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Journal of Clinical Medicine publishes Special Issues to create collections of papers on specific topics, with the aim of building a community of authors and readers to discuss the latest research and develop new ideas and research directions. Special Issues are led by Guest Editors, who are experts on the topic and all Special Issue submissions follow MDPI's standard editorial process. The journal’s Editor-in-Chief and/or designated Editorial Board Member will oversee Guest Editor appointments and Special Issue proposals, checking their content for relevance and ensuring the suitability of the material for the journal. The papers published in a Special Issue will be collected and displayed on a dedicated page of the journal’s website. Further information on MDPI's Special Issue policies and Guest Editor responsibilities can be found here. For any inquiries related to a Special Issue, please contact the Editorial Office.

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Advances in Gynecological Cancers: Diagnosis, Treatment, and Care

edited by

Marek Murawski

, Dariusz Wydra and

Ewa Szuster

submission deadline 31 Dec 2026 | Viewed by 177 | Submission Open

Keywords: preinvasive cervical disease; cervical cancer; endometrial cancer; ovarian cancer; borderline ovarian tumors; rare tumors; uterine sarcoma; vulvar cancer; vaginal cancer; fertility sparing management; biomarkers; precision medicine; targeted therapy; immunotherapy; early detection

(This special issue belongs to the Section Obstetrics & Gynecology)

State of the Art of Corneal: Current Status and Prospects

edited by Justyna Izdebska

submission deadline 31 Dec 2026 | Viewed by 128 | Submission Open

Keywords: corneal diseases; corneal transplantation; OCT; corneal imaging; refractive surgery; keratoconus; graft survival; immunosuppression

(This special issue belongs to the Section Ophthalmology)

Multiparametric Ultrasound Techniques for Liver Disease Assessments

edited by Francesco Giangregorio

submission deadline 5 Jan 2027 | 2 articles | Viewed by 7975 | Submission Open

Keywords: ultrasound; multiparametric ultrasound; hepatic ultrasound; contrast-enhanced ultrasound; contrast agents; diffuse hepatic diseases; focal liver lesions; hepatic elastography; liver stiffness; hepatic endosonography; hepatic EUS

(This special issue belongs to the Section Nuclear Medicine & Radiology)

Challenging ICU Dogma: Where Routine Practice and Evidence Collide

edited by

Yujiro Matsuishi

and Nobutake Shimojo

submission deadline 10 Jan 2027 | 2 articles | Viewed by 14346 | Submission Open

Keywords: critical care; intensive care unit (ICU); clinical dogma; de-implementation; medical reversal; routine practices; clinical decision-making

(This special issue belongs to the Section Intensive Care)

New Clinical Advances in Pancreatobiliary Diseases

edited by

Kyong Joo Lee

submission deadline 10 Jan 2027 | 4 articles | Viewed by 7431 | Submission Open

Keywords: pancreatobiliary diseases; EUS; ERCP; interventional endoscopy; targeted therapy; pancreatobiliary cancer

(This special issue belongs to the Section Gastroenterology & Hepatopancreatobiliary Medicine)

Thyroid Disorders: New Clinical Diagnosis and Management

edited by

Ioannis P. Iakovou

Rodis D. Paparodis

and

Nicholaos G. Angelopoulos

submission deadline 10 Jan 2027 | 2 articles | Viewed by 4096 | Submission Open

Keywords: thyroid disorders; clinical diagnosis; ultrasound; elastography; thyroid cancer; thyroiditis; hyperthyroidism; hypothyroidism; advanced imaging

(This special issue belongs to the Section Endocrinology & Metabolism)

Dialysis Versus Transplantation: Navigating Treatment Strategies in Chronic Kidney Disease

edited by

Andreja Figurek

submission deadline 10 Jan 2027 | Viewed by 246 | Submission Open

Keywords: chronic kidney disease; kidney failure; dialysis; kidney transplantation; renal replacement therapy; hemodialysis; peritoneal dialysis; pre-emptive transplantation; patient-centered care; quality of life; precision nephrology; biomarkers; artificial intelligence; health disparities; treatment decision-making

