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Journal of Clinical Medicine publishes Special Issues to create collections of papers on specific topics, with the aim of building a community of authors and readers to discuss the latest research and develop new ideas and research directions. Special Issues are led by Guest Editors, who are experts on the topic and all Special Issue submissions follow MDPI's standard editorial process. The journal’s Editor-in-Chief and/or designated Editorial Board Member will oversee Guest Editor appointments and Special Issue proposals, checking their content for relevance and ensuring the suitability of the material for the journal. The papers published in a Special Issue will be collected and displayed on a dedicated page of the journal’s website. Further information on MDPI's Special Issue policies and Guest Editor responsibilities can be found here. For any inquiries related to a Special Issue, please contact the Editorial Office.

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Carotid Artery Disease (CAD) and Its Complications: A Comprehensive Update

edited by Yacob G. Tedla

submission deadline 20 Apr 2026 | 1 articles | Viewed by 654 | Submission Open

Keywords: carotid artery disease; ischemic stroke; vascular dementia; transient ischemic attack; vascular imaging; carotid endarterectomy; carotid stent placement; risk stratification

(This special issue belongs to the Section Vascular Medicine)

Acute Myeloid Leukemia: Latest Advances in Diagnostics, Therapeutic Strategies and Clinical Management: 2nd Edition

edited by Michael D. Diamantidis

submission deadline 20 Apr 2026 | 1 articles | Viewed by 646 | Submission Open

Keywords: ELN; ICC and WHO 2022 AML classifications; molecular AML diagnostics; AML biology; measurable residual disease (MRD); novel targeted AML therapies; AML immunotherapies; hematopoietic stem cell transplantation (HSCT)

(This special issue belongs to the Section Hematology)

Clinical Updates in Pediatric Radiology

edited by

Meriam Koob

and

Farnaz Delavari

submission deadline 20 Apr 2026 | Viewed by 640 | Submission Open

Keywords: pediatric radiology; advances in pediatric imaging; pediatric neuroimaging; artificial in-telligence in pediatric imaging; radiomics and machine learning; low-field MRI techniques; magnetic resonance imaging in pediatrics; computed tomography in pediatrics; radiation dose optimization; patient-centred imaging protocols

(This special issue belongs to the Section Clinical Pediatrics)

Pediatric Dentistry: Real-World Clinical Insights

edited by

Ruth M. Santamaría

submission deadline 20 Apr 2026 | 1 articles | Viewed by 556 | Submission Open

Keywords: pediatric dentistry; minimally invasive dentistry; new technologies; biomaterials; innovative management approaches; caries management; pulp management; dental trauma; molar incisor hypomineralization; public health services research; epidemiological research; translational research

(This special issue belongs to the Section Dentistry, Oral Surgery and Oral Medicine)

Orofacial Pain: Innovations in Treatment Modalities and Patient Care

edited by Takahiko Nagamine

submission deadline 20 Apr 2026 | 1 articles | Viewed by 542 | Submission Open

Keywords: orofacial pain; treatment; patient care; oral dysfunction; chronic pain; burning mouth syndrome; temporomandibular joint pain: oral cenesthopathy; atypical odontalgia; phantom bite syndrome

(This special issue belongs to the Section Dentistry, Oral Surgery and Oral Medicine)

Advances in Maternal Fetal Medicine

edited by

Georgios Eleftheriou

and Anna Franca Cavaliere

submission deadline 20 Apr 2026 | 1 articles | Viewed by 474 | Submission Open

Keywords: drugs use during pregnancy; fetal treatment; pregnancy complications; infectious diseases; neonatal poor adaptation syndrome

(This special issue belongs to the Section Obstetrics & Gynecology)

Intrarenal Surgery for Kidney Stones and Other Kidney Diseases

edited by Razvan Multescu

submission deadline 20 Apr 2026 | 1 articles | Viewed by 467 | Submission Open

Keywords: intrarenal surgery; flexible ureteroscopy; percutaneous nephrolithotomy (PCNL); Mini-PCNL; thulium laser; ureteral access sheaths; flexible and navigable suction (FANS); upper urinary tract urothelial tumors

(This special issue belongs to the Section Nephrology & Urology)

Optimizing Outcomes in Emergency Medicine and Cardiopulmonary Resuscitation

edited by

Andreas S. Papazoglou

and

Dimitrios V. Moysidis

submission deadline 20 Apr 2026 | 1 articles | Viewed by 273 | Submission Open

Keywords: emergency medicine; cardiopulmonary resuscitation; prehospital care; outcome prediction; post-pesuscitation care; advanced life support; emergency response systems; medical ethics; simulation in medicine

