Clinical Advances in Surgical Treatment for Hepato–Pancreatic–Biliary (HPB) Diseases
A special issue of Journal of Clinical Medicine (ISSN 2077-0383). This special issue belongs to the section "Gastroenterology & Hepatopancreatobiliary Medicine".
Deadline for manuscript submissions: 25 November 2025 | Viewed by 44
Special Issue Editor
2. Surgical Anatomy, University of Athens, Athens, Greece
3. HPB Unit, EuroClinic, Athens, Greece
Interests: surgical oncology; hepato-biliary surgery; pancreatic surgery; multi-organ transplant
Special Issue Information
Dear Colleagues,
The field of hepatopancreaticobiliary (HPB) surgery has seen significant achievements in recent years, driven by innovations in surgical techniques, imaging, minimally invasive approaches, and perioperative care. These advances have improved outcomes for patients with complex HPB diseases, including liver, pancreatic, and biliary tract disorders. Minimally invasive techniques, including laparoscopic and robotic surgery, have revolutionized HPB surgery by reducing postoperative pain, shortening hospital stays, and improving cosmetic outcomes.
1) Advancements in imaging and intraoperative navigation have improved surgical planning and precision. Such progress and achievements include those made in 3D imaging and virtual reality, intraoperative ultrasound (IOUS), and fluorescence-guided surgery. The shift toward parenchyma-preserving techniques such as segment-oriented resections and ALPPS (associating liver partition and portal vein ligation for staged hepatectomy) has reduced postoperative liver failure and improved outcomes.
2) Advances in Pancreatic Surgery:
Pancreatic surgery remains one of the most challenging areas in HPB surgery, but recent advances have improved safety and outcomes. Advents in central pancreatectomies, enhanced recovery after surgery (ERAS) protocols, and neoadjuvant therapies being used for borderline resectable and locally advanced pancreatic cancer to improve resectability and survival are three major achievements.
3) Management of Biliary Tract Cancers:
Surgical treatment for biliary tract cancers, including cholangiocarcinoma and gallbladder cancer, has evolved with improved staging and multidisciplinary approaches. Extended hepatectomy with or without portal vein embolization (PVE) is essential in the management of cholangiocatcinomas.
4) Multidisciplinary Care and Personalized Medicine:
The integration of multidisciplinary teams (MDTs) has become standard in HPB surgery, ensuring individualized treatment plans based on tumor biology, patient comorbidities, and advanced imaging. Genomic profiling and immunotherapy are also being explored for precision oncology treatment.
Conclusion:
The field of HPB surgery has made remarkable progress, with minimally invasive techniques, advanced imaging, parenchyma-sparing resections, and multidisciplinary care leading to improved patient outcomes.
Dr. Spiros G. Delis
Guest Editor
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Keywords
- pancreas surgery
- liver resection
- minimal invasive approach
- virtual reality
- robotic surgery
- MDT
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