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Life
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Cardiovascular Diseases: From Basic Research to Clinical Application—3rd Edition
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Cardiovascular Diseases: From Basic Research to Clinical Application—3rd Edition

A special issue of Life (ISSN 2075-1729). This special issue belongs to the section "Medical Research".

Deadline for manuscript submissions: 24 April 2026 | Viewed by 1077

Special Issue Editors

Dr. Cristiana Bustea

E-Mail Website
Guest Editor
Department of Preclinical Disciplines, Faculty of Medicine and Pharmacy, University of Oradea, 410073 Oradea, Romania
Interests: cardiovascular disease; pathophysiology; oxidative stress; inflammation; hemostasis; diabetes mellitus
Special Issues, Collections and Topics in MDPI journals
Prof. Dr. Delia Mirela Tit

E-Mail Website
Guest Editor
1. Department of Pharmacy, Faculty of Medicine and Pharmacy, University of Oradea, 410028 Oradea, Romania
2. Doctoral School of Biomedical Sciences, University of Oradea, 410087 Oradea, Romania
Interests: pharmacology; alternative therapies; biochemistry; public health; therapeutics; One Health; sustainability in health; ecology
Special Issues, Collections and Topics in MDPI journals

Special Issue Information

Dear Colleagues,

We are grateful to the researchers who contributed to the first and second volume of this issue:

Cardiovascular Diseases: From Basic Research to Clinical Application: https://www.mdpi.com/journal/life/special_issues/0UO87783VR

Cardiovascular Diseases: From Basic Research to Clinical Application—2nd Edition: https://www.mdpi.com/journal/life/special_issues/CVD

We are pleased to announce the upcoming publication of our Special Issue, entitled “Cardiovascular Diseases: From Basic Research to Clinical Application—3rd Edition".

Presently, cardiovascular disease (CVD) is the most prominent threat to human health. Because CVD is still the leading cause of death, research in this field is a critical task. Although recent decades have seen tremendous progress regarding the risk factors of CVD, the molecular basis of atherosclerosis, coronary revascularization, and treatment of heart failure (these being only a few areas of research interest to be reminded), much remains to be found and the prospects are promising. In order to improve the quality and length of life of those at risk of CVD, finding better predictors of this disease and achieving better means of prevention and treatment must be targets of future research.

The purpose of this Special Issue is to identify several important advances in clinical and basic research regarding CVD that will provide the tools for further progress in the prevention and treatment of this disease. As artificial intelligence plays an increasingly important role in the prevention of CVD, it may be worth considering this aspect as well.

Therefore, it is our pleasure to cordially invite you to submit papers, which address novelties in both clinical and basic cardiovascular research, to this Special Issue. We encourage the submission of all types of manuscripts, including original studies, reviews, and short communications.

We look forward to receiving your contributions.

Dr. Cristiana Bustea
Prof. Dr. Delia Mirela Tit
Guest Editors

Manuscript Submission Information

Manuscripts should be submitted online at www.mdpi.com by registering and logging in to this website. Once you are registered, click here to go to the submission form. Manuscripts can be submitted until the deadline. All submissions that pass pre-check are peer-reviewed. Accepted papers will be published continuously in the journal (as soon as accepted) and will be listed together on the special issue website. Research articles, review articles as well as short communications are invited. For planned papers, a title and short abstract (about 100 words) can be sent to the Editorial Office for announcement on this website.

Submitted manuscripts should not have been published previously, nor be under consideration for publication elsewhere (except conference proceedings papers). All manuscripts are thoroughly refereed through a single-blind peer-review process. A guide for authors and other relevant information for submission of manuscripts is available on the Instructions for Authors page. Life is an international peer-reviewed open access monthly journal published by MDPI.

Please visit the Instructions for Authors page before submitting a manuscript. The Article Processing Charge (APC) for publication in this open access journal is 2600 CHF (Swiss Francs). Submitted papers should be well formatted and use good English. Authors may use MDPI's English editing service prior to publication or during author revisions.

Keywords

  • CVDs
  • risk factors
  • prevention
  • treatment
  • novelties in research
  • artificial intelligence

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Further information on MDPI's Special Issue policies can be found here.

Published Papers (3 papers)

