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Journal of Clinical Medicine publishes Special Issues to create collections of papers on specific topics, with the aim of building a community of authors and readers to discuss the latest research and develop new ideas and research directions. Special Issues are led by Guest Editors, who are experts on the topic and all Special Issue submissions follow MDPI's standard editorial process. The journal’s Editor-in-Chief and/or designated Editorial Board Member will oversee Guest Editor appointments and Special Issue proposals, checking their content for relevance and ensuring the suitability of the material for the journal. The papers published in a Special Issue will be collected and displayed on a dedicated page of the journal’s website. Further information on MDPI's Special Issue policies and Guest Editor responsibilities can be found here. For any inquiries related to a Special Issue, please contact the Editorial Office.

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Clinical Application of Knee Arthroscopy

edited by

Francesco Bosco

and Alessandro Carrozzo

submission deadline 30 Nov 2025 | Viewed by 113 | Submission Open

Keywords: knee surgery; arthroscopy; orthopedics; sport medicine; clinical outcomes; ligament reconstruction; meniscal repair; cartilage; postoperative rehabilitation; knee joint; tissue repair; joint preservation

(This special issue belongs to the Section Orthopedics)

Advances in the Diagnosis and Treatment of Ocular Surface Tumors and Diseases

edited by Sotiria Palioura, Carolina L. Mercado and Jaime D. Martinez

submission deadline 30 Nov 2025 | Viewed by 111 | Submission Open

Keywords: ocular surface diseases; anterior segment imaging; chemotherapeutics; immunomodulatory agents; minimally invasive surgical techniques

(This special issue belongs to the Section Ophthalmology)

Recent Progress in Rehabilitation Medicine—3rd Edition

edited by

Masahiro Kohzuki

submission deadline 30 Nov 2025 | Viewed by 99 | Submission Open

Keywords: neuro-rehabilitation; cognitive rehabilitation; spinal rehabilitation; orthopedic rehabilitation; pediatric rehabilitation; cancer rehabilitation; visceral rehabilitation; cardiac rehabilitation; pulmonary rehabilitation; renal rehabilitation; hepatic rehabilitation; rehabilitation for transplantation; fitness; peak VO2; multimorbidity and multiple disabilities (MMD); adding life to years and years to life

(This special issue belongs to the Section Clinical Rehabilitation)

Exploring Cardiomyopathy: Comprehensive Guide to Causes, Symptoms and Care

edited by

Keiichi Hirono

submission deadline 30 Nov 2025 | Viewed by 83 | Submission Open

Keywords: cardiomyopathy; heart failure; genetics; hypertrophic cardiomyopathy; dilated cardiomyopathy; left ventricular noncompaction; pediatric cardiomyopathies; cardiac imaging

(This special issue belongs to the Section Cardiology)

Challenges and Opportunities in Application of Laparoscopic, Robotic and Other Technological Advances in Gastrointestinal Surgery

edited by

Gianluca Cassese

and Fabrizio Panaro

submission deadline 30 Nov 2025 | Viewed by 79 | Submission Open

Keywords: robotic surgery; laparoscopic surgery; artificial intelligence; technological advances

(This special issue belongs to the Section General Surgery)

Current Challenges in Orthopedic Trauma Surgery

edited by Pietro Maniscalco and Fabrizio Quattrini

submission deadline 30 Nov 2025 | Viewed by 78 | Submission Open

Keywords: hip replacement; knee replacement; shoulder replacement; ankle replacement; trauma surgery; femur; future chal-lenges; surgical innovations

(This special issue belongs to the Section Orthopedics)

New Updates in Pediatric Gastroenterology

edited by

Laura Trandafir

, Alina Stanescu-Popp and Oana Belei

submission deadline 30 Nov 2025 | Viewed by 72 | Submission Open

Keywords: pediatric gastroenterology and hepatology; inflammatory bowel disease; celiac disease; gastrointestinal diseases; esophageal diseases; endoscopy; gut microbiome; inflammatory bowel disease; functional GI disorders; nutritional management; precision medicine; gut– brain axis; transitional care

