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Journal of Clinical Medicine publishes Special Issues to create collections of papers on specific topics, with the aim of building a community of authors and readers to discuss the latest research and develop new ideas and research directions. Special Issues are led by Guest Editors, who are experts on the topic and all Special Issue submissions follow MDPI's standard editorial process. The journal’s Editor-in-Chief and/or designated Editorial Board Member will oversee Guest Editor appointments and Special Issue proposals, checking their content for relevance and ensuring the suitability of the material for the journal. The papers published in a Special Issue will be collected and displayed on a dedicated page of the journal’s website. Further information on MDPI's Special Issue policies and Guest Editor responsibilities can be found here. For any inquiries related to a Special Issue, please contact the Editorial Office.

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Clinical Management of Oral Healthcare in Diverse Patient Populations: Second Edition submission deadline 25 Apr 2026 | 7 articles | Viewed by 13410 | Submission Open
Keywords: special needs patients; oral healthcare; pediatric dentistry; dental hygiene; oral pathology; orthodontics; periodontics
(This special issue belongs to the Section Dentistry, Oral Surgery and Oral Medicine)
Clinical Perspectives on Surgical Management of Knee Injuries
edited by Min Jung
submission deadline 25 Apr 2026 | 6 articles | Viewed by 10144 | Submission Open
Keywords: osteoarthritis; meniscal repair; ligament reconstruction; cartilage restoration; knee surgery
(This special issue belongs to the Section Orthopedics)
Clinical Insights into Pulmonary Hypertension
edited by Simon Schneider
submission deadline 25 Apr 2026 | 5 articles | Viewed by 9835 | Submission Open
Keywords: pulmonary hypertension; pulmonary vascular disease (PVD); pulmonary arterial hypertension (PAH); chronic thromboembolic pulmonary hypertension (CTEPH); interstitial lung disease; chronic obstructive pulmonary disease (COPD); chronic pulmonary fibrosis; emphysema; respiratory disease; physiology; diagnosis; treatment; rehabilitation; altitude research
(This special issue belongs to the Section Respiratory Medicine)
Clinical Advances in Abdominal Surgery
edited by and César P. Ramírez-Plaza
submission deadline 25 Apr 2026 | 5 articles | Viewed by 6333 | Submission Open
Keywords: abdominal surgery; oncologic surgery; minimal invasive techniques; HIPEC; PIPAC; peritoneal carcinomatosis; liver metastasis
(This special issue belongs to the Section General Surgery)
Assessment and Treatment of Trauma Patients
edited by
submission deadline 25 Apr 2026 | 2 articles | Viewed by 6232 | Submission Open
Keywords: trauma surgery; prehospital detection of trauma; assessment of trauma; trauma scale; trauma evaluation; trauma surgery
(This special issue belongs to the Section Emergency Medicine)
Advances in Structural Heart Diseases
edited by , and Erwan Donal
submission deadline 25 Apr 2026 | 2 articles | Viewed by 5001 | Submission Open
Keywords: valvular heart diseases; transcatheter interventions; TEER; LAA closure; ASD closure; interventional echocardiography; multimodality cardiac imaging; three-dimensional echocardiography
(This special issue belongs to the Section Cardiovascular Medicine)
Hand Surgery: Latest Advances and Prospects
edited by and Lorenzo Rocchi
submission deadline 25 Apr 2026 | 3 articles | Viewed by 4672 | Submission Open
Keywords: hand surgery; musculoskeletal and nerve disorders; innovative surgical procedures; minimally invasive techniques; rehabilitation strategies; robotic surgery
(This special issue belongs to the Section Orthopedics)
Advances in the Diagnosis and Treatment of Skin Cancer submission deadline 25 Apr 2026 | 2 articles | Viewed by 2479 | Submission Open
Keywords: skin cancer; melanoma; keratinocyte carcinoma; basal cell carcinoma; squamous cell carcinoma; biomarkers; immuno-therapy; prognosis
(This special issue belongs to the Section Oncology)
Catheter Ablation of Atrial Fibrillation: Current Progress and New Challenges
edited by Sorin Stefan Popescu, Roland Richard Tilz and Karl-Heinz Kuck
submission deadline 25 Apr 2026 | 2 articles | Viewed by 2165 | Submission Open
Keywords: atrial fibrillation; novel technologies; pulmonary vein isolation; same-day discharge; pulsed field ablation; cryo-ablation; radiofrequency; safety; efficacy; sustainability
