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Journal of Clinical Medicine publishes Special Issues to create collections of papers on specific topics, with the aim of building a community of authors and readers to discuss the latest research and develop new ideas and research directions. Special Issues are led by Guest Editors, who are experts on the topic and all Special Issue submissions follow MDPI's standard editorial process. The journal’s Editor-in-Chief and/or designated Editorial Board Member will oversee Guest Editor appointments and Special Issue proposals, checking their content for relevance and ensuring the suitability of the material for the journal. The papers published in a Special Issue will be collected and displayed on a dedicated page of the journal’s website. Further information on MDPI's Special Issue policies and Guest Editor responsibilities can be found here. For any inquiries related to a Special Issue, please contact the Editorial Office.

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Dental Implantology: Clinical Updates and Perspectives—2nd Edition

edited by

Roberta Gasparro

submission deadline 16 Feb 2027 | 5 articles | Viewed by 11139 | Submission Open

Keywords: dental implantology; reconstructive surgery; biomaterials; tissue engineering; regenerative medicine; digital dentis-try; periimplantitis; peri-implant soft tissues

(This special issue belongs to the Section Dentistry, Oral Surgery and Oral Medicine)

A Holistic Approach to Management of Complications in Hemodialysis

edited by

Georgia Gerogianni

submission deadline 19 Feb 2027 | 1 articles | Viewed by 599 | Submission Open

Keywords: hemodialysis; complications; holistic care management; quality of life; well-being malnutrition; hypotension; cardiovascular diseases; inflammation; vascular access

(This special issue belongs to the Section Nephrology & Urology)

AI in Maternal Fetal Medicine and Perinatal Management

edited by Ariel Many

submission deadline 20 Feb 2027 | 7 articles | Viewed by 12443 | Submission Open

Keywords: maternal fetal medicine; high-risk pregnancy; perinatal management; artificial intelligence (AI) in obstetrics; fetal growth abnormalities; preterm labor prediction

(This special issue belongs to the Section Obstetrics & Gynecology)

Advancements in Gait Rehabilitation: Innovative Approaches and Clinical Insights

edited by

Shinichi Watanabe

Nobuto Nakanishi

and

Yuki Iida

submission deadline 20 Feb 2027 | 9 articles | Viewed by 12183 | Submission Open

Keywords: sarcopenia; swallowing therapy; physical therapy; early mobilization; early rehabilitation; robot-assisted gait training; neurorehabilitation; wearable sensors

(This special issue belongs to the Section Clinical Rehabilitation)

Clinical Diagnosis and Management of Obstructive Sleep Apnea Syndrome

edited by

Graziano Montaruli

Domenico Ciavarella

and

Michele Tepedino

submission deadline 20 Feb 2027 | 6 articles | Viewed by 9649 | Submission Open

Keywords: obstructive sleep apnea (OSA); apnea-hypopnea index (AHI); oxygen desaturation index (ODI); mandibular advancement device (MAD); polysomnography; upper airway; continuous positive airway pressure (C-PAP)

(This special issue belongs to the Section Dentistry, Oral Surgery and Oral Medicine)

Sepsis: Clinical Advances and Practical Updates

edited by

Paolo Formenti

submission deadline 20 Feb 2027 | 5 articles | Viewed by 7383 | Submission Open

Keywords: sepsis pathophysiology; host immune response; biomarkers for sepsis; early sepsis diagnosis; immunotherapy in sepsis; antimicrobial stewardship

(This special issue belongs to the Section Intensive Care)

Risk Factors in Neonatal Intensive Care

edited by

Gabriela C. Zaharie

and

Melinda Matyas

submission deadline 20 Feb 2027 | 6 articles | Viewed by 6571 | Submission Open

Keywords: neonatal intensive care; infant birth; preterm; neonatal resuscitation; neonatal outcome; growth restriction; prenatal diagnosis; severe maternal pathology and its effects on a newborn; therapeutical hypothermia; parenteral nutrition; neonatal infection; retinopathy of prematurity

