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Journal of Clinical Medicine publishes Special Issues to create collections of papers on specific topics, with the aim of building a community of authors and readers to discuss the latest research and develop new ideas and research directions. Special Issues are led by Guest Editors, who are experts on the topic and all Special Issue submissions follow MDPI's standard editorial process. The journal’s Editor-in-Chief and/or designated Editorial Board Member will oversee Guest Editor appointments and Special Issue proposals, checking their content for relevance and ensuring the suitability of the material for the journal. The papers published in a Special Issue will be collected and displayed on a dedicated page of the journal’s website. Further information on MDPI's Special Issue policies and Guest Editor responsibilities can be found here. For any inquiries related to a Special Issue, please contact the Editorial Office.

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Systemic Sclerosis: State of the Art and Future Directions

edited by Antonino Mazzone and

Paola Maria Luigia Faggioli

submission deadline 12 Jun 2026 | Viewed by 45 | Submission Open

Keywords: systemic sclerosis; current knowledge; advanced knowledge; vasculopathy; interstitial lung disease; pulmonary arterial hypertension; perspectives; novelties

(This special issue belongs to the Section Dermatology)

Evidence-Based Clinical Management of Orthopaedic Trauma: 25 Years in Retrospect, and a Forecast of 25 Years to Come

edited by Dirk Stengel and

Paul Alfred Grützner

submission deadline 15 Jun 2026 | 5 articles | Viewed by 9745 | Submission Open

Keywords: evidence-based medicine; orthopaedic surgery; clinical trials; systematic reviews; patient outcomes; multiple trauma; artificial intelligence; injuries

(This special issue belongs to the Section Orthopedics)

Coronary Heart Disease: Causes, Diagnosis and Management

edited by

Andrea Denegri

submission deadline 15 Jun 2026 | 3 articles | Viewed by 9352 | Submission Open

Keywords: coronary heart disease; coronary revascularization; coronary artery disease; ischemic heart disease; atherosclerosis

(This special issue belongs to the Section Cardiology)

Male Sexual and Reproductive Health: Clinical Aspects, Metabolic Profile, Environmental Factors and Lifestyle: 2nd Edition

edited by

Fernando Mazzilli

submission deadline 15 Jun 2026 | 3 articles | Viewed by 6329 | Submission Open

Keywords: male sexual dysfunction; reproductive health; erectile dysfunction; premature ejaculation; infertility; epidemiology; causes; diagnosis; treatments; environmental factors; lifestyle

(This special issue belongs to the Section Reproductive Medicine & Andrology)

Advances in the Diagnosis and Treatment of Glaucoma

edited by

Alessio Martucci

submission deadline 15 Jun 2026 | 4 articles | Viewed by 4917 | Submission Open

Keywords: OCT; glaucoma; MIGS; neuroprotection; drug delivery systems; artificial intelligence; pharmacologic agents; per-sonalized medicine

(This special issue belongs to the Section Ophthalmology)

Arthroplasty: Advances in Surgical Techniques and Patient Outcomes—2nd Edition

edited by Senthil Sambandam

submission deadline 15 Jun 2026 | 2 articles | Viewed by 2980 | Submission Open

Keywords: hip arthroplasty; knee arthroplasty; hip fractures; arthroplasty; osteoarthritis; knee arthroscopy; joint replacement

(This special issue belongs to the Section Orthopedics)

Emergency Surgery: Clinical Updates and New Perspectives

edited by

Bruno Cirillo

submission deadline 15 Jun 2026 | 1 articles | Viewed by 1870 | Submission Open

Keywords: emergency surgery; trauma surgery; acute abdomen; hernia emergencies; surgical decision making; perioperative care; damage control surgery; emergency management; critical care surgery; multidisciplinary approach

(This special issue belongs to the Section Emergency Medicine)

