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Journal of Clinical Medicine publishes Special Issues to create collections of papers on specific topics, with the aim of building a community of authors and readers to discuss the latest research and develop new ideas and research directions. Special Issues are led by Guest Editors, who are experts on the topic and all Special Issue submissions follow MDPI's standard editorial process. The journal’s Editor-in-Chief and/or designated Editorial Board Member will oversee Guest Editor appointments and Special Issue proposals, checking their content for relevance and ensuring the suitability of the material for the journal. The papers published in a Special Issue will be collected and displayed on a dedicated page of the journal’s website. Further information on MDPI's Special Issue policies and Guest Editor responsibilities can be found here. For any inquiries related to a Special Issue, please contact the Editorial Office.

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Effect of Long-Term Insomnia on Mental Health—2nd Edition submission deadline 21 Nov 2025 | 1 articles | Viewed by 6894
Keywords: anxiety; alcohol and substance use disorders; behavioral addiction; burnout; cognitive dysfunction; depression; eating disorders; gaming addiction; problematic internet/social media use; insomnia; long-term insomnia; mood disorders; post-traumatic stress disorder; stress
(This special issue belongs to the Section Mental Health)
Research Advances in Coagulation Disorders
edited by Alberto Maino
submission deadline 21 Nov 2025 | Viewed by 182
Keywords: coagulation; bleeding disorders; thrombosis; hemophilia; clotting disorders; hematology
(This special issue belongs to the Section Hematology)
Clinical Features and Management of Psychosis
edited by , and Michael Hadjulis
submission deadline 23 Nov 2025 | 4 articles | Viewed by 8999 | Submission Open
Keywords: psychosis; clinical features of psychosis; diagnosis of psychosis; schizophrenia; psychotic depression; affective disorder with psychotic features; psychosis in substance use disorders; psychosis in neurological disorders; psychosis in medical conditions; management of psychosis; treatment of psychosis
(This special issue belongs to the Section Mental Health)
Clinical Management of Type 1 Diabetes
edited by Carmen Quirós
submission deadline 25 Nov 2025 | 7 articles | Viewed by 30641 | Submission Open
Keywords: type 1 diabetes; continuous glucose monitoring; hybrid closed loop; hypoglycemia; physical activity; new onset type 1 diabetes; pre-stage 3 type 1 diabetes; smart insulin pens
(This special issue belongs to the Section Endocrinology & Metabolism)
The “Orthogeriatric Fracture Syndrome”—Issues and Perspectives submission deadline 25 Nov 2025 | 18 articles | Viewed by 29459 | Submission Open
Keywords: geriatric trauma; fragility fracture; orthogeriatric; co-management; assessment; integrated care; osteoporosis; sarcopenia; frailty; gait disturbance; fall; rehabilitation; prehabilitation; prevention; ehealth; digitalization
(This special issue belongs to the Section Orthopedics)
Perinatal Mental Health Management submission deadline 25 Nov 2025 | 5 articles | Viewed by 20157 | Submission Open
Keywords: perinatal mental health; child mental health; problem behavior; cognitive development therapy; hyperactivity
(This special issue belongs to the Section Mental Health)
Neurovascular Diseases: Clinical Advances and Challenges
edited by , Silky Chotai, Alessandro Di Rienzo and Joham Choque-Velasquez
submission deadline 25 Nov 2025 | 11 articles | Viewed by 20146 | Submission Open
Keywords: neurovascular diseases; ischemic stroke; hemorrhagic stroke; aneurysms; vascular malformations; diagnostic imaging; minimally invasive approaches; surgical techniques; endovascular interventions; treatment algorithms
(This special issue belongs to the Section Clinical Neurology)
Clinical Pharmacology: Adverse Drug Reactions
edited by and Ivana Mudnić
submission deadline 25 Nov 2025 | 5 articles | Viewed by 19885 | Submission Open
Keywords: pharmacology; adverse drug reactions; drug interactions; pharmacovigilance; drug safety
(This special issue belongs to the Section Pharmacology)
