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Hospital-Acquired Infections in the Elderly
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Hospital-Acquired Infections in the Elderly

A special issue of Journal of Clinical Medicine (ISSN 2077-0383). This special issue belongs to the section "Epidemiology & Public Health".

Deadline for manuscript submissions: 25 November 2025 | Viewed by 751

Special Issue Editors

Dr. Nadya Kagansky

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Guest Editor
Geriatric Medical Center Shmuel Harofe, University of Tel Aviv, Rishon Le Zion, Israel
Interests: geriatric medicine; infections in elderly; polypharmacy; interventions in elderly
Special Issues, Collections and Topics in MDPI journals
Dr. Emily Lubart

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Guest Editor Assistant
The Sackler Faculty of Medicine, Tel Aviv University, Tel Aviv, Israel
Interests: geriatric medicine; ageing health; infections in elderly; rehabilitation in elderly

Special Issue Information

Dear Colleagues,

This Special Issue will comprehensively address the critical issue of hospital-acquired infections (HAIs) in the elderly, reflecting the current research consensus and identifying core problems needing resolution. The elderly are particularly vulnerable to HAIs due to their weakened immune systems, their more frequent hospitalizations, and the presence of multiple comorbidities. This Special Issue will explore the epidemiology, risk factors, prevention strategies, and treatment options for HAIs in this demographic.

The core issues to be addressed include our understanding of the specific pathogens most responsible for HAIs in the elderly, improving diagnostic accuracy and speed, and developing tailored infection control protocols. Research gaps in the efficacy of current prevention and treatment methods also need to be addressed.

The scope of the current Special Issue encompasses a wide range of topics including microbial resistance patterns, the role of healthcare workers in infection transmission, and innovative approaches in infection control and patient care. Studies employing advanced methodologies, such as genomics and machine learning, to predict and manage HAIs are particularly encouraged.

Mobilization for this Special Issue involves engaging a multidisciplinary team of researchers, clinicians, and public health experts to contribute original research articles and reviews. Collaboration across institutions and regions will be vital for gathering diverse insights and advancing the field.

Dr. Nadya Kagansky
Guest Editor

Dr. Emily Lubart
Guest Editor Assistant

Manuscript Submission Information

Manuscripts should be submitted online at www.mdpi.com by registering and logging in to this website. Once you are registered, click here to go to the submission form. Manuscripts can be submitted until the deadline. All submissions that pass pre-check are peer-reviewed. Accepted papers will be published continuously in the journal (as soon as accepted) and will be listed together on the special issue website. Research articles, review articles as well as short communications are invited. For planned papers, a title and short abstract (about 100 words) can be sent to the Editorial Office for announcement on this website.

Submitted manuscripts should not have been published previously, nor be under consideration for publication elsewhere (except conference proceedings papers). All manuscripts are thoroughly refereed through a single-blind peer-review process. A guide for authors and other relevant information for submission of manuscripts is available on the Instructions for Authors page. Journal of Clinical Medicine is an international peer-reviewed open access semimonthly journal published by MDPI.

Please visit the Instructions for Authors page before submitting a manuscript. The Article Processing Charge (APC) for publication in this open access journal is 2600 CHF (Swiss Francs). Submitted papers should be well formatted and use good English. Authors may use MDPI's English editing service prior to publication or during author revisions.

Keywords

  • hospital-acquired infections (HAIs)
  • elderly patients
  • infection control
  • microbial resistance
  • epidemiology
  • risk factors
  • prevention strategies
  • treatment options
  • diagnostic accuracy

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Published Papers (1 paper)

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Research

16 pages, 601 KiB  
Article
Comparison of Clostridioides difficile Infection Incidence in a General and a Geriatric Hospital Prior to and During the COVID-19 Pandemic
by Yochai Levy, Husam Golani, Ahmed Baya, Erica Pinco, Nira Koren, Lutzy Cojocaru, Dana Kagansky and Nadya Kagansky
J. Clin. Med. 2025, 14(13), 4664; https://doi.org/10.3390/jcm14134664 - 1 Jul 2025
Viewed by 497
Abstract
Background: Clostridioides difficile (CD) is the main cause of nosocomial diarrhea, resulting in increased morbidity and mortality, and is thought to be greatly affected by strict hygiene. In this study, we assessed changes in CD infection prevalence and outcomes pre- and during [...] Read more.
Background: Clostridioides difficile (CD) is the main cause of nosocomial diarrhea, resulting in increased morbidity and mortality, and is thought to be greatly affected by strict hygiene. In this study, we assessed changes in CD infection prevalence and outcomes pre- and during the COVID-19 pandemic (CP). Methods: This was an observational cohort performed at a tertiary medical center (MC) and a geriatric hospital (GH). Patients from both hospitals diagnosed with CD were included, and the period of one year prior to the pandemic to one year after was compared. Data was extracted from electronic medical records (EMR). Results: A total of 145 CD-associated diarrhea (CDAD) cases were diagnosed in the MC and 54 in the GH. There was no change in CDAD prevalence or mortality between the study periods in either hospital. Disease duration, measured as days with diarrhea (DWD), was shorter during the CP in the GH (10.6 days vs. 8.1 days, p < 0.01). CDAD was more prevalent in the GH during both periods; however, the disease was milder, with only three mortality cases and a significantly shorter disease duration (3.19 DWD vs. 10.67 in the MC before CP; 3.11 vs. 8.1 during CP, p < 0.01). In a survival analysis for MC patients, no significant differences were found between periods before and after adjustment for age, gender and period. Conclusions: The CP affected the duration but not the prevalence of CDAD. The milder course of CDAD in the GH may have been due to the quality of treatment provided in an academic GH and the subsequent faster diagnosis and treatment. Full article
(This article belongs to the Special Issue Hospital-Acquired Infections in the Elderly)
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