(This special issue belongs to the Section Nephrology & Urology)

Clinical Management of Attention Deficit Hyperactivity Disorder (ADHD)

edited by

Alessandro Pallucchini

submission deadline 15 Jan 2027 | 4 articles | Viewed by 11904 | Submission Open

Keywords: ADHD; addiction; neurodevelopmental disorders; levomethadone

(This special issue belongs to the Section Mental Health)

Updates on Treatment of Chronic Kidney Disease: Novel Approaches and Future Directions

edited by Pietro C. Dattolo and

Aris Tsalouchos

submission deadline 15 Jan 2027 | 4 articles | Viewed by 7660 | Submission Open

Keywords: chronic kidney disease; CKD treatment; SGLT2 inhibitors; GLP-1 receptor agonists; non-steroidal MRAs; precision medicine; renal replacement therapy; novel therapeutics; clinical trials; nephrology

(This special issue belongs to the Section Nephrology & Urology)

Clinical Updates on Pediatric Surgery

edited by Carlos Theodore Huerta and Eduardo Alfonso Perez

submission deadline 15 Jan 2027 | 5 articles | Viewed by 3619 | Submission Open

Keywords: pediatric surgery; robotic-assisted surgery; artificial intelligence; enhanced recovery after surgery; minimally inva-sive surgery; augmented reality

(This special issue belongs to the Section Clinical Pediatrics)

Pediatric Pulmonology: Current Hurdles and Future Perspectives

edited by Isabel Delgado-Pecellín and Anselmo Andrés-Martín

submission deadline 15 Jan 2027 | 2 articles | Viewed by 3554 | Submission Open

Keywords: interstitial lung diseases; neonatal screening; complex chronic patients; home mechanical ventilation; severe asthma; telemonitoring; lung development; cystic fibrosis; genetics

(This special issue belongs to the Section Clinical Pediatrics)

Current Challenges in Oral and Maxillofacial Surgery

edited by

Federica Canfora

and

Lucia Memé

submission deadline 15 Jan 2027 | 2 articles | Viewed by 3132 | Submission Open

Keywords: oral and maxillofacial surgery; surgical management; virtual surgical planning; postoperative management; orthog-nathic surgery; reconstructive techniques; minimally invasive surgery; digital technologies; 3D printing

(This special issue belongs to the Section Dentistry, Oral Surgery and Oral Medicine)

Clinical Innovation in Endoscopic Sinus and Anterior Skull Base Surgery

edited by

Samiul Muquit

and

Marios Stavrakas

submission deadline 15 Jan 2027 | 2 articles | Viewed by 2518 | Submission Open

Keywords: rhinology; endoscopic anterior skull base surgery; anterior skull base surgery; endoscopic sinus surgery; chronic rhinosinusitis (CRS); otolaryngology

(This special issue belongs to the Section Otolaryngology)

Clinical Diagnosis and Management of Erectile Dysfunction

edited by Maurizio De Rocco Ponce and

Giuseppe Grande

submission deadline 15 Jan 2027 | 2 articles | Viewed by 2213 | Submission Open

Keywords: erectile dysfunction; clinical management; cardiovascular disease; penile prosthesis; personalized medicine; hipogonadism

(This special issue belongs to the Section Reproductive Medicine & Andrology)

Cutting Edge Research on Total Knee Arthroplasty

edited by

Nahum Rosenberg

submission deadline 15 Jan 2027 | 2 articles | Viewed by 2058 | Submission Open

Keywords: total knee arthroplasty; robotic-assisted surgery; computer-navigated arthroplasty; implant design; kinematic alignment; enhanced recovery pathways; patient-reported outcomes; artificial intelligence in orthopedics; revision surgery

(This special issue belongs to the Section Orthopedics)

Aortic Surgery: State of the Art and Future Directions

edited by

Dimos E. Karangelis

submission deadline 15 Jan 2027 | 2 articles | Viewed by 1420 | Submission Open

Keywords: aortic surgery; aortic aneurysm; aortic dissection; aortic arch; biomaterials; endovascular approach; FET; TEVAR

