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JPM
Special Issues
Personalized Medicine in Ophthalmology: Diagnosis, Prevention, and Treatment
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Personalized Medicine in Ophthalmology: Diagnosis, Prevention, and Treatment

A special issue of Journal of Personalized Medicine (ISSN 2075-4426). This special issue belongs to the section "Personalized Therapy and Drug Delivery".

Deadline for manuscript submissions: 25 February 2026 | Viewed by 2810

Special Issue Editors

Dr. Antonio Di Zazzo

E-Mail Website
Guest Editor
Department of Ophthalmology, Campus Bio-Medico University Hospital, 00128 Rome, Italy
Interests: dry eye disease; cornea; refractive surgery; corneal angiogenesis
Special Issues, Collections and Topics in MDPI journals
Dr. Takenori Inomata

E-Mail Website
Guest Editor
Department of Ophthalmology, Juntendo University Graduate School of Medicine, Tokyo 1130033, Japan
Interests: dry eye; meibomian grand dysfunction; allergic conjunctivitis; regulatory T cell; smartphone; artificial intelligence; genome
Special Issues, Collections and Topics in MDPI journals

Special Issue Information

Dear Colleagues,

Ocular surface health is crucial for maintaining visual function and overall eye comfort, impacting millions around the world. Our evolving understanding of ocular surface interactions has led to new preventative, diagnostic, and therapeutic strategies that are transforming patient care. This Special Issue focuses on these advancements, emphasizing personalized approaches that enhance treatment efficacy and patient outcomes. We are particularly interested in featuring research that not only advances our diagnostic and preventive capabilities but also introduces innovative treatments, such as advanced scleral lens technologies tailored to specific patient needs.

We invite you to submit your latest research, reviews, etc., that illuminate new understandings and methodologies in ophthalmology. Whether it involves groundbreaking treatments or in-depth analyses of molecular and clinical dynamics, your contributions will pave the way for future research in personalized ocular care.

Dr. Antonio Di Zazzo
Dr. Takenori Inomata
Guest Editors

Manuscript Submission Information

Manuscripts should be submitted online at www.mdpi.com by registering and logging in to this website. Once you are registered, click here to go to the submission form. Manuscripts can be submitted until the deadline. All submissions that pass pre-check are peer-reviewed. Accepted papers will be published continuously in the journal (as soon as accepted) and will be listed together on the special issue website. Research articles, review articles as well as short communications are invited. For planned papers, a title and short abstract (about 100 words) can be sent to the Editorial Office for announcement on this website.

Submitted manuscripts should not have been published previously, nor be under consideration for publication elsewhere (except conference proceedings papers). All manuscripts are thoroughly refereed through a single-blind peer-review process. A guide for authors and other relevant information for submission of manuscripts is available on the Instructions for Authors page. Journal of Personalized Medicine is an international peer-reviewed open access monthly journal published by MDPI.

Please visit the Instructions for Authors page before submitting a manuscript. The Article Processing Charge (APC) for publication in this open access journal is 2600 CHF (Swiss Francs). Submitted papers should be well formatted and use good English. Authors may use MDPI's English editing service prior to publication or during author revisions.

Keywords

  • ocular surface
  • dry eye disease
  • scleral lenses
  • corneal disease
  • keratoconus

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Further information on MDPI's Special Issue policies can be found here.

Published Papers (1 paper)

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Review

13 pages, 286 KiB  
Review
Impact of Scleral Lenses on Visual Acuity and Ocular Aberrations in Corneal Ectasia: A Comprehensive Review
by Vincenzo Barone, Daniele Petrini, Sebastiano Nunziata, Pier Luigi Surico, Claudia Scarani, Francesco Offi, Valentina Villani, Marco Coassin and Antonio Di Zazzo
J. Pers. Med. 2024, 14(10), 1051; https://doi.org/10.3390/jpm14101051 - 11 Oct 2024
Cited by 1 | Viewed by 2424
Abstract
Corneal ectasias, including keratoconus (KC), pellucid marginal degeneration (PMD), and post-LASIK ectasia, poses significant visual rehabilitation challenges due to the resultant irregular astigmatism, myopia, and higher-order aberrations (HOAs). These conditions often resist traditional corrective methods, necessitating advanced optical solutions. Scleral lenses (SLs) have [...] Read more.
Corneal ectasias, including keratoconus (KC), pellucid marginal degeneration (PMD), and post-LASIK ectasia, poses significant visual rehabilitation challenges due to the resultant irregular astigmatism, myopia, and higher-order aberrations (HOAs). These conditions often resist traditional corrective methods, necessitating advanced optical solutions. Scleral lenses (SLs) have emerged as a primary non-surgical option for managing these complex corneal irregularities. SLs form a smooth optical interface by forming a tear-filled chamber between the lens and the cornea, effectively mitigating HOAs and improving both high-contrast and low-contrast visual acuity (VA). This review evaluates the efficacy of SLs in enhancing VA and reducing aberrations in patients with corneal ectasia. It also explores the technological advancements in SLs, such as profilometry and wavefront-guided systems, which enable more precise and customized lens fittings by accurately mapping the eye’s surface and addressing specific visual aberrations. The current body of evidence demonstrates that custom SLs significantly improve visual outcomes across various ectatic conditions, offering superior performance compared to conventional correction methods. However, challenges such as the complexity of fitting and the need for precise alignment remain. Ongoing innovations in SL technology and customization are likely to further enhance their clinical utility, solidifying their role as an indispensable tool in the management of corneal ectasias. Full article
(This article belongs to the Special Issue Personalized Medicine in Ophthalmology: Diagnosis, Prevention, and Treatment)
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