(This special issue belongs to the Section Emergency Medicine)

Clinical Update on Thoracic Trauma

edited by

Duilio Divisi

submission deadline 20 Apr 2026 | Viewed by 266 | Submission Open

Keywords: flail chest; isolated sternal fractures; manubrio-sternal dislocation; pneumothorax; hemothorax; thoracic aortic injury; heart and pulmonary vessels lesion; intercostal artery injury; diaphragm rupture; thoracoabdominal hernia; chylothorax; esophageal perforation

(This special issue belongs to the Section Respiratory Medicine)

Recent Advances in Endocrine Surgery—2nd Edition

edited by

Gregorio Scerrino

submission deadline 20 Apr 2026 | 1 articles | Viewed by 249 | Submission Open

Keywords: endocrine surgery; thyroid; thyroid cancer; parathyroid; parathyroidectomy; adrenal glands; disorders of hepatobiliary and gastrointestinal tract

(This special issue belongs to the Section General Surgery)

New Advances and Clinical Outcomes of Endocrinology

edited by Stefana Catalina Bilha and

Cristina Preda

submission deadline 20 Apr 2026 | Viewed by 245 | Submission Open

Keywords: endocrinology; obesity; metabolic and bone disease; chronic conditions

(This special issue belongs to the Section Endocrinology & Metabolism)

Prostate Surgery: The Latest Advances and Future Trends

edited by Akhil K. Das and

Bruce Gao

submission deadline 20 Apr 2026 | Viewed by 240 | Submission Open

Keywords: benign prostatic hyperplasia (BPH); minimally invasive surgical therapies (MIST); laser enucleation (HoLEP; ThuLEP); Aquablation; Rezum; robotic prostatectomy; anatomic enucleation

(This special issue belongs to the Section Nephrology & Urology)

Ischemic and Hemorrhagic Complications of Uncommon Cerebrovascular Diseases: Cutting-Edge Clinical Research, Reviews, and Expert Opinions

edited by Mariel G. Kozberg and Alexis T. Roy

submission deadline 20 Apr 2026 | Viewed by 239 | Submission Open

Keywords: cerebrovascular disease; ischemic stroke; hemorrhagic stroke; genetics; vasculopathy; headache; superficial siderosis; vascular malformations

(This special issue belongs to the Section Clinical Neurology)

Clinical Updates in Imaging of Musculoskeletal Diseases

edited by

Federico Zaottini

and

Riccardo Picasso

submission deadline 20 Apr 2026 | 1 articles | Viewed by 235 | Submission Open

Keywords: musculoskeletal imaging; ultrasound; magnetic resonance; sport imaging; rheumatology; nerve imaging

(This special issue belongs to the Section Nuclear Medicine & Radiology)

Clinical Updates and Perspectives on Transcranial Magnetic Stimulation (TMS)—2nd Edition

edited by

Mariagiovanna Cantone

submission deadline 20 Apr 2026 | Viewed by 211 | Submission Open

Keywords: non-invasive brain stimulation; transcranial magnetic stimulation; motor cortex; neuroplasticity; motor learning; dementia; stroke; movement disorders; depression; spinal cord; neuropsychiatric disorders

(This special issue belongs to the Section Clinical Neurology)

Interventional Ultrasound Associated with Rehabilitation in the Treatment of Muscolo-Skeletal Disease

edited by Stefano Galletti and

Danilo Donati

submission deadline 20 Apr 2026 | Viewed by 191 | Submission Open

Keywords: ultrasound; infiltrative treatment; musculoskeletal imaging; rehabilitation; orthopedic; rheumatology; interventional ultrasound

(This special issue belongs to the Section Nuclear Medicine & Radiology)

Global Expert Views on Aortic Valve Repair and Replacement: 2nd Edition

edited by

Jose Alberto De Agustín

submission deadline 20 Apr 2026 | Viewed by 168 | Submission Open

Keywords: aortic valve pathologies; minimally invasive approach; aortic valve repair; aortic valve replacement; imaging techniques

(This special issue belongs to the Section Cardiovascular Medicine)

Advances in Oculoplastic Surgery: From Eyelid Reconstruction to Innovative Techniques

edited by Argyrios Tzamalis

submission deadline 20 Apr 2026 | Viewed by 150 | Submission Open

Keywords: oculoplastic surgery; eyelid reconstruction; orbital surgery; novel minimally invasive; image guided

Clinical Advances in Musculoskeletal Pain

edited by

Dariusz Kosson

Barbara Lisowska

and

Paweł Łęgosz

submission deadline 20 Apr 2026 | Viewed by 117 | Submission Open

Keywords: musculoskeletal pain; chronic pain; primary musculoskeletal pain; secondary chronic musculoskeletal pain; multi-disciplinary pain treatment; imaging in interventional pain management