(This special issue belongs to the Section Cardiovascular Medicine)

Complications Related to Coronary Artery Disease and Secondary Prevention Strategies

edited by Nazanin Rajai

submission deadline 15 Jan 2027 | 1 articles | Viewed by 642 | Submission Open

Keywords: coronary artery disease; complications; secondary prevention; myocardial infarction; cardiovascular risk; heart failure; arrhythmias; imaging; biomarkers; cardiovascular pharmacotherapy

(This special issue belongs to the Section Cardiovascular Medicine)

Advances in Spine Surgery: Best Practices and Future Directions

edited by Martin N. Stienen and

Stefan Motov

submission deadline 20 Jan 2027 | 9 articles | Viewed by 16285 | Submission Open

Keywords: minimally invasive spine surgery; spinal endoscopy; spinal robotics; spinal navigation; ERAS; machine learning; artificial intelligence; complication management; revision surgery; spinal deformity; innovation; future direction

(This special issue belongs to the Section Clinical Neurology)

Effect of Long-Term Insomnia on Mental Health—2nd Edition

edited by

Aleksandra Rogowska

submission deadline 20 Jan 2027 | 2 articles | Viewed by 13538 | Submission Open

Keywords: anxiety; alcohol and substance use disorders; behavioral addiction; burnout; cognitive dysfunction; depression; eating disorders; gaming addiction; problematic internet/social media use; insomnia; long-term insomnia; mood disorders; post-traumatic stress disorder; stress

(This special issue belongs to the Section Mental Health)

Endodontic Disease: Prevalence, Risk Factors, and Treatment Outcome

edited by

Razvan Ionut Ghinea

Ioana-Sofia Pop-Ciutrilă

and

Luminita-Maria Nica

submission deadline 20 Jan 2027 | 4 articles | Viewed by 11549 | Submission Open

Keywords: endodontics; apical periodontitis; pulpitis; root canal treatment; risk factors; treatment outcomes; regenerative endodontics

(This special issue belongs to the Section Dentistry, Oral Surgery and Oral Medicine)

Clinical Management and Long-Term Prognosis in Intensive Care

edited by

Wioletta Mędrzycka-Dąbrowska

and

Sandra Lange

submission deadline 20 Jan 2027 | 9 articles | Viewed by 10948 | Submission Open

Keywords: intensive care; post-intensive care syndrome; patient safety; improved survival; mental health; mechanical ventilation

(This special issue belongs to the Section Intensive Care)

Glaucoma Surgery: Current Challenges and Future Perspectives

edited by

Tina Tzee Ling Wong

and

Esther M. Hoffmann

submission deadline 20 Jan 2027 | 8 articles | Viewed by 8974 | Submission Open

Keywords: glaucoma; filtration surgery; trabeculectomy; MIGS; scarring; anti-metabolites; wound healing; anti-fibrotics

(This special issue belongs to the Section Ophthalmology)

Targeted Diagnosis and Treatment of Shoulder and Elbow Disease: 2nd Edition

edited by

Teresa Paolucci

and

Massimiliano Mangone

submission deadline 20 Jan 2027 | 4 articles | Viewed by 8171 | Submission Open

Keywords: anterolateral deltoid split; joint pain; axillary nerve injury; rotator cuff injuries; shoulder arthroplasty; shoulder impingement syndrome; proximal humeral fracture; rehabilitation; exercise; physiotherapy; rehabilitative relapses

(This special issue belongs to the Section Orthopedics)

Acute Medical Threats: Evidence-Driven Strategies in Emergency Medicine

edited by

Alexandra Arvanitaki

submission deadline 20 Jan 2027 | 5 articles | Viewed by 7856 | Submission Open

Keywords: emergency medicine protocols; acute medical care; trauma management; resuscitation; critical care; infectious disease preparedness

(This special issue belongs to the Section Emergency Medicine)