(This special issue belongs to the Section Cardiology)
Current Trends and Future Prospects in Autoantibodies in Liver Diseases
edited by Takashi Himoto
submission deadline 25 Apr 2026 | 1 articles | Viewed by 1956 | Submission Open
Keywords: liver-specific autoantibodies; non-organ-specific autoantibodies; autoimmune liver disease; diagnosis; disease activity; treatment outcome; prognosis; virus-induced autoimmunity; drug-induced autoimmunity
(This special issue belongs to the Section Gastroenterology & Hepatopancreatobiliary Medicine)
Endometriosis and Endometrial Cancer: Challenge and Clinical Management
edited by , Tomasz Kluz and Bernhard Krämer
submission deadline 25 Apr 2026 | 1 articles | Viewed by 1919 | Submission Open
Keywords: endometriosis; endometrial cancer; non-invasive diagnosis; molecular profiling; surgical techniques; medical treatment; alternative therapies
(This special issue belongs to the Section Obstetrics & Gynecology)
Endoscopic Diagnosis and Treatments of Gastrointestinal Diseases
edited by Madalina Ilie and Mihai Ciocîrlan
submission deadline 25 Apr 2026 | 3 articles | Viewed by 1881 | Submission Open
Keywords: esogastric lesions; pancreatic diseases; colorectal lesions; hepatobiliary diseases; optical endoscopy; endoscopic ultrasound; upper and lower endoscopy; endoscopic retrograde cholangiopancreatography
(This special issue belongs to the Section Gastroenterology & Hepatopancreatobiliary Medicine)
Interventional Cardiology: Recent Advances and Future Perspectives
edited by Cristina Aurigemma and Luigi Cappannoli
submission deadline 25 Apr 2026 | 3 articles | Viewed by 1877 | Submission Open
Keywords: interventional cardiology; percutaneous coronary intervention (PCI); transcatheter aortic valve implantation (TAVI); structural heart disease; coronary artery disease; imaging and artificial intelligence; antithrombotic therapy; future technologies in cardiology; personalized cardiovascular care; minimally invasive interventions
(This special issue belongs to the Section Cardiology)
Cardiac Magnetic Resonance Imaging: Current Techniques and Future Directions
edited by Ioannis Botis and
submission deadline 25 Apr 2026 | 1 articles | Viewed by 1534 | Submission Open
Keywords: cardiac magnetic resonance imaging; cardiovascular magnetic resonance; cardiac imaging; multimodality imaging; parametric mapping; late gadolinium enhancement; myocardial perfusion; myocardial viability; cardiomyopathies; heart failure
(This special issue belongs to the Section Cardiology)
New Advances in Procedures for the Diagnosis and Treatment of Cardiovascular Disease submission deadline 25 Apr 2026 | Viewed by 1368 | Submission Open
Keywords: cardiovascular disease; diagnostic procedures; therapeutic advancements; minimally invasive interventions; precision medicine; imaging technologies; catheter-based treatments; translational research; interventional cardiology; clinical innovations
(This special issue belongs to the Section Cardiovascular Medicine)
General Surgical Oncology: Evolving Paradigms and Contemporary Challenges submission deadline 25 Apr 2026 | 1 articles | Viewed by 984 | Submission Open
Keywords: surgical oncology; minimally invasive surgery; robotic surgery; multidisciplinary cancer care; artificial intelligence in surgery; perioperative management; precision oncology; complex tumor resection; integrated surgical therapies; oncologic surgery innovation
(This special issue belongs to the Section Oncology)
Advances in Primary Sclerosing Cholangitis: Pathogenesis, Diagnosis and Emerging Therapies
edited by Konstantinos H. Katsanos and
submission deadline 25 Apr 2026 | 2 articles | Viewed by 827 | Submission Open
Keywords: cholangiocarcinoma; primary sclerosing cholangitis; cholestatic; inflammatory bowel disease; liver
(This special issue belongs to the Section Gastroenterology & Hepatopancreatobiliary Medicine)
Urologic Neoplasms: Recent Advances and Future Perspectives
edited by
submission deadline 25 Apr 2026 | 1 articles | Viewed by 777 | Submission Open
Keywords: robotic surgery; laparoscopic surgery; immunotherapy; chemotherapy; radiotherapy; prostate cancer; renal cancer; bladder cancer; upper urinary tract neoplasm; testicular cancer; penile cancer
(This special issue belongs to the Section Oncology)
Recent Advances in Pulmonary Embolism and Thrombosis: 2nd Edition
edited by and Elena Campello