Ventilation in Critical Care Medicine: 2nd Edition
edited by Gianluca Zani
submission deadline 25 Nov 2025 | 1 articles | Viewed by 13766 | Submission Open
Keywords: invasive ventilation; non-invasive ventilation; acute respiratory failure; best PEEP; respiratory weaning; respiratory mechanics; ventilation and perfusion; personalized ventilation
(This special issue belongs to the Section Intensive Care)
Glomerulonephritis: Current Diagnosis, Treatment and Future Options
edited by Ana I. Ávila and
submission deadline 25 Nov 2025 | 3 articles | Viewed by 12866 | Submission Open
Keywords: glomerulonephritis; diagnosis; management; drug therapies; treatment
(This special issue belongs to the Section Nephrology & Urology)
Challenges in Diagnosis and Treatment of Gynecological Malignancies in Young Adults
edited by , Dimitrios Haidopoulos and
submission deadline 25 Nov 2025 | 4 articles | Viewed by 11209 | Submission Open
Keywords: gynecological cancers; young adults; young women; fertility; personalized care
(This special issue belongs to the Section Obstetrics & Gynecology)
Weaning from Non-Invasive Mechanical Ventilation Approaches (NIV-NHF): Insights on How, When and Where submission deadline 25 Nov 2025 | 2 articles | Viewed by 9788 | Submission Open
Keywords: non-invasive positive pressure ventilation (NIPPV); nasal high flow oxygen; respiratory failure; intensive care units; pneumology wards; non-invasive mechanical ventilation approaches (NIV nasal high flow)
(This special issue belongs to the Section Intensive Care)
Recent Advances in Spine Tumor Diagnosis and Treatment
edited by Jae Hwan Cho
submission deadline 25 Nov 2025 | 8 articles | Viewed by 8799 | Submission Open
Keywords: spine tumor; spinal metastasis; pathologic fracture; cord compression; separation surgery; radiotherapy; interdisciplinary collaboration; surgeon’ s role; medical oncologist; radiologic oncologist; psychological aspects; pain management; innovative approaches; patient outcomes; diagnostic advancements
(This special issue belongs to the Section Clinical Neurology)
Gynecological Cancers—Surgical Management, Prognosis, and Quality of Life: 2nd Edition submission deadline 25 Nov 2025 | 5 articles | Viewed by 8694 | Submission Open
Keywords: gynecological cancers; endometrial cancer; ovarian cancer; cervical cancer; vulvar cancer; vaginal cancer; breast cancer; surgery; radiotherapy; systemic treatment; quality of life
(This special issue belongs to the Section Obstetrics & Gynecology)
Cystic Fibrosis: Novel Strategies of Diagnosis and Treatments
edited by and
submission deadline 25 Nov 2025 | 6 articles | Viewed by 7826 | Submission Open
Keywords: cystic fibrosis; CFTR modulators; stop mutations; gene therapy; mRNA therapy; novel therapies; rare pathogens
(This special issue belongs to the Section Respiratory Medicine)
A Multi-Faceted Approach to Urinary Incontinence and Other Pelvic Floor Dysfunction—from Prevention to Therapy submission deadline 25 Nov 2025 | 3 articles | Viewed by 7625 | Submission Open
Keywords: urinary incontinence; pelvic floor dysfunction; urinary and fecal incontinence; pelvic organs prolapse; pelvic pain; pelvic floor disorders
(This special issue belongs to the Section Nephrology & Urology)
Clinical Diagnosis and Management of Vestibular Disorders
edited by , Mario Habek and
submission deadline 25 Nov 2025 | 7 articles | Viewed by 7340 | Submission Open
Keywords: vertigo; dizziness; epidemiology; genetics; diagnostics; management
(This special issue belongs to the Section Otolaryngology)
Cardiothoracic Surgery and Enhanced Recovery: Recent Advances and Perspectives
edited by Edris A.F. Mahtab
submission deadline 25 Nov 2025 | 4 articles | Viewed by 7230 | Submission Open
Keywords: coronary artery bypass surgery; valve repair/replacement; minimally invasive cardiac procedures; aortic dissection repair; thoracic aortic aneurysm surgery; lung transplantation; ventricular assist devices; esophagectomy; lung surgery; heart transplantation; use of XR and AI in Enhanced recovery
(This special issue belongs to the Section General Surgery)
Advances in Dry Eye Disease Treatment: 2nd Edition
edited by and
submission deadline 25 Nov 2025 | 3 articles | Viewed by 6835 | Submission Open
