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Journal of Clinical Medicine publishes Special Issues to create collections of papers on specific topics, with the aim of building a community of authors and readers to discuss the latest research and develop new ideas and research directions. Special Issues are led by Guest Editors, who are experts on the topic and all Special Issue submissions follow MDPI's standard editorial process. The journal’s Editor-in-Chief and/or designated Editorial Board Member will oversee Guest Editor appointments and Special Issue proposals, checking their content for relevance and ensuring the suitability of the material for the journal. The papers published in a Special Issue will be collected and displayed on a dedicated page of the journal’s website. Further information on MDPI's Special Issue policies and Guest Editor responsibilities can be found here. For any inquiries related to a Special Issue, please contact the Editorial Office.

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Bleeding and Thrombotic Complications in Patients with Premalignant Hematologic Conditions: Diagnostic and Therapeutic Challenges

edited by Vasiliki Gkalea and Despina Fotiou

submission deadline 20 Feb 2026 | Viewed by 26 | Submission Open

Keywords: bleeding; thrombosis; hematologic malignancies; premalignant hematologic conditions; clonal hematopoiesis of indeterminate potential (CHIP); clonal cytopenias of undetermined significance (CCUS); monoclonal gammopathy of undetermined significance (MGUS); monoclonal B-cell lymphocytosis (MBL); monoclonal gammopathy of thrombotic significance (MGTS); VITT-like MGTS

(This special issue belongs to the Section Hematology)

Hypercholesterolemia: Update on Treatment Approaches and Outcomes

edited by

Massimiliano Ruscica

and Lucia Barbieri

submission deadline 20 Feb 2026 | Viewed by 25 | Submission Open

Keywords: hypercholesterolemia; dyslipidemia; atherosclerosis; cardiovascular risk; LDL; HDL; lipoprotein(a)

(This special issue belongs to the Section Cardiovascular Medicine)

Rheumatoid Arthritis: Insights into Appropriate Diagnosis, Treatment and Management

edited by

Satoshi Takanashi

submission deadline 20 Feb 2026 | Viewed by 25 | Submission Open

Keywords: rheumatoid arthritis; precision medicine; difficult-to-treat rheumatoid arthritis; late-onset rheumatoid arthritis; ageing society; comorbidities

(This special issue belongs to the Section Immunology)

Endoscopic Imaging for the Diagnosis and Treatment of Gastrointestinal Diseases

edited by Mariana Jinga and

Daniel Vasile Balaban

submission deadline 20 Feb 2026 | Viewed by 25 | Submission Open

Keywords: endoscopy; endoscopic ultrasound; endoscopic retrograde cholangiopancreatography; artificial intelligence; diagnosis; therapy; decision making; endobiopsy

(This special issue belongs to the Section Gastroenterology & Hepatopancreatobiliary Medicine)

Innovations in Personalized Therapy and Clinical Outcomes for Myopia and Ocular Disorders

edited by

Clara Martinez-Perez

submission deadline 20 Feb 2026 | Viewed by 24 | Submission Open

Keywords: myopia; refractive errors; visual development; childhood eye disorders; vision screening; diagnostic tools in optometry; vision-related quality of life; therapeutic strategies in optometry; artificial intelligence; public health; eye care innovation; multidisciplinary vision science

(This special issue belongs to the Section Ophthalmology)

Novel Research in Pediatric Dentistry: 2nd Edition

edited by Christian Hirsch and

Katrin Bekes

submission deadline 20 Feb 2026 | Viewed by 23 | Submission Open

Keywords: early childhood caries; primary teeth; caries prevention; caries treatment; behavioral management; molar incisor hypomineralization; dental trauma; sedation; oral health-related quality of life

(This special issue belongs to the Section Dentistry, Oral Surgery and Oral Medicine)