submission deadline 25 Apr 2026 | 1 articles | Viewed by 511 | Submission Open
Keywords: pulmonary embolism; embolism and thrombosis; thrombus aspiration for pulmonary embolism; deep vein thrombosis; venous thromboembolism
(This special issue belongs to the Section Respiratory Medicine)
Robot-Assisted Surgery: Current Trends and Future Directions
edited by , Claudio Bisegna and Michele Morelli
submission deadline 25 Apr 2026 | Viewed by 411 | Submission Open
Keywords: robotic surgery; minimally invasive surgery; urology; artificial intelligence; augmented reality; public health; innovation; laparoscopic surgery; surgical platforms; surgical outcomes
(This special issue belongs to the Section General Surgery)
New Advances in Cleft Lip and Palate and Facial Plastic Surgery
edited by , Wolfgang Zemann and Rainer Lutz
submission deadline 25 Apr 2026 | 1 articles | Viewed by 395 | Submission Open
Keywords: cleft lip repair; rhinoplasty; secondary rhinoplasty; cleft rhinoplasty; facial plastic surgery; nasolabial area; upper lid surgery
(This special issue belongs to the Section Plastic, Reconstructive and Aesthetic Surgery/Aesthetic Medicine)
Recent Developments in Reproductive Endocrinology
edited by Birute Žilaitiené and Jonas Čeponis
submission deadline 25 Apr 2026 | Viewed by 332 | Submission Open
Keywords: hypogonadism; infertility; sex hormone deficiency; reproductive endocrinology; sexual health; assisted reproduction
(This special issue belongs to the Section Endocrinology & Metabolism)
Sarcoma—Clinical Updates: 2nd Edition
edited by
submission deadline 25 Apr 2026 | 1 articles | Viewed by 230 | Submission Open
Keywords: sarcoma; osteosarcoma; ewing’ s sarcoma; chondrosarcoma; soft-tissue sarcoma; undifferentiated pleo-morphic sarcoma; liposarcoma; leiomyosarcoma; rhabdomyosarcoma; metastatic sarcoma; targeted molecular therapy; immunotherapy; orthopedic oncology
(This special issue belongs to the Section Oncology)
Novel Diagnostic and Therapeutic Approaches to Urologic Oncology
edited by , Bogdan Florin Geavlete and
submission deadline 25 Apr 2026 | Viewed by 214 | Submission Open
Keywords: diagnosis; therapy; up-to-date; uro-oncologic pathology
(This special issue belongs to the Section Oncology)
New Concepts in Minimally Invasive Spine Surgery
edited by and Michael Y. Wang
submission deadline 25 Apr 2026 | Viewed by 187 | Submission Open
Keywords: minimally invasive spine surgery; image navigation; tubular retractor; endoscopic spine surgery; virtual and aug-mented reality; lateral spine surgery
(This special issue belongs to the Section Clinical Neurology)
Liver Failure: Current Status and Future Opportunities
edited by
submission deadline 25 Apr 2026 | Viewed by 98 | Submission Open
Keywords: acute liver failure; acute-on-chronic liver failure; portal hypertension; hepatic encephalopathy; pathogenesis; management
(This special issue belongs to the Section Gastroenterology & Hepatopancreatobiliary Medicine)
New Clinical Advances in Orthopedic Oncology
edited by
submission deadline 25 Apr 2026 | Viewed by 85 | Submission Open
Keywords: orthopedic oncology; sarcoma; soft-tissue sarcoma; osteosarcoma; chondrosarcoma; Ewings sarcoma; giant cell tumor; limb salvage; mega-prosthetic reconstruction; targeted molecular therapy; immunotherapy
(This special issue belongs to the Section Orthopedics)
Diagnosis, Treatment and Prognosis of Coronary Heart Disease: 2nd Edition
edited by
submission deadline 25 Apr 2026 | Viewed by 84 | Submission Open
Keywords: coronary heart disease; acute coronary syndrome; chronic coronary syndrome; ischemia with no obstructive coronary arteries (INOCA); guideline-directed optimal medical therapy; precision medicine; artificial intelligence; interventional cardiology; percutaneous coronary intervention (PCI)
(This special issue belongs to the Section Cardiology)
Advances in Reconstructive and Aesthetic Plastic Surgery
edited by
submission deadline 25 Apr 2026 | Viewed by 82 | Submission Open
Keywords: reconstructive plastic surgery; aesthetic innovation; fat grafting; microsurgery; regenerative medicine; cell-enriched lipotransfer; 3D imaging; minimally invasive techniques; hybrid injectables
(This special issue belongs to the Section Plastic, Reconstructive and Aesthetic Surgery/Aesthetic Medicine)
Emerging Surgical Techniques in the Management of Urological Diseases
edited by
submission deadline 25 Apr 2026 | Viewed by 81 | Submission Open