(This special issue belongs to the Section Orthopedics)

Skin Cancer: Prevention, Diagnosis, Quality of Life and Treatment Outcomes

edited by Athanassios A. Kyrgidis and

Aimilios Lallas

submission deadline 20 Apr 2026 | Viewed by 112 | Submission Open

Keywords: skin cancer; melanoma; squamous cell carcinoma; basal cell carcinoma; clinical biomarkers; dermoscopy; quality of life

(This special issue belongs to the Section Dermatology)

Clinical Management for Anesthesia Critical Care

edited by Gianluca Zani

submission deadline 20 Apr 2026 | Viewed by 111 | Submission Open

Keywords: anesthesia; critical care medicine; clinical management; critically ill patients; organ failure; organ dysfunction; per-sonalized therapy; outcome; technical skills; non-technical skills

(This special issue belongs to the Section Anesthesiology)

The Latest Research on Male Infertility

edited by Gianmaria Salvio and Nicola delli Muti

submission deadline 20 Apr 2026 | Viewed by 106 | Submission Open

Keywords: idiopathic male infertility; unexplained male infertility; semen quality; testicular dysfunction; male hypogonadism; gonadal failure

(This special issue belongs to the Section Reproductive Medicine & Andrology)

Innate Immunity in Overdrive: Novel Insights into Autoinflammatory Syndromes

edited by Alessandro Conforti

submission deadline 20 Apr 2026 | Viewed by 94 | Submission Open

Keywords: autoinflammatory diseases; innate immunity; inflammasome; cytokines; Interleukin-1; monogenic syndromes; polygenic autoinflammatory disorders; adult-onset Still’ s disease; Behç et’ s disease; targeted therapy; disease registries; real-world evidence; VEXAS syndrome; UBA1 mutations; precision medicine; biomarkers; outcome assessment

(This special issue belongs to the Section Immunology & Rheumatology)

Heart Failure: Treatment and Clinical Perspectives

edited by Geza Halasz, Domenico Gabrielli and Francesco Grigioni

submission deadline 20 Apr 2026 | Viewed by 94 | Submission Open

Keywords: heart failure; chronic heart failure; acute heart failure; treatment; cardiac imaging; diagnostics; patient outcomes; prognosis

(This special issue belongs to the Section Cardiology)

Myocardial Infarction: The Latest Advances and Prospects

edited by

Stylianos Daios

and Antonios Ziakas

submission deadline 20 Apr 2026 | Viewed by 93 | Submission Open

Keywords: coronary artery disease; myocardial infarction; PPCI; echocardiography; antiplatelet agents; radial access; global longitudinal strain

(This special issue belongs to the Section Cardiology)

Clinical Advances in Minimally Invasive Spinal Treatment: 2nd Edition

edited by

Akihiko Hiyama

Haruki Funao

and

Masayuki Ishihara

submission deadline 20 Apr 2026 | Viewed by 91 | Submission Open

Keywords: robotic-assisted spine surgery; artificial intelligence (AI); machine learning (ML); cement-augmented pedicle screws; cement leakage risk stratification; osteoporosis pharmacotherapy; surgical navigation systems; image-guided spine surgery; predictive analytics in spine care; spine technology innovation

(This special issue belongs to the Section Orthopedics)

Hip and Knee Arthroplasty: Update on Clinical Management

edited by Maximilian F. Kasparek

submission deadline 20 Apr 2026 | Viewed by 91 | Submission Open

Keywords: total hip arthroplasty (THA); total knee arthroplasty (TKA); revision arthroplasty; implant fixation; cemented; cementless; hybrid; alignment in TKA; mechanical alignment; kinematic alignment; restricted kinematic alignment; functional alignment; navigation; robotic-assisted surgery; patient-specific instrumentation; additive manufacturing; 3D printing; personalized implant

(This special issue belongs to the Section Orthopedics)

Advances and Challenges in Head and Neck Reconstructive Surgery

edited by

Valeria Navach

Olindo Massarelli

and Luca Calabrese

submission deadline 20 Apr 2026 | Viewed by 90 | Submission Open

Keywords: reconstructive surgery; head and neck; innovation; microsurgery; virtual surgical planning; 3D-printed implants; tissue engineering

(This special issue belongs to the Section Plastic, Reconstructive and Aesthetic Surgery/Aesthetic Medicine)

