The 15th Anniversary of Life: Endothelial Glycocalyx—A Determinant of Endothelial Function and Vascular Reactivity
A special issue of Life (ISSN 2075-1729). This special issue belongs to the section "Physiology and Pathology".
Deadline for manuscript submissions: 24 April 2026 | Viewed by 5
Special Issue Editor
Interests: cardiovascular physiology; microcirculation; nutrition; endothelium; hypertension; oxidative stress
Special Issues, Collections and Topics in MDPI journals
Special Issue Information
Dear Colleagues,
Endothelial dysfunction (ED) is a universal pathophysiological process that affects all parts of the vascular system, from large conducting blood vessels to functionally crucial microcirculation. The endothelial glycocalyx (eGC) layer on the endothelial surface is crucial for microvascular health and in various clinical stages of conditions and diseases. Oxidative stress and inflammation at the microcirculatory level contribute to the development of ED and the progression of numerous organ damage, as well increasing overall cardiovascular (CV) risk. CVD is the cause of 1/3 of all worldwide deaths. Analysis of the disruption of molecular mechanisms at the eGC level could provide important pathophysiological insights into the development and maintenance of vascular dysfunction in CVD and CKD, as well as potentially lead to the discovery of new biomarkers for assessing CVD and CKD status and possible therapy outcomes. Thus, in this Special Issue, we invite original and review studies performed in human, animal, and other models that explore the role of the endothelial glycocalyx primarily in CVD, but also in other diseases with ED in the background, such as chronic kidney disease, autoimmune disease, high salt intake, and others.
Prof. Dr. Ines Drenjančević
Guest Editor
Manuscript Submission Information
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Keywords
- endothelial glycocalyx
- cardiovascular system
- oxidative stress
- inflammation
- nutrition
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