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Journal of Clinical Medicine publishes Special Issues to create collections of papers on specific topics, with the aim of building a community of authors and readers to discuss the latest research and develop new ideas and research directions. Special Issues are led by Guest Editors, who are experts on the topic and all Special Issue submissions follow MDPI's standard editorial process. The journal’s Editor-in-Chief and/or designated Editorial Board Member will oversee Guest Editor appointments and Special Issue proposals, checking their content for relevance and ensuring the suitability of the material for the journal. The papers published in a Special Issue will be collected and displayed on a dedicated page of the journal’s website. Further information on MDPI's Special Issue policies and Guest Editor responsibilities can be found here. For any inquiries related to a Special Issue, please contact the Editorial Office.

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Clinical Outcomes in Lumbar Spinal Stenosis Treatment
edited by Rafał Staszkiewicz and
submission deadline 20 Mar 2027 | 2 articles | Viewed by 1163 | Submission Open
Keywords: lumbar spinal stenosis; clinical outcomes; decompression surgery; conservative management; molecular biomarkers; inflammation and fibrosis; neurotrophic factors; personalized medicine; siganling pathways; quality of life
(This special issue belongs to the Section Orthopedics)
Novel Research in Cardiovascular Imaging
edited by Stanciu Silviu and
submission deadline 20 Mar 2027 | 1 articles | Viewed by 998 | Submission Open
Keywords: echocardiography; cardiac CT; CMR; nuclear medicine; artificial intelligence
(This special issue belongs to the Section Cardiovascular Medicine)
Pulmonary Hypertension and Chronic Lung Disease: Diagnosis and Management submission deadline 20 Mar 2027 | 1 articles | Viewed by 964 | Submission Open
Keywords: pulmonary hypertension; chronic obstructive pulmonary disease (COPD); chronic lung disease; epidemiology; exacerbations; comorbidities; risk factors; diabetes; systemic inflammation; real-world data
(This special issue belongs to the Section Respiratory Medicine)
Updates on Reconstructive Urology
edited by
submission deadline 20 Mar 2027 | 1 articles | Viewed by 922 | Submission Open
Keywords: reconstructive urology; urethral stenosis; urethroplasty; urethral diverticulum; ureteral stenosis; male incontinence; urinary diversion; hypospadias; microsurgery; experimental microsurgery; bladder diverticulum; neobladder
(This special issue belongs to the Section Nephrology & Urology)
Current Therapeutic Approaches to Addictive Disorders
edited by Linda Haddad
submission deadline 20 Mar 2027 | 1 articles | Viewed by 890 | Submission Open
Keywords: addiction treatment; dependence; withdrawal management; relapse prevention; recovery; rehabilitation and support
(This special issue belongs to the Section Mental Health)
Advances in Interventional Cardiology: From Access to Outcomes
edited by James Cotton and Benjamin Wrigley
submission deadline 20 Mar 2027 | 1 articles | Viewed by 854 | Submission Open
Keywords: interventional cardiology; acute coronary syndrome; chronic coronary syndrome; TAVI; TAVR; TEER; TMVR; T-TEER; TTVR; service redesign
(This special issue belongs to the Section Cardiology)
New Insights in Trauma and Emergency Surgery
edited by Kai Oliver Jensen and Valentin Neuhaus
submission deadline 20 Mar 2027 | 1 articles | Viewed by 802 | Submission Open
Keywords: trauma and emergency surgery; multiple trauma; orthopedic trauma; surgery; concepts in trauma
(This special issue belongs to the Section Emergency Medicine)
New Perspective of Oral and Maxillo-Facial Surgery: 2nd Edition
edited by , and Alessandra Lucchese
submission deadline 20 Mar 2027 | 1 articles | Viewed by 777 | Submission Open
Keywords: maxillofacial surgery; esthetic surgery; orthognatic surgery; TMJ disorders; TMJ surgery; dental implant surgery; 3D imaging; printing applications; tissue engineering; personalized treatment planning; artificial intelligence; squamous cell carcinoma; skin tumors; plastic and reconstructive surgery; head and neck surgery; ENT surgery
(This special issue belongs to the Section Dentistry, Oral Surgery and Oral Medicine)