Pharmacotherapy of Mental Diseases: Latest Developments

edited by

Lavinia Maria Hogea

and

Laura Alexandra Nussbaum

submission deadline 20 Apr 2026 | Viewed by 86 | Submission Open

Keywords: brain stimulation; mental health; novel intervention; pharmacotherapy; psychotherapy; quality of life; psychologi-cal well-being; treatment personalization in mental diseases

(This special issue belongs to the Section Mental Health)

Vertebral Fractures and Spinal Cord Injury: Advances in Management

edited by

Marc Dreimann

and Martin Stangenberg

submission deadline 20 Apr 2026 | Viewed by 86 | Submission Open

Keywords: fracture management; spinal cord injuries; artificial intelligence; machine learning; spinal trauma

(This special issue belongs to the Section Orthopedics)

Recent Management and Future Perspectives on Knee Arthroplasty

edited by

Georgios Komnos

submission deadline 20 Apr 2026 | Viewed by 86 | Submission Open

Keywords: knee arthroplasty; individualized approach; implant designs; robotic-assisted; knee alignment

(This special issue belongs to the Section Orthopedics)

Advances in the Management of Pediatric Neuromuscular Diseases

edited by Nicolas Deconinck

submission deadline 20 Apr 2026 | Viewed by 84 | Submission Open

Keywords: pediatric neuromuscular diseases; neuromuscular disorders (NMD); pediatric; genetic NMD; juvenile myasthenia gravis; chronic demyelinating polyneuropathy; next generation sequencing (NGS); spinal muscular atrophy; Duchenne muscular dystrophy; clinical guidelines

(This special issue belongs to the Section Clinical Neurology)

New Insights in Joint Arthroplasty—2nd Edition

edited by

Richard Lass

submission deadline 20 Apr 2026 | Viewed by 82 | Submission Open

Keywords: total hip arthroplasty; total knee arthroplasty; robotic-assisted technology and navigation; modern implant materials; modern implant fixation techniques; alignment in TKA; spinopelvic alignment in THA

(This special issue belongs to the Section Orthopedics)

New Insights into Retinal Diseases

edited by Fabio Scarinci and Giulio Pocobelli

submission deadline 20 Apr 2026 | Viewed by 82 | Submission Open

Keywords: optical coherence tomography; optical coherence tomography angiography; vitreoretinal diseases; retinal imaging analysis; biomarkers; segmentation; retinal ischemia; retinal blood flow; choroidal blood flow

(This special issue belongs to the Section Ophthalmology)

Advanced Applications of Magnetic Resonance Imaging (MRI) in Clinical Diagnosis

edited by Francescamaria Donati

submission deadline 20 Apr 2026 | Viewed by 80 | Submission Open

Keywords: magnetic resonance imaging (MRI); clinical diagnosis; high-field MRI; diffusion-weighted imaging (DWI); perfusion MRI (pMRI); artificial intelligence in imaging; diagnostic imaging; early disease detection; disease monitoring; treatment planning

(This special issue belongs to the Section Nuclear Medicine & Radiology)

Schizophrenia and Psychotic Disorders: Clinical Updates

edited by Octavian Vasiliu and

Adela Magdalena Ciobanu

submission deadline 20 Apr 2026 | Viewed by 80 | Submission Open

Keywords: schizophrenia spectrum disorder; mobile health apps; antipsychotics; repetitive transcranial magnetic stimulation; artificial intelligence; machine learning; augmented reality; neuroimaging; treatment resistance; quality of life; comorbidities

(This special issue belongs to the Section Mental Health)

Coronary Artery Disease: Recent Developments and Emerging Trends

edited by

Attila Kardos

and Tarun Mittal

submission deadline 20 Apr 2026 | Viewed by 77 | Submission Open

Keywords: coronary atherosclerosis; diagnostic strategies; therapeutic options; timing of intervention; artificial intelligence; novel therapeutic pathways

(This special issue belongs to the Section Cardiology)

Peritoneal Dialysis and Hemodialysis: Early and Late Outcomes

edited by Keren Cohen-Hagai and

David Pereg

submission deadline 20 Apr 2026 | Viewed by 75 | Submission Open

Keywords: peritoneal dialysis; dialysis; hemodialysis; chronic kidney disease; end-stage renal disease

(This special issue belongs to the Section Nephrology & Urology)

Geriatric Fracture Care: Bridging Orthopedics and Gerontology

edited by Tom Knauf and Daphne Asimenia Eschbach

submission deadline 20 Apr 2026 | Viewed by 74 | Submission Open

Keywords: geriatric fracture; proximal femur fractures; hip fracture; geriatric trauma patient; ortho-geriatric treatment; periprosthetic fracture; end of life decision; orthopedic surgery in the elderly

