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New Advances in Prenatal Diagnosis and Newborn Medicine, 2nd Edition

A special issue of Journal of Clinical Medicine (ISSN 2077-0383). This special issue belongs to the section "Obstetrics & Gynecology".

Deadline for manuscript submissions: 20 October 2026 | Viewed by 650

Special Issue Editors


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Guest Editor
1. Capio Specialized Center for Gynecology, Postgången 53, 171 45 Solna, Sweden
2. Department of Obstetrics and Gynecology, University of Szeged, H-6725 Szeged, Hungary
Interests: molecular; ultrasound and clinical characterization of pregnancy complications; placental histology
Special Issues, Collections and Topics in MDPI journals

E-Mail Website
Guest Editor
Department of Obstetrics and Gynecology, University of Szeged, H-6725 Szeged, Hungary
Interests: perinatal ultrasound; serum markers for complications of pregnancy; histopathology of the placenta; neonatal pathological conditions
Special Issues, Collections and Topics in MDPI journals

Special Issue Information

Dear Colleagues,

It is my pleasure to invite you to contribute to the Special Issue entitled “New Advances in Prenatal Diagnosis and Newborn Medicine, 2nd Edition”. This is a new edition; we published 6 papers in the first edition. For more details, please visit: https://www.mdpi.com/journal/jcm/special_issues/51G255373K.

An increasing amount of evidence points to the pivotal role of proangiogenic, angiogenic, immunological and inflammatory factors in fetoplacental growth and development. These factors are produced by different cell types of the placenta (extravillous and intravillous trophoblasts, amniotic and chorionic cells, natural killer cells, T lymphocytes, macrophages, etc.) and accumulate in different fetomaternal body fluid compartments. The levels of these factors are different in various pathological conditions of the pregnancy and are capable of predicting pregnancy outcomes, pathological conditions of the pregnancy, and may interrelate with intrauterine sonographic and birth parameters. 

Growing knowledge about the overproduction or underproduction of these factors helps us to understand the etiology and pathomechanisms of disorders, including preeclampsia, pregestational and gestational diabetes, and growth alterations of fetuses, which will contribute to the improvement of perinatal outcomes and reduce maternal and neonatal mortality. 

The aim of this Special Issue is to provide an overview of new molecular pathways and serological and sonographic markers for the etiopathogenesis of pathological conditions in pregnancies. We encourage laboratory and clinical researchers to submit their works that contribute to the improvement of pregnancy outcomes in pathological conditions of pregnancy. Thus, all original research articles or reviews on topics related to pregnancy complications are welcome in this Special Issue. 

Topics will comprise the following: 

  • Complications of pregnancy: fetal growth restriction, large for gestational age, pregestational and gestational diabetes, preeclampsia and hypertension in pregnant women, molecular markers, etiopathogenesis, pathophysiology, causes, and complications. 
  • Neonatal condition, i.e., small for gestational age or large for gestational age.
  • Placenta and amniotic fluid in pathological conditions of pregnancy: what is pathognomonic in different conditions?
  • Fetal and neonatal complications.

Dr. Zoltan Kozinszky
Dr. Andrea Suranyi
Guest Editors

Manuscript Submission Information

Manuscripts should be submitted online at www.mdpi.com by registering and logging in to this website. Once you are registered, click here to go to the submission form. Manuscripts can be submitted until the deadline. All submissions that pass pre-check are peer-reviewed. Accepted papers will be published continuously in the journal (as soon as accepted) and will be listed together on the special issue website. Research articles, review articles as well as short communications are invited. For planned papers, a title and short abstract (about 250 words) can be sent to the Editorial Office for assessment.

Submitted manuscripts should not have been published previously, nor be under consideration for publication elsewhere (except conference proceedings papers). All manuscripts are thoroughly refereed through a single-blind peer-review process. A guide for authors and other relevant information for submission of manuscripts is available on the Instructions for Authors page. Journal of Clinical Medicine is an international peer-reviewed open access semimonthly journal published by MDPI.

Please visit the Instructions for Authors page before submitting a manuscript. The Article Processing Charge (APC) for publication in this open access journal is 2600 CHF (Swiss Francs). Submitted papers should be well formatted and use good English. Authors may use MDPI's English editing service prior to publication or during author revisions.

Keywords

  • sonographic parameters
  • molecular markers
  • extravillous and villous trophoblast
  • perinatal ultrasound
  • serum markers for complications of pregnancy
  • histopathology of the placenta
  • neonatal pathological conditions

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Published Papers (1 paper)

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Research

10 pages, 312 KB  
Article
The Association Between Diabetes Mellitus During Pregnancy and Retinopathy of Prematurity
by Lara Saaida, Eilon Shany, Ahed Imtirat, Nitzan Burrack, Victor Novack and Tamar Eshkoli
J. Clin. Med. 2026, 15(7), 2790; https://doi.org/10.3390/jcm15072790 - 7 Apr 2026
Viewed by 377
Abstract
Background/Objectives: We aimed to evaluate the association between diabetes mellitus (DM) during pregnancy and retinopathy of prematurity (ROP) in preterm infants younger than 32 gestational weeks or infants with low birthweight (<1500 g). Methods: We conducted a retrospective nested case–control study [...] Read more.
Background/Objectives: We aimed to evaluate the association between diabetes mellitus (DM) during pregnancy and retinopathy of prematurity (ROP) in preterm infants younger than 32 gestational weeks or infants with low birthweight (<1500 g). Methods: We conducted a retrospective nested case–control study of all premature infants who were born alive and survived the post-delivery hospitalization period in Soroka Medical Center, with either gestational age younger than 32 weeks or birthweight less than 1500 g, during the years 2013–2021. The infants were divided into two groups according to ROP status. Multivariable Generalized Estimating Equations (GEE) were used to analyze the association between ROP and DM, adjusting for potential confounders, including maternal age, diabetes type (GDM vs. pre-gestational DM), gestational age, birthweight (<1250 g), duration of oxygen supplementation, antenatal corticosteroid courses, and birth plurality. Results: During the study period, there were 881 pairs of women and newborns who met the inclusion criteria. The ROP group included 345 infants (39.1%). Twenty-two (6.4%) of the mothers in the ROP group were diagnosed with DM during pregnancy compared with 52 of 536 (9.7%) in the control group (p = 0.082). ROP was associated with oxygen treatment (OR 1.05; 95% CI, 1.03–1.08; p < 0.001), birthweight < 1250 g (OR 2.70; 95% CI, 1.93–3.78; p < 0.001) and advanced maternal age (OR 1.04; 95% CI, 1.01–1.06; p = 0.006). Prenatal steroid treatment was identified as a significant protective factor against ROP (OR 0.73; 95% CI, 0.60–0.89; p = 0.002). No statistically significant association was observed between maternal DM and ROP (OR 0.62; 95% CI 0.34–1.13; p = 0.12). These findings should be interpreted cautiously given the retrospective design and the limited availability of glycemic control data. Conclusions: Maternal diabetes mellitus was not significantly associated with the risk of ROP in this cohort. Full article
(This article belongs to the Special Issue New Advances in Prenatal Diagnosis and Newborn Medicine, 2nd Edition)
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