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Journal of Clinical Medicine publishes Special Issues to create collections of papers on specific topics, with the aim of building a community of authors and readers to discuss the latest research and develop new ideas and research directions. Special Issues are led by Guest Editors, who are experts on the topic and all Special Issue submissions follow MDPI's standard editorial process. The journal’s Editor-in-Chief and/or designated Editorial Board Member will oversee Guest Editor appointments and Special Issue proposals, checking their content for relevance and ensuring the suitability of the material for the journal. The papers published in a Special Issue will be collected and displayed on a dedicated page of the journal’s website. Further information on MDPI's Special Issue policies and Guest Editor responsibilities can be found here. For any inquiries related to a Special Issue, please contact the Editorial Office.

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Tumor Microenvironment—Current Status and Therapeutic Targets

edited by

Rashi Kalra

submission deadline 28 Aug 2026 | 2 articles | Viewed by 3751 | Submission Open

Keywords: tumor microenvironment (TME); cancer immunology; immune checkpoint inhibitors; cancer biology; targeted therapies

(This special issue belongs to the Section Oncology)

Towards a New Paradigm: Opioid-Free and Opioid-Sparing Strategies in Modern Anesthesia

edited by

Kassiani Theodoraki

submission deadline 28 Aug 2026 | 2 articles | Viewed by 3634 | Submission Open

Keywords: opioid-free anesthesia; opioid-sparing strategies; multimodal analgesia; regional anesthesia; non-opioid analgesics; enhanced recovery after surgery (ERAS); perioperative pain management; postoperative analgesia; anesthesia innovation; chronic pain prevention; patient-centered anesthesia; clinical outcomes in anesthesia

(This special issue belongs to the Section Anesthesiology)

Clinical Therapeutic Advances of Mitral Regurgitation

edited by Angelo Squeri

submission deadline 28 Aug 2026 | 4 articles | Viewed by 3302 | Submission Open

Keywords: mitral regurgitation; mitral valve prolapse; cardiovascular interventions; heart surgery; echocardiography; mag-netic resonance imaging; computed tomography

(This special issue belongs to the Section Cardiovascular Medicine)

Emerging Therapies: Clinical Trials and Insights in Psoriasis

edited by

Beata Kowalewska

and Elżbieta Krajewska-Kułak

submission deadline 28 Aug 2026 | 3 articles | Viewed by 2616 | Submission Open

Keywords: psoriasis; clinical trials; biomarkers; psychodermatology; treatment; modern therapy; individualized therapy

(This special issue belongs to the Section Dermatology)

Epidemiology Associated Risks and Intervention Strategies of Childhood Obesity

edited by

María M. Morales Suárez-Varela

Antonio Castillo-Paredes

and Eduardo Guzmán-Muñoz

submission deadline 28 Aug 2026 | Viewed by 623 | Submission Open

Keywords: childhood obesity; overweight; eating disorders; nutritional programs; psychological interventions; physical activity exercise; sport; physical well-being; mental well-being; quality of life

(This special issue belongs to the Section Clinical Pediatrics)

Drug-Related Problems: Clinical Pharmacy and Safety of Pharmacotherapy

edited by

Mariola Drozd

and

Jakub Pawlikowski

submission deadline 30 Aug 2026 | 3 articles | Viewed by 5795 | Submission Open

Keywords: adverse drug reaction; drug-related problems; drug formulation technology; safety of pharmacotherapy; clinical pharmacy; pharmaceutical care; pharmacology

(This special issue belongs to the Section Pharmacology)

Clinical Updates in Trauma and Emergency Medicine

edited by Yong-Soo Cho and Hyun Ho Ryu

submission deadline 31 Aug 2026 | 5 articles | Viewed by 8796 | Submission Open

Keywords: emergency medicine; epidemiology; cardiovascular disease

(This special issue belongs to the Section Emergency Medicine)