Keywords: dry eye disease; meibomian gland; tear substitutes; corticosteroids; cyclosporin; antibiotics; non-steroid anti-inflammatory drugs; biological tear substitutes; nutrients; pulsed light
(This special issue belongs to the Section Ophthalmology)
Clinical Utility of Optical Coherence Tomography in Ophthalmology: 2nd Edition submission deadline 25 Nov 2025 | 4 articles | Viewed by 6676 | Submission Open
Keywords: optical coherence tomography; ophthalmology; intraoperative OCT; en face OCT; wide-field OCT; retinal diseases; glaucoma; cornea; strabismus; cataract
(This special issue belongs to the Section Ophthalmology)
New Perspectives in Lumbar Spine Surgery: Treatment and Management
edited by
submission deadline 25 Nov 2025 | 4 articles | Viewed by 6206 | Submission Open
Keywords: lumbar surgery; spine surgery; minimally invasive techniques; advanced imaging; surgical innovations; patient outcomes; evidence-based practices; postoperative care; rehabilitation strategies; surgical management
(This special issue belongs to the Section Orthopedics)
Research and Applications in Clinical Pharmacy Based on Pharmacokinetics and Pharmacogenetics
edited by
submission deadline 25 Nov 2025 | 3 articles | Viewed by 5735 | Submission Open
Keywords: pharmacokinetics; clinical pharmacy; personalized medicine; drug therapy management; therapeutic drug monitoring
(This special issue belongs to the Section Pharmacology)
Advanced Techniques for the Treatment of Complex Coronary Artery Disease: 2nd Edition
edited by Simone Calcagno
submission deadline 25 Nov 2025 | 3 articles | Viewed by 5579 | Submission Open
Keywords: coronary calcified lesion; IVUS; OCT; intravascular lithotripsy; bifurcation coronary lesions; left main; chronic total occlusions; multivessel disease; STEMI; NSTEMI
(This special issue belongs to the Section Cardiovascular Medicine)
Novel Insights into the Diagnosis and Management of Inflammatory Bowel Disease (IBD)
edited by
submission deadline 25 Nov 2025 | 4 articles | Viewed by 3794 | Submission Open
Keywords: inflammatory bowel disease; non-invasive biomarkers; abdominal ultrasonography; colonoscopy; biologic therapy; small molecules; mucosal healing; brain-gut axis; dysbiosis; colorectal dysplasia
(This special issue belongs to the Section Gastroenterology & Hepatopancreatobiliary Medicine)
Recent Developments and Emerging Trends in Aortic Surgery
edited by Daniele Linardi
submission deadline 25 Nov 2025 | 4 articles | Viewed by 3767 | Submission Open
Keywords: aortic aneurysm; aortic dissection; endovascular repair; minimally invasive approaches; thoracic aorta; abdominal aorta; aortic valve-sparing surgery; aortic stent grafts
(This special issue belongs to the Section Vascular Medicine)
Assessing Strategies and Challenges in Heart Failure: An Update
edited by
submission deadline 25 Nov 2025 | 2 articles | Viewed by 3527 | Submission Open
Keywords: cardiac MR; coronary microvascular dysfunction; diagnosis; endothelial function; heart failure; myocardial metabolism; prognosis
(This special issue belongs to the Section Cardiology)
Recent Advances in Intracranial Aneurysm Treatment
edited by Victor Volovici
submission deadline 25 Nov 2025 | 2 articles | Viewed by 3355 | Submission Open
Keywords: intracranial aneurysm; cerebrovascular disease; microneurosurgery; endovascular treatment; subarachnoid hemorrhage
(This special issue belongs to the Section Clinical Neurology)
Thoracic Surgery: Recent Developments and Future Challenges
edited by and Lucio Cagini
submission deadline 25 Nov 2025 | 1 articles | Viewed by 2747 | Submission Open
Keywords: VATS; RATS; ERAS; sublobar resection; minimally invasive thoracic surgery; target therapy; nodule localization
(This special issue belongs to the Section Respiratory Medicine)
Vascular Surgery: Current Advances and Future Directions
edited by Giovanni Coppi
submission deadline 25 Nov 2025 | 2 articles | Viewed by 2591 | Submission Open
Keywords: stroke; carotid artery stenosis; carotid artery stenting; carotid endarterectomy; occlusion
(This special issue belongs to the Section General Surgery)
Recent Developments and Emerging Trends of Echocardiography in Cardiac Disease
edited by Petri Gudmundsson
submission deadline 25 Nov 2025 | 2 articles | Viewed by 2584 | Submission Open