New Insights into Orthodontic Treatment

edited by Federico Brugnami and Simonetta Meuli

submission deadline 20 Feb 2026 | Viewed by 23 | Submission Open

Keywords: digital orthodontics; clear aligners; artificial intelligence; digital superimpositions; cone beam computed tomography; growing patients; periodontal patients; maxillofacial surgery; long-term stability; prediction of orthodontic movements

(This special issue belongs to the Section Dentistry, Oral Surgery and Oral Medicine)

Endocrine Disorders in Children: 2nd Edition

edited by

Juan Pedro López-Siguero

submission deadline 20 Feb 2026 | Viewed by 23 | Submission Open

Keywords: endocrinology; pediatrics; hormones; genetics; growth; nutrition; development ; adolescence ; prevention

(This special issue belongs to the Section Clinical Pediatrics)

Novel Developments in Digestive Endoscopy

edited by

Arnaldo Amato

submission deadline 20 Feb 2026 | Viewed by 22 | Submission Open

Keywords: endoscopy for IBD; AI in endoscopy; therapeutic endoscopy; EUS; interventional EUS; AI in digestive endoscopy; quality in endoscopy

(This special issue belongs to the Section Gastroenterology & Hepatopancreatobiliary Medicine)

Rising Star: Advanced Physical Therapy and Expansion

edited by

Hyolyun Roh

submission deadline 20 Feb 2026 | Viewed by 21 | Submission Open

Keywords: physical therapy; digital therapeutic technology; geriatric diseases; pediatric; psychology of physical therapies; clinical approach

(This special issue belongs to the Section Clinical Rehabilitation)

Metastatic Colorectal Cancer Beyond Second-Line Treatment

edited by Jacopo Giuliani

submission deadline 20 Feb 2026 | Viewed by 21 | Submission Open

Keywords: metastatic colorectal cancer; subsequent lines; chemotherapy; targeted agents; radiotherapy; local therapy

(This special issue belongs to the Section Gastroenterology & Hepatopancreatobiliary Medicine)

Breakthroughs in Spine Biomechanics: Diagnostics and Treatment Approaches for Body Posture, Scoliosis and Chronic Back Pain

edited by

Maciej Rachwał

and

Joanna Baran

submission deadline 20 Feb 2026 | Viewed by 21 | Submission Open

Keywords: spinal biomechanics; spinal pathologies; idiopathic scoliosis; postural abnormalities; spinal pain syndromes; spinal deformities; chronic spinal pain

(This special issue belongs to the Section Orthopedics)

Breast Cancer: Symptoms, Types, Causes & Treatment

edited by Min-Jeong Cho and Sara Myers

submission deadline 20 Feb 2026 | Viewed by 20 | Submission Open

Keywords: ductal carcinoma in situ (DCIS); breast cancer; breast cancer prevention; minimally invasive surgery; innovative imaging technologies

(This special issue belongs to the Section Obstetrics & Gynecology)

Clinical Insights and Emerging Strategies in Chronic Pain Management

edited by

Cheol Lee

submission deadline 20 Feb 2026 | Viewed by 19 | Submission Open

Keywords: chronic pain; neuropathic pain; multimodal pain management; digital health; real-world evidence; interdiscipli-nary care

(This special issue belongs to the Section Anesthesiology)

Advances and Updates in Migraine

edited by

Hartmut Göbel

and Carl H. Göbel

submission deadline 20 Feb 2026 | Viewed by 18 | Submission Open

Keywords: migraine; chronic migraine; headache disorders; CGRP antibodies; gepants; ditans; triptans; precision medicine; neuromodulation; comorbidities; disability burden; pediatric migraine; ICHD-3 classification; neurotransmitters; preventive therapy; translational headache research

(This special issue belongs to the Section Clinical Neurology)

Clinical Advances in Meningioma Surgery

edited by

Makoto Nakamura

submission deadline 20 Feb 2026 | Viewed by 17 | Submission Open

Keywords: meningioma; cranial neurosurgery; brain tumors; skull base surgery; endoscopic neurosurgery; intraoperative techniques; surgical outcomes; minimally invasive neurosurgery; perioperative management; clinical meningioma research