Infectious Diseases and Host Responses: Clinical, Immunological, and Outcome-Orientated Perspectives

edited by

Nicoleta Negruț

submission deadline 31 Aug 2026 | 3 articles | Viewed by 3310 | Submission Open

Keywords: microbiology; infection; resistance; epidemiology; microbiome; prevention; therapy

(This special issue belongs to the Section Infectious Diseases)

Chronic Obstructive Pulmonary Disease (COPD): Treatment and Management—Second Edition

edited by

Maurizio Marvisi

and Alfredo Antonio Chetta

submission deadline 31 Aug 2026 | 3 articles | Viewed by 2238 | Submission Open

Keywords: chronic obstructive pulmonary disease (COPD); treatable traits; precision medicine; COPD comorbidities; COPD mortality

(This special issue belongs to the Section Respiratory Medicine)

The New Perspective in Transcatheter Aortic Valve Implantation (TAVI)

edited by Salvatore Giordano, Arturo Giordano and Nicola Corcione

submission deadline 31 Aug 2026 | 3 articles | Viewed by 1858 | Submission Open

Keywords: transcatheter aortic valve implantation (TAVI); structural heart intervention; aortic stenosis; valve technology and durability; imaging and procedural optimization

(This special issue belongs to the Section Cardiovascular Medicine)

Interventional Cardiology: Emerging Insights into Therapeutic Advancements

edited by Dong-Hyeok Kim

submission deadline 31 Aug 2026 | 1 articles | Viewed by 1734 | Submission Open

Keywords: conduction system pacing (CSP); left bundle branch area pacing (LBBAP); interventional electrophysiology; advanced pacing strategies; heart failure device therapy

(This special issue belongs to the Section Cardiology)

Recent Advances and Future Perspectives on Spinal Surgeries

edited by

Sung-kyu Kim

submission deadline 31 Aug 2026 | 1 articles | Viewed by 922 | Submission Open

Keywords: minimally invasive spine procedures; robotic-assisted spine surgery; image-guided navigation; spinal implants and biomaterials; artificial intelligence in spinal care; regenerative spine therapies; clinical outcomes in spine surgery; future trends in spinal interventions

(This special issue belongs to the Section Orthopedics)

Management of Complex Orthopaedic Trauma and Bone Infection

edited by

Georg Mattiassich

submission deadline 31 Aug 2026 | 1 articles | Viewed by 433 | Submission Open

Keywords: complex orthopaedic trauma; fracture-related infection (FRI); bone and implant-associated infection; chronic osteomyelitis; post-traumatic infection; biofilm-associated infection; advanced fracture management; limb reconstruction; nonunion and delayed union; multidisciplinary trauma care

(This special issue belongs to the Section Orthopedics)

Clinical Management of Type 1 Diabetes: 2nd Edition

edited by Carmen Quirós

submission deadline 31 Aug 2026 | Viewed by 300 | Submission Open

Keywords: type 1 diabetes; continuous glucose monitoring; hybrid closed loop; hypoglycemia; physical activity; new onset type 1 diabetes; pre-stage 3 type 1 diabetes; smart insulin pens

(This special issue belongs to the Section Endocrinology & Metabolism)

Molecular Mechanisms and Therapeutic Strategies in Pediatric Immune Dysregulation

edited by Rita Consolini and

Giorgio Costagliola

submission deadline 31 Aug 2026 | Viewed by 185 | Submission Open

Keywords: immune dysregulation; autoimmunity; inborn errors of immunity; targeted therapies; immunomodulatory treatments; genetics; gene therapy; hematopoietic stem cell transplantation

(This special issue belongs to the Section Immunology & Rheumatology)

Advances in Maxillofacial Surgery—Historical and Future Perspectives and Controversies

edited by

Kamil Nelke

Maciej Dobrzyński

and

Michał Gontarz

submission deadline 1 Sep 2026 | 8 articles | Viewed by 11346 | Submission Open

Keywords: oral oncology; facial skeleton; oral cavity; surgical approaches; head and neck; parotid tumors; jaw cysts and tumors; bone healing; patient-specific solutions; surgery planning; artificial intelligence; soft tissues; cancers and tumors of the oral cavity; microsurgery perspectives; open surgery; endoscopic surgery; trauma surgery; facial traumatology; bone and soft tissues healing after trauma; jaw deformities; orthognathic surgery today and tomorrow

