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Journal of Clinical Medicine publishes Special Issues to create collections of papers on specific topics, with the aim of building a community of authors and readers to discuss the latest research and develop new ideas and research directions. Special Issues are led by Guest Editors, who are experts on the topic and all Special Issue submissions follow MDPI's standard editorial process. The journal’s Editor-in-Chief and/or designated Editorial Board Member will oversee Guest Editor appointments and Special Issue proposals, checking their content for relevance and ensuring the suitability of the material for the journal. The papers published in a Special Issue will be collected and displayed on a dedicated page of the journal’s website. Further information on MDPI's Special Issue policies and Guest Editor responsibilities can be found here. For any inquiries related to a Special Issue, please contact the Editorial Office.

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Clinical Advances in the Management of Abdominal and Thoracoabdominal Aortic Aneurysms

edited by

Daniela Mazzaccaro

submission deadline 20 Jan 2027 | 4 articles | Viewed by 2566 | Submission Open

Keywords: abdominal aneurysm; thoraco-abdominal; computed-tomography angiography; branched endograft; branched endovascular aortic repair; fenestrated endograft; open surgery; 3-D printing

(This special issue belongs to the Section Vascular Medicine)

Acute and Chronic Heart Failure: Clinical Updates and Perspectives—2nd Edition

edited by Luigi Cappannoli and Cristina Aurigemma

submission deadline 20 Jan 2027 | 3 articles | Viewed by 2380 | Submission Open

Keywords: acute heart failure; chronic heart failure; devices; drug therapy; percutaneous ventricular assist devices; cardiogenic shock; arrhythmias; ischemic heart disease

(This special issue belongs to the Section Cardiovascular Medicine)

The Treatment of BPO with Minimal Invasive Approach

edited by

Lukas Lusuardi

submission deadline 20 Jan 2027 | 2 articles | Viewed by 2110 | Submission Open

Keywords: benign prostatic obstruction (BPO); prostatectomy; non-muscle invasive bladder cancer; muscle invasive bladder cancer; robotic surgery

(This special issue belongs to the Section Nephrology & Urology)

Bladder Cancer: Diagnosis, Treatment and Future Opportunities

edited by

Jørgen Bjerggaard Jensen

submission deadline 20 Jan 2027 | 2 articles | Viewed by 2084 | Submission Open

Keywords: urology; bladder cancer; urothelial cancer; non-muscle invasive bladder cancer; muscle invasive bladder cancer

(This special issue belongs to the Section Nephrology & Urology)

Clinical Progress in Oral and Maxillofacial Surgery

edited by Luis M. Junquera and Giuseppe Consorti

submission deadline 20 Jan 2027 | 2 articles | Viewed by 2061 | Submission Open

Keywords: oral and maxillofacial surgery; craniofacial surgery; facial deformity; cleft lip and palate; TMJ surgery

(This special issue belongs to the Section Dentistry, Oral Surgery and Oral Medicine)

Clinical Updates of Physical Therapy in Rehabilitation

edited by

Sofia Xergia

submission deadline 20 Jan 2027 | 1 articles | Viewed by 1974 | Submission Open

Keywords: neurological rehabilitation; musculoskeletal rehabilitation; special populations; new technology in physical therapy

(This special issue belongs to the Section Clinical Rehabilitation)

Advances in Male Infertility: Diagnosis, Management and ART Integration

edited by Despoina Mavrogianni and Sofoklis Stavros

submission deadline 20 Jan 2027 | 1 articles | Viewed by 1941 | Submission Open

Keywords: male infertility; assisted reproductive technologies (ART); intracytoplasmic sperm injection (ICSI); genetic testing; hormonal profiling; seminal biomarkers; sperm retrieval techniques; sperm selection; stem cell therapy; gene editing; reproductive endo-crinology; early pregnancy; implantation failure; recurrent miscarriage

(This special issue belongs to the Section Reproductive Medicine & Andrology)