(This special issue belongs to the Section Clinical Neurology)

Diagnosis and Treatment of Gastrointestinal Malignancies

edited by

Carmelo Laface

and Gianmauro Numico

submission deadline 20 Feb 2026 | Viewed by 17 | Submission Open

Keywords: gastrointestinal cancers; immunotherapy; targeted therapy; chemotherapy; microsatellite instability; driver mutations

(This special issue belongs to the Section Oncology)

New Insights into Management of Chronic Rhinosinusitis

edited by

Giandomenico Maggiore

submission deadline 20 Feb 2026 | Viewed by 17 | Submission Open

Keywords: chronic rhinosinusitis; management; surgery; minimally invasive surgery; surgical oncology; cancer surgery; skull base surgery; hoarseness; laryngeal neoplasms; laryngoscopy; general surgery; X-ray computed tomography

(This special issue belongs to the Section Otolaryngology)

Orthopedic Trauma: Diagnosis, Treatment and Rehabilitation

edited by

Emmanouil Liodakis

submission deadline 20 Feb 2026 | Viewed by 17 | Submission Open

Keywords: orthopedic trauma; fragility fractures; biomechanics; bone defect; pelvic ring; acetabular fractures; amputation; re-habilitation

(This special issue belongs to the Section Orthopedics)

Deep Vein Thrombosis and Pulmonary Embolism: Clinical Treatment and Management—Second Edition

edited by

Pablo Demelo-Rodríguez

submission deadline 20 Feb 2026 | Viewed by 16 | Submission Open

Keywords: pulmonary embolism; thrombophilia; deep vein thrombosis; venous thromboembolism; anticoagulation therapy; thrombectomy; bleeding; cancer-associated thrombosis

(This special issue belongs to the Section Hematology)

Innovations and Challenges in the Burden and Rehabilitation of Musculoskeletal Disorders

edited by

Carla Sílvia Fernandes

Marta Campos Ferreira

and

Oscar F. Goncalves

submission deadline 20 Feb 2026 | Viewed by 16 | Submission Open

Keywords: musculoskeletal diseases; rehabilitation; physical therapy modalities; telemedicine; mobile applications; health information technology; patient-centered care; quality of life; health care innovation

(This special issue belongs to the Section Clinical Rehabilitation)

Diagnosis and Treatment of Cardiovascular Diseases in the Elderly

edited by

Carmelo Massimiliano Rao

submission deadline 20 Feb 2026 | Viewed by 15 | Submission Open

Keywords: cardiovascular diseases; elderly population; diagnosis and management; age-related pathophysiology; frailty and cognitive impairment

(This special issue belongs to the Section Geriatric Medicine)

Cardio-Oncology: Clinical Advances in Cardiotoxicity Detection, Imaging and Therapeutic Strategies

edited by

Nicola Maurea

and

Alfredo Mauriello

submission deadline 20 Feb 2026 | Viewed by 14 | Submission Open

Keywords: cardio-oncology; cardiovascular toxicity; targeted therapies; echocardiography; PET/CT

(This special issue belongs to the Section Cardiology)

Clinical Updates and Personalized Medicine in Hepatocellular Carcinoma and Liver Transplantation

edited by Adriano Pellicelli

submission deadline 20 Feb 2026 | Viewed by 13 | Submission Open

Keywords: hepatocellular carcinoma; transarterial chemoembolization (TACE); transarterial radioembolization (TARE); liver transplant; immune checkpoint inhibitors (ICI); tyrosine kinase inhibitor; liver function assessment; Child-Pugh score; bridging to liver transplantation; immuno escape

(This special issue belongs to the Section Gastroenterology & Hepatopancreatobiliary Medicine)