Gender Differences and Diversity in the Treatment of Gastric Cancer and Other Malignancies

edited by Claus Schildberg and Frank Meyer

submission deadline 15 Jun 2026 | 2 articles | Viewed by 1417 | Submission Open

Keywords: gastric cancer; other cancers; other treatment; gender differences; diversity; new challances

(This special issue belongs to the Section Gastroenterology & Hepatopancreatobiliary Medicine)

Clinical Updates on Valvular Heart Diseases: A New Era in Personalized Treatment

edited by Massimiliano Mariani

submission deadline 15 Jun 2026 | 2 articles | Viewed by 1273 | Submission Open

Keywords: valvular heart disease; structural heart intervention; imaging in valve disease; interventional echocardiography; minimally invasive cardiac surgery; aortic valve intervention; tricuspid valve intervention; valve intervention in GUCH; patient-specific therapy; advanced diagnostic techniques; gutting-edge cardiac imaging; catheter-based interventions; innovative cardiac therapies

(This special issue belongs to the Section Cardiology)

Thoracic Surgery: Current Practice and Future Directions: 2nd Edition

edited by

Dania Nachira

submission deadline 15 Jun 2026 | 3 articles | Viewed by 1258 | Submission Open

Keywords: NSCLC; mediastinum; thymoma; esophageal disease; immunotherapy; new technologies; minimally invasive surgery; VATS; RATS

(This special issue belongs to the Section Respiratory Medicine)

Blood Cancers: Current Status and Future Challenges

edited by

Salvatore Perrone

and Massimo Breccia

submission deadline 15 Jun 2026 | 1 articles | Viewed by 1118 | Submission Open

Keywords: acute myeloid leukemia; hematology; leukemia; venetoclax; blood disorders

(This special issue belongs to the Section Hematology)

Cardiac Arrest: Strategies, Innovations, and Improvements in Outcomes

edited by

Kei Hayashida

submission deadline 15 Jun 2026 | Viewed by 965 | Submission Open

Keywords: cardiac arrest; cardiopulmonary resuscitation; post-cardiac arrest syndrome; neurological outcomes

(This special issue belongs to the Section Cardiology)

New Clinical Advances in Pediatric Asthma

edited by

Davor Plavec

submission deadline 15 Jun 2026 | 1 articles | Viewed by 871 | Submission Open

Keywords: pediatric asthma; clinical management; treatment advances; diagnostic advances; biologic therapy; inhaled steroids; control of asthma; exacerbation prevention; quality of life

(This special issue belongs to the Section Clinical Pediatrics)

Transjugular Intrahepatic Portosystemic Shunt: Challenges and Perspectives—2nd Edition

edited by

Lorenzo Ridola

, Stefania Gioia and

Silvia Nardelli

submission deadline 15 Jun 2026 | 1 articles | Viewed by 594 | Submission Open

Keywords: hepatic encephalopathy; spontaneous portal-systemic shunts; transjugular intrahepatic portosystemic shunt; cirrhosis; portal hypertension; sarcopenia; myosteatosis; gastrointestinal bleeding; ascites; non cirrhotic portal hypertension

(This special issue belongs to the Section Gastroenterology & Hepatopancreatobiliary Medicine)

Congenital Heart Diseases: Epidemiology, Treatment and Lifelong Support

edited by Sebastian Freilinger,

Renate Oberhoffer-Fritz

Harald Kaemmerer

and Oliver Dewald

submission deadline 15 Jun 2026 | 1 articles | Viewed by 467 | Submission Open

Keywords: congenital heart disease (CHD); adults with CHD; epidemiology; comorbidities; intervention; surgical treatment; psychological aspects; quality of life (QoL); risk factors; rehabilitation; health promotion; prevention; health literacy; physical activity; lifelong support

(This special issue belongs to the Section Cardiology)

Clinical Advances in Cancer Imaging

edited by

Paul-Andrei Ștefan

submission deadline 15 Jun 2026 | Viewed by 205 | Submission Open

Keywords: pelvic oncology; cancer imaging; CT; MRI; tumor staging; treatment response; morphological criteria; gynecologic cancer; bladder cancer; rectal cancer; artificial intelligence; radiomics; texture analysis; image biomarkers; clinical imaging