Clinical Advances in Ocular Surgeries: Innovations in Cataract, Retinal, and Beyond

edited by

Seung Pil Bang

and Yu Cheol Kim

submission deadline 20 Jan 2027 | 3 articles | Viewed by 1835 | Submission Open

Keywords: cataract surgery; retinal surgery; intraocular lenses; femtosecond laser; minimally invasive vitrectomy; ocular imaging; surgical innovation; ocular trauma; corneal transplantation; glaucoma surgery

(This special issue belongs to the Section Ophthalmology)

Clinical Updates on Perioperative Pain Management: 3rd Edition

edited by

Felice Eugenio Agro

Giuseppe Pascarella

and

Fabio Costa

submission deadline 20 Jan 2027 | 2 articles | Viewed by 1697 | Submission Open

Keywords: anesthesia and intensive care; pain management; spinal anesthesia; postoperative pain; breast surgery; fascial plane blocks; abdominal surgery; cardiac surgery; thoracotomy; knee surgery; orthopedic surgery; hip surgery; ultrasound

(This special issue belongs to the Section Anesthesiology)

Hypertrophic Cardiomyopathy: New Insights into Complications and Treatment

edited by Ilaria Dentamaro and Ciro Santoro

submission deadline 20 Jan 2027 | 2 articles | Viewed by 1673 | Submission Open

Keywords: hypertrophic cardiomyopathy; complications; risk stratification; multimodality imaging; myosin inhibitors; precision medicine

(This special issue belongs to the Section Cardiology)

Coronary Artery Bypass Grafting: Contemporary Clinical Research Update

edited by

Arian Arjomandi Rad

submission deadline 20 Jan 2027 | 2 articles | Viewed by 1287 | Submission Open

Keywords: coronary artery bypass grafting; arterial grafts; graft patency; hybrid coronary revascularization; perioperative management; outcomes research; risk stratification; frailty; minimally invasive/robotic CABG; antithrombotic therapy

(This special issue belongs to the Section Cardiology)

Aortic Valve Replacement: Current Trends, Future Perspectives, and Emerging Technologies

edited by

Jorge Nuche

submission deadline 20 Jan 2027 | 2 articles | Viewed by 1177 | Submission Open

Keywords: aortic valve; heart valve prosthesis; transcatheter aortic valve replacement; surgical aortic valve replacement; aortic valve insufficiency; minimally invasive surgical procedures; treatment outcome; vulnerable populations

(This special issue belongs to the Section Cardiology)

New Insights into Hepato-Biliary Diseases: Translating Science into Practice

edited by

Elisa Ceccherini

and

Antonella Cecchettini

submission deadline 20 Jan 2027 | 1 articles | Viewed by 1154 | Submission Open

Keywords: hepato-biliary diseases; biomarkers; drug discovery; liver organoids and microfluidics; pathogenesis

(This special issue belongs to the Section Gastroenterology & Hepatopancreatobiliary Medicine)

Clinical Update on Aortic Valve Disease Treatments

edited by

Giovanni Concistre

submission deadline 20 Jan 2027 | 1 articles | Viewed by 1149 | Submission Open

Keywords: aortic valve disease; minimally invasive surgery; transcatheter procedures; echocardiography; diagnosis; therapy; innovation

(This special issue belongs to the Section Cardiology)

Clinical Trends and Prospects in Urology Surgery: 2nd Edition

edited by

Lazaros Tzelves

submission deadline 20 Jan 2027 | 1 articles | Viewed by 1094 | Submission Open

Keywords: robotic surgery; laparoscopic surgery; endourology; minimally invasive surgery; artificial intelligence

(This special issue belongs to the Section Nephrology & Urology)

Advances in Perinatal Mental Health: Prevention, Screening, Treatment, and Support Across Pregnancy and Postpartum

edited by

Rena Bina

submission deadline 20 Jan 2027 | 2 articles | Viewed by 900 | Submission Open

Keywords: perinatal mental health; prevention; screening; access to care; eHealth; treatment; environmental factors; cross-cultural; systems of care; innovative methodologies