Diagnosis and Treatment of Pleura and Lung: Clinical Advances in Intensive Care submission deadline 20 Mar 2027 | 1 articles | Viewed by 754 | Submission Open
Keywords: thoracic drainage; lung recruitment; lung ultrasound; pleural effusion; pneumothrax; B-line; lung atelectasis
(This special issue belongs to the Section Intensive Care)
Clinical Research on Robot-Assisted Thoracic Surgery and Lung Surgery
edited by Marco Scarci
submission deadline 20 Mar 2027 | 1 articles | Viewed by 750 | Submission Open
Keywords: robot-assisted thoracic surgery; robotic lung surgery; minimally invasive surgery; lobectomy; segmentectomy; thoracic oncology; surgical outcomes; learning curve; clinical research; robotic technology
(This special issue belongs to the Section General Surgery)
Cataract and Refractive Surgery, and Intraocular Lens (IOL) Implantation: Advancing Diagnosis and Management
edited by Olga Reitblat
submission deadline 20 Mar 2027 | 1 articles | Viewed by 622 | Submission Open
Keywords: cataract surgery; premium intraocular lenses (IOLs); IOL power calculation; visual outcomes; refractive cataract surgery; multifocal IOL; extended depth of focus (EDOF) IOL; toric IOL; full range; vision IOL; biometry
(This special issue belongs to the Section Ophthalmology)
Rebuilding the Knee: From Repair to Replacement and Recovery
edited by Young-Jin Seo
submission deadline 20 Mar 2027 | 1 articles | Viewed by 522 | Submission Open
Keywords: cartilage; meniscus; total knee arthroplasty; knee surgery; anterior cruciate ligament injuries; posterior cruciate ligament injuries; ligament reconstruction; patellofemoral disorders; osteotomy; sports medicine; rehabilitation; functional recovery
(This special issue belongs to the Section Orthopedics)
Thyroid Cancer: Diagnosis, Surgical Treatment and Postoperative Radioactive Iodine Therapy: 2nd Edition
edited by Alfred A. Simental
submission deadline 20 Mar 2027 | 1 articles | Viewed by 472 | Submission Open
Keywords: thyroid nodule; thyroid ultrasound; radiofrequency ablation; molecular analysis; thyroid surgery
(This special issue belongs to the Section Oncology)
Colorectal Surgery: Advances in Modern Clinical Management submission deadline 20 Mar 2027 | 1 articles | Viewed by 469 | Submission Open
Keywords: colorectal cancer management; surgery; complications; organ preservation; screening; colonic diverticular disease; colonic diverticulitis; hemorrhoids
(This special issue belongs to the Section Gastroenterology & Hepatopancreatobiliary Medicine)
Exploring Diagnostic and Therapeutic Advances in Neurodegenerative Disorders submission deadline 20 Mar 2027 | Viewed by 355 | Submission Open
Keywords: neurodegenerative disease; Parkinson’s disease; Alzheimer’s disease; Friedreich’s ataxia; Huntington’s disease; Lewy body dementia; dementia; immunosenescence; inflammaging
(This special issue belongs to the Section Clinical Neurology)
Digital Innovations in Obstetrics and Gynecology: Artificial Intelligence, Diagnostic Advances, Minimally Invasive Surgery, and Clinical Decision-Making
edited by
submission deadline 20 Mar 2027 | 1 articles | Viewed by 348 | Submission Open
Keywords: obstetrics; gynecology; artificial intelligence; machine learning; minimally invasive surgery; digital health
(This special issue belongs to the Section Machine Learning and Artificial Intelligence in Clinical Medicine)
Clinical Recent Advances in the Surgical Treatment of Heart Valve Disease
edited by and Aleksander Dokollari
submission deadline 20 Mar 2027 | Viewed by 329 | Submission Open
Keywords: heart valve surgery; prosthetic valves; intervention surgery; minimally invasive and robotic surgery; valve repair and replacement
(This special issue belongs to the Section Cardiology)
Clinical Advances in Pediatric Hepatobiliary Surgery
edited by Ioannis A. Ziogas
submission deadline 20 Mar 2027 | Viewed by 324 | Submission Open
Keywords: pediatric hepatobiliary surgery; pediatric transplantation; pediatric surgery; liver transplantation; biliary atresia; choledochal cyst; liver cancer
(This special issue belongs to the Section Clinical Pediatrics)
New Clinical Insight: From Open Surgery to Minimally Invasive Foot and Ankle Surgery
edited by Enrique A. Testa and Daniel Poggio