(This special issue belongs to the Section Gastroenterology & Hepatopancreatobiliary Medicine)

Ischemic Stroke: Diagnosis and Treatment

edited by

Theodoros Karapanayiotides

and

Ioanna Koutroulou

submission deadline 30 Nov 2025 | Viewed by 71 | Submission Open

Keywords: stroke; reperfusion therapies; neuroimaging; brain ischemia; intracerebral hemorrhage; intravenous thrombolysis; mechanical thrombectomy

(This special issue belongs to the Section Clinical Neurology)

Role of Platelet in Inflammation, Infection, and Immune Response

edited by

Amir Houshang Shemirani

submission deadline 30 Nov 2025 | Viewed by 70 | Submission Open

Keywords: platelets; platelet count; dual antiplatelet therapy; inflammation; thrombosis; inflammation; hemostasis; immune response

(This special issue belongs to the Section Hematology)

Cirrhosis and Its Complications: Prognosis and Clinical Management

edited by

Ana-Maria Singeap

submission deadline 30 Nov 2025 | Viewed by 69 | Submission Open

Keywords: cirrhosis; complications; spontaneous bacterial peritonitis; portal hypertension; ascites; hepatorenal syndrome; hepatic encephalopathy; liver transplantation; acute-on-chronic liver failure; hepatocellular carcinoma; quality of life; prognosis; clinical management

(This special issue belongs to the Section Gastroenterology & Hepatopancreatobiliary Medicine)

Integrated Clinical Approaches to Managing Multimorbidity and Multiple Disabilities: Advances in Rehabilitation and Therapeutic Strategies

edited by

Masahiro Kohzuki

submission deadline 30 Nov 2025 | Viewed by 67 | Submission Open

Keywords: heart; lung; kidney; liver; bone; brain

(This special issue belongs to the Section Clinical Rehabilitation)

Novel Insights into the Clinical Management of Retinal Detachment

edited by Francesco Sabatino

submission deadline 30 Nov 2025 | Viewed by 61 | Submission Open

Keywords: retinal detachment; oil toxicity; gas tamponade; pars plana vitrectomy; scleral buckle; pneumatic retinopexy; surgical techniques; retinal imaging; retinal displacement

(This special issue belongs to the Section Ophthalmology)

Multiparametric Ultrasound Techniques for Liver Disease Assessments

edited by Francesco Giangregorio

submission deadline 30 Nov 2025 | Viewed by 60 | Submission Open

Keywords: ultrasound; multiparametric ultrasound; hepatic ultrasound; contrast-enhanced ultrasound; contrast agents; diffuse hepatic diseases; focal liver lesions; hepatic elastography; liver stiffness; hepatic endosonography; hepatic EUS

(This special issue belongs to the Section Nuclear Medicine & Radiology)

Clinical Research and Personalized Medicine in Inflammatory Bowel Disease

edited by Alfredo Papa and Loris Riccardo Lopetuso

submission deadline 30 Nov 2025 | Viewed by 60 | Submission Open

Keywords: inflammatory bowel disease (IBD); personalized medicine; precision medicine; Crohn’ s disease; ulcerative colitis; targeted therapy; artificial intelligence

(This special issue belongs to the Section Gastroenterology & Hepatopancreatobiliary Medicine)

Orthodontics: State of the Art and Prospects

edited by Beatriz Tarazona-Álvarez and

Natalia Zamora-Martínez

submission deadline 30 Nov 2025 | Viewed by 60 | Submission Open

Keywords: digital orthodontics; clear aligners; 3D printing; accelerated orthodontics; digital treatment plan; nanotechnology

(This special issue belongs to the Section Dentistry, Oral Surgery and Oral Medicine)

Orthopedic Surgery: Latest Advances and Perspectives

edited by

Mitchell K. Ng

submission deadline 30 Nov 2025 | Viewed by 59 | Submission Open

Keywords: motion preservation; pain management; robotics/computer navigation; degenerative disc disease; orthobiologics; arthroplasty; trauma

