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Focus on Multiple Myeloma: Diagnosis, Therapy and Clinical Outcome
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Focus on Multiple Myeloma: Diagnosis, Therapy and Clinical Outcome

A special issue of Journal of Clinical Medicine (ISSN 2077-0383). This special issue belongs to the section "Hematology".

Deadline for manuscript submissions: 20 February 2027 | Viewed by 731

Editor

Dr. Martina Kleber

E-Mail Website
Guest Editor
1. Department of Internal Medicine, Clinic Hirslanden Zurich, 8032 Zurich, Switzerland
2. Faculty of Medicine, University of Basel, Klingelbergstrasse 61, 4056 Basel, Switzerland
Interests: multiple myeloma; bood and marrow transplantation; hematology; hematopoietic cell transplantation; Waldenström’s macroglobulinemia; AL amyloidosis; liver cancer; meta-analysis; immunotherapy
Special Issues, Collections and Topics in MDPI journals

Special Issue Information

Dear Colleagues,

Multiple myeloma (MM) is a complex hematological malignancy defined by abnormal plasma cell proliferation. Over the past decade, significant advances have been made in its diagnosis, diagnostic innovations, and treatment.

Prognosis and clinical outcome have improved substantially over the past two decades. Cytogenetic risk factors, depth of response, and minimal residual disease (MRD) status remain critical prognostic indicators.

While these advances have improved patient outcomes, ongoing research focuses on relapsed/refractory MM (RRMM): exploring novel therapies (CAR T-cell, BiTE), deciphering resistance mechanisms, testing non-immune options, and optimizing combination therapies to balance efficacy and safety. Moreover, ongoing research focuses on early detection, individualized therapy, and innovative therapeutic options towards a functional cure.

This Special Issue compiles cutting-edge research on MM progress, challenges, and future directions, welcoming submissions on advances in diagnosis, therapy, and its transition towards an improved clinical outcome and prognosis.

We are looking forward to your submissions.

Dr. Martina Kleber
Guest Editor

Manuscript Submission Information

Manuscripts should be submitted online at www.mdpi.com by registering and logging in to this website. Once you are registered, click here to go to the submission form. Manuscripts can be submitted until the deadline. All submissions that pass pre-check are peer-reviewed. Accepted papers will be published continuously in the journal (as soon as accepted) and will be listed together on the special issue website. Research articles, review articles as well as short communications are invited. For planned papers, a title and short abstract (about 250 words) can be sent to the Editorial Office for assessment.

Submitted manuscripts should not have been published previously, nor be under consideration for publication elsewhere (except conference proceedings papers). All manuscripts are thoroughly refereed through a single-anonymized peer-review process. A guide for authors and other relevant information for submission of manuscripts is available on the Instructions for Authors page. Journal of Clinical Medicine is an international peer-reviewed open access semimonthly journal published by MDPI.

Please visit the Instructions for Authors page before submitting a manuscript. The Article Processing Charge (APC) for publication in this open access journal is 2600 CHF (Swiss Francs). Submitted papers should be well formatted and use good English. Authors may use MDPI's English editing service prior to publication or during author revisions.

Keywords

  • multiple myeloma
  • novel therapies
  • treatment approach
  • prognosis
  • clinical outcome

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Published Papers (1 paper)

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Research

14 pages, 1565 KB  
Article
CNS Involvement of Multiple Myeloma—A Case Series and Narrative Literature Review
by Andreea Andrunache, Mihai Emanuel Himcinschi, Sinziana Barbu, Larisa Emilia Zidaru, Didona Alexa, Monica Popescu, Sara Mihaela Apuscaroaie, Delia Codruta Popa, Iulia Ursuleac, Daniel Coriu and Sorina-Nicoleta Badelita
J. Clin. Med. 2026, 15(10), 3927; https://doi.org/10.3390/jcm15103927 - 20 May 2026
Viewed by 492
Abstract
Background: Central nervous system (CNS) involvement in multiple myeloma (MM) represents an extramedullary manifestation of the disease, which is often really challenging for clinicians, as the neurological symptoms could easily overlap with those related to hypercalcemia, uremia, high viscosity of the blood, [...] Read more.
Background: Central nervous system (CNS) involvement in multiple myeloma (MM) represents an extramedullary manifestation of the disease, which is often really challenging for clinicians, as the neurological symptoms could easily overlap with those related to hypercalcemia, uremia, high viscosity of the blood, or treatment-related neuropathy. Objectives: this retrospective study was conducted at Fundeni Clinical Institute in Bucharest, aiming to identify and systematically analyze a series of clinical cases diagnosed with extramedullary disease. Methods: We have identified 6 out of 583 patients with CNS involvement in our centre between 2019 and 2025. The diagnosis of meningeal myelomatosis was established through cerebrospinal fluid analysis, whereas CNS plasmacytomas were confirmed by CT-guided biopsy followed by immunohistochemistry evaluation. Results: All cases of CNS involvement occurred at relapse, with intervals from initial MM diagnosis to CNS involvement ranging from 9 months to 10 years. CNS-MM was linked to particular features, such as high-risk cytogenetics (four out of six patients), elevated lactate dehydrogenase, and the presence of extramedullary disease, highlighting its association with aggressive disease behaviour. Discussions: Although CNS-MM is correlated with poor prognosis, prolonged survival in one of our patients resulted from multimodal treatment, which included craniospinal radiotherapy, DPd systemic treatment, and intrathecal therapy (over 39 months). This aggressive approach effectively controlled both systemic disease and high-risk CNS involvement. Immunoglobulin isotype switching is a rare form of clonal evolution in MM, illustrated by the same patient whose disease evolved from IgA kappa at diagnosis to IgA lambda at CNS relapse, showing clonal heterogeneity and providing clinical evidence of clonal evolution. Conclusions: CNS involvement in MM usually occurs in a relapsed/refractory setting in patients with advanced, high-risk disease, and it is usually associated with extramedullary disease. Despite using multimodal therapies, outcomes remain poor, highlighting the need for novel and tailored agents. Full article
(This article belongs to the Special Issue Focus on Multiple Myeloma: Diagnosis, Therapy and Clinical Outcome)
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