(This special issue belongs to the Section Clinical Pediatrics)

Parkinson's Disease: Recent Advances in Diagnosis and Treatment

edited by

Mariachiara Sensi

and

Fabiana Colucci

submission deadline 20 Feb 2027 | 6 articles | Viewed by 6213 | Submission Open

Keywords: Parkinson’s disease; disease-modifying therapies; artificial intelligence; microbiome; alpha-synuclein; neuroimaging

(This special issue belongs to the Section Clinical Neurology)

Innovations in the Clinical Management of Retinal Diseases: Emerging Therapies and Visual Rehabilitation

edited by

Francisco J. Povedano-Montero

submission deadline 20 Feb 2027 | 3 articles | Viewed by 4698 | Submission Open

Keywords: retinal diseases; macular degeneration; maculopathies; diabetic retinopathy; retinal vascular occlusions; retinitis pigmentosa

(This special issue belongs to the Section Ophthalmology)

New Clinical Advances in Breast Reconstruction

edited by

Nobuyuki Mitsukawa

submission deadline 20 Feb 2027 | 5 articles | Viewed by 4450 | Submission Open

Keywords: breast reconstruction; autologous (flap) reconstruction; implant-based reconstruction; microsurgery and perforator flaps; robotic surgery/endoscopic surgery; fat grafting (lipofilling); patient-reported outcomes; reconstructive surgical innovation

(This special issue belongs to the Section Plastic, Reconstructive and Aesthetic Surgery/Aesthetic Medicine)

Clinical Advances in Scoliosis and Spinal Disorders: Diagnosis and Management

edited by Tejas Subramanian

submission deadline 20 Feb 2027 | 4 articles | Viewed by 4368 | Submission Open

Keywords: spine surgery; adult spinal deformity; frailty; sarcopenia; muscle health; postoperative recovery; patient-reported outcomes

(This special issue belongs to the Section Orthopedics)

Myopic Optic Neuropathy (MON) and Glaucomatous Optic Neuropathy (GON): Current Concepts and Clinical Implications

edited by

Etsuo Chihara

submission deadline 20 Feb 2027 | 4 articles | Viewed by 4221 | Submission Open

Keywords: myopic optic neuropathy; glaucomatous optic neuropathy; tilting; axonal transport; lamina cribrosa

(This special issue belongs to the Section Ophthalmology)

Innovations in Neurorehabilitation—2nd Edition

edited by

Syoichi Tashiro

submission deadline 20 Feb 2027 | 3 articles | Viewed by 4111 | Submission Open

Keywords: clinical neurophysiology; neuroengineering; robotics; non-invasive transcranial brain stimulation; spinal stimula-tion; regenerative rehabilitation; neuroimaging; brain–computer interface; brain-spinal interface; virtual reality; higher-level cognitive functions; vision rehabilitation

(This special issue belongs to the Section Clinical Rehabilitation)

Ocular Surface Disease: Epidemiology, Diagnosis and Management

edited by

Sandeep K. Dhallu

and

Nicole Carnt

submission deadline 20 Feb 2027 | 3 articles | Viewed by 4106 | Submission Open

Keywords: dry eye disease; risk factors; ocular surface disease; inflammatory biomarkers; anterior segment imaging; emerging therapies

(This special issue belongs to the Section Ophthalmology)

Cardiovascular Imaging: Diagnosis and Therapeutic Guidance in Clinical Practice

edited by

Stefano Figliozzi

submission deadline 20 Feb 2027 | 3 articles | Viewed by 3568 | Submission Open

Keywords: cardiovascular magnetic resonance; cardiac imaging; T1 and T2 mapping; myocardial tissue characterization; late gadolinium enhancement; ischemic heart disease; cardiomyopathies; valvular heart disease; therapeutic guidance; precision medicine; mitral valve prolapse

(This special issue belongs to the Section Cardiology)

