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Personalized Medicine for Oral and Maxillofacial Surgery
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Personalized Medicine for Oral and Maxillofacial Surgery

A special issue of Journal of Personalized Medicine (ISSN 2075-4426). This special issue belongs to the section "Personalized Therapy and Drug Delivery".

Deadline for manuscript submissions: 31 March 2026 | Viewed by 705

Special Issue Editor

Dr. Paolo Faccioni

E-Mail Website
Guest Editor
Dentistry and Maxillo-Facial Surgery Unit, Department of Surgery, Dentistry, Paediatrics and Gynaecology, University of Verona, Piazzale L.A. Scuro 10, 37134 Verona, Italy
Interests: maxillo-facial surgery; dentistry; orthognathic surgery; orthodontics

Special Issue Information

Dear Colleagues,

Dentistry is a dynamic discipline, continuously shaped by technological innovation, data-driven decision making, and a growing interest in personalized care. Recent innovations in digital tools, artificial intelligence (AI), and biomedical sciences are redefining diagnostic protocols, treatments, and clinical outcomes across all areas of dental practice.

In modern oral and maxillofacial surgeries, virtual surgical planning (VSP) has become an essential component of routine practice. The generation of high-resolution 3D anatomical models through VSP enables precise and individualized intraoperative decision making. When integrated with intraoral scanning, facial scanning, and CAD/CAM technologies, these tools support the fabrication of patient-specific devices.

A significant leap forward is also being driven by artificial intelligence (AI), which facilitates efficient data analysis, predictive modeling, and clinical decision support, improving both diagnostic and therapeutic workflows.

Concurrently, advances in biomedical research are increasingly being translated into clinical practice. The integration of omics sciences, such as genomics, proteomics, and salivary biomarkers, offers novel pathways for understanding diseases and for developing personalized prevention and treatment strategies.

This Special Issue invites original research, comprehensive reviews, and other paper types on the application of digital dentistry, artificial intelligence, and omics technologies in dentistry and oral and maxillofacial surgery. The goal is to explore how these innovations are shaping clinical practice and advancing dental research.

Dr. Paolo Faccioni
Guest Editor

Manuscript Submission Information

Manuscripts should be submitted online at www.mdpi.com by registering and logging in to this website. Once you are registered, click here to go to the submission form. Manuscripts can be submitted until the deadline. All submissions that pass pre-check are peer-reviewed. Accepted papers will be published continuously in the journal (as soon as accepted) and will be listed together on the special issue website. Research articles, review articles as well as short communications are invited. For planned papers, a title and short abstract (about 250 words) can be sent to the Editorial Office for assessment.

Submitted manuscripts should not have been published previously, nor be under consideration for publication elsewhere (except conference proceedings papers). All manuscripts are thoroughly refereed through a single-blind peer-review process. A guide for authors and other relevant information for submission of manuscripts is available on the Instructions for Authors page. Journal of Personalized Medicine is an international peer-reviewed open access monthly journal published by MDPI.

Please visit the Instructions for Authors page before submitting a manuscript. The Article Processing Charge (APC) for publication in this open access journal is 2600 CHF (Swiss Francs). Submitted papers should be well formatted and use good English. Authors may use MDPI's English editing service prior to publication or during author revisions.

Keywords

  • digital dentistry
  • CAD/CAM
  • artificial intelligence
  • omics
  • oral surgery
  • maxillofacial surgery

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Further information on MDPI's Special Issue policies can be found here.

Published Papers (1 paper)

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Review

13 pages, 874 KB  
Review
Facial Clefts and the Trigeminal Nerve: A Narrative Review of the Literature and Clinical Considerations in the Era of Personalized Medicine
by Natalia Lucangeli, Matilde S. Cannistrà, Domenico Scopelliti, Pasquale Parisi, Domenico Tripodi, Patrick Barbet and Claudio Cannistrà
J. Pers. Med. 2025, 15(11), 556; https://doi.org/10.3390/jpm15110556 - 15 Nov 2025
Viewed by 500
Abstract
Background Facial clefts are rare congenital malformations, occurring in approximately 1 in 700 live births for cleft lip and palate and fewer than 1 in 100,000 for atypical Tessier clefts. They pose significant diagnostic and surgical challenges. While genetic, vascular, and environmental factors [...] Read more.
Background Facial clefts are rare congenital malformations, occurring in approximately 1 in 700 live births for cleft lip and palate and fewer than 1 in 100,000 for atypical Tessier clefts. They pose significant diagnostic and surgical challenges. While genetic, vascular, and environmental factors are well documented, growing embryological evidence suggests that the trigeminal nerve may also contribute to craniofacial development. This narrative review explores the association between trigeminal nerve development and facial clefts, aiming to provide a neurodevelopmental perspective with clinical implications, particularly in the context of personalized medicine, where patient-specific neuroanatomical and developmental factors can guide tailored care. Methods A narrative review of embryological, anatomical, and clinical data was conducted. Histological analyses of malformed fetuses and normal human embryos were integrated with published studies. Clinical findings were compared with Paul Tessier’s facial cleft classification and mapped against trigeminal innervation territories. Results Two groups of facial clefts emerged according to the timing of trigeminal disruption. Early embryonic damage (before 10 weeks of gestation) produces superficial epidermal continuity with fibrotic tissue replacing normal deep structures. Later fetal damage results in complete clefts with full tissue discontinuity. The distribution of these clefts corresponds to trigeminal nerve terminal branch territories, supporting the hypothesis that trigeminal innervation exerts trophic effects on craniofacial morphogenesis through neurohormonal signaling. Conclusions Early impairment of trigeminal development may play a pivotal role in the pathogenesis of certain clefts. The spatial and temporal relationship between nerve development and morphogenesis should be considered in classification and surgical planning. However, limitations of this narrative approach include selective literature coverage and lack of quantitative synthesis. Future directions include single-cell transcriptomics, organoid models, and fetal MRI tractography to clarify trigeminal–mesenchyme interactions and inform therapeutic strategies. These advances may foster a personalized medicine approach, enabling more precise prenatal diagnosis, individualized surgical planning, and optimized long-term outcomes. Full article
(This article belongs to the Special Issue Personalized Medicine for Oral and Maxillofacial Surgery)
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