(This special issue belongs to the Section Orthopedics)

New Insights into Acne Vulgaris Treatment and Management Strategies

edited by Jo Linda Maria Sinagra

submission deadline 30 Nov 2025 | Viewed by 58 | Submission Open

Keywords: acne; hormonal treatments; isotretinoin; laser therapy; antibiotic

(This special issue belongs to the Section Dermatology)

Current Advances and Future Perspectives in Interventional Cardiology

edited by

Jacob Zeitani

submission deadline 30 Nov 2025 | Viewed by 55 | Submission Open

Keywords: trans-catheter valve repair and replacement; advanced coronary intervention; AI in decision making for trans-catheter aortic root and arch replacement; LAA occlusion; anti-arrhythmic therapy; right side of the heart

(This special issue belongs to the Section Cardiology)

Novel Aspects of Endocrine Care: From Patient-Centred Management of Endocrine Diseases to Guidelines Standards

edited by

Mara Carsote

and

Claudiu Nistor

submission deadline 30 Nov 2025 | Viewed by 55 | Submission Open

Keywords: endocrine tumour; hormone; biomarker; neuroendocrine tumour; thyroidectomy; parathyroidectomy; bone; ad-renal gland; osteoporosis; pituitary gland; autoimmune; antibody; clinical study; computed tomography

(This special issue belongs to the Section Endocrinology & Metabolism)

Key Quality Indicators in Diagnosis and Treatment of Respiratory Diseases

edited by

Fotios Sampsonas

submission deadline 30 Nov 2025 | Viewed by 55 | Submission Open

Keywords: key quality indicators; respiratory disorders; audit; quality improvement; real-life data

(This special issue belongs to the Section Respiratory Medicine)

Anesthesia and Perioperative Management of Organ Transplants

edited by

Uzung Yoon

and Ji-Hye Kwon

submission deadline 30 Nov 2025 | Viewed by 55 | Submission Open

Keywords: liver transplantation; coagulation; reperfusion syndrome; perioperative evaluation; coronary artery disease; CDC; DBD; living donor liver transplant; pulmonary evaluation; hepatorenal syndrome; portopulmonary hypertension

(This special issue belongs to the Section Anesthesiology)

Percutaneous Coronary Intervention: Latest Advances and Future Prospects

edited by

Alessandro Mandurino-Mirizzi

submission deadline 30 Nov 2025 | Viewed by 54 | Submission Open

Keywords: percutaneous coronary intervention; coronary artery disease; intravascular imaging; intracoronary physiology; high-risk percutaneous coronary intervention; calcified coronary stenosis; chronic total occlusion; bifurcation disease

(This special issue belongs to the Section Cardiology)

Spine Surgery Innovations: Clinically Advanced Treatment and Technologies

edited by Jang W. Yoon

submission deadline 30 Nov 2025 | Viewed by 53 | Submission Open

Keywords: minimally invasive spine surgery; artificial intelligence; wearable biometrics; big data; smartphone accelerometer

(This special issue belongs to the Section Orthopedics)

Novel Developments on Diagnosis and Treatment of Gastrointestinal Cancer

edited by Bhaumik Patel

submission deadline 30 Nov 2025 | Viewed by 51 | Submission Open

Keywords: colorectal cancer; gastric cancer; biomarker; novel therapy; immune microenvironment; gut microbiota; molecular mechanisms

(This special issue belongs to the Section Gastroenterology & Hepatopancreatobiliary Medicine)

Challenges in the Diagnosis and Treatment of Glaucoma

edited by

Abdelaziz Abdelaal

submission deadline 30 Nov 2025 | Viewed by 49 | Submission Open

Keywords: glaucoma diagnosis; glaucoma progression; glaucoma biomarkers; intraocular pressure (IOP) management; corneal hysteresis; machine learning in glaucoma detection; neuroprotection in glaucoma; surgery and laser therapy

(This special issue belongs to the Section Ophthalmology)