Stroke Care: From Acute Interventions to Long-Term Recovery

edited by

Aikaterini Theodorou

and

Georgios Tsivgoulis

submission deadline 20 Feb 2027 | 2 articles | Viewed by 3233 | Submission Open

Keywords: cerebrovascular diseases; acute ischemic stroke; intravenous thrombolysis; endovascular thrombectomy; intracerebral hemorrhage; etiology; cerebral amyloid angiopathy; stroke rehabilitation

(This special issue belongs to the Section Clinical Neurology)

Clinical Management of Patients Before and After Kidney Transplantation

edited by

Izabela Zakrocka

submission deadline 20 Feb 2027 | 4 articles | Viewed by 2672 | Submission Open

Keywords: chronic kidney disease; kidney function; kidney replacement therapy; kidney transplantation; kidney graft survival; post-transplant complications

(This special issue belongs to the Section Nephrology & Urology)

Clinical Research on Minimally Invasive Spine Surgery

edited by Daniel Fahim

submission deadline 20 Feb 2027 | 5 articles | Viewed by 2610 | Submission Open

Keywords: minimally invasive spine surgery; spine tumors; spine trauma; spine fractures; lumbar stenosis; lumbar spondylolisthesis; lumbar disc herniation; lumbar radiculopathy; thoracic disc herniations; cervical radiculopathy

(This special issue belongs to the Section Orthopedics)

Advanced Endoscopy and Imaging in Gastrointestinal Diseases

edited by

Iancu Dana Monica

and

Paul-Andrei Ștefan

submission deadline 20 Feb 2027 | 3 articles | Viewed by 2519 | Submission Open

Keywords: advanced endoscopy; gastrointestinal imaging; minimally invasive therapy; early diagnosis; image-guided intervention; surgical planning; patient outcomes; gastrointestinal diseases

(This special issue belongs to the Section Gastroenterology & Hepatopancreatobiliary Medicine)

Advances in Anterior Cruciate Ligament Injury Treatment

edited by

Goran Vrgoč

submission deadline 20 Feb 2027 | 3 articles | Viewed by 2454 | Submission Open

Keywords: anterior cruciate ligament (ACL) injury; ACL reconstruction techniques; nonoperative ACL treatment; ACL graft; knee biomechanics; return-to-sport assessment; ACL rehabilitation; neuromuscular and proprioceptive training; athletic injuries; performance-enhancing substances; reinjury prevention; psychological readiness; ACL performance testing; osteoarthritis risk

(This special issue belongs to the Section Orthopedics)

Thoracic Surgery Today: Innovations, Challenges, and Future Perspectives

edited by Jeffrey B. Velotta and

Ory Wiesel

submission deadline 20 Feb 2027 | 3 articles | Viewed by 2202 | Submission Open

Keywords: thoracic surgery; minimally invasive thoracic surgery; innovation; esophageal surgery; robotic-assisted thoracic surgery; lung cancer; advanced techniques; thoracic surgical oncology; mediastinal surgery; mesothelioma surgery

(This special issue belongs to the Section General Surgery)

Clinical Advances and Future Challenges for Occupational Health

edited by

Gabriele D’Ettorre

and Vincenza Pellicani

submission deadline 20 Feb 2027 | 3 articles | Viewed by 2002 | Submission Open

Keywords: work-related disease; precision medicine; gender differences; aging workforce; preventive strategies

(This special issue belongs to the Section Epidemiology & Public Health)

Clinical Research Advances in Gynecologic Oncology

edited by

Maciej Skrzypczak

submission deadline 20 Feb 2027 | 1 articles | Viewed by 1969 | Submission Open

Keywords: ovarian cancer; endometrial cancer; breast cancer; molecular biology; gynecological cancers

(This special issue belongs to the Section Oncology)

Chronic Kidney Disease: From Diagnosis to Treatment

edited by Debra Hain

submission deadline 20 Feb 2027 | 2 articles | Viewed by 1927 | Submission Open

Keywords: chronic kidney disease; type 2 diabetes; diabetic complications; hemodialysis; nephrology nursing; older adults; palliative care; therapy; hypertension

