: exercise and chronic disease; cardiovascular dysfunction/disease; metabolic syndrome; aging; athletic training; sports medicine; rehabilitation

(This special issue belongs to the Section Physiology and Pathology)

Sports Biomechanics, Injury, and Physiotherapy

edited by Manos Stefanakis

submission deadline 30 Nov 2025 | Viewed by 100 | Submission Open

Keywords: sports injuries; epidemiology; data-driven rehabilitation; objective assessment; injury prevention; return to play

(This special issue belongs to the Section Physiology and Pathology)

Pleural and Pulmonary Fibrosis: Pathogenesis and Possible Treatment Strategies

edited by Oluwaseun Adeyanju

submission deadline 30 Nov 2025 | Viewed by 78 | Submission Open

Keywords: pulmonary fibrosis; pleural fibrosis; pathogenesis; therapeutic strategies; inflammation

(This special issue belongs to the Section Physiology and Pathology)

Advances in Pulmonology: Transforming Diagnosis and Treatment of Lung Diseases