(This special issue belongs to the Section Oncology)

Dental Implantology: Clinical Updates and Perspectives—2nd Edition

edited by

Roberta Gasparro

submission deadline 15 Jun 2026 | Viewed by 105 | Submission Open

Keywords: dental implantology; reconstructive surgery; biomaterials; tissue engineering; regenerative medicine; digital dentis-try; periimplantitis; peri-implant soft tissues

(This special issue belongs to the Section Dentistry, Oral Surgery and Oral Medicine)

New Advances of Infectious Disease Epidemiology

edited by

Francisco Guillen-Grima

submission deadline 15 Jun 2026 | Viewed by 90 | Submission Open

Keywords: infectious disease epidemiology; genomic sequencing; computational modeling; collaborative surveillance; digital epidemiology; one health; pandemic intelligence; public health data integration; emerging pathogens; epidemiologic insights

(This special issue belongs to the Section Epidemiology & Public Health)

Traumatic Brain Injury: Clinical Diagnosis and Management

edited by Alessio Caccioppola

submission deadline 15 Jun 2026 | Viewed by 84 | Submission Open

Keywords: glasgow coma scale; intracranial pressure monitoring; traumatic brain injury; diffuse axonal injury; post-traumatic epilepsy; decompressive craniectomy; neuromonitoring

(This special issue belongs to the Section Brain Injury)

Current Challenges and Opportunities in Assisted Reproductive Technologies

edited by Andrea Milostić-Srb and

Davor Jezek

submission deadline 15 Jun 2026 | Viewed by 68 | Submission Open

Keywords: artificial reproductive technologies; ART; mental health effect on ART; IVF; AI in reproductive medicine

(This special issue belongs to the Section Obstetrics & Gynecology)

Clinical Advancements in Foot and Ankle Surgery: 2nd Edition

edited by

Ho-seong Lee

submission deadline 15 Jun 2026 | Viewed by 66 | Submission Open

Keywords: flat foot; hindfoot motion; diabetic foot; hallux valgus; foot infection; foot trauma

(This special issue belongs to the Section Orthopedics)

Clinical Diagnosis and Management of Erectile Dysfunction

edited by Maurizio De Rocco Ponce and

Giuseppe Grande

submission deadline 15 Jun 2026 | Viewed by 32 | Submission Open

Keywords: erectile dysfunction; clinical management; cardiovascular disease; penile prosthesis; personalized medicine; hipogonadism

(This special issue belongs to the Section Reproductive Medicine & Andrology)

Aortic Surgery: State of the Art and Future Directions

edited by

Dimos E. Karangelis

submission deadline 15 Jun 2026 | Viewed by 31 | Submission Open

Keywords: aortic surgery; aortic aneurysm; aortic dissection; aortic arch; biomaterials; endovascular approach; FET; TEVAR

(This special issue belongs to the Section Cardiovascular Medicine)

Novel Diagnostic and Therapeutic Perspectives in Systemic Sclerosis

edited by Mislav Radić

submission deadline 15 Jun 2026 | Viewed by 31 | Submission Open

Keywords: systemic sclerosis; biomarkers; diagnosis; treatment; diagnostic imaging technique; early detection

(This special issue belongs to the Section Immunology & Rheumatology)

Gynecologic Oncology: Current Therapies and New Frontiers

edited by Laura Paleari and Mariangela Rutigliani

submission deadline 19 Jun 2026 | Viewed by 58 | Submission Open

Keywords: ovarian cancers; gynecological cancer; drug delivery; AI; screening; new therapies

(This special issue belongs to the Section Obstetrics & Gynecology)