(This special issue belongs to the Section Mental Health)

Acute Myeloid Leukemia: From Molecular Complexity to Precision Medicine

edited by Matteo Molica

submission deadline 20 Jan 2027 | 1 articles | Viewed by 811 | Submission Open

Keywords: acute myeloid leukemia; molecular diagnostics; targeted therapy; measurable residual disease; risk stratification

(This special issue belongs to the Section Hematology)

Neuroinflammation and Neuroimmunology in Neurological Disorders

edited by Łukasz A. Poniatowski

submission deadline 20 Jan 2027 | 1 articles | Viewed by 756 | Submission Open

Keywords: neuroinflammation; neuroimmunology; neurodegenerative diseases; Parkinson’s disease; multiple sclerosis; stroke; traumatic brain injury; hydrocephalus; neurosurgical disorders; neurological disorders; biomarkers; clinical diagnosis; management strategies

(This special issue belongs to the Section Clinical Neurology)

Symptoms, Diagnosis and Treatments of Tricuspid Regurgitation

edited by

Diana Ruxandra Hădăreanu

and Cristina Florescu

submission deadline 20 Jan 2027 | 1 articles | Viewed by 747 | Submission Open

Keywords: tricuspid regurgitation; right heart failure; echocardiography; multimodality cardiac imaging; valvular heart disease; tricuspid valve surgery; transcatheter edge-to-edge repair

(This special issue belongs to the Section Cardiology)

Oral Autoimmune Diseases: Diagnosis and Clinical Management

edited by Zuzanna Ślebioda

submission deadline 20 Jan 2027 | 1 articles | Viewed by 637 | Submission Open

Keywords: Sjögren syndrome; lupus erythematous; lichen planus; Behçet’s disease; recurrent aphthous stomatitis; pemphigus vulgaris; mucous membrane pemphigoid; autoimmune disease; oral mucosa

(This special issue belongs to the Section Dentistry, Oral Surgery and Oral Medicine)

Hysterectomy Surgery—Recent Developments and Emerging Trends

edited by

Anastasia Prodromidou

Themos Grigoriadis

and Dimitrios Zacharakis

submission deadline 20 Jan 2027 | Viewed by 626 | Submission Open

Keywords: hysterectomy; minimally invasive hysterectomy; robotic surgery; vaginal hysterectomy; surgical innovation; perioperative care

(This special issue belongs to the Section Obstetrics & Gynecology)

Foot and Ankle Fracture Management and Complication Insights

edited by Jaeho Cho

submission deadline 20 Jan 2027 | 1 articles | Viewed by 535 | Submission Open

Keywords: foot and ankle fractures; clinical anatomy; trauma management; post-traumatic arthritis; surgical techniques

(This special issue belongs to the Section Orthopedics)

Contemporary Management of Acute and Chronic Liver Disease: Advances in Diagnosis and Therapy

edited by Manisha Verma

submission deadline 20 Jan 2027 | 1 articles | Viewed by 532 | Submission Open

Keywords: acute and chronic liver disease; cirrhosis; risk stratification; emerging therapies; artificial intelligence

(This special issue belongs to the Section Gastroenterology & Hepatopancreatobiliary Medicine)

Clinical Research Progress in Atrial Fibrillation

edited by

Roddy Hiram

submission deadline 20 Jan 2027 | Viewed by 509 | Submission Open

Keywords: atrial fibrillation; atrial arrhythmias; cardiac fibrosis; inflammation; electrical remodeling

(This special issue belongs to the Section Cardiology)

Innovations, Biomarkers, and Challenges in Cancer Immunotherapy

edited by

Mohammad Mousaei Ghasroldasht

and Mahzad Akbarpour

submission deadline 20 Jan 2027 | Viewed by 481 | Submission Open

Keywords: next-generation cellular therapies; CAR-NK cell therapy; CAR-T cell therapy; combination strategies; exosomes; T-cell engagers; oncolytic viruses; cancer immunotherapy; biomarkers for therapy response; translational immunotherapy; tumor microenvironment modulation; immune evasion mechanisms

