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Journal of Clinical Medicine publishes Special Issues to create collections of papers on specific topics, with the aim of building a community of authors and readers to discuss the latest research and develop new ideas and research directions. Special Issues are led by Guest Editors, who are experts on the topic and all Special Issue submissions follow MDPI's standard editorial process. The journal’s Editor-in-Chief and/or designated Editorial Board Member will oversee Guest Editor appointments and Special Issue proposals, checking their content for relevance and ensuring the suitability of the material for the journal. The papers published in a Special Issue will be collected and displayed on a dedicated page of the journal’s website. Further information on MDPI's Special Issue policies and Guest Editor responsibilities can be found here. For any inquiries related to a Special Issue, please contact the Editorial Office.

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Latest Advances in Assisted Reproductive Technologies (ART)/In Vitro Fertilization (IVF)
edited by Ravit Nahum
submission deadline 20 Oct 2026 | 1 articles | Viewed by 1405 | Submission Open
Keywords: IVF; POR; embryo selection; endometrium; technology
(This special issue belongs to the Section Obstetrics & Gynecology)
Current Concepts in Outcomes and Outcome Assessment in Oculoplastic Care
edited by Yinon Shapira
submission deadline 20 Oct 2026 | 3 articles | Viewed by 1387 | Submission Open
Keywords: oculoplastic care; clinical outcomes; outcome assessment; eyelid and orbital disorders; lacrimal disease; anophthalmic rehabilitation; aesthetic and reconstructive ophthalmic plastic surgery
(This special issue belongs to the Section Ophthalmology)
Clinical Advances in Neurocritical Care: Treatment and Patient Outcomes
edited by and Michael Schneck
submission deadline 20 Oct 2026 | 2 articles | Viewed by 1378 | Submission Open
Keywords: neurocritical care; stroke; intracerebral hemorrhage; subarachnoid hemorrhage; traumatic brain injury; reperfusion therapy; mechanical thrombectomy; neuromonitoring; continuous EEG; intracranial pressure; neuroimaging; status epilepticus; neuroprotection; targeted temperature management; hemodynamic management; biomarkers; prognostication; neuro‑ICU quality improvement; health disparities; neurorehabilitation; patient outcomes
(This special issue belongs to the Section Clinical Neurology)
Coronary Artery Disease: Recent Developments and Emerging Trends
edited by and Tarun Mittal
submission deadline 20 Oct 2026 | 2 articles | Viewed by 1376 | Submission Open
Keywords: coronary atherosclerosis; diagnostic strategies; therapeutic options; timing of intervention; artificial intelligence; novel therapeutic pathways
(This special issue belongs to the Section Cardiology)
Clinical Research in Neuro-Ophthalmology
edited by and Hyuna Kim
submission deadline 20 Oct 2026 | 2 articles | Viewed by 1359 | Submission Open
Keywords: neuro-ophthalmology; optic neuropathy; visual pathway; biomarker; clinical research; epidemiologic study; AI
(This special issue belongs to the Section Ophthalmology)
Physical Therapy in Neurorehabilitation: 2nd Edition submission deadline 20 Oct 2026 | 2 articles | Viewed by 1342 | Submission Open
Keywords: physical therapy; transcutaneous electrical nerve stimulation (TENS); muscle strengthening; balance exercising; pain; quality of life; neurodegenerative disorders; neuromuscular disorders; stroke; demyelinating disorders
(This special issue belongs to the Section Clinical Neurology)
Current Updates in Interventional Cardiology
edited by Dobrin Iotkov Vassilev
submission deadline 20 Oct 2026 | 2 articles | Viewed by 1257 | Submission Open
Keywords: interventional cardiology; innovation; intravascular imaging; complex PCI; structural heart interventions; personalized treatment strategy
(This special issue belongs to the Section Cardiology)
Advances in the Management and Understanding of Adult Respiratory Diseases
edited by Hirotsugu Ohkubo
submission deadline 20 Oct 2026 | 2 articles | Viewed by 1251 | Submission Open
Keywords: chronic lung disease; interstitial lung disease; chronic obstructive pulmonary disease; bronchiectasis; nutrition and sarcopenia; pulmonary rehabilitation; imaging and prognosis
(This special issue belongs to the Section Respiratory Medicine)