Keywords: minimally invasive; robotics; partial nephrectomy; radical prostatectomy; focal therapy; benign prostatic hyperplasia; prostate cancer; bladder cancer
(This special issue belongs to the Section Nephrology & Urology)
Complex Scenarios in Reverse Shoulder Arthroplasty: Bone Loss, Revisions, and Surgical Solutions
edited by Francesco Franceschi, Angelo Baldari and Antonio Caldaria
submission deadline 25 Apr 2026 | Viewed by 64 | Submission Open
Keywords: shoulder arthroplasty; revision shoulder arthroplasty; humeral fracture; failed shoulder prosthesis; bone loss management; implant failure
(This special issue belongs to the Section Orthopedics)
Personalized Therapy and Clinical Outcome for Retinal Diseases
edited by
submission deadline 25 Apr 2026 | Viewed by 61 | Submission Open
Keywords: retinal diseases; retinal imaging; clinical outcomes; artificial intelligence; biomarkers; optical coherence tomography (OCT); vitrectomy
(This special issue belongs to the Section Ophthalmology)
Sex- and Age-Related Differences in Exercise Response: Clinical Implications for Health and Disease
edited by
submission deadline 26 Apr 2026 | 2 articles | Viewed by 1131 | Submission Open
Keywords: exercise intervention; clinical exercise physiology; sex differences; age-related response; metabolic disorders; personalized medicine; physical activity; chronic disease management
(This special issue belongs to the Section Sports Medicine)
Recent Advances in the Diagnosis and Treatment of Gastrointestinal Diseases
edited by
submission deadline 27 Apr 2026 | 5 articles | Viewed by 4931 | Submission Open
Keywords: advanced endoscopy; innovation in GI; pathophysiology of GI disorders; artificial intelligence in GI; gastrointestinal diseases
(This special issue belongs to the Section Gastroenterology & Hepatopancreatobiliary Medicine)
Advancing Minimally Invasive Spine Surgery: A Special Edition on Endoscopic Spine Surgery
edited by and Gregory W. Basil
submission deadline 28 Apr 2026 | 4 articles | Viewed by 6524 | Submission Open
Keywords: minimally invasive spine surgery (MIS); endoscopic spine surgery (ESS); spine surgery; percutaneous spine surgery; full-endoscopic spine surgery; biportal endoscopic spine surgery (BESS); unilateral biportal endoscopy (UBE); percutaneous endoscopic lumbar discectomy (PELD); endoscopic decompression; transforaminal endoscopic lumbar discectomy (TELD); interlaminar endoscopic lumbar discectomy (IELD); endoscopic lumbar fusion; endoscopic transforaminal lumbar interbody fusion (Endo-TLIF)
(This special issue belongs to the Section Clinical Neurology)
Recent Advances and Clinical Outcomes of Hip and Knee Arthroplasty
edited by
submission deadline 28 Apr 2026 | 3 articles | Viewed by 2224 | Submission Open
Keywords: hip arthroplasty; knee arthroplasty; joint replacement; clinical outcomes; surgical innovation; patient recovery; prosthetics; perioperative care
(This special issue belongs to the Section Orthopedics)
Selected Papers from the 3rd International Online Conference on Clinical Medicine submission deadline 28 Apr 2026 | 1 articles | Viewed by 1497 | Submission Open
Keywords: cardiology; cardiovascular medicine; nephrology; urology; emergency medicine; nuclear medicine & radiology; general surgery; clinical rehabilitation; respiratory medicine; anesthesiology
Current Trends in Hand Surgery
edited by and Florian Frueh
submission deadline 28 Apr 2026 | 1 articles | Viewed by 1158 | Submission Open
Keywords: microsurgery; minimally invasive; arthroscopy; sonography; nerve surgery; joint replacement
(This special issue belongs to the Section Orthopedics)
Symptoms and Treatment of Cardiac Amyloidosis
edited by Syed Bukhari
submission deadline 28 Apr 2026 | Viewed by 271 | Submission Open
Keywords: cardiac amyloidosis; transthyretin amyloidosis; light chain amyloidosis; cardiac magnetic resonance; echocardiography; nuclear scintigraphy; endomyocardial biopsy; gene silencers; transthyretin stabilizers; immunotherapy
(This special issue belongs to the Section Cardiology)
Periodontal and Other Associated Oral Diseases: Diagnosis and Management in the Context of Systemic Pathology, 2nd Edition submission deadline 30 Apr 2026 | 4 articles | Viewed by 7277 | Submission Open
Keywords: periodontitis; oral diseases; periimplantitis; biomarkers; cytokines; oxidative stress markers; PCR test; point-of-care test; CBCT; periodontal treatment; immunomodulatory therapy; local drug delivery
(This special issue belongs to the Section Otolaryngology)