(This special issue belongs to the Section Oncology)

Prevention, Treatment, and Prognosis of Cerebral Aneurysms

edited by

Murai Yasuo

submission deadline 20 Jan 2027 | Viewed by 389 | Submission Open

Keywords: cerebral aneurysm; subarachnoid hemorrhage; clipping; interventional surgery; mortarity; long-term; surgical complication; bypass

(This special issue belongs to the Section Clinical Neurology)

Current Perspectives and Emerging Trends in Cardiothoracic Surgery

edited by Zsolt Szabo and

Zsolt Molnar

submission deadline 20 Jan 2027 | Viewed by 382 | Submission Open

Keywords: minimally invasive cardiac surgery; minimally invasive thoracic surgery; minimally invasive valve surgery; non-intubated and spontaneous ventilation techniques; thymus surgery; prehabilitation; chronic comorbidities (DM, COPD); cardiopulmonary bypass outcomes; extracorporeal life support (ECLS); emerging trends in cardiothoracic surgery

(This special issue belongs to the Section General Surgery)

Myocardial Infarction: Current Status and Future Challenges—2nd Edition

edited by Isaac Pascual and

Rebeca Lorca

submission deadline 20 Jan 2027 | Viewed by 346 | Submission Open

Keywords: myocardial infarction; acute coronary syndrome (ACS); ischemic heart disease; coronary artery disease (CAD); percutaneous coronary intervention; pharmacological therapy; cardiovascular risk factors

(This special issue belongs to the Section Cardiology)

Clinical Advances in Hemodialysis: 2nd Edition

edited by Maurizio Bossola

submission deadline 20 Jan 2027 | Viewed by 345 | Submission Open

Keywords: hemodialysis; interdialytic weight gain; symptom burden and quality of life; impaired cognitive function; fatigue; dietary restrictions; depression; anxiety; frailty; polypharmacy

(This special issue belongs to the Section Nephrology & Urology)

Human Immunodeficiency Virus: From Clinical Studies to Patient Outcomes

edited by Vítor Duque

submission deadline 20 Jan 2027 | Viewed by 323 | Submission Open

Keywords: HIV/AIDS; clinical trials; patient outcomes; clinical translational research

(This special issue belongs to the Section Infectious Diseases)

Current Advances and Unmet Needs in Autoimmune Inflammatory Rheumatic Diseases

edited by

Shunsuke Mori

submission deadline 20 Jan 2027 | Viewed by 242 | Submission Open

Keywords: autoimmune inflammatory rheumatic diseases; rheumatoid arthritis; connective tissue disorders; comorbidities; unmet medical needs; immune-targeted therapies

(This special issue belongs to the Section Immunology & Rheumatology)

Recent Advances in the Treatment of Chronic Kidney Disease (CKD)

edited by

Giacomo Garibotto

and

Elisa Russo

submission deadline 20 Jan 2027 | Viewed by 200 | Submission Open

Keywords: chronic kidney disease; therapy; diabetic nephropathy; obesity; hypertension; MRA; incretins; SGLT2i; kidney fibrosis; hyperkalemia; cardiovascular

(This special issue belongs to the Section Nephrology & Urology)

Anterior Cruciate Ligament Injury Reconstruction and Rehabilitation

edited by Andrea Volpin and Nicholas Colyvas

submission deadline 20 Jan 2027 | Viewed by 180 | Submission Open

Keywords: anterior cruciate ligament; ACL reconstruction; ACL rehabilitation; sports knee injuries; graft selection; return to sport; revision ACL reconstruction; knee biomechanics; meniscal injury; injury prevention

(This special issue belongs to the Section Orthopedics)