Multimorbidity and Polypharmacy: From Clinical Complexity to Patient Safety submission deadline 20 Oct 2026 | 1 articles | Viewed by 1226 | Submission Open
Keywords: multimorbidity; polypharmacy; patient safety; medication management; diabetes
(This special issue belongs to the Section Pharmacology)
Eating Disorders and Psychological Disorders: Current Challenges and New Perspectives submission deadline 20 Oct 2026 | 1 articles | Viewed by 1201 | Submission Open
Keywords: eating disorders; psychological comorbidities; psychological disorders; psychological factors; multidimensional investigation; person-centered approach; subjective experience
(This special issue belongs to the Section Mental Health)
Endocrine Tumors: Diagnosis, Treatment and Management—2nd Edition
edited by
submission deadline 20 Oct 2026 | 2 articles | Viewed by 1161 | Submission Open
Keywords: neuroendocrine tumors; thyroid cancer; adrenal gland tumors; pituitary adenomas; parathyroid tumors; pancreatic neuroendocrine tumors; surgical management; radiotherapy
(This special issue belongs to the Section Endocrinology & Metabolism)
Clinical Advances in Wound Healing and Inflammation Management
edited by Carlotta Scarpa
submission deadline 20 Oct 2026 | 1 articles | Viewed by 1141 | Submission Open
Keywords: vascular ulcers; inflammation; traumatic ulcers; burns; regenerative medicine; mononuclear cells; pressure sores; wound technologies
(This special issue belongs to the Section Plastic, Reconstructive and Aesthetic Surgery/Aesthetic Medicine)
Hepatobiliary and Pancreatic Diseases: New Perspectives and Innovative Techniques
edited by
submission deadline 20 Oct 2026 | 1 articles | Viewed by 1115 | Submission Open
Keywords: hepatobiliary diseases; pancreatic diseases; AI in hepatobiliary and pancreatic diseases; minimally invasive and robotic surgery; clinical medicine
(This special issue belongs to the Section Gastroenterology & Hepatopancreatobiliary Medicine)
New Advances in Prenatal Diagnosis and Newborn Medicine, 2nd Edition submission deadline 20 Oct 2026 | 1 articles | Viewed by 1081 | Submission Open
Keywords: sonographic parameters; molecular markers; extravillous and villous trophoblast; perinatal ultrasound; serum markers for complications of pregnancy; histopathology of the placenta; neonatal pathological conditions
(This special issue belongs to the Section Obstetrics & Gynecology)
Advancing Ultrasound Techniques with Artificial Intelligence in Clinical Research
edited by
submission deadline 20 Oct 2026 | 1 articles | Viewed by 1013 | Submission Open
Keywords: artificial intelligence; point-of-care ultrasound; machine learning; deep learning; medical imaging; clinical decision support
(This special issue belongs to the Section Machine Learning and Artificial Intelligence in Clinical Medicine)
New Insights into Liver Cirrhosis and Portal Hypertension
edited by Gerond V. Lake-Bakaar
submission deadline 20 Oct 2026 | 2 articles | Viewed by 1007 | Submission Open
Keywords: cirrhosis; portal hypertension; liver resection; hepatocellular carcinoma; hepatic blood flow; varices; portosystemic collaterals; hepatic sinusoids
(This special issue belongs to the Section Gastroenterology & Hepatopancreatobiliary Medicine)
Spine Surgery: Current Challenges and Future Perspectives
edited by Omri Maayan
submission deadline 20 Oct 2026 | 1 articles | Viewed by 1005 | Submission Open
Keywords: orthopedic surgery; spine surgery; minimally invasive spine surgery; adult spinal deformity; patient-reported outcomes; navigation and robotics; artificial intelligence; surgical outcomes; value-based care; enhanced recovery after surgery; quality improvement; motion-preservation; machine learning; predictive analytics
(This special issue belongs to the Section Orthopedics)
Recent Advances and Future Trends in Shoulder Surgery
edited by Giovanni Merolla
submission deadline 20 Oct 2026 | 1 articles | Viewed by 912 | Submission Open
Keywords: rotator cuff; shoulder instability; acromion-clavicular joint; arthroplasty; shoulder rehabilitation
(This special issue belongs to the Section Orthopedics)
Rheumatoid Arthritis: New Insights and Challenges
edited by
submission deadline 20 Oct 2026 | 1 articles | Viewed by 885 | Submission Open
Keywords: DMARDs (disease-modifying anti-rheumatic drugs); boDMARDs (biological DMARDs); bsDMARDs (biosimilar DMARDs); csDMARDs (conventional synthetic DMARDs); rheumatoid arthritis; tsDMARDs (targeted synthetic DMARDs)