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Research

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16 pages, 397 KB  
Article
Inflammation, Autonomic Control, and Adiposity in Adolescents: Links to Early Cardiovascular Risk
by Vladimir Micieta, Ingrid Tonhajzerova, Nikola Ferencova and Zuzana Visnovcova
Life 2025, 15(9), 1450; https://doi.org/10.3390/life15091450 - 16 Sep 2025
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Abstract
Cardiovascular diseases (CVDs) are generally associated with adulthood, although the underlying processes may begin in childhood and adolescence. Thus, detecting increased cardiovascular risk in adolescence is essential for prevention. In this cross-sectional study, we comprehensively evaluated the inter-relationships between inflammatory markers, cardiac autonomic [...] Read more.
Cardiovascular diseases (CVDs) are generally associated with adulthood, although the underlying processes may begin in childhood and adolescence. Thus, detecting increased cardiovascular risk in adolescence is essential for prevention. In this cross-sectional study, we comprehensively evaluated the inter-relationships between inflammatory markers, cardiac autonomic control indexed by heart rate variability (HRV), and adiposity measures in healthy adolescents, with sex-stratified analyses. We examined 90 adolescents (55 females; age 15.8 ± 1.5 years; BMI 21.4 ± 3.3 kg/m2). We found mixed (positive and negative) associations between inflammatory markers and HRV indices among the entire adolescent group (absolute r range: 0.266–0.395, p < 0.05 for all), while only negative associations in the male group, and only positive associations in the female group (absolute r range: 0.373–0.404, p < 0.05 for all). Furthermore, predominantly positive associations between inflammatory markers and adiposity measures were found among the adolescent group (absolute r range: 0.298–0.338, p < 0.05 for all) and female group (absolute r range: 0.342–0.485, p < 0.05 for all), while contrasting negative associations were found in the male group (absolute r range: 0.421–0.497, p < 0.05 for all). These associations, representing early pathways to cardiovascular vulnerability, seem sex-dependent, but longitudinal confirmation is required. Full article
(This article belongs to the Special Issue Cardiovascular Diseases: From Basic Research to Clinical Application—3rd Edition)
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Review

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14 pages, 674 KB  
Review
DynamX Bioadaptor as an Emerging and Promising Innovation in Interventional Cardiology
by Julia Soczyńska, Kamila Butyńska, Mateusz Dudek, Wiktor Gawełczyk, Sławomir Woźniak and Piotr Gajewski
Life 2025, 15(10), 1549; https://doi.org/10.3390/life15101549 - 2 Oct 2025
Abstract
Coronary artery disease (CAD) remains a major cause of mortality worldwide. Among the standard therapeutic approaches are percutaneous coronary interventions (PCI) employing stents. The main limitation of the procedure lies in the permanent stiffening of the vessel wall. The DynamX Bioadaptor, representing a [...] Read more.
Coronary artery disease (CAD) remains a major cause of mortality worldwide. Among the standard therapeutic approaches are percutaneous coronary interventions (PCI) employing stents. The main limitation of the procedure lies in the permanent stiffening of the vessel wall. The DynamX Bioadaptor, representing a new generation of vascular stents, combines the advantages of standard implants with a unique mechanism—“uncaging.” Its helical structure, linked by a biodegradable material, enables the restoration of the vessel’s natural functions. This breakthrough concept in interventional cardiology holds the potential to establish a new standard of care for patients suffering from CAD. In this work, we aim to synthesize the available evidence concerning the characteristics of the DynamX Bioadaptor and its impact on vascular physiology. We provide a comprehensive review and evaluation of current clinical reports on its use, analyzing the available literature in comparison with other stent technologies. Recognizing that the DynamX Bioadaptor is a relatively recent innovation, we also seek to identify existing gaps in the literature and propose future directions for research to fully assess its long-term clinical potential. Full article
(This article belongs to the Special Issue Cardiovascular Diseases: From Basic Research to Clinical Application—3rd Edition)
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Other

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12 pages, 1590 KB  
Case Report
Patient Diagnosed Initially with Peripartum Cardiomyopathy, Later Rediagnosed with Peripartum Myocardial Infarction: A Case Report
by Spas Kitov, Maria-Florance Kitova, Meri Hristamyan and Lyudmila Vladimirova-Kitova
Life 2025, 15(10), 1502; https://doi.org/10.3390/life15101502 - 24 Sep 2025
Viewed by 53
Abstract
Differentiating peripartum cardiomyopathy (PPCM) from pregnancy-associated myocardial infarction (PAMI) is challenging due to shared risk factors. We report a case of a 35-year-old woman who suffered a seizure and cardiac arrest in the final month of her second pregnancy. Echocardiography showed a normal [...] Read more.
Differentiating peripartum cardiomyopathy (PPCM) from pregnancy-associated myocardial infarction (PAMI) is challenging due to shared risk factors. We report a case of a 35-year-old woman who suffered a seizure and cardiac arrest in the final month of her second pregnancy. Echocardiography showed a normal left ventricular ejection fraction (LVEF). Three days later, she developed heart failure symptoms and a marked reduction in LVEF. After one month of treatment, LVEF nearly normalized, but regional wall motion abnormalities subsequently appeared, prompting coronary angiography, which showed normal coronary arteries. Thus, PPCM was diagnosed. One year later, cardiac magnetic resonance imaging, performed due to her wish for another pregnancy, showed a scar consistent with a previous transmural myocardial infarction. We interpret this as a case of PAMI. Despite medical contraindications, she became pregnant one year after the infarction and delivered via C-section. Five years post-event, there are no signs of heart failure. This case lies in the gray zone of pregnancy-related cardiac complications and highlights the importance of multimodality imaging for thorough structural and functional assessment. Full article
(This article belongs to the Special Issue Cardiovascular Diseases: From Basic Research to Clinical Application—3rd Edition)
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