Current Challenges and Perspectives in Liver Transplantation
A special issue of Journal of Clinical Medicine (ISSN 2077-0383). This special issue belongs to the section "Gastroenterology & Hepatopancreatobiliary Medicine".
Deadline for manuscript submissions: 30 June 2025 | Viewed by 254
Special Issue Editors
2. Faculty of Medicine, Carol Davila University of Medicine and Pharmacy, 050474 Bucharest, Romania
Interests: liver diseases; liver transplantation; surgery; hepatocellular carcinoma; liver cirrhosis; liver failure; cirrhosis; liver diseases and immunology
Interests: transplantation; liver transplantation; surgery; hepatobiliary surgery; laparoscopic surgery; robotic HPB surgery
Special Issues, Collections and Topics in MDPI journals
2. Mediclinic City Hospital, Dubai, United Arab Emirates
Interests: paediatric kidney and liver transplantation; adult kidney and liver transplantation; liver transplantation; paediatric and adult liver tumours; dialysis access for children; kidney auto transplantation
Special Issue Information
Dear Colleagues,
In recent years, the criteria for deceased donor liver transplantation (DDLT) have expanded to include older donors, those with multiple comorbidities, donors after circulatory death (DCD), and grafts with significant steatosis. This shift responds to the rising demand for liver transplants from candidates with increasingly demanding clinical conditions. However, using lower quality grafts and accepting higher risk recipients poses an elevated risk of post-transplant complications, including early allograft dysfunction and vascular and biliary complications.
Additionally, a new trend in selecting hepatocellular carcinoma (HCC) patients for liver transplantation seeks to combine traditional morphological parameters—such as tumour size and number—with advanced markers of tumour biology and patient immune function. Furthermore, new liver malignancies tend to become indications for LT and living donor liver transplantation (LDLT) can be a viable option to expand donor pool.
Technological advancements have introduced innovative diagnostic and therapeutic tools, including immunotherapy, radiomics, genomic testing, and machine perfusion, which have the potential to transform clinical practice.
As a result, the transplant community faces the challenge of integrating these new technologies into liver transplantation management, requiring a multidisciplinary approach. This Special Issue aims to explore these pressing clinical issues and the impact of technological advancements on LT based on existing experiences.
Dr. Bogdan Dorobanţu
Prof. Dr. Umberto Cillo
Prof. Dr. Waldo Concepcion
Guest Editors
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Keywords
- liver transplantation
- liver surgery
- liver cirrhosis
- liver disease
- alcoholic and non-alcoholic steatohepatitis
- cholangiocarcinoma
- hepatocellular carcinoma
- auxiliary liver transplantation
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