Innovation and Translation in Cardiovascular Interventions

A special issue of Life (ISSN 2075-1729). This special issue belongs to the section "Medical Research".

Deadline for manuscript submissions: 31 March 2026 | Viewed by 241

Special Issue Editor


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Guest Editor
Department of Cardiology, National Medical Institute of the Ministry of Interior and Administration, Woloska 137 Street, 02-507 Warsaw, Poland
Interests: interventional cardiology; coronary physiology; intravascular imaging; translational cardiovascular research; drug–device combination therapies

Special Issue Information

Dear Colleagues,

We are pleased to announce the launch of a Special Issue entitled “Innovation and Translation in Cardiovascular Interventions.” This Special Issue will focus on recent advances that are shaping the field of cardiovascular therapy, spanning the full spectrum from preclinical discovery to real-world clinical application.

Cardiovascular interventions continue to evolve rapidly, driven by technological breakthroughs, novel device development, pharmacologic innovation, and an improved understanding of pathophysiology. This Special Issue aims to showcase original research, high-quality reviews, and perspective articles that highlight how innovative strategies are improving patient outcomes and translating into practice.

We invite contributions on topics including (but not limited to) the following:

  • Development and evaluation of new interventional devices and technologies.
  • Image-guided and physiology-guided percutaneous procedures.
  • Drug–device combinations and bioresorbable platforms.
  • Translational research bridging preclinical and clinical cardiovascular science.
  • Novel pharmacologic approaches supporting interventional strategies.
  • Advances in structural heart interventions.
  • Artificial intelligence and digital health applications in interventional cardiology.
  • Health economics, implementation science, and registries evaluating innovation adoption.

Article Types:

  • Original research articles;
  • Systematic and narrative reviews;
  • Short communications;
  • Technical notes and perspectives.

We invite you and your colleagues to submit your work and share your insights with the international cardiovascular research community

Dr. Jacek Bil
Guest Editor

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Keywords

  • cardiovascular interventions
  • innovation
  • translational research
  • interventional cardiology
  • structural heart disease
  • device development
  • percutaneous therapy
  • imaging guidance
  • physiology-guided intervention
  • drug–device combination
  • artificial intelligence
  • digital health
  • bioresorbable scaffolds
  • clinical translation
  • cardiovascular technology

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Published Papers (1 paper)

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Research

14 pages, 948 KiB  
Article
Near-Infrared Spectroscopy Patterns as Indicator of Perioperative Stroke in Acute Type A Aortic Dissection
by Henrik Heuer, André Truong, Christian Schach, Lukas Krämer, Jozef Micek, Franz Josef Putz, Bernhard Flörchinger, Fiona Rohlffs, Christof Schmid and Jing Li
Life 2025, 15(8), 1295; https://doi.org/10.3390/life15081295 - 14 Aug 2025
Viewed by 168
Abstract
Neurologic complications remain a major cause of morbidity in patients undergoing surgical repair of acute type A aortic dissection (ATAAD). Near-infrared spectroscopy (NIRS) is used for continuous, noninvasive monitoring of cerebral oxygenation during cardiopulmonary bypass; however, its utility in predicting perioperative stroke remains [...] Read more.
Neurologic complications remain a major cause of morbidity in patients undergoing surgical repair of acute type A aortic dissection (ATAAD). Near-infrared spectroscopy (NIRS) is used for continuous, noninvasive monitoring of cerebral oxygenation during cardiopulmonary bypass; however, its utility in predicting perioperative stroke remains inadequately defined. A retrospective cohort study was conducted in 175 patients who underwent ATAAD repair between 2015 and 2023. Patients were stratified by the occurrence of perioperative stroke (n = 47, 26.9%). Intraoperative NIRS data, including cerebral regional oxygen saturation (crSO2) values at key procedural timepoints and signal variability with band power and crest factor, were analyzed in conjunction with demographic, anatomic, and postoperative variables. Patients with stroke exhibited significantly lower minimum NIRS values during deep hypothermic circulatory arrest (DHCA) (left: 46.7 (15.7–69.4) vs. 52.2 (22.0–81.6); right: 47.0 (23.3–78.5) vs. 56.3 (20.2–85.0); p = 0.03 and p < 0.01). Within the stroke group, NIRS signal variability was significantly greater (crest factor and standard deviation; p < 0.05) and showed blunted recovery post-DHCA. crSO2 values below 50% were more frequent in the stroke group (p = 0.04). Right common carotid artery dissection was more prevalent in the stroke group (40% vs. 23%, p = 0.04). ICU length of stay was significantly increased in patients with stroke. Cerebral desaturation and NIRS signal instability during DHCA are significantly associated with perioperative stroke in ATAAD repair. These findings support the prognostic value of intraoperative cerebral oximetry in detecting critical ischemic thresholds and identifying at-risk perfusion patterns. Full article
(This article belongs to the Special Issue Innovation and Translation in Cardiovascular Interventions)
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