(This special issue belongs to the Section Dentistry, Oral Surgery and Oral Medicine)

Rehabilitation Strategies for Chronic Musculoskeletal Pain

edited by Ana Isabel de la Llave Rincon and

César Fernández-de-las-Peñas

submission deadline 1 Sep 2026 | 2 articles | Viewed by 2628 | Submission Open

Keywords: pain; musculoskeletal; rehabilitation; treatment; classification

(This special issue belongs to the Section Clinical Rehabilitation)

Optimizing the Surgical Journey: From Abdominal Operation to Recovery

edited by

Alessio Giordano

and Carlo Bergamini

submission deadline 1 Sep 2026 | 2 articles | Viewed by 1392 | Submission Open

Keywords: surgical complications; comanagement; comorbidities; elective surgical procedure; emergency surgery procedure; multidisciplinary approach; hospitalist

(This special issue belongs to the Section General Surgery)

Current Practice and Future Directions in Hemodialysis and Peritoneal Dialysis

edited by

Johannes Wild

submission deadline 1 Sep 2026 | Viewed by 331 | Submission Open

Keywords: kidney replacement therapy; hemodialysis; peritoneal dialysis; dialysis nursing; continuous renal replacement therapy; incremental dialysis; decremental dialysis

(This special issue belongs to the Section Nephrology & Urology)

Clinical Advances of Retinal and Vitreous Diseases: Current Status and Prospect

edited by Lorenzo De Angelis, Francesco Barca and Stanislao Rizzo

submission deadline 5 Sep 2026 | 6 articles | Viewed by 5236 | Submission Open

Keywords: vitreoretinal surgery; retinal multimodal imaging; gene therapy; retinal diseases; age-related macular degeneration; vascular retinal disease; imaging technologies in ophthalmology

(This special issue belongs to the Section Ophthalmology)

New Technologies and Translational Approach for an Early Diagnosis of Bipolar Spectrum and Hyperactive and Novelty Seeking Profiles

edited by

Massimo Tusconi

, Serdar Dursun and

Germano Orru

submission deadline 10 Sep 2026 | 5 articles | Viewed by 17560 | Submission Open

Keywords: psychiatry; mental health; bipolar disorders; mood; biomarkers; new technology; BD

(This special issue belongs to the Section Mental Health)

Challenges and Opportunities in Prenatal Diagnosis

edited by

Diana Massalska

and

Julia Bijok

submission deadline 10 Sep 2026 | 11 articles | Viewed by 16896 | Submission Open

Keywords: prenatal diagnosis; genetic testing; fetal imaging; fetal therapy; personalized prenatal medicine

(This special issue belongs to the Section Obstetrics & Gynecology)

Non-Invasive Respiratory Support: Current Insights and Future Directions

edited by Giovanni Misseri and

Cesare Gregoretti

submission deadline 10 Sep 2026 | 4 articles | Viewed by 12132 | Submission Open

Keywords: respiratory failure; high-flow nasal cannula (HFNC); noninvasive ventilation (NIV); noninvasive positive pressure ventilation (NPPV); hypoxia; perioperative care; weaning; ICU; respiratory care; respiratory physiology; pneumology; home-care ventilation; artificial intelligence; personalized medicine

(This special issue belongs to the Section Respiratory Medicine)

Clinical Diagnosis and Management of Corneal Diseases

edited by

Eirini-Kanella Panagiotopoulou

Georgios Labiris

and Panagiota Ntonti

submission deadline 10 Sep 2026 | 4 articles | Viewed by 5559 | Submission Open

Keywords: corneal imaging; corneal disease diagnosis; corneal therapeutics; regenerative corneal treatments; artificial intelligence in corneal diagnostics; corneal cross-linking; lamellar keratoplasty

