Cellular Responses to Hypoxia
A special issue of Life (ISSN 2075-1729). This special issue belongs to the section "Cell Biology and Tissue Engineering".
Deadline for manuscript submissions: 31 March 2026 | Viewed by 7
Special Issue Editor
Interests: cellular hypoxia; cancer biology; alternative splicing; RNA splicing; hypoxia dependent changes in cells; splicing factors
Special Issues, Collections and Topics in MDPI journals
Special Issue Information
Dear Colleagues,
The journal Life is announcing a Special Issue titled "Cellular Responses to Hypoxia" and is now inviting researchers to submit manuscripts.
Topic Scope: Studies related to cellular responses to hypoxia (low oxygen), molecular mechanisms, adaptive pathways, disease relevance (e.g., cancer and ischemia), and hypoxia signaling.
Molecular oxygen sustains intracellular bioenergetics and is consumed by numerous biochemical reactions, making it essential for most species on Earth. Accordingly, decreased oxygen concentration (hypoxia) is a major stressor that generally disrupts the life of aerobic species and is a prominent feature of pathological states encountered in bacterial infection, inflammation, wounds, cardiovascular defects and cancer. Therefore, key adaptive mechanisms to cope with hypoxia have evolved in mammals. Systemically, these adaptations include increased ventilation, cardiac output, blood vessel growth and circulating red blood cell numbers. On a cellular level, ATP-consuming reactions are suppressed and metabolism is altered until oxygen homeostasis is restored. A critical question is how mammalian cells sense oxygen levels to coordinate diverse biological outputs during hypoxia.
Types of Papers Accepted: Original research articles, reviews, etc.
Submissions will undergo rigorous peer review.
Submission Deadline: 31 March 2026.
For submission, authors should follow the journal’s guidelines for authors.
Dr. Arvydas Kanopka
Guest Editor
Manuscript Submission Information
Manuscripts should be submitted online at www.mdpi.com by registering and logging in to this website. Once you are registered, click here to go to the submission form. Manuscripts can be submitted until the deadline. All submissions that pass pre-check are peer-reviewed. Accepted papers will be published continuously in the journal (as soon as accepted) and will be listed together on the special issue website. Research articles, review articles as well as short communications are invited. For planned papers, a title and short abstract (about 100 words) can be sent to the Editorial Office for announcement on this website.
Submitted manuscripts should not have been published previously, nor be under consideration for publication elsewhere (except conference proceedings papers). All manuscripts are thoroughly refereed through a single-blind peer-review process. A guide for authors and other relevant information for submission of manuscripts is available on the Instructions for Authors page. Life is an international peer-reviewed open access monthly journal published by MDPI.
Please visit the Instructions for Authors page before submitting a manuscript. The Article Processing Charge (APC) for publication in this open access journal is 2600 CHF (Swiss Francs). Submitted papers should be well formatted and use good English. Authors may use MDPI's English editing service prior to publication or during author revisions.
Keywords
- hypoxia
- cellular responses
- molecular mechanisms
- hypoxia signaling
- adaptive pathways
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