(This special issue belongs to the Section Nephrology & Urology)

Clinical Advances and Challenges in Liver Transplantation: 3rd Edition

edited by

Paola Aceto

submission deadline 20 Feb 2027 | 2 articles | Viewed by 1857 | Submission Open

Keywords: liver transplantation (LT); elderly donors; steatotic livers; donors after circulatory death (DCD); hepatocellular carcinoma (HCC); perioperative management

(This special issue belongs to the Section Gastroenterology & Hepatopancreatobiliary Medicine)

Clinical Management of Traumatic Brain Injury

edited by Adam James Wells and Peter Hutchinson

submission deadline 20 Feb 2027 | 2 articles | Viewed by 1782 | Submission Open

Keywords: traumatic brain injury; clinical management TBI; neurocritical care; neuromonitoring; trauma neurosurgery; artificial intelligence

(This special issue belongs to the Section Clinical Neurology)

Clinical Management of Vitreous and Retinal Disorders

edited by Samuel Asanad

submission deadline 20 Feb 2027 | 2 articles | Viewed by 1742 | Submission Open

Keywords: OCT; OCTA; AMD; neurodegenerative disease; surgical techniques; retinal detachment; retinal blood flow; retinal biomarkers; gene therapy

(This special issue belongs to the Section Ophthalmology)

Cardiotoxicity Within Cardio-Oncology: Clinical Advances from Prediction to Management

edited by

Massimiliano Camilli

submission deadline 20 Feb 2027 | 2 articles | Viewed by 1698 | Submission Open

Keywords: cardio-oncology; cardiotoxicity; cancer therapy–related cardiac dysfunction; heart failure in cancer patients; biomarkers; multimodality imaging; risk stratification; cardioprotection; cancer survivors' care; multidisciplinary approach

(This special issue belongs to the Section Cardiology)

Obsessive–Compulsive Disorder: Clinical Advances and Future Perspectives—Second Edition

edited by Andrea Fagiolini

submission deadline 20 Feb 2027 | 2 articles | Viewed by 1573 | Submission Open

Keywords: obsessions–compulsions; anxiety; OCD symptoms; treatment options; functional impairment

(This special issue belongs to the Section Mental Health)

New Insights into Transcatheter Mitral Valve Therapy

edited by Antonio Sisinni and

Rodrigo Estévez-Loureiro

submission deadline 20 Feb 2027 | 2 articles | Viewed by 1531 | Submission Open

Keywords: mitral regurgitation; transcatheter mitral valve therapy; TEER; TMVR; MitraClip; pascal; valve-in-valve; multimodality imaging; outcomes; structural heart interventions

(This special issue belongs to the Section Cardiovascular Medicine)

Diagnosis and Management of Corneal Diseases

edited by Nicola Cardascia

submission deadline 20 Feb 2027 | 2 articles | Viewed by 1522 | Submission Open

Keywords: corneal surgery; lamellar keratoplasty; bioengineered corneal grafts; regenerative medicine; cell-based therapies; tissue-based therapies; Intraoperative imaging; corneal wound healing; lmmune modulation; graft survival; translational research; multimodal diagnostics; clinical outcomes; corneal transparency restoration; ophthalmic surgical innovation

(This special issue belongs to the Section Ophthalmology)

Dental Care and Oral Health in Adolescents and Children

edited by

Karolina Gerreth

submission deadline 20 Feb 2027 | 1 articles | Viewed by 1344 | Submission Open

Keywords: oral health; oral diseases; diagnosis; dental treatment; treatment methods; general health; pediatric dentistry; special care dentistry; immunodeficiency; pediatric dental surgery

(This special issue belongs to the Section Dentistry, Oral Surgery and Oral Medicine)