Clinical Advances in Skin Cancer: A Closer Look at Non-Melanoma Types

edited by Andrea Paradisi

submission deadline 20 Jan 2027 | 4 articles | Viewed by 7319 | Submission Open

Keywords: basal cell carcinoma; squamous cell carcinoma; actinic keratosis; diagnosis; treatment; non-melanoma skin cancer (NMSC)

(This special issue belongs to the Section Dermatology)

Molecular Injection Therapy in Orthopedic and Musculoskeletal Disorders: Conservative Approaches and Innovative Treatments

edited by

Niccola Funel

, Paolo Domenico Parchi and Andrea del Chiaro

submission deadline 20 Jan 2027 | 5 articles | Viewed by 7249 | Submission Open

Keywords: injection therapy; conservative approaches; medical devices; collagen; polyribonucleotide; plasma-rich platelets; hyaluronic acids; anti-inflammatory therapy; tendinitis, osteoarthritis, musculoskeletal disorder, pain reduction; regenerative medicine; new clinical approaches; physiotherapy; comparative studies: surgery vs. conservative approaches

(This special issue belongs to the Section Orthopedics)

Heart Failure: Challenges and Future Options

edited by Pedro Caravaca-Pérez and Marta Farrero-Torres

submission deadline 20 Jan 2027 | 7 articles | Viewed by 7241 | Submission Open

Keywords: heart failure; cardiorenal syndrome; heart transplantation; ventricular assist devices; biomarkers; precision medicine; advanced therapies; diuretic resistance; risk stratification; multidisciplinary care

(This special issue belongs to the Section Cardiovascular Medicine)

Advances in Minimally Invasive Otolaryngology: Precision Techniques and Functional Outcomes

edited by Giovanni Colombo and

Matteo Di Bari

submission deadline 20 Jan 2027 | 5 articles | Viewed by 6127 | Submission Open

Keywords: advances in otolaryngology; endoscopic surgery; head and neck surgery; functional outcomes; quality of life

(This special issue belongs to the Section Otolaryngology)

Clinical Updates in Transfusion Medicine and Patient Blood Management

edited by

Carlos Jerico

and

José Antonio García-Erce

submission deadline 20 Jan 2027 | 2 articles | Viewed by 5124 | Submission Open

Keywords: anaemia; bleeding; blood transfusion; patient blood management; transfusion medicine

(This special issue belongs to the Section Hematology)

Hospital-Acquired Infections: Insights, Prevention, and Control Strategies

edited by

Andrea Fabbri

submission deadline 20 Jan 2027 | 4 articles | Viewed by 4986 | Submission Open

Keywords: healthcare-acquired infections; bloodstream infections; hospital‐acquired pneumonia; intestinal infections; clostridium difficile; surgical site infections; urinary tract infections; emergency department

(This special issue belongs to the Section Epidemiology & Public Health)

Aortic Valve Disease: Current Evolution and Future Opportunities

edited by Gianluigi Perri

submission deadline 20 Jan 2027 | 4 articles | Viewed by 4921 | Submission Open

Keywords: aortic valve disease; aortic valve repair; Ross procedure; aortic valve replacement; diagnosis of aortic valve disease

(This special issue belongs to the Section Cardiology)

Artificial Intelligence and Machine Learning in Clinical Practice

edited by Theodosis Kalamatianos and

Ioannis Kakkos

submission deadline 20 Jan 2027 | 6 articles | Viewed by 4795 | Submission Open

Keywords: artificial intelligence in healthcare; medical image/signal analysis; clinical decision support systems; predictive analytics; personalized medicine; explainable AI; diagnosis; prognosis

(This special issue belongs to the Section General Surgery)

Advancements in the Treatment of Myeloproliferative Neoplasms and Myelodysplastic Syndromes

edited by Ivan Krečak, Marko Skelin and Zinaida Perić

submission deadline 20 Jan 2027 | 4 articles | Viewed by 4166 | Submission Open

Keywords: myeloproliferative neoplasms; myelodysplastic syndromes; treatment; risk stratification; prognosis