Cardiac Rehabilitation: Current Strategies and Future Directions

edited by Andrzej Kleinrok and

Marlena Krawczyk-Suszek

submission deadline 20 Jan 2027 | Viewed by 176 | Submission Open

Keywords: cardiac rehabilitation; secondary prevention; cardiovascular disease; cardiovascular risk; exercise training; telerehabilitation; digital health; patient adherence; personalised medicine; wearable technologies; artificial intelligence; quality of life; multidisciplinary care; mental support

(This special issue belongs to the Section Cardiology)

Towards Precision Oncology in Bone Sarcomas: New Insights into Osteosarcoma and Chondrosarcoma

edited by Andrea Sambri and Alessandro Bruschi

submission deadline 20 Jan 2027 | Viewed by 166 | Submission Open

Keywords: osteosarcoma; chondrosarcoma; bone sarcoma; molecular diagnostics; tumor microenvironment; precision oncology; surgical oncology; limb-salvage surgery; targeted therapy; prognostic biomarkers

(This special issue belongs to the Section Oncology)

Takotsubo Syndrome: From Diagnosis to Treatment

edited by Gregor Poglajen and Christian Templin

submission deadline 20 Jan 2027 | Viewed by 132 | Submission Open

Keywords: Takotsubo syndrome; stress cardiomyopathy; acute heart failure; catecholamines; myocardial stunning; microvascular dysfunction; cardiac imaging; cardiogenic shock; biomarkers; personalized therapy

(This special issue belongs to the Section Cardiology)

Pancreatic Diseases Through the Lens of EUS and ERCP: From Risk Stratification to Intervention

edited by

Maria Cristina Conti-Bellocchi

submission deadline 20 Jan 2027 | Viewed by 120 | Submission Open

Keywords: endosonography; endoscopic retrograde cholangiopancreatography; pancreatic diseases; risk assessment; fine‑needle biopsy; stents; minimally invasive procedures; advanced imaging; artificial intelligence in endoscopy

(This special issue belongs to the Section Gastroenterology & Hepatopancreatobiliary Medicine)

Ablation, Embolization, and Stenting: Current Trends in Interventional Radiology

edited by Praveen Peddu

submission deadline 22 Jan 2027 | 4 articles | Viewed by 5002 | Submission Open

Keywords: interventional radiology; ablation; embolization; stenting; minimally invasive therapy

(This special issue belongs to the Section Nuclear Medicine & Radiology)

Beyond the Kidney: Managing Chronic Kidney Disease in the Era of Cardio-Metabolic-Kidney Syndrome

edited by

Maria Amicone

and

Antonio Pisani

submission deadline 22 Jan 2027 | 1 articles | Viewed by 1553 | Submission Open

Keywords: chronic kidney disease; disease-modifying therapy; physical exercise; cardio-metabolic-kidney syndrome; SGLT2 in-hibitors; MRA; renal nutrition; innovative therapies; low protein diet

(This special issue belongs to the Section Nephrology & Urology)

Spine Surgery Innovations: Treatments and Technologies

edited by

Marco D. Burkhard

and

Tomoyuki Asada

submission deadline 22 Jan 2027 | 2 articles | Viewed by 1524 | Submission Open

Keywords: AI; robotics; navigation; muscle preservation; minimally invasive surgery; motion preservation; alignment targets; implant materials; bone growth factors; custom-made implants

(This special issue belongs to the Section Orthopedics)

Advancements in Individualized Plastic and Reconstructive Surgery: Second Edition

edited by

Paul Immanuel Heidekrueger

, Peter Niclas Broer and Denis C. Ehrl

submission deadline 24 Jan 2027 | 4 articles | Viewed by 4861 | Submission Open

Keywords: patient-specific reconstructive procedures; microsurgical precision techniques; autologous tissue transplantation; digital imaging and customization; biomaterials in reconstructive surgery; tissue engineering for plastic reconstruction; flap surgery innovations; personalized cleft surgery; personalized aesthetic surgery

(This special issue belongs to the Section Plastic, Reconstructive and Aesthetic Surgery/Aesthetic Medicine)