(This special issue belongs to the Section Immunology & Rheumatology)
Uterine Fibroids—Quality of Life and Minimally Invasive Therapy Options
edited by and Maciej Wilczak
submission deadline 20 Oct 2026 | 1 articles | Viewed by 869 | Submission Open
Keywords: uterine fibroids; radiofrequency ablation; pain; quality of life; menstrual bleeding
(This special issue belongs to the Section Obstetrics & Gynecology)
Sepsis and Organ Dysfunction: New Insights into Diagnosis and Treatment—Second Edition
edited by
submission deadline 20 Oct 2026 | 1 articles | Viewed by 864 | Submission Open
Keywords: intensive care; sepsis; shock; biomarkers; rapid methods for pathogen identification; multiorgan dysfunction syndrome; extracorporeal methods; mortality
(This special issue belongs to the Section Intensive Care)
Endoscopic Application of Pancreatic and Biliary Diseases: Diagnosis and Treatment submission deadline 20 Oct 2026 | 1 articles | Viewed by 832 | Submission Open
Keywords: endoscopic retrograde cholangiopancreatography (ERCP); endoscopic ultrasound (EUS); drainage; lumen-apposing metal stent (LAMS); pancreatoscopy; cholangioscopy; pancreatic cancer; pancreatitis; biliary cancer; cholangitis; gallbladder; walled-off necrosis; lithotripsy; radiofrequency ablation (RFA); photodynamic therapy (PDT); necrosectomy; EUS-guided gastroenteroanastomosis
(This special issue belongs to the Section Gastroenterology & Hepatopancreatobiliary Medicine)
Technological Innovations in Spine Surgery: Diagnosis and Management
edited by
submission deadline 20 Oct 2026 | 1 articles | Viewed by 814 | Submission Open
Keywords: spine surgery; neurosurgery; spinal imaging; surgical navigation; robotic spine surgery; artificial intelligence; ma-chine learning; minimally invasive spine surgery; spinal trauma; spinal tumors; surgical innovation; intraoperative technology; outcome prediction; precision surgery; digital health
(This special issue belongs to the Section Orthopedics)
Insights from Cardiopulmonary Exercise Testing to Cardiac Rehabilitation
edited by
submission deadline 20 Oct 2026 | 2 articles | Viewed by 797 | Submission Open
Keywords: cardiac rehabilitation; exercise physiology; exercise performance; exercise testing; physical activity assessment; exercise; physical activity; oxygen consumption; cardiopulmonary exercise testing
(This special issue belongs to the Section Cardiology)
Inflammatory Bowel Diseases: From Diagnosis to Treatment
edited by and Akira Horiuchi
submission deadline 20 Oct 2026 | 1 articles | Viewed by 756 | Submission Open
Keywords: inflammatory bowel disease; Crohn’s disease; ulcerative colitis; diagnosis and biomarker; biologics and small molecule; treat-to-target strategies; precision medicine
(This special issue belongs to the Section Gastroenterology & Hepatopancreatobiliary Medicine)
Smart Anesthesia and Perioperative Care: AI, Monitoring, and Outcomes submission deadline 20 Oct 2026 | 1 articles | Viewed by 753 | Submission Open
Keywords: anesthesia; perioperative outcomes; machine learning; artificial intelligence; wearable monitoring; patient safety; critical care; postoperative surveillance
(This special issue belongs to the Section Anesthesiology)
The Latest Research on Male Infertility
edited by Gianmaria Salvio and Nicola delli Muti
submission deadline 20 Oct 2026 | 1 articles | Viewed by 732 | Submission Open
Keywords: idiopathic male infertility; unexplained male infertility; semen quality; testicular dysfunction; male hypogonadism; gonadal failure
(This special issue belongs to the Section Reproductive Medicine & Andrology)
Current Perspectives and Emerging Insights in Urological Cancer submission deadline 20 Oct 2026 | 1 articles | Viewed by 721 | Submission Open
Keywords: prostate cancer; renal cancer; bladder cancer; urogenital cancer; urological cancer; biopsy; diagnosis; therapy
(This special issue belongs to the Section Nephrology & Urology)
Cutaneous Oncology: Advances in Melanoma, Basal Cell Carcinoma and Other Skin Cancers
edited by Emanuela Passoni, and
submission deadline 20 Oct 2026 | 1 articles | Viewed by 673 | Submission Open
Keywords: melanoma; basal cell carcinoma; squamous cell carcinoma; nevi; dermoscopy; skin cancers; skin tumors
(This special issue belongs to the Section Dermatology)
Arterial Stiffness: A Key Determinant of Cardiovascular Risk in Clinical Medicine
edited by Hack-Lyoung Kim
submission deadline 20 Oct 2026 | 1 articles | Viewed by 649 | Submission Open
