jcm-logo

Journal Browser

Journal Browser

Ischemic Stroke: Diagnosis, Treatment, and Management

A special issue of Journal of Clinical Medicine (ISSN 2077-0383). This special issue belongs to the section "Clinical Neurology".

Deadline for manuscript submissions: closed (25 November 2025) | Viewed by 1307

Special Issue Editors


E-Mail Website
Guest Editor
Neurology Unit, Stroke Unit, Department of Neuromotor Physiology and Rehabilitation, Azienda Unità Sanitaria Locale – IRCCS di Reggio Emilia, Reggio Emilia, Italy
Interests: stroke; neuroimaging; neurointerventional; angiography; rare neurovascular disorders; small vessel disease
Special Issues, Collections and Topics in MDPI journals

E-Mail
Guest Editor
Neuroradiology Unit, Azienda Unità Sanitaria Locale-IRCCS di Reggio Emilia, Viale Risorgimento 80, 42123 Reggio Emilia, Italy
Interests: MRI; angiography; vascular imaging; acute stroke treatment; rare neurovascular diseases; CVT; CAA; hemorrhagic stroke
Special Issues, Collections and Topics in MDPI journals

Special Issue Information

Dear Colleagues,

Stroke is still a predominant cause of mortality and the first cause of disability worldwide. In the last decade, the outcome of ischemic stroke has significantly improved due to the advancement of established and scientifically supported treatments. These therapies have expanded intravenous thrombolysis and endovascular thrombectomy, initiated the transition from alteplase to tenecteplase, and reinforced the importance of Stroke Units as treatment venues. This is likely the first case in which a treatment modality demonstrated the value of therapy in changing patients’ outcomes. Nevertheless, several gaps remain in ischemic stroke management and knowledge. These include diagnostic, therapeutic, and care pathway organization in different aspects of this complex and variable disease. These gaps exist in various age groups, males and females, rare causes, frequent but neglected conditions, large and medium vessel occlusions, small vessel diseases, highly organized settings, and low-resource situations. This Special Issue aims to collect contributions from clinical practice to highlight and overcome these gaps, identify them, and propose solutions.

Dr. Maria Luisa Zedde
Dr. Rosario Pascarella
Guest Editors

Manuscript Submission Information

Manuscripts should be submitted online at www.mdpi.com by registering and logging in to this website. Once you are registered, click here to go to the submission form. Manuscripts can be submitted until the deadline. All submissions that pass pre-check are peer-reviewed. Accepted papers will be published continuously in the journal (as soon as accepted) and will be listed together on the special issue website. Research articles, review articles as well as short communications are invited. For planned papers, a title and short abstract (about 250 words) can be sent to the Editorial Office for assessment.

Submitted manuscripts should not have been published previously, nor be under consideration for publication elsewhere (except conference proceedings papers). All manuscripts are thoroughly refereed through a single-blind peer-review process. A guide for authors and other relevant information for submission of manuscripts is available on the Instructions for Authors page. Journal of Clinical Medicine is an international peer-reviewed open access semimonthly journal published by MDPI.

Please visit the Instructions for Authors page before submitting a manuscript. The Article Processing Charge (APC) for publication in this open access journal is 2600 CHF (Swiss Francs). Submitted papers should be well formatted and use good English. Authors may use MDPI's English editing service prior to publication or during author revisions.

Keywords

  • ischemic stroke
  • diagnosis
  • treatment
  • stroke unit
  • stroke care
  • stroke etiology
  • thrombolysis
  • EVT
  • rare causes of stroke
  • cerebral vein thrombosis

Benefits of Publishing in a Special Issue

  • Ease of navigation: Grouping papers by topic helps scholars navigate broad scope journals more efficiently.
  • Greater discoverability: Special Issues support the reach and impact of scientific research. Articles in Special Issues are more discoverable and cited more frequently.
  • Expansion of research network: Special Issues facilitate connections among authors, fostering scientific collaborations.
  • External promotion: Articles in Special Issues are often promoted through the journal's social media, increasing their visibility.
  • Reprint: MDPI Books provides the opportunity to republish successful Special Issues in book format, both online and in print.

Further information on MDPI's Special Issue policies can be found here.

Published Papers (1 paper)

Order results
Result details
Select all
Export citation of selected articles as:

Other

20 pages, 553 KB  
Systematic Review
RNA-Based Biomarkers for Diagnostic Discrimination of Ischemic and Hemorrhagic Stroke: A Systematic Review
by Jan Emmerich, Aditya Chanpura, Frank C. Barone, Alison E. Baird, Tyler M. Lu, Kristian Barlinn, Ben W. M. Illigens, Arturo Tamayo, Hagen B. Huttner and Timo Siepmann
J. Clin. Med. 2026, 15(4), 1392; https://doi.org/10.3390/jcm15041392 - 10 Feb 2026
Viewed by 713
Abstract
Background: Diagnostic discrimination between ischemic stroke (IS) and hemorrhagic stroke (HS) is required for successful intervention with time-critical acute treatments. The available data on blood-based RNA biomarkers and discrimination between IS and HS are limited. This systematic review aimed to examine and [...] Read more.
Background: Diagnostic discrimination between ischemic stroke (IS) and hemorrhagic stroke (HS) is required for successful intervention with time-critical acute treatments. The available data on blood-based RNA biomarkers and discrimination between IS and HS are limited. This systematic review aimed to examine and summarize the existing literature on potentially useful blood-based RNA biomarkers that may aid in preclinical acute diagnosis. Methods: We systematically reviewed the literature on the ability of blood-based RNA biomarkers to discriminate between IS and HS according to PRISMA guidelines. We searched PubMed, EMBASE, The Cochrane Library, and The Web of Science for eligible randomized controlled trials, observational studies, and case–control studies published in the English language without time limitation. The risk of bias was evaluated using the Newcastle–Ottawa Scale. Results: We included eight studies with a total of 728 patients (436 with IS and 292 with HS) in our review. The study quality was good in five and fair in three investigations. No meta-analysis was performed due to high heterogeneity in methods and study endpoints. Reported biomarkers include miRNA-124-3p, miRNA-16, miRNA-340-5p, lncRNA XIST (X-inactive specific transcript), PFKFB3 mRNA (6-phosphofructo-2-kinase/fructose-2,6-biphosphatase), tRNA derivatives, tRNA fragments, extracellular miRNAs, transcriptome changes, and MCEMP1 gene expression. Assessment techniques varied widely across studies, ranging from RNA sequencing to qPCR, microarray, human transcriptome array, and ELISA. MicroRNA-124-3p, miRNA-340-5p, lncRNA XIST, PFKFB3 mRNA, and MCEMP1 gene expression differed significantly between IS and HS. In one study, principal component analysis and unsupervised learning demonstrated the utility of hierarchical clustering of differentially expressed exons to discriminate between HS and IS. Conclusions: This review demonstrates the utility of single RNA-based targets and clusters that may have diagnostic value in distinguishing IS from HS. However, the current body of evidence is limited by considerable methodological heterogeneity between studies. Registration: This systematic review was prospectively registered on PROSPERO on 21 April 2023 (CRD42023411203). Full article
(This article belongs to the Special Issue Ischemic Stroke: Diagnosis, Treatment, and Management)
Show Figures

Figure 1

Back to TopTop