Updates in the Diagnosis, Imaging, and Treatment of Retinal and Macular Diseases

edited by

Makoto Inoue

submission deadline 24 Jan 2027 | 4 articles | Viewed by 4292 | Submission Open

Keywords: retinal diseases; macular degeneration; diagnostic imaging; OCT/OCTA; artificial intelligence; deep learning; clinical ophthalmology; gene therapy; treatment innovations

(This special issue belongs to the Section Ophthalmology)

Current Insights into Atopic Dermatitis

edited by Francisco José Navarro-Trivino

submission deadline 24 Jan 2027 | Viewed by 153 | Submission Open

Keywords: atopic dermatitis; type 2 inflammation; skin barrier; biologics; JAK inhibitors; precision medicine; chronic pruritus

(This special issue belongs to the Section Dermatology)

Artificial Intelligence (AI) and Deep Learning (DL) in Medical Imaging

edited by

Francesco Pucciarelli

submission deadline 25 Jan 2027 | 6 articles | Viewed by 15870 | Submission Open

Keywords: artificial intelligence; deep learning; imaging; diagnosis; precision medicine; oncologic

(This special issue belongs to the Section Nuclear Medicine & Radiology)

Advances in Diagnosis and Management of Pancreatobiliary Disorders—2nd Edition

edited by

Francesca Lodato

submission deadline 25 Jan 2027 | 11 articles | Viewed by 13194 | Submission Open

Keywords: pancreas diseases; pancreatic tumors; biliary tract diseases and neoplams; ERCP; EUS; cholangioscopy

(This special issue belongs to the Section Gastroenterology & Hepatopancreatobiliary Medicine)

Cardiogenic Shock and Cardiac Arrest: Updates, Challenges and Opportunities

edited by

Torben K. Becker

submission deadline 25 Jan 2027 | 5 articles | Viewed by 9272 | Submission Open

Keywords: cardiac arrest; extracorporeal membrane oxygenation; extracorporeal CPR; cardiopulmonary resuscitation; cardiogenic shock; resuscitation; prognostication

(This special issue belongs to the Section Cardiology)

Advances in Gastroenterology and Hepatology: Bridging Basic Science, Clinical Insights, and Translational Medicine

edited by

Abdulrahman Ismaiel

and

Ștefan Lucian Popa

submission deadline 25 Jan 2027 | 6 articles | Viewed by 8551 | Submission Open

Keywords: hepatology; gastroenterology; IBD; IBS; MASLD; liver cirrhosis; artificial intelligence; disorders of gut–brain interaction; cancer; gut microbiota; diagnosis; management

(This special issue belongs to the Section Gastroenterology & Hepatopancreatobiliary Medicine)

Non-Small Cell Lung Cancer (NSCLC): Recent Advances in Clinical Diagnosis and Treatment

edited by

Cesare Guida

submission deadline 25 Jan 2027 | 11 articles | Viewed by 8333 | Submission Open

Keywords: novel screening tool; cancer biomarkers; predictive marker of immunotherapy; targeted therapy; radiotherapy; non-small cell lung cancer

(This special issue belongs to the Section Oncology)

Clinical Advances in Spinal Neurosurgery

edited by Jang-Won Yoon

submission deadline 25 Jan 2027 | 6 articles | Viewed by 7560 | Submission Open

Keywords: minimally invasive spine surgery; lateral lumbar interbody fusion; endoscopic spine surgery; patient-reported out-comes; functional assessment; perioperative care; surgical decision-making

(This special issue belongs to the Section Clinical Neurology)

Autoimmune-Induced Alopecia and Emerging Therapies in Hair Loss—2nd Edition

edited by David Saceda-Corralo

submission deadline 25 Jan 2027 | 2 articles | Viewed by 7461 | Submission Open

Keywords: autoimmune-induced alopecia; alopecia areata; cicatricial alopecia; occurs; hair loss; frontal fibrosing alopecia

(This special issue belongs to the Section Dermatology)

Displaying special issue 851-900 on page 18 of 30.

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