Keywords: cardiology; cardiovascular medicine; arterial stiffness; pulse wave velocity; central hemodynamics; vascular aging; hypertension; atherosclerosis; arteriosclerosis; cardiovascular risk stratification
(This special issue belongs to the Section Cardiology)
Clinical Advances in Radiation Treatment of Head and Neck Cancers
edited by Daniela Dumitrescu, and Dragoș-Ovidiu Alexandru
submission deadline 20 Oct 2026 | 1 articles | Viewed by 600 | Submission Open
Keywords: head and neck cancer; radiation therapy; IMRT and VMAT; Image-guided and adaptive radiotherapy; CT, MRI, and PET imaging; post-radiotherapy response assessment; radiation-induced toxicity; skin and mucosal toxicity; dental, maxillofacial, and reconstructive complications; multimodal oncologic treatment
(This special issue belongs to the Section Nuclear Medicine & Radiology)
Clinical Translational Electrophysiology and Therapeutic Innovation in Cardiovascular Disease
edited by Mena Abdelsayed
submission deadline 20 Oct 2026 | 1 articles | Viewed by 570 | Submission Open
Keywords: cardiac electrophysiology; arrhythmias; translational cardiology; hiPSC-derived cardiomyocytes; lon channels; precision medicine; drug repurposing; computational modeling; neuromodulation; mechanobiology; digital twins
(This special issue belongs to the Section Cardiovascular Medicine)
Clinical Insights into New Therapeutic Strategies of Atrial Fibrillation submission deadline 20 Oct 2026 | 1 articles | Viewed by 553 | Submission Open
Keywords: atrial fibrillation; rhythm control; catheter ablation; pulsed field ablation; stroke prevention; anticoagulation strategies; left atrial appendage closure; wearable technologies; artificial intelligence in cardiology; precision medicine
(This special issue belongs to the Section Cardiovascular Medicine)
Cardiogenic Shock: New Insights into Diagnosis, Management and Prognosis
edited by Faisal Rahman
submission deadline 20 Oct 2026 | 1 articles | Viewed by 540 | Submission Open
Keywords: cardiogenic shock; patient outcomes; mechanical circulatory support; hemodynamics; care disparities; healthcare
(This special issue belongs to the Section Cardiology)
Innovations in Minimally Invasive Spine Surgery (MISS): Diagnosis and Management
edited by Seong Son
submission deadline 20 Oct 2026 | Viewed by 437 | Submission Open
Keywords: spinal disease; innovative diagnosis; advanced technique; minimally invasive spine surgery; surgical technology; full-endoscopic spine surgery; uniportal endosopy; unilateral biportal endoscopy; biportal endoscopic surgery
(This special issue belongs to the Section Orthopedics)
Advances in the Management of Pediatric Neuromuscular Diseases
edited by Nicolas Deconinck
submission deadline 20 Oct 2026 | Viewed by 418 | Submission Open
Keywords: pediatric neuromuscular diseases; neuromuscular disorders (NMD); pediatric; genetic NMD; juvenile myasthenia gravis; chronic demyelinating polyneuropathy; next generation sequencing (NGS); spinal muscular atrophy; Duchenne muscular dystrophy; clinical guidelines
(This special issue belongs to the Section Clinical Neurology)
Up-to-Date Orthopedic Treatment and Care for Osteoporotic Fracture of the Elderly submission deadline 20 Oct 2026 | Viewed by 392 | Submission Open
Keywords: osteoporotic fractures; elderly patients; orthopedic surgery; minimally invasive techniques; fracture rehabilitation; kyphoplasty
(This special issue belongs to the Section Orthopedics)
Management of Coronary Syndrome for Better Outcome
edited by , and Antonio Luca Maria Parlati
submission deadline 20 Oct 2026 | Viewed by 358 | Submission Open
Keywords: acute coronary syndrome; chronic coronary syndrome; percutaneous coronary intervention; dual antiplatelet therapy; intravascular imaging; risk stratification; secondary prevention; cardiovascular outcomes; artificial intelligence; digital health
(This special issue belongs to the Section Cardiology)
New Insights into Breast Neoplasms: Prevention, Multidisciplinary Management and Beyond the Core Team submission deadline 20 Oct 2026 | Viewed by 350 | Submission Open
Keywords: breast cancer; tumor heterogeneity; estrogen receptor; progesterone receptor; triple-negative breast cancer; metastasis; immunotherapy; targeted therapy; early detection; prognosis; adjuvant treatment
(This special issue belongs to the Section Oncology)
Navigating Pathways for Children Who Are Deaf or Hard of Hearing: Emerging Opportunities and Challenges
