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Journal of Personalized Medicine
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Journal of Personalized Medicine, Volume 15, Issue 9

September 2025 - 51 articles

Cover Story: Takotsubo syndrome (TTS), predominantly considered a benign, self-limiting condition with a favorable long-term prognosis and no significant impact on the survival of patients, is a heterogeneous disease with various presentation patterns. Epidemiological studies estimate that TTS accounts for about 2% to 3% of all patients presenting with symptoms of acute coronary syndrome (ACS), rising to 5% to 6% among female patients. This review article aims to provide an overview of the long-term survival of patients with TTS, highlighting potential risk factors and comorbidities that may worsen prognosis. It also explores the risk of recurrence, the utility of advanced imaging modalities for prognosis assessment, and the implications of chronic therapeutic strategies in the long-term management of TTS patients. View this paper
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Articles (51)

  • Article
  • Open Access
505 Views
15 Pages
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High Cerebral Oxygen Saturation Levels During One-Lung Ventilation Predict Better Cognitive and Clinical Outcomes After Thoracic Surgery: A Retrospective Observational Study

  • Ignacio Garutti,
  • Francisco de la Gala,
  • Javier Hortal,
  • Almudena Reyes,
  • Elena de la Fuente,
  • David Martinez-Gascueña,
  • Carlos Alberto Calvo,
  • Santiago Hernández,
  • Estrela Caamaño and
  • Carlos Simón
  • + 2 authors
J. Pers. Med.2025, 15(9), 445;https://doi.org/10.3390/jpm15090445

22 September 2025

Background: Cerebral desaturation during one-lung ventilation (OLV) in thoracic surgery has been associated with postoperative cognitive dysfunction (POCD). While the adverse effects of low intraoperative regional cerebral oxygen saturation (rScO2) a...

Full Article
  • Article
  • Open Access
543 Views
10 Pages
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Diabetes Phenotypes in Patients Presenting a Myocardial Infarction: Progress Towards Precision Medicine?

  • Christelle Lacqua,
  • Arnaud Barbou,
  • Marianne Zeller,
  • Ludwig Serge Aho Glele,
  • Héloïse Adam,
  • Florence Bichat,
  • Jean-Michel Petit,
  • Yves Cottin and
  • Mathieu Boulin
J. Pers. Med.2025, 15(9), 444;https://doi.org/10.3390/jpm15090444

21 September 2025

Background/Objectives: Despite advances in personalized medicine, diabetes classification and management have remained widely unchanged for decades. The aims of the present study were to determine profiles of patients with type 2 diabetes at the time...

Full Article
  • Commentary
  • Open Access
733 Views
11 Pages
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Future of Valvular Heart Disease and Structural Heart Interventions: Why So Much Excitement?

  • Eirini Beneki and
  • Julia Grapsa
J. Pers. Med.2025, 15(9), 443;https://doi.org/10.3390/jpm15090443

19 September 2025

Valvular heart disease (VHD) is becoming increasingly prevalent in the aging population and continues to be a major contributor to cardiovascular morbidity and mortality. Advances in non-invasive imaging, able to confirm the presence and severity of...

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  • Article
  • Open Access
663 Views
16 Pages
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The Role of Age at Onset on the Clinical Course and Biochemical Parameters of Anorexia Nervosa

  • Lorenzo Ferrario,
  • Andrea Costantino,
  • Letizia Maria Affaticati,
  • Massimo Clerici,
  • Antonios Dakanalis,
  • Enrico Capuzzi and
  • Massimiliano Buoli
J. Pers. Med.2025, 15(9), 442;https://doi.org/10.3390/jpm15090442

17 September 2025

Background: Anorexia nervosa (AN) has the highest mortality rate among psychiatric disorders, making early diagnosis and tailored management crucial. This study aimed to evaluate the impact of age at onset (AAO)—childhood/adolescence versus adu...

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  • Article
  • Open Access
473 Views
11 Pages
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Cluster-Based Immunization Patterns in Diabetes Mellitus: Insights for Personalized Preventive Care

  • Teresa Gisinger,
  • Alexandra Kautzky-Willer and
  • Michael Leutner
J. Pers. Med.2025, 15(9), 441;https://doi.org/10.3390/jpm15090441

16 September 2025

Background: We investigated immunization status and preventive care among diabetes mellitus (DM) patients by stratifying them into clinically distinct risk clusters based on comorbidities, reflecting a personalized medicine approach. Methods: Using t...

Full Article
  • Systematic Review
  • Open Access
1,259 Views
22 Pages
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The Precision Paradigm in Periodontology: A Multilevel Framework for Tailored Diagnosis, Treatment, and Prevention

  • Gianna Dipalma,
  • Angelo Michele Inchingolo,
  • Francesco Inchingolo,
  • Irene Palumbo,
  • Lilla Riccaldo,
  • Mariafrancesca Guglielmo,
  • Roberta Morolla,
  • Andrea Palermo,
  • Grazia Marinelli and
  • Alessio Danilo Inchingolo
J. Pers. Med.2025, 15(9), 440;https://doi.org/10.3390/jpm15090440

16 September 2025

Background: Precision medicine in periodontology seeks to individualize prevention, diagnosis, and treatment based on biological, genetic, behavioral, and environmental factors. This approach addresses the limitations of standardized protocols, which...

Full Article
  • Review
  • Open Access
2,365 Views
35 Pages
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Personalizing Cochlear Implant Care in Single-Sided Deafness: A Distinct Paradigm from Bilateral Hearing Loss

  • Emmeline Y. Lin,
  • Stephanie M. Younan,
  • Karen C. Barrett and
  • Nicole T. Jiam
J. Pers. Med.2025, 15(9), 439;https://doi.org/10.3390/jpm15090439

15 September 2025

Background: Cochlear implants (CIs) serve diverse populations with hearing loss, but patients with single-sided deafness (SSD) often show lower post-implantation usage and satisfaction than bilateral CI users. This disparity may stem from their norma...

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  • Article
  • Open Access
1,100 Views
14 Pages
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Association of Insulin Resistance with Dysglycemia in Elder Koreans: Age- and Sex-Specific Cutoff Values

  • Sang Min Yoon and
  • Boyoung Park
J. Pers. Med.2025, 15(9), 438;https://doi.org/10.3390/jpm15090438

15 September 2025

Background/Objectives: Dysglycemia including pre-diabetes mellitus (Pre-DM) and type 2 diabetes mellitus (T2DM) is associated with insulin resistance. This study aimed to support personalized early diagnosis of dysglycemia by proposing optimal, sex-...

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  • Review
  • Open Access
4 Citations
5,068 Views
26 Pages
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Anti-Amyloid Monoclonal Antibodies for Alzheimer’s Disease: Evidence, ARIA Risk, and Precision Patient Selection

  • Amer E. Alkhalifa,
  • Abdulrahman Al Mokhlf,
  • Hande Ali,
  • Nour F. Al-Ghraiybah and
  • Vasiliki Syropoulou
J. Pers. Med.2025, 15(9), 437;https://doi.org/10.3390/jpm15090437

15 September 2025

Alzheimer’s disease (AD) is the most common cause of dementia, pathologically defined by extracellular amyloid-β (Aβ) plaques and intracellular tau neurofibrillary tangles. Recent U.S. Food and Drug Administration (FDA) approvals of a...

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