(This special issue belongs to the Section Geriatric Medicine)

Advancements in Minimally Invasive Neurosurgery

edited by Sanjeeva Jeyaretna and Kumar Abhinav

submission deadline 20 Apr 2026 | Viewed by 74 | Submission Open

Keywords: minimally invasive surgery; skull base surgery; neurosurgery; transorbital; endoscopic transnasal

(This special issue belongs to the Section Clinical Neurology)

Up-to-Date Orthopedic Treatment and Care for Osteoporotic Fracture of the Elderly

edited by

Oded Hershkovich

and

Raphael Lotan

submission deadline 20 Apr 2026 | Viewed by 73 | Submission Open

Keywords: osteoporotic fractures; elderly patients; orthopedic surgery; minimally invasive techniques; fracture rehabilitation; kyphoplasty

(This special issue belongs to the Section Orthopedics)

Female Infertility: Clinical Diagnosis and Treatment—Second Edition

edited by

Laurie Henry

submission deadline 20 Apr 2026 | Viewed by 68 | Submission Open

Keywords: infertility; assisted reproductive techniques; diagnosis; implantation; gametes

(This special issue belongs to the Section Obstetrics & Gynecology)

Clinical Advances in Risk Minimization Through Robot-Assisted Surgery

edited by Radko Komadina

submission deadline 20 Apr 2026 | Viewed by 67 | Submission Open

Keywords: robot-assisted technology; robotic surgery; laparoscopic surgery; spinal surgery; robot-assisted gynecological operations; robot-assisted operations in urology; robot-assisted prostatectomy

(This special issue belongs to the Section General Surgery)

Clinical Advances in Endodontic Dentistry

edited by

Luciano Giardino

and

Luigi Generali

submission deadline 20 Apr 2026 | Viewed by 64 | Submission Open

Keywords: antimicrobial agents; biofilm; confocal laser scanning microscopy; endodontic materials; irrigants; microbiome; micro-CT; regenerative endodontics

(This special issue belongs to the Section Dentistry, Oral Surgery and Oral Medicine)

New Advances in Orthopedic Knee Joint Preserving and Reconstructive Surgery

edited by

Dong Jin Ryu

and

Sung-Sahn Lee

submission deadline 20 Apr 2026 | Viewed by 64 | Submission Open

Keywords: cartilage regeneration; patient-specific instrumentation; knee robotic surgery; patient-specific surgical device; future orthopedics

(This special issue belongs to the Section Orthopedics)

New Sights in Retinal Diseases Therapeutics: Innovation and Clinical Practice

edited by

Giacomo Boscia

Pasquale Viggiano

, Stefano Dore and Alfonso Savastano

submission deadline 20 Apr 2026 | Viewed by 62 | Submission Open

Keywords: retinal diseases; central serous chorioretinopathy; age-related macular degeneration; eye diseases; diabetic retinopathy

(This special issue belongs to the Section Ophthalmology)

New Insights into Breast Neoplasms: Prevention, Multidisciplinary Management and Beyond the Core Team

edited by

Marco Materazzo

and

Antonia Girardi

submission deadline 20 Apr 2026 | Viewed by 61 | Submission Open

Keywords: breast cancer; tumor heterogeneity; estrogen receptor; progesterone receptor; triple-negative breast cancer; metastasis; immunotherapy; targeted therapy; early detection; prognosis; adjuvant treatment

(This special issue belongs to the Section Oncology)

Insights from Cardiopulmonary Exercise Testing to Cardiac Rehabilitation

edited by

Gaia Cattadori

submission deadline 20 Apr 2026 | Viewed by 58 | Submission Open

Keywords: cardiac rehabilitation; exercise physiology; exercise performance; exercise testing; physical activity assessment; exercise; physical activity; oxygen consumption; cardiopulmonary exercise testing

(This special issue belongs to the Section Cardiology)

Recent Advancements in Nuclear Medicine and Radiology: 2nd Edition

edited by Adriaan A. Lammertsma

submission deadline 20 Apr 2026 | Viewed by 58 | Submission Open

Keywords: PET; SPECT; CT; MRI; AI; image analysis; kinetic analysis

(This special issue belongs to the Section Nuclear Medicine & Radiology)

Novel Advances in Lower Limb Trauma and Orthopaedic Surgery

edited by Konstantinos Tsikopoulos and

Panagiotis Givissis

submission deadline 20 Apr 2026 | Viewed by 58 | Submission Open

Keywords: lower limb orthopedic surgery; trauma; infection; research

(This special issue belongs to the Section Orthopedics)

Displaying special issue 1151-1200 on page 24 of 31.

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