edited by Valerie Sung and
submission deadline 20 Oct 2026 | Viewed by 348 | Submission Open
Keywords: childhood hearing loss; deaf; hard of hearing; children; families; lived experience; family-centered early intervention; gene therapy; screening; congenital cytomegalovirus; hearing technologies; cochlear implants
(This special issue belongs to the Section Otolaryngology)
Maternal–Fetal Medicine: Clinical Updates and Perspectives
edited by and Hadas Miremberg
submission deadline 20 Oct 2026 | Viewed by 342 | Submission Open
Keywords: preterm labor; hypertensive disorders of pregnancy; fetal growth restriction; gestational diabetes; multiple pregnancy
(This special issue belongs to the Section Obstetrics & Gynecology)
Technological Advances and Innovations in Spine Surgery
edited by
submission deadline 20 Oct 2026 | Viewed by 341 | Submission Open
Keywords: neurosurgery; spine surgery; lumbar spine; lumbar spondylolisthesis; artificial disk/artificial facet replacement; motion preservation; patient-specific implants; enabling technologies; use of AI
(This special issue belongs to the Section Clinical Neurology)
Personalized Medicine in Psychiatry: Precision Approaches to Diagnosis and Treatment
edited by Simran Maggo
submission deadline 20 Oct 2026 | Viewed by 330 | Submission Open
Keywords: pharmacogenomics; precision medicine; precision psychiatry; pharmacogenomic testing; pharmacogenomic bioinfor-matics
(This special issue belongs to the Section Mental Health)
Optimizing Post-Return of Spontaneous Circulation (Post-ROSC) Management for Out-of-Hospital Cardiac Arrest (OHCA): Strategies to Enhance Survival, Neurological Recovery, and Social Reintegration
edited by
submission deadline 20 Oct 2026 | Viewed by 321 | Submission Open
Keywords: return of spontaneous circulation (ROSC); quality of life; psychological distress; post-ROSC management; return to society
(This special issue belongs to the Section Cardiology)
Clinical Highlights and Digital Evolution in Trauma and Orthopedic Surgery submission deadline 20 Oct 2026 | Viewed by 316 | Submission Open
Keywords: trauma surgery; orthopedic surgery; musculoskeletal trauma; joint reconstruction; minimally invasive techniques; surgical innovation; implant technology; sports injuries; evidence-based orthopedics; clinical translational research; digital surgery; research reproducibility
(This special issue belongs to the Section Orthopedics)
Best Practices in Kidney Transplantation Across the Continuum: Evaluation to Graft Failure
edited by Sami Alasfar
submission deadline 20 Oct 2026 | 1 articles | Viewed by 292 | Submission Open
Keywords: kidney transplantation; allograft rejection; biomarkers; immunosuppression; failing allograft; retransplantation; transplant outcomes
(This special issue belongs to the Section Nephrology & Urology)
Advances in Mapping and Catheter Ablation of Ventricular Tachycardia
edited by , , , Antonio Bisignani and Stefano Bianchi
submission deadline 20 Oct 2026 | Viewed by 289 | Submission Open
Keywords: catheter ablation; ventricular tachycardia; sudden cardiac death; structural heart disease
(This special issue belongs to the Section Cardiology)
A New Era of Myalgic Encephalomyelitis (ME) Evolving from Myalgic Encephalomyelitis/Chronic Fatigue Syndrome (ME/CFS)
edited by
submission deadline 20 Oct 2026 | Viewed by 284 | Submission Open
Keywords: myalgic encephalomyelitis; chronic fatigue syndrome; post-exertional malaise; central nervous system; neuroinflammation; orthostatic intolerance; disequilibrium; neuroimmune disorder
(This special issue belongs to the Section Clinical Neurology)
Recent Updates in Minimally Invasive Surgery
edited by Simona Parisi and
submission deadline 20 Oct 2026 | Viewed by 281 | Submission Open
Keywords: mini-invasive surgery; robotic surgery; patient compliance; mini-invasive diagnostic procedures; patient comfort
(This special issue belongs to the Section General Surgery)
State of the Art: Updates in Preterm Labor and Preterm Birth—2nd Edition
edited by and Moti Gulersen
submission deadline 20 Oct 2026 | Viewed by 275 | Submission Open
Keywords: prenatal diagnosis; fetal neurosonography; detection of fetal anomalies in the first trimester; preterm birth; antenatal corticosteroids; cerclage; mutiple gestations
(This special issue belongs to the Section Obstetrics & Gynecology)
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