Gynecologic and Obstetric Pathologies: From Birth to Menopause (Third Edition)

edited by

Panagiotis Christopoulos

submission deadline 20 Jun 2026 | 6 articles | Viewed by 18638 | Submission Open

Keywords: obstetrics; gynecology; pathology; pediatric and adolescent gynecology; menopause; urinary disorders; infertility; gynecologic oncology; maternal– fetal medicine; incontinence; menstruation; reproduction; polycystic ovarian syndrome; endometriosis; dysmenorrhea; assisted reproduction; IVF; laparoscopy; hysteroscopy; gynecologic robotic surgery; high-risk pregnancy

(This special issue belongs to the Section Obstetrics & Gynecology)

Advances in Trauma Care and Emergency Medicine

edited by

Lothar Andreas Schwarte

Patrick Schober

and

Georgios F. Giannakopoulos

submission deadline 20 Jun 2026 | 2 articles | Viewed by 12721 | Submission Open

Keywords: trauma; trauma care; emergency medicine; pre-hospital; emergency room; intensive care unit

(This special issue belongs to the Section Emergency Medicine)

Clinical Advances in Metabolic Dysfunction-Associated Steatotic Liver Disease

edited by Hirsh D. Trivedi

submission deadline 20 Jun 2026 | 5 articles | Viewed by 8952 | Submission Open

Keywords: metabolic dysfunction-associated steatotic liver disease; MASLD; non-alcoholic fatty liver disease; NAFLD; liver disease; liver fibrosis; metabolic syndrome

(This special issue belongs to the Section Gastroenterology & Hepatopancreatobiliary Medicine)

Advancements in Gait Rehabilitation: Innovative Approaches and Clinical Insights

edited by

Shinichi Watanabe

Nobuto Nakanishi

and

Yuki Iida

submission deadline 20 Jun 2026 | 4 articles | Viewed by 5467 | Submission Open

Keywords: sarcopenia; swallowing therapy; physical therapy; early mobilization; early rehabilitation; robot-assisted gait training; neurorehabilitation; wearable sensors

(This special issue belongs to the Section Clinical Rehabilitation)

Evidence-Based Diagnosis and Clinical Management of Low Back Pain

edited by

William J. Hanney

and

Michael Masaracchio

submission deadline 20 Jun 2026 | 2 articles | Viewed by 4845 | Submission Open

Keywords: low back pain; classification systems; risk stratification; health services research; management strategies; timing and sequencing; prognosis; predictor; clinical decision making; primary care

(This special issue belongs to the Section Clinical Rehabilitation)

AI in Maternal Fetal Medicine and Perinatal Management

edited by Ariel Many

submission deadline 20 Jun 2026 | 2 articles | Viewed by 4676 | Submission Open

Keywords: maternal fetal medicine; high-risk pregnancy; perinatal management; artificial intelligence (AI) in obstetrics; fetal growth abnormalities; preterm labor prediction

(This special issue belongs to the Section Obstetrics & Gynecology)

Maternal–Fetal Medicine: Current Status, Challenges, and Future Directions

edited by Jessian Munoz

submission deadline 20 Jun 2026 | 3 articles | Viewed by 4091 | Submission Open

Keywords: maternal– fetal medicine; preterm delivery; preterm birth management; newborn; obstetrics; high-risk pregnancy; perinatal outcome; placenta accreta; fetal surgery

(This special issue belongs to the Section Obstetrics & Gynecology)

Advancements in Femtosecond Laser Applications

edited by Luca Schwarzenbacher, Eva Stifter and Philipp Roberts

submission deadline 20 Jun 2026 | 4 articles | Viewed by 4070 | Submission Open

Keywords: femtosecond laser; cataract surgery; DSAEK; DALK; femto-CAIRS; congenital cataract

(This special issue belongs to the Section Ophthalmology)

Antithrombotic Therapies for Acute Coronary Syndrome and Atrial Fibrillation

edited by

Mojca Božič Mijovski

submission deadline 20 Jun 2026 | 2 articles | Viewed by 2849 | Submission Open

Keywords: atrial fibrillation; acute coronary syndrome; antiplatelet agents; anticoagulants; thrombolysis; direct coagulation factor inhibitors; medical laboratory technology

