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Breast Cancer: New Advances in Diagnosis and Personalized Therapies
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Breast Cancer: New Advances in Diagnosis and Personalized Therapies

A special issue of Journal of Personalized Medicine (ISSN 2075-4426). This special issue belongs to the section "Personalized Therapy and Drug Delivery".

Deadline for manuscript submissions: 31 December 2026 | Viewed by 1393

Special Issue Editors

Dr. Pierluigi Maria Rinaldi

E-Mail Website
Guest Editor
Radiology Unit, Mater Olbia Hospital (Qatar Foundation Endowment and Policlinico Universitario Agostino Gemelli IRCCS Foundation), Strada Statale 125 Orientale Sarda, 07026 Olbia, Italy
Interests: breast radiology; mammography; breast ultrasound; breast MRI; oncological radiology; abdominal and pelvic ultrasound (US) and US Doppler; osteo-articular ultrasound; endocavitary ultrasound; Computed Tomography (CT); CT angiography, including cardio-vascular imaging
Special Issues, Collections and Topics in MDPI journals
Dr. Sabatino D'Archi

E-Mail Website
Guest Editor
Multidisciplinary Breast Center, Department of Women, Children and Public Health Sciences, Fondazione Policlinico Universitario Agostino Gemelli IRCCS, Università Cattolica del Sacro Cuore, 00168 Rome, Italy
Interests: breast cancer; breast pathology; breast reconstruction; breast surgery; contralateral prophylactic mastectomy; mastectomy; oncoplastic surgery; surgical oncology
Special Issues, Collections and Topics in MDPI journals

Special Issue Information

Dear Colleagues,

Against the rapidly evolving landscape of breast cancer research and clinical practice, staying abreast of cutting-edge advancements is essential. This Special Issue will provide a comprehensive and up-to-date overview of the latest innovations in breast cancer diagnosis and management, fostering interdisciplinary dialogue among researchers and clinicians.

This Special Issue will provide an overview of the state of the art at this moment in time, with respect to innovations and achievements regarding diagnosis using various techniques (laboratory, genetics, imaging) in breast cancer and intermediate-grade pathology (B3), as well as medical, surgical, radiotherapeutic, and minimally invasive interventional therapies, with a focus on progress and the future and an emphasis on the rapid entry of artificial intelligence (AI) into this field. We welcome original research articles, reviews, and perspectives that will contribute to shaping the next era of breast cancer research.

Dr. Pierluigi Maria Rinaldi
Dr. Sabatino D'Archi
Guest Editors

Manuscript Submission Information

Manuscripts should be submitted online at www.mdpi.com by registering and logging in to this website. Once you are registered, click here to go to the submission form. Manuscripts can be submitted until the deadline. All submissions that pass pre-check are peer-reviewed. Accepted papers will be published continuously in the journal (as soon as accepted) and will be listed together on the special issue website. Research articles, review articles as well as short communications are invited. For planned papers, a title and short abstract (about 250 words) can be sent to the Editorial Office for assessment.

Submitted manuscripts should not have been published previously, nor be under consideration for publication elsewhere (except conference proceedings papers). All manuscripts are thoroughly refereed through a single-blind peer-review process. A guide for authors and other relevant information for submission of manuscripts is available on the Instructions for Authors page. Journal of Personalized Medicine is an international peer-reviewed open access monthly journal published by MDPI.

Please visit the Instructions for Authors page before submitting a manuscript. The Article Processing Charge (APC) for publication in this open access journal is 2600 CHF (Swiss Francs). Submitted papers should be well formatted and use good English. Authors may use MDPI's English editing service prior to publication or during author revisions.

Keywords

  • breast cancer
  • Breast Imaging Reporting and Data System 3 (BI-RADS 3)
  • imaging
  • radiomics
  • therapy
  • AI

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Further information on MDPI's Special Issue policies can be found here.