Innovations in Microsurgical Reconstruction: Bridging Challenges in Breast and Limb Reconstruction

edited by Gordon K. Lee,

Sik Namgoong

and

Dung Nguyen

submission deadline 30 Nov 2025 | Viewed by 47 | Submission Open

Keywords: microsurgery; breast reconstruction; limb reconstruction; perforator flaps; super microsurgery; surgical innovation; reconstructive surgery; lymphedema; tissue engineering; diabetic foot reconstruction; wound healing; cell therapy

(This special issue belongs to the Section Plastic, Reconstructive and Aesthetic Surgery/Aesthetic Medicine)

Surgical Management of Maxillofacial Fractures and Reconstruction of Facial Deformities

edited by Gian Marco Prucher,

Andrea Cassoni

and Francesco Arcuri

submission deadline 30 Nov 2025 | Viewed by 46 | Submission Open

Keywords: head and neck reconstruction; facial fractures; minimally invasive treatments; facial reconstruction; bioengineering in head and neck disorders; CAD/CAM in maxillo facial trauma and deformities

(This special issue belongs to the Section Plastic, Reconstructive and Aesthetic Surgery/Aesthetic Medicine)

Interventional Cardiology: Clinical Advances and Future Perspectives

edited by Antonio Landi and

Andrea Milzi

submission deadline 30 Nov 2025 | Viewed by 46 | Submission Open

Keywords: percutaneous coronary intervention; myocardial infarction; interventional cardiology; cardiac catheterization; coronary artery disease; antithrombotic therapy; intravascular imaging; acute coronary syndrome; chronic coronary syndrome

(This special issue belongs to the Section Cardiology)

Clinical Advances in Neuroprognostication and Outcome Prediction After Cardiac Arrest

edited by

Erik Roman-Pognuz

submission deadline 30 Nov 2025 | Viewed by 44 | Submission Open

Keywords: neuroprognostication; cardiac arrest; neurological outcome prediction; biomarkers in brain injury; multimodal prog-nostic tools; EEG monitoring; somatosensory evoked potentials (SSEPs); magnetic resonance imaging (MRI) in prognos-tication; post-cardiac arrest care; hypoxic– ischemic brain injury; withdrawal of life-sustaining treatment (WLST); inten-sive care prognostic strategies

(This special issue belongs to the Section Cardiovascular Medicine)

Assisted Reproductive Technology and Infertility Treatment: Current Updates and Perspectives—2nd Edition

edited by Nikos Nikolettos and

Angeliki Tiptiri-Kourpeti

submission deadline 30 Nov 2025 | Viewed by 42 | Submission Open

Keywords: assisted reproduction technology (ART); infertility; treatment; reproduction; IVF

(This special issue belongs to the Section Reproductive Medicine & Andrology)

Minimally Invasive Gastrointestinal Surgery: Clinical Advances and Prospects

edited by Jun Suh Lee

submission deadline 30 Nov 2025 | Viewed by 41 | Submission Open

Keywords: minimally invasive surgery; gastrointestinal surgery; laparoscopic surgery; robotic surgery; surgical innovation

(This special issue belongs to the Section Gastroenterology & Hepatopancreatobiliary Medicine)

Thrombotic Risk and Its Management Across Diverse Clinical Settings

edited by Samuel Bogdan Todor and Ana Maria Vlǎdǎreanu

submission deadline 30 Nov 2025 | Viewed by 38 | Submission Open

Keywords: thrombosis; thrombotic risk; hematologic disorders; thrombophilia; myeloproliferative neoplasms; antithrombotic therapy; cardiovascular diseases; biomarkers

(This special issue belongs to the Section Hematology)

Kidney Transplantation: Recent Advances and Challenges

edited by Jose Torrealba

submission deadline 30 Nov 2025 | Viewed by 37 | Submission Open

Keywords: kidney allograft; pathology; HLA and antibodies; management

(This special issue belongs to the Section Nephrology & Urology)