Sequelae of COVID-19: Clinical to Prognostic Follow-Up submission deadline 30 Apr 2026 | 5 articles | Viewed by 4815 | Submission Open
Keywords: COVID-19; post-COVID-19 syndromes; sequelae of COVID-19; pathophysiological pathways; multiorgan sequelae; long-term management of post-COVID-19 syndromes; quality of life; long-term prognosis of COVID-19
(This special issue belongs to the Section Vascular Medicine)
Interstitial Lung Diseases: New Treatments and Future Directions
edited by Justyna Fijołek
submission deadline 30 Apr 2026 | 1 articles | Viewed by 3324 | Submission Open
Keywords: Interstitial Lung Disease (ILD); pulmonary fibrosis; orphan lung disease; AAV-ILD; occupational ILD; rheumatic lung disease; treatment strategies; emerging therapies; precision medicine; future directions
(This special issue belongs to the Section Respiratory Medicine)
Advances in Gastroenterological Surgery
edited by Alan Biloslavo and Antonio La Greca
submission deadline 30 Apr 2026 | 2 articles | Viewed by 2953 | Submission Open
Keywords: mini-invasive surgery; technology; artificial intelligence; negative pressure; indocyanine green; ultrasound; GE surgery; emergency surgery; precision surgery
(This special issue belongs to the Section Gastroenterology & Hepatopancreatobiliary Medicine)
Rehabilitation Strategies for Neurological Disorders: Advances and Insights
edited by Delia Cinteză and Mihai Berteanu
submission deadline 30 Apr 2026 | 4 articles | Viewed by 2881 | Submission Open
Keywords: neurorehabilitation; physical medicine; virtual reality; AI in rehabilitation medicine; robotic rehabilitation; telerehabilitation; advanced technologies; upper neuromotor lesions; peripheral neuropathies; wearable sensor devices; assessment; goal-setting; individual rehabilitation plan
(This special issue belongs to the Section Clinical Rehabilitation)
Diabetic Retinopathy Screening: Current Advances and Future Options submission deadline 30 Apr 2026 | 1 articles | Viewed by 1283 | Submission Open
Keywords: diabetic retinopathy; diabetic retinopathy screening; retinal imaging; age-related macular degeneration; artificial intelli-gence; image analysis; color fundus photography; optical coherence tomography imaging; telemedicine
(This special issue belongs to the Section Ophthalmology)
New Advances in the Management of Voice Disorders: 2nd Edition submission deadline 30 Apr 2026 | 1 articles | Viewed by 1260 | Submission Open
Keywords: voice disorders; laryngology; laryngoscope; acoustic analysis; dysphonia; voice surgery; diagnosis; treatment; rehabilitation; vocal folds; voice assessment/measures
(This special issue belongs to the Section Otolaryngology)
Clinical Challenges and Innovations in Cochlear Implantation and Hearing Rehabilitation
edited by
submission deadline 30 Apr 2026 | 1 articles | Viewed by 243 | Submission Open
Keywords: cochlear implant outcomes; clinical efficiency; barriers to care; cochlear implant surgery; cochlear implant referral; cochlear implant evaluation; cochlear implant candidacy; rehabilitation; rehabilitation strategies; quality of life
(This special issue belongs to the Section Otolaryngology)
Skin Cancers: Update on Clinical Treatment and Management
edited by Nazzaro Gianluca
submission deadline 30 Apr 2026 | Viewed by 199 | Submission Open
Keywords: basal cell carcinoma; squamous cell carcinoma; melanoma; skin cancers; dermoscopy; ultrasonography; immunotherapy; biomarker; prevention; diagnosis; treatment; innovative treatments; prognosis
(This special issue belongs to the Section Dermatology)
New Clinical Advances in Depressive Disorders and Treatment-Resistant Depression
edited by Giacomo d'Andrea and Miriam Olivola
submission deadline 30 Apr 2026 | Viewed by 123 | Submission Open
Keywords: treatment-resistant depression; MDD; ketamine; esketamine; rTMS; psylocibin; bipolar depression; clinical pheno-typing; precision psychiatry; biomarkers
(This special issue belongs to the Section Mental Health)
New Clinical Advances in Psoriasis and Psoriatic Arthritis: 2nd Edition
edited by and Alessandra Narcisi
submission deadline 30 Apr 2026 | Viewed by 121 | Submission Open
Keywords: psoriasis; psoriatic arthritis; inflammatory skin disease; inflammatory autoimmune disease; immunotherapy; autoimmunity; comorbidities; therapeutic; diagnosis; treatment; management; biologics
(This special issue belongs to the Section Dermatology)
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