Published Papers (2 papers)

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Review

22 pages, 2215 KB  
Review
Alternative Treatment Positions over Supine in Adjuvant Whole Breast RT: Prone, Lateral or What Else? A Comprehensive Narrative Review
by Ilaria Benevento, Angela Solazzo, Luciana Rago, Antonietta Montagna, Barbara D’Andrea, Fabrizio Sanna, Salvatrice Campoccia, Antonella Bianculli, Raffaele Tucciariello, Alessia Telesca, Vito Metallo, Francesco Marino, Carmen Linda Ginetti Buccino, Mario Ferrara, Irene Schirò, Teresa Virgilio, Anna Zeccola and Grazia Lazzari
J. Pers. Med. 2026, 16(5), 233; https://doi.org/10.3390/jpm16050233 - 27 Apr 2026
Abstract
Whole breast radiotherapy in adjuvant breast cancer (BC) treatment has been commonly delivered in supine positioning for more than 50 years. Its widespread use is related to the broad availability of simple and common breast board immobilization devices, which exploit the natural recumbent [...] Read more.
Whole breast radiotherapy in adjuvant breast cancer (BC) treatment has been commonly delivered in supine positioning for more than 50 years. Its widespread use is related to the broad availability of simple and common breast board immobilization devices, which exploit the natural recumbent position of the body with arms above the head, the good match with linac tables and well-established set up procedures. However, in scenarios like painful arm discomfort in patients with post-surgery arm or arthritic limitation, unfavorable chest geometry like pectus excavatum (PE), large and pendulous breasts in obese women and cardiac morbidity in left sided BC, supine position seems very uncomfortable for patients and troublesome for radiation oncologists. The question is how to proceed when supine IMRT or DIBH are ineffective strategies? Alternative positions have been analyzed over the past twenty years, starting with a lot of trials testing prone positioning variants with and without DIBH, lateral decubitus or upright standing radiotherapy. A better recognition of new treatment position options in BC adjuvant therapy may provide more opportunities for personalized radiotherapy in this population, to ensure they receive an appropriate, safe and comfortable treatment. Full article
(This article belongs to the Special Issue Breast Cancer: New Advances in Diagnosis and Personalized Therapies)
18 pages, 450 KB  
Review
Post-NAC Microcalcifications in Breast Cancer: Rethinking Surgical Indications in the Era of Precision Oncology
by Sabatino D’Archi, Beatrice Carnassale, Lorenzo Scardina, Cristina Accetta, Flavia De Lauretis, Alba Di Leone, Antonio Franco, Federica Gagliardi, Stefano Magno, Francesca Moschella, Maria Natale, Alejandro Martin Sanchez, Marta Silenzi, Pierluigi Maria Rinaldi and Gianluca Franceschini
J. Pers. Med. 2026, 16(1), 49; https://doi.org/10.3390/jpm16010049 - 12 Jan 2026
Viewed by 824
Abstract
Residual microcalcifications after neoadjuvant chemotherapy (NAC) in breast cancer remain a complex diagnostic and therapeutic challenge. Although NAC has significantly improved pathologic complete response (pCR) rates and transformed surgical approaches, the persistence or evolution of microcalcifications may not accurately reflect residual disease. This [...] Read more.
Residual microcalcifications after neoadjuvant chemotherapy (NAC) in breast cancer remain a complex diagnostic and therapeutic challenge. Although NAC has significantly improved pathologic complete response (pCR) rates and transformed surgical approaches, the persistence or evolution of microcalcifications may not accurately reflect residual disease. This discrepancy complicates radiologic interpretation, impacts surgical decision-making, and may lead to overtreatment or unnecessary mastectomies. This review synthesizes current evidence on the radiologic–pathologic correlation of post-NAC microcalcifications, their prognostic value, and their relevance to guiding surgical management in contemporary precision oncology. A narrative review of the literature was performed, focusing on imaging evolution after NAC, pathologic correlations, predictive and prognostic implications, and the role of microcalcifications in defining optimal surgical strategies, ranging from breast-conserving surgery to mastectomy. Emerging contributions from digital breast tomosynthesis, contrast-enhanced mammography (CEM), Magnetic Resonance (MR) and radiomics are also examined. Studies consistently demonstrate that residual microcalcifications are often poor predictors of viable tumor tissue after NAC. Up to half of cases with persistent calcifications may reflect minimal or absent residual invasive cancer, whereas calcifications may also persist in areas of treatment-induced necrosis or fibrosis. Reliance on calcifications alone may therefore lead to unnecessary extensive resections. Conversely, specific morphologic patterns, especially fine pleomorphic or branching calcifications, are more strongly associated with residual malignancy. Advanced imaging and radiomics show promise in improving predictive accuracy. Residual microcalcifications after NAC should not be interpreted as a direct surrogate of residual disease. A multimodal assessment integrating imaging evolution, tumor biology, and treatment response is essential to optimize surgical planning and avoid overtreatment. Precision surgery in the NAC era increasingly requires individualized decision-making supported by advanced imaging and robust radiologic–pathologic correlation. Full article
(This article belongs to the Special Issue Breast Cancer: New Advances in Diagnosis and Personalized Therapies)
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