Interdisciplinary Approach to Diabetes Mellitus: From Pathophysiology to Diagnosis and Therapeutic Challenges: 2nd Edition

Dear Colleagues,

After the success of the first edition of this Special Issue, we intend to publish a second edition, and we invite you to submit your research for publication.

https://www.mdpi.com/journal/life/special_issues/W64SCZA0W3

Diabetes mellitus, a complex syndrome characterized by abnormalities in every aspect of cellular energy metabolism, and its complications are one of the most important health problems in the world. The major pathophysiological mechanisms underlying the pathogenesis of diabetes mellitus and its complications involve insulin resistance, immunological defect, an impaired incretin effect, gluco- and lipotoxicity, inflammation, oxidative stress, endoplasmic reticulum stress, defective autophagy mechanisms, proapoptotic pathways, modification of the intestinal microbiome, and abnormal mitochondrial function in insulin-sensitive tissues such as the liver, skeletal muscle, adipose tissue, blood vessels, the nervous system, and the myocardium.

In recent years, evidence-based treatment algorithms have been proposed for patients with diabetes, focusing on patients comorbidities as a critical determinant of the selection of the most appropriate treatment. Nowadays, it is widely recognized that diabetes mellitus is associated not only with cardiovascular mortality, but also with poor quality of life due to its association with chronic kidney disease, sarcopenia, cancer, and dementia. To overcome these problems, it is important to better understand the disease process of diabetes and its complications and develop new treatment strategies. Acute complications include hypoglycemia, diabetic ketoacidosis, hyperglycemic hyperosmolar state, and hyperglycemic diabetic coma. Chronic vascular (chronic microvascular complications: nephropathy, neuropathy and retinopathy; chronic macrovascular complications: coronary artery disease, peripheral arterial disease and cerebrovascular disease) and non-vascular complications are also involved.

The purpose of this Special Issue is to provide a platform to disseminate knowledge about diabetes. We invite submissions of both original research and comprehensive review articles. Potential topics include, but are not limited to, the following:

• Work on the molecular mechanisms of diabetes-related diseases;
• Potential new biomarkers for the prediction of diabetes and its complications;
• Physiopathological concepts related to the mechanisms described above;
• Innovative diagnostic tools and technologies for early detection, risk assessment, and monitoring;
• Diabetes and metabolic syndrome;
• Diseases associated with diabetes (vascular and non-vascular complications);
• Advancements in pharmacological and non-pharmacological approaches to improve treatment outcomes and treatment strategies (medical nutrition, metabolic surgery, drugs, and innovative approaches based on nanotechnology or artificial intelligence) in the context of precision diabetology.

Dr. Daniela Maria Tanase
Prof. Dr. Mariana Floria
Prof. Dr. Ionela Lacramioara Serban
Guest Editors

Manuscript Submission Information

Manuscripts should be submitted online at www.mdpi.com by registering and logging in to this website. Once you are registered, click here to go to the submission form. Manuscripts can be submitted until the deadline. All submissions that pass pre-check are peer-reviewed. Accepted papers will be published continuously in the journal (as soon as accepted) and will be listed together on the special issue website. Research articles, review articles as well as short communications are invited. For planned papers, a title and short abstract (about 100 words) can be sent to the Editorial Office for announcement on this website.

Submitted manuscripts should not have been published previously, nor be under consideration for publication elsewhere (except conference proceedings papers). All manuscripts are thoroughly refereed through a single-blind peer-review process. A guide for authors and other relevant information for submission of manuscripts is available on the Instructions for Authors page. Life is an international peer-reviewed open access monthly journal published by MDPI.

Please visit the Instructions for Authors page before submitting a manuscript. The Article Processing Charge (APC) for publication in this open access journal is 2600 CHF (Swiss Francs). Submitted papers should be well formatted and use good English. Authors may use MDPI's English editing service prior to publication or during author revisions.

• hyperlipidemia
• neuropathy
• nephropathy
• retinopathy
• psychological effects
• epigenetic imprinting
• molecular profiling
• glucose control
• vascular damage and regeneration
• diabetes complications