Keywords: echocardiography development; artificial intelligence (AI) integration; real-time 3D and 4D imaging; portable and handheld devices; contrast-enhanced imaging; tissue characterization; integration with other modalities; quantitative analysis; tele-echocardiography
(This special issue belongs to the Section Cardiology)
The Rebirth of Ventral Skull Base Surgery through Multiportal Approaches: Endonasal, Transorbital, Transmaxillary and Transoral Routes
edited by Matteo de Notaris and Francesco Corrivetti
submission deadline 25 Nov 2025 | 3 articles | Viewed by 2327 | Submission Open
Keywords: skull base surgery; neuroendoscopy; neuroanatomy; multiportal approaches; technical advancements
(This special issue belongs to the Section Clinical Neurology)
Modern Blood Banking and Transfusion in Clinical Practice: Second Edition
edited by
submission deadline 25 Nov 2025 | 2 articles | Viewed by 1856 | Submission Open
Keywords: blood transfusion therapy; patient blood management; restrictive transfusion; cell therapy; platelet transfusion
(This special issue belongs to the Section Hematology)
Interstitial Lung Disease Secondary to Autoimmune Disorders: Recent Advances and Novel Perspectives
edited by , and Francesco Ferro
submission deadline 25 Nov 2025 | 1 articles | Viewed by 1791 | Submission Open
Keywords: interstitial lung disease; lung involvement; connective tissue diseases; rheumatoid arthritis; systemic vasculitis; radiomics; lung ultrasound; biomarkers; pathogenetic immunological pathways; therapeutic targets
(This special issue belongs to the Section Respiratory Medicine)
Treatment and Prognosis of Spinal Surgery
edited by Andy Ton and Shane Shahrestani
submission deadline 25 Nov 2025 | 2 articles | Viewed by 1544 | Submission Open
Keywords: spinal surgery; minimally invasive surgery (MIS); robotic-assisted surgery; patient-reported outcomes (PROs); postoper-ative outcomes; predictive analytics; radiographic predictors; endoscopic; disk arthroplasty; single position surgery
(This special issue belongs to the Section Clinical Neurology)
Clinical Advances in Surgical Treatment for Hepato–Pancreatic–Biliary (HPB) Diseases
edited by
submission deadline 25 Nov 2025 | 1 articles | Viewed by 1531 | Submission Open
Keywords: pancreas surgery; liver resection; minimal invasive approach; virtual reality; robotic surgery; MDT
(This special issue belongs to the Section Gastroenterology & Hepatopancreatobiliary Medicine)
Advances in the Clinical Management of Perioperative Anesthesia: 2nd Edition
edited by Alessia Mattei, Rita Cataldo and
submission deadline 25 Nov 2025 | 3 articles | Viewed by 1304 | Submission Open
Keywords: perioperative outcomes (surgical; anesthetic; medical); evidence-based care; perioperative guidelines and consensus statements; preoperative evaluation and risk scores; preoperative testing; surgical optimization and enhanced surgical recovery programs; intensive care unit
(This special issue belongs to the Section Anesthesiology)
Hospital-Acquired Infections in the Elderly
edited by Nadya Kagansky and Emily Lubart
submission deadline 25 Nov 2025 | 1 articles | Viewed by 1255 | Submission Open
Keywords: hospital-acquired infections (HAIs); elderly patients; infection control; microbial resistance; epidemiology; risk factors; prevention strategies; treatment options; diagnostic accuracy
(This special issue belongs to the Section Epidemiology & Public Health)
Current Clinical Advances in Urinary Incontinence
edited by Adolf Lukanovic, David Lukanović and Mija Blaganje
submission deadline 25 Nov 2025 | 2 articles | Viewed by 1219 | Submission Open
Keywords: female urinary incontinence; stress urinary incontinence; overactive bladder; diagnosis; prevention; conservative treatment; minimally invasive treatment; surgery; mid-urethral sling; new approach; energy-based devices
(This special issue belongs to the Section Nephrology & Urology)
Diabetic Foot: Emerging Prevention Strategies and Epidemiology submission deadline 25 Nov 2025 | 1 articles | Viewed by 1141 | Submission Open
Keywords: diabetic foot; foot clinics; epidemiology; prevention; screening; amputation; podiatry
(This special issue belongs to the Section Endocrinology & Metabolism)