Thoracic Surgery Between Tradition and Innovations

edited by Jacopo Vannucci

submission deadline 30 Nov 2025 | Viewed by 36 | Submission Open

Keywords: thoracic surgery; lung cancer; pulmonary resections; pleural disease; perioperative medicine; mesothelioma; lung transplantation; chest wall resection and reconstruction; esophageal cancer; thoracic trauma; emergency; pulmonary metastasectomy

(This special issue belongs to the Section General Surgery)

Clinical Research in Vascular Access Devices

edited by

Antonio Gidaro

submission deadline 30 Nov 2025 | Viewed by 36 | Submission Open

Keywords: short peripheral catheters; long peripheral catheters; midline; peripherally inserted central catheters (PICCs); femoral-inserted central catheters (FICCs); centrally inserted central catheters (CICCs); totally implantable venous access devices (TIVAD); catheter-related bloodstream infection (CRBSI); catheter-associated bloodstream infection (CABSI); central line-associated bloodstream infection (CLABSI); catheter-related thrombosis (CRT); fibroblastic sleeve; infiltration; extravasation

(This special issue belongs to the Section Vascular Medicine)

Transcatheter Aortic Valve Implantation- Clinical Management and Future Challenges

edited by Mohamed Farag

submission deadline 30 Nov 2025 | Viewed by 22 | Submission Open

Keywords: transcatheter aortic valve implantation; TAVI; bicuspid aortic valve; small annulus; prosthesis– patient mismatch; coronary reaccess; valve-in-valve TAVI; leaflet modification

(This special issue belongs to the Section Cardiovascular Medicine)

AI in Maternal Fetal Medicine and Perinatal Management

edited by Ariel Many

submission deadline 5 Dec 2025 | Viewed by 58 | Submission Open

Keywords: maternal fetal medicine; high-risk pregnancy; perinatal management; artificial intelligence (AI) in obstetrics; fetal growth abnormalities; preterm labor prediction

(This special issue belongs to the Section Obstetrics & Gynecology)

State of the Art: Updates in Preterm Labor and Preterm Birth

edited by

Eran Bornstein

and Moti Gulersen

submission deadline 10 Dec 2025 | 3 articles | Viewed by 2692 | Submission Open

Keywords: prenatal diagnosis; preterm birth; antenatal corticosteroids; cerclage; multiple gestations

(This special issue belongs to the Section Obstetrics & Gynecology)

Cardiac Arrhythmias: Current Status and Future Directions

edited by

Jackson J. Liang

submission deadline 10 Dec 2025 | 1 articles | Viewed by 1447 | Submission Open

Keywords: ventricular tachycardia; atrial fibrillation; catheter ablation; novel therapies; complex arrhythmias

(This special issue belongs to the Section Cardiology)

Clinical Advances in Arthroscopic Shoulder Surgery

edited by Anup Ajit Shah, Michael J. O’Brien and Asheesh Bedi

submission deadline 10 Dec 2025 | Viewed by 297 | Submission Open

Keywords: rotator cuff; biologic tuberoplasty; lower trapezius tendon transfer; arthroscopic Latarjet; arthroscopic bone block; augmentation of the cuff

(This special issue belongs to the Section Orthopedics)

Latest Research on Male Infertility

edited by

Manesh Kumar Panner Selvam

submission deadline 10 Dec 2025 | Viewed by 278 | Submission Open

Keywords: testis; sperm; seminal plasma; spermatogenesis; fertilization; omics; proteomics; oxidative stress; sperm DNA fragmentation; varicocele; male infertility; testicular cancer; infertility management; ART

(This special issue belongs to the Section Reproductive Medicine & Andrology)

Innovative Endodontics

edited by

Federico Foschi

submission deadline 10 Dec 2025 | Submission Open

Keywords: regenerative endodontics; bioceramics; guided endodontics; AI in endodontics; pericervical dentine; reduced taper; irrigation adjuvant; pulp regeneration

(This special issue belongs to the Section Dentistry, Oral Surgery and Oral Medicine)