Innovative Approaches to the Challenges of Neurodegenerative Disease

edited by Brian T. Bicknell

submission deadline 20 Feb 2026 | Viewed by 13 | Submission Open

Keywords: neurodegenerative disease; Parkinson’ s disease; Alzheimer’ s disease; multiple sclerosis; amyotrophic lateral sclerosis

(This special issue belongs to the Section Clinical Neurology)

Progress and Innovation in the Clinical Management of Psychosis

edited by

Valerio Ricci

submission deadline 20 Feb 2026 | Viewed by 13 | Submission Open

Keywords: psychosis; schizophrenia; clinical interventions; neurobiological mechanisms; early intervention

(This special issue belongs to the Section Mental Health)

Advances in the Personalized Management of Chronic Obstructive Pulmonary Disease (COPD)

edited by

Athena Gogali

and Georgios Hillas

submission deadline 20 Feb 2026 | Viewed by 8 | Submission Open

Keywords: artificial intelligence; biologics; biomarkers; diagnostics; oscillometry; COPD pharmacotherapy; imaging

(This special issue belongs to the Section Respiratory Medicine)

Clinical Advances in Sepsis and Septic Shock

edited by

Lucia Filippi

and Lorenzo Ghiadoni

submission deadline 20 Feb 2026 | Submission Open

Keywords: sepsis-induced coagulopathy; endothelial dysfunction in sepsis; fluid balance in sepsis

(This special issue belongs to the Section Emergency Medicine)

Current and Emerging Treatment Options for Aortic Aneurysms

edited by Spyros Ioannis Papadoulas and

Vasileios Leivaditis

submission deadline 24 Feb 2026 | Submission Open

Keywords: thoracic aortic aneurysms; abdominal aortic aneurysm; vascular surgery; cardiac surgery; treatment

(This special issue belongs to the Section Vascular Medicine)

Advancing Clinical Medicine through Artificial Intelligence (AI) and Digital Technology: 2nd Edition

edited by

Antonio Jorge Forte

submission deadline 25 Feb 2026 | Viewed by 54 | Submission Open

Keywords: artificial intelligence; clinical medicine; medical imaging; precision medicine; clinical decision support systems; patient care; healthcare practices; early disease detection; patient outcomes

(This special issue belongs to the Section Intensive Care)

Clinical Research Progress in Diabetes and Cardiovascular Diseases

edited by

Ken-ichi Aihara

submission deadline 25 Feb 2026 | Viewed by 47 | Submission Open

Keywords: diabetes; cardiovascular diseases; risk factor; vascular function; diagnosis; treatment

(This special issue belongs to the Section Cardiovascular Medicine)

Spinal Surgery: Recent Advance and Future Perspective

edited by

Yoshiharu Kawaguchi

submission deadline 25 Feb 2026 | Viewed by 42 | Submission Open

Keywords: spine surgery; diagnostic technology; AI; images; biomarkers; genetics; robotic surgery; minimum invasive surgery; pain control; VR

(This special issue belongs to the Section Orthopedics)

Clinical Updates of Diagnosis and Treatment in Chronic Kidney Disease (CKD)

edited by

Juan F. Navarro-González

, Carmen Mora-Fernández and

Javier Donate-Correa

submission deadline 25 Feb 2026 | Viewed by 39 | Submission Open

Keywords: CKD; CKD progression; biomarkers; disease-modifying treatments; diabetic kidney disease; cardiorenal disease; glomerunephritis; genetic kidney diseases

(This special issue belongs to the Section Nephrology & Urology)

Alzheimer’s Disease and Related Disorders: Recent Advances in Prevention, Diagnosis and Therapy

edited by

Daniel H. S. Silverman

submission deadline 25 Feb 2026 | Viewed by 35 | Submission Open

Keywords: cognition; prodromal; Alzheimer’ s; Alzheimer; dementia; mild cognitive impairment; mild decline in cognition; disease-modifying; amyloid; tau; neuroinflammation; biomarkers; neuroimaging; PET; PET/CT; PET/MRI