submission deadline 20 Mar 2027 | Viewed by 320 | Submission Open
Keywords: minimally invasive surgery; foot surgery; ankle surgery; trauma surgery; orthopedic surgery; ankle arthroscopy
(This special issue belongs to the Section Orthopedics)
Clinical Updates on Anesthesia and Perioperative Medicine
edited by Béla Fülesdi and
submission deadline 20 Mar 2027 | Viewed by 309 | Submission Open
Keywords: anesthesia; perioperative complications; residual neuromuscular block; postoperative pulmonary complications; intensive care unit acquired weakness; intensive care medicine; airway management; patient safety
(This special issue belongs to the Section Anesthesiology)
Colorectal Surgery: Current Concept and Emerging Trends
edited by
submission deadline 20 Mar 2027 | Viewed by 306 | Submission Open
Keywords: colorectal surgery; robotic surgery; neoadjuvant treatment; minimally invasive techniques; enhanced recovery
(This special issue belongs to the Section Gastroenterology & Hepatopancreatobiliary Medicine)
Optimizing Outcomes in Pancreato-Biliary Care: Integrating Technology, Technique, and Personalized Approaches
edited by
submission deadline 20 Mar 2027 | Viewed by 282 | Submission Open
Keywords: pancreato-biliary care; pancreatic diseases; biliary diseases; hepato-pancreato-biliary (HPB) surgery; interventional endoscopy; interventional radiology; minimally invasive surgery; EUS-guided procedures; ERCP; personalized care/personalized medicine; multidisciplinary care; clinical outcomes; robotics and AI in PB care
(This special issue belongs to the Section Gastroenterology & Hepatopancreatobiliary Medicine)
Head and Neck Surgery: Immunotherapy’s Role in Shaping Treatment Paradigms
edited by
submission deadline 20 Mar 2027 | Viewed by 238 | Submission Open
Keywords: head and neck surgery; otorhinolaryngology; ENT; transoral surgery; laryngeal surgery; laryngeal carcinoma; sinonasal surgery; oral cancer; oropharyngeal cancer; laryngectomy; immunotherapy; head and neck cancer; cutaneous cancer
(This special issue belongs to the Section Otolaryngology)
Contactless Magnetocardiography and Related Novel Methods for Non-Invasive Experimental and Clinical Functional Imaging of Normal and Abnormal Cardiac Electrophysiology submission deadline 20 Mar 2027 | Viewed by 231 | Submission Open
Keywords: magnetocardiography; non-invasive functional imaging of cardiac electrophysiology; arrhythmogenic mechanisms; atrial fibrillation; magnetoionography; antiarrhythmic drugs; artificial intelligence
(This special issue belongs to the Section Cardiology)
Game-Changing Advances in Minimally Invasive Spine Surgery
edited by Rouzbeh Motiei-Langroudi
submission deadline 20 Mar 2027 | Viewed by 224 | Submission Open
Keywords: minimally invasive spine surgery (MISS); technological innovation; navigation systems/robotic-assisted; endoscopic techniques; artificial intelligence/machine learning
(This special issue belongs to the Section Clinical Neurology)
Atrial Fibrillation: Contemporary Evidence from Prevention to Catheter Ablation
edited by , Radu Gabriel Vătăşescu and Dragos Cozma
submission deadline 20 Mar 2027 | Viewed by 167 | Submission Open
Keywords: atrial fibrillation; prevention; risk-factor modification; screening; rhythm control; catheter ablation; stroke prevention; outcomes
(This special issue belongs to the Section Cardiology)
Advances in Mental Health: All Ages and Multidisciplinary Clinical Perspectives
edited by Clara González-Sanguino and
submission deadline 20 Mar 2027 | Viewed by 153 | Submission Open
Keywords: stigma; discrimination; mental health; clinical psychology; depression and anxiety
(This special issue belongs to the Section Mental Health)
Hemophilia: Current Trends and Future Directions: 2nd Edition submission deadline 20 Mar 2027 | 1 articles | Viewed by 131 | Submission Open
Keywords: hemophilia; prophylaxis; gene therapy; burden of illness; quality of life; patient reported outcomes; hemarthrosis; women and hemophilia
(This special issue belongs to the Section Hematology)
Psychosis Across Disciplines: Emerging Perspectives in Neuroscience, Psychiatry, and Therapy
edited by Inmaculada Peñuelas-Calvo, Roberto Rodríguez-Jiménez and
submission deadline 20 Mar 2027 | Viewed by 108 | Submission Open
Keywords: psychosis; lifespan; neuroimaging; psychotherapy; prevention