(This special issue belongs to the Section Hematology)

Deep Vein Thrombosis and Pulmonary Embolism: Clinical Treatment and Management—Second Edition

edited by

Pablo Demelo-Rodríguez

submission deadline 20 Jan 2027 | 3 articles | Viewed by 3710 | Submission Open

Keywords: pulmonary embolism; thrombophilia; deep vein thrombosis; venous thromboembolism; anticoagulation therapy; thrombectomy; bleeding; cancer-associated thrombosis

(This special issue belongs to the Section Hematology)

Artificial Intelligence in Exercise, Rehabilitation and Health Promotion: A Clinical Perspective

edited by

Ki-Hyuk Lee

and

Koji Koyama

submission deadline 20 Jan 2027 | 3 articles | Viewed by 3656 | Submission Open

Keywords: artificial intelligence; machine learning and deep learning; large language models (LLMs); explainable AI; exercise and physical activity; rehabilitation and sports medicine; clinical applications; chronic disease and preventive health; digital health and big data analytics

(This special issue belongs to the Section Sports Medicine)

Clinical Perspectives on Obesity and Bariatric Surgery: Outcomes and Complications

edited by Dilhana S. Badurdeen

submission deadline 20 Jan 2027 | 4 articles | Viewed by 3594 | Submission Open

Keywords: obesity; bariatric surgery; metabolic surgery; Roux-en-Y Gastric Bypass (RYGB); sleeve gastrectomy; revisional bariatric surgery; complications; outcomes; weight loss maintenance; metabolic syndrome; type 2 diabetes remission; nutritional deficiencies; gastrointestinal adaptation; quality of life; long-term follow-up

(This special issue belongs to the Section General Surgery)

Bronchoscopy and Interventional Pulmonology

edited by Bryan S. Benn and

Jonathan Kurman

submission deadline 20 Jan 2027 | 4 articles | Viewed by 3330 | Submission Open

Keywords: navigation-guided bronchoscopy; Robotic-guided bronchoscopy; 3D imaging integration; lung nodule/peripheral pulmonary lesion marking; transbronchial lung cryobiopsy and interstitial lung disease; malignant and benign central airway obstruction and stenosis; airway stents; pleuroscopic procedures; bronchoscopic lung volume reduction

(This special issue belongs to the Section Respiratory Medicine)

Clinical Insights in Pediatric Dentistry

edited by

Giulia Orilisi

submission deadline 20 Jan 2027 | 2 articles | Viewed by 3238 | Submission Open

Keywords: pediatric dentistry; caries management; dental trauma; preventive dentistry; behavior management; interdisciplinary care; clinical innovations

(This special issue belongs to the Section Dentistry, Oral Surgery and Oral Medicine)

Cardiac Imaging in Cardiovascular Disorders

edited by Leif-Christopher Engel

submission deadline 20 Jan 2027 | 3 articles | Viewed by 3225 | Submission Open

Keywords: coronary CT angiography; cardiac magnetic resonance imaging; molecular imaging; echocardiography; stress echocardiography; myocardial perfusion imaging

(This special issue belongs to the Section Cardiology)

Spine Surgery: Current Challenges and Opportunities

edited by Kambiz Sarahrudi

submission deadline 20 Jan 2027 | 4 articles | Viewed by 3199 | Submission Open

Keywords: vertebral fracture; spine trauma; spinal cord injury; adjacent segment degeneration; infection; spondylodiscitis; verte-bral metastasis; osteoporotic fracture; fracture of sacrum; disk degeneration; degenerative spine surgery; minimally invasive spine surgery

(This special issue belongs to the Section Orthopedics)

New Advances in Congenital Heart Disease

edited by

Efrén Martínez-Quintana

submission deadline 20 Jan 2027 | 3 articles | Viewed by 2987 | Submission Open

Keywords: congenital heart disease; pediatric cardiology; adult congenital heart disease; cardiac surgery; interventional cardiology; long-term outcomes; cardiac imaging

(This special issue belongs to the Section Cardiology)