Clinical Advances in Endocarditis: From Diagnosis to Treatment

edited by Ram Sharony and Katia Orvin

submission deadline 20 Feb 2027 | 2 articles | Viewed by 1290 | Submission Open

Keywords: endocarditis; infective endocarditis; prosthetic valve endocarditis; TAVR endocarditis; advanced cardiac imaging

(This special issue belongs to the Section Cardiology)

Neuroimmunological Disorders: Mechanisms and Therapies

edited by

Christos Bakirtzis

and

Marina Kleopatra Boziki

submission deadline 20 Feb 2027 | 1 articles | Viewed by 1272 | Submission Open

Keywords: neuroinflammatory; multiple sclerosis; neuromyelitis optica spectrum disorders; mog associated disease; autoimmune/paraneoplastic encephalitis

(This special issue belongs to the Section Clinical Neurology)

Arterial Stiffness and Cardiovascular Risk: New Advances and Challenges

edited by

Andrea Grillo

submission deadline 20 Feb 2027 | 2 articles | Viewed by 1224 | Submission Open

Keywords: arterial stiffness; vascular aging; anti-inflammation; cardiovascular risk; personalized medicine

(This special issue belongs to the Section Cardiovascular Medicine)

Endoscopic Innovations in Gastrointestinal Diseases: From Diagnosis to Therapy

edited by Mattia Brigida and Gianluca Andrisani

submission deadline 20 Feb 2027 | 1 articles | Viewed by 1223 | Submission Open

Keywords: endoscopic innovation; gastrointestinal diseases; advanced endoscopic imaging; therapeutic endoscopy; artificial intelligence; minimally invasive therapy; personalized medicine

(This special issue belongs to the Section Gastroenterology & Hepatopancreatobiliary Medicine)

New Clinical Insights into Acute Respiratory Failure

edited by

Christophe Guervilly

submission deadline 20 Feb 2027 | 1 articles | Viewed by 1139 | Submission Open

Keywords: acute respiratory failure; pathophysiology; advances respiratory monitoring; respiratory support strategies; respiratory mechanics; mechanical ventilation; respiratory drive; patient-ventilator asynchrony

(This special issue belongs to the Section Intensive Care)

Novel Insights into the Use of Artificial Intelligence in Clinical Medicine

edited by Sharon C. Kiang and Roger T. Tomihama

submission deadline 20 Feb 2027 | 1 articles | Viewed by 1086 | Submission Open

Keywords: artificial intelligence; disease predictive models; wearable technology; surgical innovation; molecular targeting; big data science; machine learning; deep learning

Pharmacological Pain Management Advances

edited by Michael A. Ueberall

submission deadline 20 Feb 2027 | 1 articles | Viewed by 1064 | Submission Open

Keywords: pain management; drug therapy; analgesics; co-analgesics; drug safety and drug interactions; real-world evidence

(This special issue belongs to the Section Anesthesiology)

Clinical Management Strategies for Coronary Artery Disease and Revascularization

edited by

Marco Spagnolo

submission deadline 20 Feb 2027 | 1 articles | Viewed by 1035 | Submission Open

Keywords: coronary artery disease; coronary revascularization; coronary physiology; coronary imaging; antithrombotic therapy

(This special issue belongs to the Section Cardiovascular Medicine)

Contemporary Issues and Emerging Trends in Colorectal Surgery

edited by

Marco Caricato

and

Gianluca Mascianà

submission deadline 20 Feb 2027 | 1 articles | Viewed by 1007 | Submission Open

Keywords: abdominal surgery; minimally invasive surgery; colorectal surgery; colorectal cancer; inflammatory bowel disease; image-guided surgery; transational research; artificial intelligence; operative endoscopy; screening; early diagnosis; ERAS

(This special issue belongs to the Section Gastroenterology & Hepatopancreatobiliary Medicine)