Endometriosis: Current Insights and Treatments
edited by Mercedes Espada Vaquero
submission deadline 25 Nov 2025 | 1 articles | Viewed by 1080 | Submission Open
Keywords: endometriosis; chronic pelvic pain; pelvic floor dysfunction; hormonal treatment; gynecological surgery; diagnosis; hysteroscopy; infertility
(This special issue belongs to the Section Obstetrics & Gynecology)
Approaches and Challenges in Oral Rehabilitation
edited by and Takayuki Kosaka
submission deadline 25 Nov 2025 | 1 articles | Viewed by 1038 | Submission Open
Keywords: oral rehabilitation; oral health; systemic health; dental innovation; neuroplasticity
(This special issue belongs to the Section Dentistry, Oral Surgery and Oral Medicine)
Emerging Treatment Options in Aortic Valve Disease and Aortic Stenosis
edited by Borut Geršak and Robert Phillip Gallegos
submission deadline 25 Nov 2025 | 1 articles | Viewed by 1018 | Submission Open
Keywords: aortic stenosis; minimally invasive surgery; transcatheter aortic valve replacement; surgical treatment; diagnostic strategies; re-operation/redo AVR; calcified root; valve in valve
(This special issue belongs to the Section Cardiology)
Recent Advances in Adverse Pregnancy and Neonatal Outcomes
edited by
submission deadline 25 Nov 2025 | 1 articles | Viewed by 950 | Submission Open
Keywords: maternal and fetal; adverse pregnancy; neonatal outcomes; newborns; cesarean section
(This special issue belongs to the Section Obstetrics & Gynecology)
New Insights in Paediatric Endocrinology
edited by
submission deadline 25 Nov 2025 | 1 articles | Viewed by 474 | Submission Open
Keywords: endocrinology; pediatrics; hormones; therapy and treatment; adolescents; newborns
(This special issue belongs to the Section Clinical Pediatrics)
Ischemic Stroke: Diagnosis, Treatment, and Management
edited by and Rosario Pascarella
submission deadline 25 Nov 2025 | Viewed by 449 | Submission Open
Keywords: ischemic stroke; diagnosis; treatment; stroke unit; stroke care; stroke etiology; thrombolysis; EVT; rare causes of stroke; cerebral vein thrombosis
(This special issue belongs to the Section Clinical Neurology)
Recent Advances in Diagnosis and Treatment of Comorbid Disorders in Interstitial Lung Diseases
edited by and Domenica Francesca Mariniello
submission deadline 25 Nov 2025 | Viewed by 240 | Submission Open
Keywords: interstitial lung disease; ILD; progressive pulmonary fibrosis; artificial intelligence; management
(This special issue belongs to the Section Respiratory Medicine)
Enhancing Safety and Outcomes in Complex Spine Surgery
edited by Ahmed Ramadan Sadek
submission deadline 25 Nov 2025 | Viewed by 230 | Submission Open
Keywords: spinal surgery; spinal deformity; scoliosis; sciatica; back and neck pain
(This special issue belongs to the Section Clinical Neurology)
Minimally Invasive Laparoendoscopic Procedures in Abdominal Emergencies submission deadline 25 Nov 2025 | Viewed by 186 | Submission Open
Keywords: laparoscopic surgery; robotic surgery; minimally invasive surgery; hepatobiliary surgery; pancreatic surgery; gastrointestinal surgery; general surgery; emergency surgery; trauma; recent advances in laparoscopic surgery; surgical training in laparoscopy; endoscopic surgery; the feasibility and safety of laparoscopic; endoscopic co-operative surgery for the treatment of digestive pathology
(This special issue belongs to the Section General Surgery)
Advances in Ablation Therapy for Atrial Fibrillation: Innovations and Clinical Applications
edited by Ioanna Koniari
submission deadline 25 Nov 2025 | Viewed by 180 | Submission Open
Keywords: atrial fibrillation; ablation; PFA; PVI; non-thermal energy; mapping system
(This special issue belongs to the Section Cardiology)
Ventricular Assist Devices: Clinical Advances in Practice and Future Perspectives
edited by Balakrishnan M. Mahesh
submission deadline 25 Nov 2025 | Viewed by 174 | Submission Open
Keywords: ventricular assist device; mechanical circulatory support; pulsatile pneumatic devices; microaxial intraventricular de-vices; magnetically levitated devices; cardiac transplantation; donor circulatory death; normothermic regional perfusion
(This special issue belongs to the Section Cardiology)
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