(This special issue belongs to the Section Mental Health)
Advancing Precision Care in Neuropathic Pain: From Biomarkers to Neuromodulation to Artificial Intelligence
edited by Saurabh Kataria and
submission deadline 20 Mar 2027 | Viewed by 105 | Submission Open
Keywords: neuropathic pain; precision medicine; neuromodulation; spinal cord stimulation; peripheral nerve stimulation; ul-trasound-guided interventions; pain phenotyping; personalized therapeutics; opioid alternatives
(This special issue belongs to the Section Clinical Neurology)
Clinical Updates in Type 2 Diabetes and Related Complications
edited by
submission deadline 20 Mar 2027 | Viewed by 99 | Submission Open
Keywords: type 2 diabetes; chronic complications; microvascular disease; macrovascular disease; treatment
(This special issue belongs to the Section Endocrinology & Metabolism)
Pediatric Orthopedics: Diagnosis, Treatment, and Comprehensive Management
edited by Michał Latalski and
submission deadline 20 Mar 2027 | Viewed by 96 | Submission Open
Keywords: pediatric orthopedics; cerebral palsy; SMA; spinal deformities; developmental dysplasia of the hip; clubfoot; neuro-orthopedics; gait analysis; pediatric traumatology; skeletal dysplasia; biomechanics; congenital musculoskeletal anomalies
(This special issue belongs to the Section Orthopedics)
Clinical Advances in Extracorporeal Membrane Oxygenation (ECMO)—Second Edition
edited by and
submission deadline 20 Mar 2027 | Viewed by 93 | Submission Open
Keywords: extracorporeal membrane oxygenation; ECMO; multi-organ failure; outcomes; V-A ECMO; ECPR; V-V ECMO; translational research; clinical research
(This special issue belongs to the Section Intensive Care)
The State of the Art in Robotic Thoracic Surgery: Innovation, Complexity and Outcomes
edited by Michael Zervos
submission deadline 20 Mar 2027 | Viewed by 92 | Submission Open
Keywords: thoracic surgery; robotic surgery; single-port robotic surgery; robotic-assisted thoracic surgery; minimally invasive surgery; lung cancer
(This special issue belongs to the Section General Surgery)
Recent Advances in Clinical Perspectives on the Diagnosis and Treatment of Endometriosis
edited by Paweł Basta and
submission deadline 20 Mar 2027 | Viewed by 85 | Submission Open
Keywords: endometriosis; deep endometriosis; endometrioma; infertility; laparoscopy; minimally invasive techniques; biomarkers; pain; pelvic pain; adenomyosis; adhesions; dysmenorrhea; dyspareunia
(This special issue belongs to the Section Obstetrics & Gynecology)
Clinical Physical Therapy: Current Advances and Future Challenges submission deadline 20 Mar 2027 | Viewed by 80 | Submission Open
Keywords: clinical physical therapy; chronic musculoskeletal disorders; chronic pain management; manual therapy; mind–body medicine; biopsychosocial model; autoimmune diseases; fatigue syndromes; bottom-up and top-down regulation; neurophysiological mechanisms
(This special issue belongs to the Section Clinical Rehabilitation)
Therapies for Heart Failure: Clinical Updates and Perspectives: 2nd Edition
edited by Cristina Tudoran, Stela Iurciuc and Dragos Cozma
submission deadline 20 Mar 2027 | Viewed by 77 | Submission Open
Keywords: mechanisms of heart failure; new therapies for heart failure; chronic and acute heart failure; new approaches to managing heart failure patients; special populations; clinical outcome
(This special issue belongs to the Section Cardiology)
Developmental Transfusion Biology in Neonatal–Perinatal Medicine
edited by Thomas G. Brune
submission deadline 20 Mar 2027 | Viewed by 77 | Submission Open
Keywords: neonatal transfusion; preterm infants; fetal hemoglobin; cord blood; delayed cord clamping; oxygen transport; developmental hematology
(This special issue belongs to the Section Clinical Pediatrics)
Gastrointestinal Surgery: New Insights into Tumor Metabolism and Translational Oncology
edited by Konstantinos Romanidis
submission deadline 20 Mar 2027 | Viewed by 70 | Submission Open
Keywords: gastrointestinal cancer; tumor metabolism; translational oncology; surgical oncology; metabolic profiling; artificial intelligence
(This special issue belongs to the Section Gastroenterology & Hepatopancreatobiliary Medicine)
