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Emerging Treatment Options in Aortic Valve Disease and Aortic Stenosis

A special issue of Journal of Clinical Medicine (ISSN 2077-0383). This special issue belongs to the section "Cardiology".

Deadline for manuscript submissions: 25 November 2025 | Viewed by 618

Special Issue Editors


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Guest Editor
Faculty of Medicine, University of Ljubljana, 1000 Ljubljana, Slovenia
Interests: minimally invasive aortic valve surgery; mitral valve; aortic valve; minimally invasive atrial fibrillation ablation; sutureless aortic valves

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Guest Editor
1. Division of Cardiac Surgery, Creighton University School of Medicine, 2616 Burt St, Omaha, NE 68178, USA
2. CHI Creighton University Bergan Mercy Medical Center, 7500 Mercy Rd, Omaha, NE 68124, USA
Interests: heart failure; minimally invasive valve surgery; structural heart disease–TAVR; mitraclip

Special Issue Information

Dear Colleagues,

This Special Issue on "Emerging Treatment Options in Aortic Valve Disease and Aortic Stenosis" aims to explore the latest advancements and innovative approaches in the diagnosis, management, and treatment of aortic valve disease and aortic stenosis. This Issue will feature contributions from leading experts in the field, providing comprehensive insights into novel therapeutic strategies, surgical techniques, and interventional procedures. The goal is to enhance understanding and improve patient outcomes through the dissemination of cutting-edge research and clinical practices. Agenda with Article Titles:

  1. Introduction to Aortic Valve Disease and Aortic Stenosis
  • Overview of Aortic Valve Disease
  • Pathophysiology of Aortic Stenosis
  • Epidemiology and Risk Factors
  1. Advancements in Diagnostic Techniques
  • Innovations in Echocardiography for Aortic Stenosis
  • Role of Cardiac MRI in Aortic Valve Assessment
  • Biomarkers in the Diagnosis of Aortic Valve Disease
  1. Surgical Treatment Options
  • Advances in Aortic Valve Replacement Surgery
  • Minimally Invasive Surgical Techniques
  • Outcomes and Complications of Surgical Interventions
  1. Transcatheter Aortic Valve Replacement (TAVR)
  • Indications and Patient Selection for TAVR
  • Procedural Techniques and Innovations
  • Long-term Outcomes and Follow-up Care
  1. Pharmacological Management
  • Medical Therapy for Aortic Stenosis: Current Evidence
  • Emerging Drug Therapies for Aortic Valve Disease
  • Role of Anticoagulation in Aortic Valve Management
  1. Innovative Interventional Procedures
  • Balloon Aortic Valvuloplasty: Indications and Techniques
  • Novel Catheter-Based Therapies
  • Future Directions in Interventional Cardiology
  1. Patient-Centered Care and Quality of Life
  • Impact of Aortic Valve Disease on Quality of Life
  • Rehabilitation and Lifestyle Modifications
  1. Future Perspectives and Research Directions
  • Emerging Technologies in Aortic Valve Disease Treatment
  • Genetic and Molecular Research in Aortic Stenosis
  • Clinical Trials and Future Research Priorities

Prof. Dr. Borut Geršak
Dr. Robert Phillip Gallegos
Guest Editors

Manuscript Submission Information

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Keywords

  • aortic stenosis
  • minimally invasive surgery
  • transcatheter aortic valve replacement
  • surgical treatment
  • diagnostic strategies
  • re-operation/redo AVR
  • calcified root
  • valve in valve

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Published Papers (1 paper)

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Research

15 pages, 1362 KB  
Article
Surgical and Clinical Aspects Associated with Double-Valve Infective Endocarditis
by Sonia Lerta, Gloria Sangaletti, Vincenzo Antonio Villano, Flavia Puci, Eraldo Kushta, Pasquale Totaro, Filippo Amoroso, Giulia Magrini, Pietro Valsecchi, Raffaele Bruno and Elena Seminari
J. Clin. Med. 2025, 14(15), 5589; https://doi.org/10.3390/jcm14155589 - 7 Aug 2025
Viewed by 340
Abstract
Background: Double-valve infective endocarditis (DVIE) accounts for 15–20% of all endocarditis and represents a challenge due to the increased incidence of embolic events and congestive heart failure compared to infective endocarditis (IE) affecting one valve. This study aims to evaluate patients’ characteristics, [...] Read more.
Background: Double-valve infective endocarditis (DVIE) accounts for 15–20% of all endocarditis and represents a challenge due to the increased incidence of embolic events and congestive heart failure compared to infective endocarditis (IE) affecting one valve. This study aims to evaluate patients’ characteristics, surgical procedures, complications, and mortality associated with DVIE in our tertiary hospital in Italy. The Endocarditis Registry STEADY includes patients admitted with IE from January 2009 to March 2024 (n = 398). Sixty-three of them (16%) had DVIE. Methods: We conducted a retrospective single-center observational study, analyzing demographic, clinical, and microbiological data in DVIE patients, comparing those treated surgically (surgical group, SG) with those treated medically (non-surgical group, NSG). Results: The groups were homogeneous in age, microbiological yields, type of valve involved, and risk factors for infective endocarditis. The surgical group presented significantly more cancer history, intracardiac complications, and new-onset arrhythmias compared to the non-surgical group. Median hospital stay was similar in both groups. In SG, the most common postoperative complication was new rhythm disorders; other complications such as cardiac tamponade, pericardial effusion, and pneumothorax were rare. In-hospital mortality was similar between groups; however, one-year survival was higher in the surgical group (72% vs. 54%, p = 0.031). In our series, 16 patients were over 75 years old (25%), and 7 of them (44%) underwent cardiac surgery. One-year survival in the surgical group was also higher in this subgroup. Conclusions: Surgical treatment, when indicated, may improve the prognosis of patients with DVIE, including elderly patients. Full article
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