Interstitial Lung Diseases: New Treatments Based on Treatable Traits

edited by Francesco Amati

submission deadline 20 Jan 2027 | 1 articles | Viewed by 2826 | Submission Open

Keywords: interstitial lung diseases; progressive pulmonary fibrosis; phenotypes; endotypes; treatment; precision medicine

(This special issue belongs to the Section Respiratory Medicine)

Osteoporosis: A Renascent Impact of Vertebral Fractures in the Diagnosis and Management

edited by Csaba Horvath

submission deadline 20 Jan 2027 | 3 articles | Viewed by 2639 | Submission Open

Keywords: osteoporosis; vertebral fractures; imminent fracture risk; FRAX; bone densitometry; vertebral fracture assessment

(This special issue belongs to the Section Orthopedics)

Clinical Advances in the Management of Abdominal and Thoracoabdominal Aortic Aneurysms

edited by

Daniela Mazzaccaro

submission deadline 20 Jan 2027 | 4 articles | Viewed by 2605 | Submission Open

Keywords: abdominal aneurysm; thoraco-abdominal; computed-tomography angiography; branched endograft; branched endovascular aortic repair; fenestrated endograft; open surgery; 3-D printing

(This special issue belongs to the Section Vascular Medicine)

Acute and Chronic Heart Failure: Clinical Updates and Perspectives—2nd Edition

edited by Luigi Cappannoli and Cristina Aurigemma

submission deadline 20 Jan 2027 | 3 articles | Viewed by 2395 | Submission Open

Keywords: acute heart failure; chronic heart failure; devices; drug therapy; percutaneous ventricular assist devices; cardiogenic shock; arrhythmias; ischemic heart disease

(This special issue belongs to the Section Cardiovascular Medicine)

The Treatment of BPO with Minimal Invasive Approach

edited by

Lukas Lusuardi

submission deadline 20 Jan 2027 | 2 articles | Viewed by 2141 | Submission Open

Keywords: benign prostatic obstruction (BPO); prostatectomy; non-muscle invasive bladder cancer; muscle invasive bladder cancer; robotic surgery

(This special issue belongs to the Section Nephrology & Urology)

Bladder Cancer: Diagnosis, Treatment and Future Opportunities

edited by

Jørgen Bjerggaard Jensen

submission deadline 20 Jan 2027 | 2 articles | Viewed by 2098 | Submission Open

Keywords: urology; bladder cancer; urothelial cancer; non-muscle invasive bladder cancer; muscle invasive bladder cancer

(This special issue belongs to the Section Nephrology & Urology)

Clinical Progress in Oral and Maxillofacial Surgery

edited by Luis M. Junquera and Giuseppe Consorti

submission deadline 20 Jan 2027 | 2 articles | Viewed by 2081 | Submission Open

Keywords: oral and maxillofacial surgery; craniofacial surgery; facial deformity; cleft lip and palate; TMJ surgery

(This special issue belongs to the Section Dentistry, Oral Surgery and Oral Medicine)

Clinical Updates of Physical Therapy in Rehabilitation

edited by

Sofia Xergia

submission deadline 20 Jan 2027 | 1 articles | Viewed by 1998 | Submission Open

Keywords: neurological rehabilitation; musculoskeletal rehabilitation; special populations; new technology in physical therapy

(This special issue belongs to the Section Clinical Rehabilitation)

Advances in Male Infertility: Diagnosis, Management and ART Integration

edited by Despoina Mavrogianni and Sofoklis Stavros

submission deadline 20 Jan 2027 | 1 articles | Viewed by 1946 | Submission Open

Keywords: male infertility; assisted reproductive technologies (ART); intracytoplasmic sperm injection (ICSI); genetic testing; hormonal profiling; seminal biomarkers; sperm retrieval techniques; sperm selection; stem cell therapy; gene editing; reproductive endo-crinology; early pregnancy; implantation failure; recurrent miscarriage

(This special issue belongs to the Section Reproductive Medicine & Andrology)

Displaying special issue 801-850 on page 17 of 30.

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