Clinical Updates on Geriatric Oncology

edited by Cherif N. Boutros

submission deadline 12 Dec 2025 | Viewed by 29 | Submission Open

Keywords: geriatric oncology; cancer in elderly; geriatric cancer care; frailty; access to cancer care

(This special issue belongs to the Section Geriatric Medicine)

Cataract and Refractive Surgery and Intraocular Lens Implantation: Clinical Advances and Perspectives

edited by Janusz Skrzypecki

submission deadline 15 Dec 2025 | Viewed by 432 | Submission Open

Keywords: cataract surgery; intraocular lens power calculation; intraocular lenses; EDoF IOL; multifocal IOL; monofocal IOL; laser refractive surgery

(This special issue belongs to the Section Ophthalmology)

Cancers of the Pelvic Organs: Contemporary Management and Actions for Improving Patients’ Quality of Life: 2nd Edition

edited by

Agnieszka Mazur-Bialy

and

Marcin Opławski

submission deadline 15 Dec 2025 | Viewed by 256 | Submission Open

Keywords: gynecological cancers; e.g.; endometrial; cervical; ovarian; and vulvar cancer; urogenital tract cancers in men; e.g.; bladder; prostate; penis; and testicular cancer; gastrointestinal cancers; complications of oncological treatment; e.g.; pelvic floor disfunction: incontinence and POP; patients’ quality of life and possibilities of its improvement; oncofertility; physiotherapy; oncology treatment (modern surgical approach; including robotics; chemotherapy; radiotherapy; immunotherapy; targeted therapy); biological basis of pathogenesis and cancer progression; biological markers; anticancer agents; cancer prophylaxis and prevention— current trends and opportunities

(This special issue belongs to the Section Oncology)

Advances in the Diagnosis and Treatment of Glaucoma

edited by

Alessio Martucci

submission deadline 15 Dec 2025 | Viewed by 93 | Submission Open

Keywords: OCT; glaucoma; MIGS; neuroprotection; drug delivery systems; artificial intelligence; pharmacologic agents; per-sonalized medicine

(This special issue belongs to the Section Ophthalmology)

Clinical Prediction, Diagnosis, and Treatment of Ovarian Cancer and Other Gynecologic Tumors

edited by Eleni T. Timotheadou and Emmanouil Saloustros

submission deadline 15 Dec 2025 | Viewed by 75 | Submission Open

Keywords: ovarian; endometrial; cervical; chemotherapy; immunotherapy; primary debulking surgery; interval debulking; fertility-sparing surgery; PARP inhibitors; radiotherapy; HIPEC; sex cord tumors; dysgerminoma; leiomyosarcoma; liquid biopsies; circulating tumor cells; ctDNA

(This special issue belongs to the Section Obstetrics & Gynecology)

Male Sexual and Reproductive Health: Clinical Aspects, Metabolic Profile, Environmental Factors and Lifestyle: 2nd Edition

edited by

Fernando Mazzilli

submission deadline 15 Dec 2025 | Viewed by 47 | Submission Open

Keywords: male sexual dysfunction; reproductive health; erectile dysfunction; premature ejaculation; infertility; epidemiology; causes; diagnosis; treatments; environmental factors; lifestyle

(This special issue belongs to the Section Reproductive Medicine & Andrology)

Latest Advances in Pediatric Surgery

edited by Francesco Macchini and Andrea Zanini

submission deadline 15 Dec 2025 | Viewed by 45 | Submission Open

Keywords: pediatric surgery; innovations; fluorescence-guided surgery; pediatric robotic surgery; minimally invasive surgery

(This special issue belongs to the Section General Surgery)

Arthroplasty: Advances in Surgical Techniques and Patient Outcomes—2nd Edition

edited by Senthil Sambandam

submission deadline 15 Dec 2025 | Viewed by 44 | Submission Open

Keywords: hip arthroplasty; knee arthroplasty; hip fractures; arthroplasty; osteoarthritis; knee arthroscopy; joint replacement

(This special issue belongs to the Section Orthopedics)

Displaying special issue 1151-1200 on page 24 of 27.

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