Precision Medicine in Otorhinolaryngology: From Diagnostics to Personalized Therapy

A special issue of Journal of Personalized Medicine (ISSN 2075-4426). This special issue belongs to the section "Personalized Therapy in Clinical Medicine".

Deadline for manuscript submissions: 25 January 2027 | Viewed by 944

Editors


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Guest Editor Assistant
Otorhinolaryngology Head & Neck Surgery Unit, Casa di Cura Humanitas San Pio X, Milan, Italy
Interests: rhinology; skull base; rhinosinusitis; upper airways; sleep apnea; OSAS

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Guest Editor
Otorhinolaryngology Unit, Humanitas University, Humanitas Clinical and Research Center-IRCCS, 20089 Rozzano, Italy
Interests: rhinosinusitis; personalized medicine; endoscopic surgery; snoring; transoral surgery
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Special Issue Information

Dear Colleagues,

In recent years, clinicians and researchers have increasingly emphasized the importance of incorporating a subjective dimension of diseases to achieve a more holistic understanding of patients' overall health. This shift aligns with the World Health Organization's definition of health as “a state of complete physical, mental, emotional, and social well-being, and not merely the absence of disease or infirmity.” With the patient now being rightfully placed at the center of the therapeutic process, a novel, personalized approach to disease management is emerging across many medical fields. Otorhinolaryngology, in particular, has benefitted significantly from recent advancements in tailored treatments.

Today, patients with head and neck tumors may receive individualized therapies informed by the inflammatory and molecular profile of neoplastic cells. Similarly, those suffering from recalcitrant sinonasal inflammatory conditions, such as chronic rhinosinusitis, may now avoid repeated surgeries or prolonged steroid use through targeted medical strategies. Even patients affected by obstructive sleep apnea can now be offered treatment options customized to their specific polysomnographic patterns and upper airway anatomy, providing viable alternatives to conventional continuous positive airway pressure (CPAP) therapy.

The aim of this Special Issue is to highlight and promote recent advances, skills, and techniques that reflect the growing importance of personalized medicine in the field of otorhinolaryngology. I warmly invite you to contribute original articles that showcase novel insights and innovations in this area. In a world that continues to evolve, medicine must evolve with it!

Dr. Francesco Giombi
Dr. Luca Malvezzi
Guest Editors

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Keywords

  • personalized medicine
  • sinusitis
  • OSA
  • molecular antibodies
  • rhinology
  • oncology
  • head and neck
  • artificial intelligence

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Published Papers (1 paper)

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Review

37 pages, 1403 KB  
Review
A Pressure-Centered Mechanistic Framework for Precision Otology: The Neuro–Vascular–Mechanical–Inflammatory–Autonomic (NVMIA) Regulatory Architecture
by Hee-Young Kim
J. Pers. Med. 2026, 16(6), 315; https://doi.org/10.3390/jpm16060315 - 12 Jun 2026
Viewed by 520
Abstract
Eustachian tube dysfunction (ETD) and related pressure-mediated otologic disorders often present with fluctuating auditory, vestibular, and pressure-related symptoms that are difficult to explain using static structural or symptom-based diagnostic labels alone. This conceptual review proposes the Neuro–Vascular–Mechanical–Inflammatory–Autonomic (NVMIA) framework as a hypothesis-generating architecture [...] Read more.
Eustachian tube dysfunction (ETD) and related pressure-mediated otologic disorders often present with fluctuating auditory, vestibular, and pressure-related symptoms that are difficult to explain using static structural or symptom-based diagnostic labels alone. This conceptual review proposes the Neuro–Vascular–Mechanical–Inflammatory–Autonomic (NVMIA) framework as a hypothesis-generating architecture for organizing such variability. Within this framework, middle ear pressure (MEP) is interpreted as a clinically measurable physiologic variable through which interacting neural, vascular, mechanical, inflammatory, and autonomic influences may become mechanically expressed and clinically observable. The framework does not present NVMIA-based patterns as validated diagnostic categories, clinical decision tools, or treatment algorithms. Rather, it proposes provisional regulatory patterns that may help generate testable hypotheses regarding pressure-regulatory instability, cross-axis coupling, symptom fluctuation, and physiologic reversibility. Mechanical impedance may function as an accessible reference plane for future empirical assessment, while neural, vascular, inflammatory, and autonomic domains are conceptualized as modulatory axes that may alter symptom expression and response variability. The review further outlines future validation needs, including dynamic MEP measurement, patient-reported outcome integration, longitudinal response assessment, and cautious computational modeling. By reframing ETD as a model of state-dependent regulatory instability, the NVMIA framework provides a conceptual basis for future studies in precision otology while emphasizing that prospective validation is required before clinical implementation. Full article
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