(This special issue belongs to the Section Clinical Neurology)

Plastic and Reconstructive Surgery: Clinical Advances and Future Opportunities

edited by Rami S Kantar

submission deadline 25 Feb 2026 | Viewed by 31 | Submission Open

Keywords: plastic surgery; reconstructive surgery; cleft lips; palates; post-traumatic reconstruction; facial transplantation; craniofacial surgery; cleft surgery

(This special issue belongs to the Section Plastic, Reconstructive and Aesthetic Surgery/Aesthetic Medicine)

Helicobacter pylori-Associated Intestinal Diseases and Beyond

edited by

Antonio Facciorusso

submission deadline 25 Feb 2026 | 1 articles | Viewed by 27 | Submission Open

Keywords: IBD; Hp; stomach; celiac disease; diverticulosis; diverticulitis

(This special issue belongs to the Section Gastroenterology & Hepatopancreatobiliary Medicine)

Hospital-Acquired Infections: Evolving Threats and Epidemiological Insights

edited by

Amir Nutman

submission deadline 25 Feb 2026 | Viewed by 27 | Submission Open

Keywords: hospital-acquired infections; healthcare-associated infections; antimicrobial resistance; multidrug-resistant organisms (MDRO); infection prevention and control; outbreak investigation; patient safety; healthcare epidemiology

(This special issue belongs to the Section Infectious Diseases)

Current Advances and Future Perspectives of Sepsis and Septic Shock

edited by Filippo Mearelli and Gianni Biolo

submission deadline 25 Feb 2026 | Viewed by 19 | Submission Open

Keywords: sepsis; epidemiology; biomarkers; diagnosis; predictive models; prognostication

(This special issue belongs to the Section Emergency Medicine)

Clinical Advances of Retinal and Vitreous Diseases: Current Status and Prospect

edited by Lorenzo De Angelis, Francesco Barca and Stanislao Rizzo

submission deadline 25 Feb 2026 | Viewed by 18 | Submission Open

Keywords: vitreoretinal surgery; retinal multimodal imaging; gene therapy; retinal diseases; age-related macular degeneration; vascular retinal disease; imaging technologies in ophthalmology

(This special issue belongs to the Section Ophthalmology)

Segmentectomy and Lobectomy in Early-Stage Lung Cancer Management

edited by Yujin Kudo

submission deadline 25 Feb 2026 | Viewed by 17 | Submission Open

Keywords: lung cancer; segmentectomy; lobectomy; thoracic surgery; early-stage NSCLC; oncologic outcomes; pulmonary function; surgical planning

(This special issue belongs to the Section Respiratory Medicine)

Application of Echocardiography in Clinical Practice

edited by

Shemy Carasso

submission deadline 25 Feb 2026 | Viewed by 12 | Submission Open

Keywords: echocardiography; three-dimensional imaging; mechanical imaging; strain; artificial intelligence; interventional echocardiography; POCUS; hand-held echocardiography; cancer therapy and cardiotoxicity

(This special issue belongs to the Section Cardiovascular Medicine)

Clinical Update on the Diagnosis and Treatment of Heart Failure

edited by Giulia Nardi and Alessio Mattesini

submission deadline 26 Feb 2026 | 3 articles | Viewed by 6052 | Submission Open

Keywords: ejection fraction; acute heart failure; multidisciplinary management; right heart failure; left ventricle remodeling systems; HF percutaneous treatment; pharmacotherapy; HF prevention; cardiomyopathies

(This special issue belongs to the Section Cardiovascular Medicine)

Unraveling Myopia: Current Science, Clinical Impact, and Future Horizons

edited by Neeraj K Singh and Pablo De Gracia

submission deadline 27 Feb 2026 | Viewed by 101 | Submission Open

Keywords: accommodation; contact lenses; ophthalmic lenses; myopia progression; epidemiology; myopia control interventions; pharmaceutical treatments; environmental and behavioral risk factors; imaging innovations in myopia