Advances in Rhinosinusitis and Nasal Polyposis: From Emerging Trends and Therapeutic Opportunities to Surgery

edited by Gian Luca Fadda, Giovanni Cavallo and

Giuseppe Guida

submission deadline 20 Feb 2027 | 1 articles | Viewed by 978 | Submission Open

Keywords: nasal polyps; chronic rhinosinusitis; asthma; endoscopic sinus surgery; anatomical variation; biologic treatment; type-2 inflammation; paranasal sinuses; CRSwNP; late response; long term; remission; dupilumab; control

(This special issue belongs to the Section Otolaryngology)

Endoscopic Management of Pancreaticobiliary Disease: Updates and Future Directions

edited by

Keisuke Iwata

submission deadline 20 Feb 2027 | 2 articles | Viewed by 925 | Submission Open

Keywords: pancreaticobiliary disease; ERCP; interventional EUS; tissue acquisition; early detection of pancreaticobiliary malignancy; management of AEs

(This special issue belongs to the Section Gastroenterology & Hepatopancreatobiliary Medicine)

Orthopedic Oncology Updates and Controversial Issues

edited by Yehuda Kollender and Ron Batash

submission deadline 20 Feb 2027 | Viewed by 741 | Submission Open

Keywords: soft tissue sarcoma; bone sarcoma; oligometastatic; atypical behavior tumor; cryosurgery; rare diseases; surgery; radiation therapy; immunotherapy; chemotherapy

(This special issue belongs to the Section Orthopedics)

Focus on Multiple Myeloma: Diagnosis, Therapy and Clinical Outcome

edited by

Martina Kleber

submission deadline 20 Feb 2027 | 1 articles | Viewed by 730 | Submission Open

Keywords: multiple myeloma; novel therapies; treatment approach; prognosis; clinical outcome

(This special issue belongs to the Section Hematology)

Cardiac Arrest: Beyond Survival—Precision Neuroprognostication After Cardiac Arrest

edited by

Chun-song Youn

submission deadline 20 Feb 2027 | 2 articles | Viewed by 702 | Submission Open

Keywords: cardiac arrest; outcome; prognostication; targeted temperature management; post-cardiac arrest care

(This special issue belongs to the Section Cardiology)

Robotic-Assisted Hepato-Pancreato-Biliary (HPB) Surgery: Advances and Clinical Perspectives

edited by

Michele Tedeschi

and Riccardo Memeo

submission deadline 20 Feb 2027 | 1 articles | Viewed by 690 | Submission Open

Keywords: liver surgery; pancreatic surgery; HPB surgery; robotic surgery; robotic systems; advances in HPB surgery

(This special issue belongs to the Section Gastroenterology & Hepatopancreatobiliary Medicine)

Clinical Frontiers in Myocardial Infarction: From Acute Revascularization to Long-Term Secondary Prevention

edited by

Nikolaos Stalikas

submission deadline 20 Feb 2027 | 1 articles | Viewed by 689 | Submission Open

Keywords: complete revascularization; myocardial infarction; vulnerable plaque; imaging guided PCI; biomarkers; secondary prevention; microvascular disease; endothelial dysfunction

(This special issue belongs to the Section Cardiology)

Advances in the Field of Cariology

edited by

Aline Castilho

and

Frank Lippert

submission deadline 20 Feb 2027 | 1 articles | Viewed by 622 | Submission Open

Keywords: dental caries; caries diagnosis; caries risk assessment; minimally invasive dentistry; preventive strategies

(This special issue belongs to the Section Dentistry, Oral Surgery and Oral Medicine)

New Concepts in the Diagnosis and Treatment of Orthopedic Diseases in Children—2nd Edition

edited by

Sergio De Salvatore

and

Laura Ruzzini

submission deadline 20 Feb 2027 | Viewed by 401 | Submission Open

Keywords: pediatric orthopedics; flatfoot; genu valgum; genu varum; hip dysplasia; clubfoot; early onset scoliosis; Scheuermann disease; perthes; epiphysiolysis; scoliosis; pediatric trauma

(This special issue belongs to the Section Clinical Pediatrics)

Displaying special issue 1151-1200 on page 24 of 30.

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