Mental Health: Clinical Advances in Personalized Medicine

A special issue of Journal of Personalized Medicine (ISSN 2075-4426). This special issue belongs to the section "Personalized Therapy and Drug Delivery".

Deadline for manuscript submissions: 15 July 2025 | Viewed by 784

Special Issue Editors


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Guest Editor
Department of Neurosciences and Psychiatry, University of Toledo College of Medicine & Life Sciences, Toledo, OH 43614, USA
Interests: acute trauma; PTSD; MRI neuroimaging; mental illness and resilience; translational and clinical research

E-Mail Website
Guest Editor
Department of Psychiatry and Behavioral Science, Texas A&M University, Houston, TX 77030, USA
Interests: computational psychiatry; functional MRI neuroimaging; anxiety disorders; PTSD; cognitive psychology

Special Issue Information

Dear Colleagues,

One in eight people worldwide lives with a mental disorder, making it one of the most common health problems globally. Mental health is the ability to cope with the stresses in life, learn and remember, and adapt to the environment. Mental illness not only causes significant physical and emotional suffering but also increases the risk of premature death. Treatment for mental health conditions is not a one-size-fits-all approach. Mental health can be influenced by many factors at multiple levels—individual, familial, societal and environmental. Not everyone exposed to a risk factor will experience mental health problems, and the risk factors can vary across the lifespan. Understanding the brain's response to these risk factors and pathological neurocircuitry mechanisms underlying mental disorders is an important step for developing effective treatment plans and facilitating recovery for psychiatric patients. Therefore, innovative approaches to diagnose and treat mental illness are urgently needed.

The Special Issue “Mental Health: Clinical Advances in Personalized Medicine” aims to explore the mechanisms of mental illnesses of different etiologies and to discover advanced methods for diagnosis and treatment. This initiative aligns with the global efforts to improve mental health care and well-being while supporting those affected by mental illnesses.

We invite authors to submit original works in the above fields in the form of clinical research, literature review, translational research, meta-analyses, etc. This Special Issue will foster a deeper understanding of vulnerability and resilience in mental disorders and promote the development of effective and personalized treatments.

Dr. Hong Xie
Dr. Jony Sheynin
Guest Editors

Manuscript Submission Information

Manuscripts should be submitted online at www.mdpi.com by registering and logging in to this website. Once you are registered, click here to go to the submission form. Manuscripts can be submitted until the deadline. All submissions that pass pre-check are peer-reviewed. Accepted papers will be published continuously in the journal (as soon as accepted) and will be listed together on the special issue website. Research articles, review articles as well as short communications are invited. For planned papers, a title and short abstract (about 100 words) can be sent to the Editorial Office for announcement on this website.

Submitted manuscripts should not have been published previously, nor be under consideration for publication elsewhere (except conference proceedings papers). All manuscripts are thoroughly refereed through a single-blind peer-review process. A guide for authors and other relevant information for submission of manuscripts is available on the Instructions for Authors page. Journal of Personalized Medicine is an international peer-reviewed open access monthly journal published by MDPI.

Please visit the Instructions for Authors page before submitting a manuscript. The Article Processing Charge (APC) for publication in this open access journal is 2600 CHF (Swiss Francs). Submitted papers should be well formatted and use good English. Authors may use MDPI's English editing service prior to publication or during author revisions.

Keywords

  • mental health
  • risk biomarker
  • neurocircuitry
  • well-being and resilience
  • neuroimaging
  • personalized treatment

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Published Papers (1 paper)

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Research

17 pages, 3482 KiB  
Article
COVID-19 Pandemic Impacts on STRESS, PTSD, and Prefrontal Cortical Thickness in Pre-Pandemic Trauma Survivors
by Sharad Chandra, Atheer Amer, Chia-Hao Shih, Qin Shao, Xin Wang and Hong Xie
J. Pers. Med. 2025, 15(4), 127; https://doi.org/10.3390/jpm15040127 - 26 Mar 2025
Viewed by 290
Abstract
Background/Objectives: The COVID-19 pandemic increased psychiatric symptoms in patients with pre-pandemic mental health conditions. However, the effects of pandemic on the brain, stress, and mental illness remain largely conjectural. Our objective was to examine how the pandemic affected prefrontal cortical thicknesses (CTs), [...] Read more.
Background/Objectives: The COVID-19 pandemic increased psychiatric symptoms in patients with pre-pandemic mental health conditions. However, the effects of pandemic on the brain, stress, and mental illness remain largely conjectural. Our objective was to examine how the pandemic affected prefrontal cortical thicknesses (CTs), stress, and PTSD symptoms in people with pre-pandemic trauma histories. Methods: Fifty-one survivors from a pre-pandemic trauma study who had completed a pre-pandemic PTSD Checklist-5 (PCL) to assess PTSD symptoms and a sMRI scan to measure prefrontal CTs were re-recruited after the pandemic. They subsequently completed the COVID Stress Scale (CSS) to assess stress, the Clinician Administered PTSD Scale-5 (CAPS) to diagnose PTSD, and a second sMRI scan. COVID-19 infection was self-reported. Associations between stress and symptom assessments and post-pandemic CTs, differences in CTs in PTSD vs. non-PTSD groups, and changes in pre- to post-pandemic CTs were examined. Results: Pre-pandemic PCL scores were positively associated with CSS scores which, in turn, were higher in the PTSD group. Thicker IFG-opercularis CTs were associated with COVID-19 infection. Post-pandemic rMFG and IFG-orbitalis CTs were positively associated with CAPS scores. rACC CTs were negatively associated with CSS scores. Pre- to post-pandemic rMFG and frontal pole CTs thickened in the PTSD group but thinned in the non-PTSD group, whereas rACC CTs thinned in the PTSD group but thickened in the non-PTSD group. Conclusions: These findings provide novel evidence that the COVID-19 pandemic had diverse effects involving prefrontal cortex structure, stress, and PTSD symptoms in subjects with pre-pandemic trauma history and suggest that treatments are needed to counter these diverse effects. Full article
(This article belongs to the Special Issue Mental Health: Clinical Advances in Personalized Medicine)
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