(This special issue belongs to the Section Ophthalmology)

Hysterectomy Surgery—Recent Developments and Emerging Trends

edited by

Anastasia Prodromidou

Themos Grigoriadis

and Dimitrios Zacharakis

submission deadline 28 Feb 2026 | Viewed by 89 | Submission Open

Keywords: hysterectomy; minimally invasive hysterectomy; robotic surgery; vaginal hysterectomy; surgical innovation; perioperative care

(This special issue belongs to the Section Obstetrics & Gynecology)

Headache Disorders: New Advances in Management and Treatment Strategies: 2nd Edition

edited by

Andreas A. Argyriou

Emmanouil V. Dermitzakis

and

Vikelis Michail

submission deadline 28 Feb 2026 | Viewed by 66 | Submission Open

Keywords: headache; migraine; cluster headache; tension-type headache; post-traumatic headache; calcitonin gene-related peptide; monoclonal antibodies; preventive therapy; acute treatment; pathophysiology; neuromodulation; pain management; drug development; gepants; ditan

(This special issue belongs to the Section Clinical Neurology)

Current and Emerging Treatment Options in Chronic Liver Diseases

edited by Chandana B. Herath

submission deadline 28 Feb 2026 | Viewed by 53 | Submission Open

Keywords: liver disease; liver fibrosis; liver cirrhosis; portal hypertension; liver cancer; therapies; immunological therapies for liver cancer; diabetic liver; type 2 diabetes and obesity; spontaneous bacterial peritonitis

(This special issue belongs to the Section Gastroenterology & Hepatopancreatobiliary Medicine)

Clinical Updates in Cardiovascular Computed Tomography (CT)

edited by

Antonella Meloni

submission deadline 28 Feb 2026 | Viewed by 48 | Submission Open

Keywords: cardiovascular CT; coronary CTA; plaque imaging; artificial intelligence; low-dose imaging; structural heart disease; cardiac imaging; high-risk plaque; atherosclerosis; coronary artery disease; valve calcification; thrombus detection

(This special issue belongs to the Section Cardiovascular Medicine)

Epidemiology Associated Risks and Intervention Strategies of Childhood Obesity

edited by

María M. Morales Suárez-Varela

Antonio Castillo-Paredes

and Eduardo Guzmán-Muñoz

submission deadline 28 Feb 2026 | Viewed by 45 | Submission Open

Keywords: childhood obesity; overweight; eating disorders; nutritional programs; psychological interventions; physical activity exercise; sport; physical well-being; mental well-being; quality of life

(This special issue belongs to the Section Clinical Pediatrics)

Towards a New Paradigm: Opioid-Free and Opioid-Sparing Strategies in Modern Anesthesia

edited by

Kassiani Theodoraki

submission deadline 28 Feb 2026 | Viewed by 34 | Submission Open

Keywords: opioid-free anesthesia; opioid-sparing strategies; multimodal analgesia; regional anesthesia; non-opioid analgesics; enhanced recovery after surgery (ERAS); perioperative pain management; postoperative analgesia; anesthesia innovation; chronic pain prevention; patient-centered anesthesia; clinical outcomes in anesthesia

(This special issue belongs to the Section Anesthesiology)

New Insights into Head and Neck Surgery—2nd Edition

edited by

Gábor Dénes Répássy

submission deadline 28 Feb 2026 | Viewed by 32 | Submission Open

Keywords: otorhinolaryngology; head and neck surgery; ear surgery; sinonasal surgery; skull base surgery; salivary gland surgery; thyroid gland surgery; head and neck cancer surgery

(This special issue belongs to the Section General Surgery)

Displaying special issue 1301-1350 on page 27 of 29.

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