(This special issue belongs to the Section Cardiology)

Novel Aspects of Endocrine Care: From Patient-Centred Management of Endocrine Diseases to Guidelines Standards

edited by

Mara Carsote

and

Claudiu Nistor

submission deadline 20 Jun 2026 | 2 articles | Viewed by 2184 | Submission Open

Keywords: endocrine tumour; hormone; biomarker; neuroendocrine tumour; thyroidectomy; parathyroidectomy; bone; ad-renal gland; osteoporosis; pituitary gland; autoimmune; antibody; clinical study; computed tomography

(This special issue belongs to the Section Endocrinology & Metabolism)

Current Challenges and Perspectives in Liver Transplantation

edited by Bogdan Dorobanţu,

Umberto Cillo

and Waldo Concepcion

submission deadline 20 Jun 2026 | 1 articles | Viewed by 1380 | Submission Open

Keywords: liver transplantation; liver surgery; liver cirrhosis; liver disease; alcoholic and non-alcoholic steatohepatitis; cholangiocarcinoma; hepatocellular carcinoma; auxiliary liver transplantation

(This special issue belongs to the Section Gastroenterology & Hepatopancreatobiliary Medicine)

Current Perspectives and Innovations in Urogynecology

edited by Stavros Athanasiou

submission deadline 20 Jun 2026 | 1 articles | Viewed by 996 | Submission Open

Keywords: urogynecology; pelvic organ prolapse; urinary incontinence; overactive bladder; pelvic floor surgery; reconstructive surgery; minimally invasive surgery; pelvic floor disorders; innovative surgical techniques; quality of life

(This special issue belongs to the Section Obstetrics & Gynecology)

Cardiovascular Imaging: Diagnosis and Therapeutic Guidance in Clinical Practice

edited by

Stefano Figliozzi

submission deadline 20 Jun 2026 | 1 articles | Viewed by 870 | Submission Open

Keywords: cardiovascular magnetic resonance; cardiac imaging; T1 and T2 mapping; myocardial tissue characterization; late gadolinium enhancement; ischemic heart disease; cardiomyopathies; valvular heart disease; therapeutic guidance; precision medicine; mitral valve prolapse

(This special issue belongs to the Section Cardiology)

Therapies for Heart Failure: Clinical Updates and Perspectives

edited by Cristina Tudoran, Stela Iurciuc and Dragos Cozma

submission deadline 20 Jun 2026 | 1 articles | Viewed by 584 | Submission Open

Keywords: mechanisms of heart failure; new therapies for heart failure; chronic and acute heart failure; new approaches to managing heart failure patients; special populations; clinical outcome

(This special issue belongs to the Section Cardiology)

The New Era of Urological Surgery: Technology-Enhanced Clinical Outcomes

edited by

Razvan-George Rahota

and

Guillaume Ploussard

submission deadline 20 Jun 2026 | Viewed by 545 | Submission Open

Keywords: urology; surgery; robotic surgery; artificial intelligence; urological cancer

(This special issue belongs to the Section Nephrology & Urology)

Clinical Advances in the Pharmacotherapy of Diabetes

edited by Jonathan Watanabe,

Joshua J. Neumiller

and

Cheyenne Frazier

submission deadline 20 Jun 2026 | 1 articles | Viewed by 470 | Submission Open

Keywords: diabetes; microvascular complications; macrovascular complications; diabetes technology; pharmacoepidemiology; care delivery; novel therapies

(This special issue belongs to the Section Pharmacology)

Stroke in Patients with Atrial Fibrillation: Risk, Manifestation and Prevention

edited by

Iwona Gorczyca-Głowacka

submission deadline 20 Jun 2026 | 1 articles | Viewed by 440 | Submission Open

Keywords: anticoagulant treatment; atrial fibrillation; arrhythmia; personalized medicine; stroke