(This special issue belongs to the Section Ophthalmology)

Clinical Diagnosis and Therapeutic Approaches for Acute and Chronic Coronary Syndromes

edited by Rocco Antonio Montone

submission deadline 10 Sep 2026 | 2 articles | Viewed by 4732 | Submission Open

Keywords: coronary artery disease; clinical diagnosis; therapeutic approaches; atherosclerosis; risk factors; percutaneous cor-onary intervention; acute coronary syndrome; MINOCA; INOCA

(This special issue belongs to the Section Cardiology)

Updates on Physiotherapy in Pain Management

edited by

Stefanos Karanasios

and George Gioftsos

submission deadline 10 Sep 2026 | 3 articles | Viewed by 3450 | Submission Open

Keywords: pain management; physiotherapy; chronic pain; rehabilitation; pain assessment; patient outcomes; musculoskeletal; central sensitization; pain sensitivity; analgesia; pain modulation; exercise therapy; pain education; telerehabilitation; health-related quality of life; pain coping strategies

(This special issue belongs to the Section Clinical Rehabilitation)

Prevention, Diagnosis, and Clinical Treatment of Corneal Diseases

edited by Rossella Anna Maria Colabelli-Gisoldi and

Fabio Scarinci

submission deadline 10 Sep 2026 | 4 articles | Viewed by 3061 | Submission Open

Keywords: dry eye disease; cornea transplant; stem cell therapy; corneal imaging; cornea disease; deep anterior lamellar keratoplasty; descemet stripping automated endothelial keratoplasty; descemet membrane endothelial keratoplasty; keratoconus; eye bank

(This special issue belongs to the Section Ophthalmology)

Robotic Urologic Surgery: Clinical Applications and Advances

edited by Athanasios N. Kostakopoulos and

Nikolaos Kostakopoulos

submission deadline 10 Sep 2026 | 2 articles | Viewed by 1436 | Submission Open

Keywords: robotic surgery; robotic urology; advances in robotics; urologic surgery; minimally invasive urologic surgery; robotic partial nephrectomy; robotic radical prostatectomy

(This special issue belongs to the Section Nephrology & Urology)

Knee Surgery: Clinical Treatment and Management

edited by Nikolai Ramadanov

submission deadline 10 Sep 2026 | 2 articles | Viewed by 851 | Submission Open

Keywords: knee surgery; sports knee injuries; ligament reconstruction; meniscal surgery; cartilage repair; knee osteotomy; knee arthroplasty; clinical outcomes; surgical techniques

(This special issue belongs to the Section Orthopedics)

Clinical Management and Rehabilitation of Sports Injuries and Musculoskeletal Disorders

edited by

Francesco Oliva

Alessio Giai Via

and Francesco Cuozzo

submission deadline 10 Sep 2026 | 1 articles | Viewed by 520 | Submission Open

Keywords: sports injuries; musculoskeletal disorders; injury prevention; sports medicine; rehabilitation

(This special issue belongs to the Section Sports Medicine)

Management of Inguinal Hernia Surgery, Chronic Pain and Technological Future

edited by

Alfredo Moreno Egea

submission deadline 10 Sep 2026 | Viewed by 320 | Submission Open

Keywords: inguinal hernia; chronic pain; radical cure; technology; medical and surgery future

(This special issue belongs to the Section General Surgery)

Cardiac Intensive Care Units: Clinical Advances and Future Challenges

edited by Luca Baldetti

submission deadline 10 Sep 2026 | Viewed by 312 | Submission Open

Keywords: cardiac intensive care; heart failure; cardiogenic shock; mechanical circulatory support; invasive hemodynamic monitoring; acute cardiac care; shock; myocardial infarction

(This special issue belongs to the Section Cardiology)

Improving Short- and Long-Term Neurological Outcomes in Perioperative Anesthesia and Critical Care

edited by

Michele Salvagno

and

Marta Baggiani

submission deadline 10 Sep 2026 | Viewed by 310 | Submission Open

Keywords: perioperative brain injury; neuroprotection; multimodal neuromonitoring; delirium; neurocritical care; cerebral perfusion and oxygenation; precision anesthesia; artificial intelligence in critical care