Clinical Challenges and Advances in Hepatobiliary and Pancreatic Surgery submission deadline 20 Mar 2027 | Viewed by 53 | Submission Open
Keywords: pancreatic cancer; pancreatic cancer surgery; neoadjuvant chemotherapy; perioperative management; surgical approaches
(This special issue belongs to the Section Gastroenterology & Hepatopancreatobiliary Medicine)
Diagnostic and Interventional Radiology: Advances in Treatment of Small Tumors
edited by Carolina Lanza
submission deadline 20 Mar 2027 | Viewed by 39 | Submission Open
Keywords: interventional radiology; MRI; contrast-enhanced ultrasound; CT; liver; kidney; lung; prostate; breast; multimodal imaging; diagnostic imaging; tumor
(This special issue belongs to the Section Nuclear Medicine & Radiology)
Advances in Neuro-Oncology: Diagnostics and Treatment
edited by and Derek A. Wainwright
submission deadline 20 Mar 2027 | Viewed by 30 | Submission Open
Keywords: glioblastoma; glioma; meningioma; brain metastases; blood–brain barrier
(This special issue belongs to the Section Clinical Neurology)
Dentistry and Oral Surgery: Current Status and Future Prospects, 2nd Edition submission deadline 20 Mar 2027 | Viewed by 23 | Submission Open
Keywords: dentistry; oral surgery; dental implantology; prosthodontics; restorative dentistry; periodontology; digital dentistry; computer-guided surgery; artificial intelligence
(This special issue belongs to the Section Dentistry, Oral Surgery and Oral Medicine)
Sarcopenia: Prevention and Treatment Options
edited by Steven Phu
submission deadline 21 Mar 2027 | 2 articles | Viewed by 1011 | Submission Open
Keywords: sarcopenia; skeletal muscle; ageing; falls; frailty; exercise; rehabilitation; nutrition
(This special issue belongs to the Section Geriatric Medicine)
Macular Diseases: From Diagnosis to Treatment
edited by
submission deadline 22 Mar 2027 | 2 articles | Viewed by 2081 | Submission Open
Keywords: age-related macular degeneration; retinal vascular diseases; intraocular tumours; retinal imaging; OCT; OCT angiography; anti-VEGF; laser therapy; macular surgery; gene therapy; biomarkers; progression; intravitreal injections; biomarkers
(This special issue belongs to the Section Ophthalmology)
Psychological Affliction in Pregnancy, Delivery and Postpartum Period: A Multidisciplinary Approach submission deadline 24 Mar 2027 | 4 articles | Viewed by 1895 | Submission Open
Keywords: maternal mental health; pregnancy; postpartum depression; perinatal anxiety; midwifery; multidisciplinary care
(This special issue belongs to the Section Mental Health)
Rewriting Metastatic Colorectal Cancer Management: Innovative Frontiers in Clinical Diagnosis and Personalized Oncology submission deadline 24 Mar 2027 | Viewed by 344 | Submission Open
Keywords: molecular profiling; liquid biopsy; targeted therapy; immunotherapy; biomarkers treatment; sequencing; tumor heterogeneity; personalized medicine
(This special issue belongs to the Section Oncology)
Emergency Surgery: Clinical Updates and Key Insights
edited by
submission deadline 24 Mar 2027 | Viewed by 74 | Submission Open
Keywords: minimally invasive emergency surgery; biomarkers; point-of-care imaging (POCI); frailty assessment; surgical decision-making; risk stratification; damage control surgery; enhanced recovery (ERAS); patient outcomes; multidisciplinary care
(This special issue belongs to the Section Emergency Medicine)
Thoracic Surgery: Updates and New Trends
edited by
submission deadline 25 Mar 2027 | 4 articles | Viewed by 6848 | Submission Open
Keywords: minimally invasive surgery; new technology; diagnosis; bronchoscopy; robotic system; artificial intelligence
(This special issue belongs to the Section Respiratory Medicine)
Update on Acute Severe Respiratory Infections: 2nd Edition submission deadline 25 Mar 2027 | 6 articles | Viewed by 5498 | Submission Open
Keywords: acute severe respiratory infection (ASRI); acute respiratory distress syndrome (ARDS); severe pneumonia; sepsis; ICU; viral respiratory infection; COVID-19; bacterial co-infection; diagnostic technology; treatment strategy; mechanical ventilation; extracorporeal membrane oxygenation (ECMO); antibiotics; non-antibiotics; pulmonary rehabilitation
(This special issue belongs to the Section Respiratory Medicine)
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