(This special issue belongs to the Section Cardiology)

Novel Insights into the Use of Artificial Intelligence in Clinical Medicine

edited by Sharon C. Kiang and Roger T. Tomihama

submission deadline 20 Jun 2026 | 1 articles | Viewed by 415 | Submission Open

Keywords: artificial intelligence; disease predictive models; wearable technology; surgical innovation; molecular targeting; big data science; machine learning; deep learning

Parkinson's Disease: Recent Advances in Diagnosis and Treatment

edited by

Mariachiara Sensi

and

Fabiana Colucci

submission deadline 20 Jun 2026 | Viewed by 349 | Submission Open

Keywords: Parkinson’ s disease; disease-modifying therapies; artificial intelligence; microbiome; alpha-synuclein; neuroimaging

(This special issue belongs to the Section Clinical Neurology)

Neuroimmunological Disorders: Mechanisms and Therapies

edited by

Christos Bakirtzis

and

Marina Kleopatra Boziki

submission deadline 20 Jun 2026 | 1 articles | Viewed by 335 | Submission Open

Keywords: neuroinflammatory; multiple sclerosis; neuromyelitis optica spectrum disorders; mog associated disease; autoimmune/paraneoplastic encephalitis

(This special issue belongs to the Section Clinical Neurology)

Advanced Endoscopy and Imaging in Gastrointestinal Diseases

edited by

Iancu Dana Monica

and

Paul-Andrei Ștefan

submission deadline 20 Jun 2026 | 1 articles | Viewed by 299 | Submission Open

Keywords: advanced endoscopy; gastrointestinal imaging; minimally invasive therapy; early diagnosis; image-guided intervention; surgical planning; patient outcomes; gastrointestinal diseases

(This special issue belongs to the Section Gastroenterology & Hepatopancreatobiliary Medicine)

New Advances in Oral and Facial Surgery: 2nd Edition

edited by

Olindo Massarelli

submission deadline 20 Jun 2026 | 1 articles | Viewed by 269 | Submission Open

Keywords: squamous cell carcinoma; oro-pharyngeal tumors; skin tumors; plastic and reconstructive surgery; facial plastic surgery; facial reanimation; facial nerve palsy; head and neck surgery; maxillofacial surgery; aesthetic surgery; orthognatic surgery; dental implant surgery

(This special issue belongs to the Section Dentistry, Oral Surgery and Oral Medicine)

Pulmonary Critical Care: Integrating Bedside Physiology and Advanced Monitoring in the Management of Severe Respiratory Diseases

edited by

Gaetano Scaramuzzo

submission deadline 20 Jun 2026 | Viewed by 213 | Submission Open

Keywords: lung monitoring; ARDS; ARF; biomarkers; lung physiology; pneumonia; lung ultrasound; artificial intelligence; COPD; EIT

(This special issue belongs to the Section Respiratory Medicine)

Clinical Advances and Challenges in Liver Transplantation: 3rd Edition

edited by

Paola Aceto

submission deadline 20 Jun 2026 | 1 articles | Viewed by 184 | Submission Open

Keywords: liver transplantation (LT); elderly donors; steatotic livers; donors after circulatory death (DCD); hepatocellular carcinoma (HCC); perioperative management

(This special issue belongs to the Section Gastroenterology & Hepatopancreatobiliary Medicine)

Physiotherapy and Therapeutic Exercise in Modern Clinical Practice

edited by Andoni Carrasco Uribarren,

Luis Ceballos-Laita

and

Carolina Climent-Sanz

submission deadline 20 Jun 2026 | Viewed by 123 | Submission Open

Keywords: exercise therapy; physiotherapy; therapeutic exercise; musculoskeletal disorders; musculoskeletal rehabilitation; pain management; patient-centered care; physiotherapy; rehabilitation technology

(This special issue belongs to the Section Orthopedics)

Displaying special issue 1251-1300 on page 26 of 32.

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