(This special issue belongs to the Section Intensive Care)

Photodynamic Therapy and Optical Diagnostics in Cancer: Clinical Advances, Translational Innovation and Future Prospects

edited by

Waseem Jerjes

submission deadline 10 Sep 2026 | Viewed by 309 | Submission Open

Keywords: photodynamic therapy; optical diagnostics; photodiagnosis; optical imaging; cancer treatment; photosensitisers; light-based therapy; PDT dosimetry; fluorescence imaging; optical coherence tomography; raman spectroscopy; elastic scattering spectroscopy; hyperspectral imaging; image-guided surgery; optical biopsy; minimally invasive oncology; combination cancer therapies; translational photomedicine; clinical outcomes; precision oncology

(This special issue belongs to the Section Oncology)

Clinical Practice of Imaging in Coronary Interventional Therapy

edited by Nobuaki Suzuki

submission deadline 10 Sep 2026 | Viewed by 245 | Submission Open

Keywords: coronary artery disease; cardiac imaging; intravascular ultrasound; near-infrared spectroscopy; optical coherence tomography; fractional flow reserve computed tomography

(This special issue belongs to the Section Cardiology)

Cardiac Amyloidosis and Amyloid Cardiomyopathy: Advances in Cardiovascular Care

edited by Marcus Anthony Urey

submission deadline 10 Sep 2026 | Viewed by 216 | Submission Open

Keywords: amyloidosis; diagnostics; disease progression; restrictive cardiomyopathy; degraders; silencers; stabilizers

(This special issue belongs to the Section Cardiology)

Recent Advances in Lymphedema

edited by Shinsuke Akita

submission deadline 10 Sep 2026 | Viewed by 212 | Submission Open

Keywords: lymphedema; lymphaticovenular anastomosis (LVA); vascularized lymph node transfer (VLNT); immediate lymphatic reconstruction; indocyanine green lymphography; ultrasonography; bioimpedance analysis; imaging and staging of lymphedema; fibrosis and inflammation; patient-reported outcome measures

(This special issue belongs to the Section Plastic, Reconstructive and Aesthetic Surgery/Aesthetic Medicine)

Gynecologic Robotic Surgery: Evolution, Current Status and Future Directions

edited by Youn-Jee Chung

submission deadline 13 Sep 2026 | 2 articles | Viewed by 1405 | Submission Open

Keywords: laparoscopy; robot surgery; minimally invasive surgery; gynecology; endometriosis; myoma; adenomyosis

(This special issue belongs to the Section Obstetrics & Gynecology)

Musculoskeletal Spine Disorders: Clinical Management, Rehabilitation Strategies, and Technological Innovations

edited by

Maria Chiara Maccarone

Nicola Manocchio

and Calogero Foti

submission deadline 14 Sep 2026 | 2 articles | Viewed by 1191 | Submission Open

Keywords: spine disorders; rehabilitation; physical exercise; low back pain; scoliosis; adolescent idiopathic scoliosis

(This special issue belongs to the Section Orthopedics)

Biomarkers and Diagnostics in Neurological Diseases

edited by Maria Ioanna Stefanou

submission deadline 15 Sep 2026 | 10 articles | Viewed by 19699 | Submission Open

Keywords: biomarkers; neurological diseases; diagnosis; lipoprotein(a); neurofilament protein; tau peptide; neuroimaging

(This special issue belongs to the Section Clinical Neurology)

Advances in Diagnosis and Treatment of Endometriosis

edited by

Arrigo Fruscalzo

and

Anis Feki

submission deadline 15 Sep 2026 | 6 articles | Viewed by 10856 | Submission Open

Keywords: endometriosis; adenomyosis; diagnosis; classification; therapy; progesterone

(This special issue belongs to the Section Obstetrics & Gynecology)

Thyroid Disease: Updates from Diagnosis to Treatment: 2nd Edition

edited by

Luca Giovanella

and

Petra Petranović Ovčariček

submission deadline 15 Sep 2026 | 7 articles | Viewed by 9140 | Submission Open

Keywords: autoimmune thyroid diseases; thyroiditis; thyroid cancers; PET/CT; hyperthyroidism

(This special issue belongs to the Section Endocrinology & Metabolism)

Current Challenges in Clinical Dentistry: 3rd Edition

edited by

Eiji Tanaka

and

Susumu Abe

submission deadline 15 Sep 2026 | 2 articles | Viewed by 4602 | Submission Open

Keywords: artificial intelligence; clinical dentistry; cutting-edge device and technology; dental material; challenging hypothesis; preventive dentistry; sleep medicine; digital dentistry; smart dentistry; stomatognathic function

(This special issue belongs to the Section Dentistry, Oral Surgery and Oral Medicine)

Plastic and Reconstructive Surgery: Clinical Advances and Future Opportunities

edited by Rami S Kantar

submission deadline 15 Sep 2026 | 5 articles | Viewed by 4203 | Submission Open

Keywords: plastic surgery; reconstructive surgery; cleft lips; palates; post-traumatic reconstruction; facial transplantation; craniofacial surgery; cleft surgery

(This special issue belongs to the Section Plastic, Reconstructive and Aesthetic Surgery/Aesthetic Medicine)

Latest Advances in Thoracic Surgery: 2nd Edition

edited by

Hideki Ujiie

submission deadline 15 Sep 2026 | 2 articles | Viewed by 3997 | Submission Open

Keywords: lung cancer; surgical oncology; robotic surgery; thoracic surgery; lung diseases; minimally invasive surgery

(This special issue belongs to the Section Respiratory Medicine)

Clinical Advances in Obesity and Bariatric Surgery—2nd Edition

edited by Valentin Mocanu and Jerry Dang

submission deadline 15 Sep 2026 | 3 articles | Viewed by 3034 | Submission Open

Keywords: obesity; bariatric surgery; metabolic surgery; anti-obesity medications; obesity treatment

(This special issue belongs to the Section Endocrinology & Metabolism)

Risk Prediction in Mechanical Circulatory Support (MCS) and Cardiac Transplantation

edited by

Nandini Nair

submission deadline 15 Sep 2026 | 3 articles | Viewed by 2980 | Submission Open

Keywords: advanced heart failure; mechanical circulatory support (MCS); cardiac transplantation; heart transplantation; risk prediction

(This special issue belongs to the Section Cardiology)

Clinical Management and Challenges of Sepsis and Septic Shock

edited by

Matteo Guarino

and

Michele Domenico Spampinato

submission deadline 15 Sep 2026 | 2 articles | Viewed by 1552 | Submission Open

Keywords: sepsis; septic shock; hemodynamic management; biomarkers; cardiovascular dysfunction; point-of-care ultrasound; precision medicine; emergency medicine; critical care

(This special issue belongs to the Section Intensive Care)

Advances in Pancreatic Cancer: Diagnosis and Therapy

edited by Eleonora Lai,

Nicola Silvestris

and

Mario Scartozzi

submission deadline 15 Sep 2026 | 1 articles | Viewed by 1187 | Submission Open

Keywords: pancreatic cancer diagnosis; endoscopic ultrasound; neoadjuvant chemotherapy; surgical resection; targeted therapy; immunotherapy

(This special issue belongs to the Section Gastroenterology & Hepatopancreatobiliary Medicine)

Advances in Cardiac Resynchronization Treatment: 2nd Edition

edited by

George Leventopoulos

, Konstantinos A. Gatzoulis, Konstantinos Aronis and

Dimitris L. Tsiachris

submission deadline 15 Sep 2026 | 1 articles | Viewed by 927 | Submission Open

Keywords: conduction system; risk stratification; resynchronization; cardiac pacing; sudden cardiac death

(This special issue belongs to the Section Cardiology)

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