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Journal of Clinical Medicine publishes Special Issues to create collections of papers on specific topics, with the aim of building a community of authors and readers to discuss the latest research and develop new ideas and research directions. Special Issues are led by Guest Editors, who are experts on the topic and all Special Issue submissions follow MDPI's standard editorial process. The journal’s Editor-in-Chief and/or designated Editorial Board Member will oversee Guest Editor appointments and Special Issue proposals, checking their content for relevance and ensuring the suitability of the material for the journal. The papers published in a Special Issue will be collected and displayed on a dedicated page of the journal’s website. Further information on MDPI's Special Issue policies and Guest Editor responsibilities can be found here. For any inquiries related to a Special Issue, please contact the Editorial Office.

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Clinical Management of Type 1 Diabetes

edited by Carmen Quirós

submission deadline 25 Nov 2025 | 7 articles | Viewed by 30923 | Submission Open

Keywords: type 1 diabetes; continuous glucose monitoring; hybrid closed loop; hypoglycemia; physical activity; new onset type 1 diabetes; pre-stage 3 type 1 diabetes; smart insulin pens

(This special issue belongs to the Section Endocrinology & Metabolism)

Neurovascular Diseases: Clinical Advances and Challenges

edited by

Roberto Colasanti

, Silky Chotai, Alessandro Di Rienzo and Joham Choque-Velasquez

submission deadline 25 Nov 2025 | 11 articles | Viewed by 20569 | Submission Open

Keywords: neurovascular diseases; ischemic stroke; hemorrhagic stroke; aneurysms; vascular malformations; diagnostic imaging; minimally invasive approaches; surgical techniques; endovascular interventions; treatment algorithms

(This special issue belongs to the Section Clinical Neurology)

Clinical Pharmacology: Adverse Drug Reactions

edited by

Andrej Belančić

and Ivana Mudnić

submission deadline 25 Nov 2025 | 5 articles | Viewed by 20464 | Submission Open

Keywords: pharmacology; adverse drug reactions; drug interactions; pharmacovigilance; drug safety

(This special issue belongs to the Section Pharmacology)

Perinatal Mental Health Management

edited by

Sigita Lesinskienë

submission deadline 25 Nov 2025 | 6 articles | Viewed by 20374 | Submission Open

Keywords: perinatal mental health; child mental health; problem behavior; cognitive development therapy; hyperactivity

(This special issue belongs to the Section Mental Health)

Ventilation in Critical Care Medicine: 2nd Edition

edited by Gianluca Zani

submission deadline 25 Nov 2025 | 1 articles | Viewed by 13898 | Submission Open

Keywords: invasive ventilation; non-invasive ventilation; acute respiratory failure; best PEEP; respiratory weaning; respiratory mechanics; ventilation and perfusion; personalized ventilation

(This special issue belongs to the Section Intensive Care)

Glomerulonephritis: Current Diagnosis, Treatment and Future Options

edited by Ana I. Ávila and

Montserrat M. Díaz-Encarnación

submission deadline 25 Nov 2025 | 3 articles | Viewed by 12952 | Submission Open

Keywords: glomerulonephritis; diagnosis; management; drug therapies; treatment

(This special issue belongs to the Section Nephrology & Urology)

Challenges in Diagnosis and Treatment of Gynecological Malignancies in Young Adults

edited by

Oraianthi Fiste

, Dimitrios Haidopoulos and

Michalis Liontos

submission deadline 25 Nov 2025 | 4 articles | Viewed by 11371 | Submission Open

Keywords: gynecological cancers; young adults; young women; fertility; personalized care

(This special issue belongs to the Section Obstetrics & Gynecology)

Weaning from Non-Invasive Mechanical Ventilation Approaches (NIV-NHF): Insights on How, When and Where

edited by

Antonio Matías Esquìnas

submission deadline 25 Nov 2025 | 2 articles | Viewed by 9954 | Submission Open

Keywords: non-invasive positive pressure ventilation (NIPPV); nasal high flow oxygen; respiratory failure; intensive care units; pneumology wards; non-invasive mechanical ventilation approaches (NIV nasal high flow)

(This special issue belongs to the Section Intensive Care)

Recent Advances in Spine Tumor Diagnosis and Treatment

edited by Jae Hwan Cho

submission deadline 25 Nov 2025 | 8 articles | Viewed by 8874 | Submission Open

Keywords: spine tumor; spinal metastasis; pathologic fracture; cord compression; separation surgery; radiotherapy; interdisciplinary collaboration; surgeon’ s role; medical oncologist; radiologic oncologist; psychological aspects; pain management; innovative approaches; patient outcomes; diagnostic advancements

(This special issue belongs to the Section Clinical Neurology)

Gynecological Cancers—Surgical Management, Prognosis, and Quality of Life: 2nd Edition

edited by

Valentina Elisabetta Bounous

submission deadline 25 Nov 2025 | 5 articles | Viewed by 8762 | Submission Open

Keywords: gynecological cancers; endometrial cancer; ovarian cancer; cervical cancer; vulvar cancer; vaginal cancer; breast cancer; surgery; radiotherapy; systemic treatment; quality of life

(This special issue belongs to the Section Obstetrics & Gynecology)

Cystic Fibrosis: Novel Strategies of Diagnosis and Treatments

edited by

Michal Gur

and

Lea Bentur

submission deadline 25 Nov 2025 | 6 articles | Viewed by 7890 | Submission Open

Keywords: cystic fibrosis; CFTR modulators; stop mutations; gene therapy; mRNA therapy; novel therapies; rare pathogens

(This special issue belongs to the Section Respiratory Medicine)

A Multi-Faceted Approach to Urinary Incontinence and Other Pelvic Floor Dysfunction—from Prevention to Therapy

edited by

Agnieszka Mazur-Bialy

submission deadline 25 Nov 2025 | 3 articles | Viewed by 7687 | Submission Open

Keywords: urinary incontinence; pelvic floor dysfunction; urinary and fecal incontinence; pelvic organs prolapse; pelvic pain; pelvic floor disorders

(This special issue belongs to the Section Nephrology & Urology)

Clinical Diagnosis and Management of Vestibular Disorders

edited by

Sinisa Maslovara

, Mario Habek and

Andro Košec

submission deadline 25 Nov 2025 | 7 articles | Viewed by 7420 | Submission Open

Keywords: vertigo; dizziness; epidemiology; genetics; diagnostics; management

(This special issue belongs to the Section Otolaryngology)

Cardiothoracic Surgery and Enhanced Recovery: Recent Advances and Perspectives

edited by Edris A.F. Mahtab

submission deadline 25 Nov 2025 | 4 articles | Viewed by 7285 | Submission Open

Keywords: coronary artery bypass surgery; valve repair/replacement; minimally invasive cardiac procedures; aortic dissection repair; thoracic aortic aneurysm surgery; lung transplantation; ventricular assist devices; esophagectomy; lung surgery; heart transplantation; use of XR and AI in Enhanced recovery

(This special issue belongs to the Section General Surgery)

Advances in Dry Eye Disease Treatment: 2nd Edition

edited by

Piera Versura

and

Murat Dogru

submission deadline 25 Nov 2025 | 3 articles | Viewed by 6920 | Submission Open

Keywords: dry eye disease; meibomian gland; tear substitutes; corticosteroids; cyclosporin; antibiotics; non-steroid anti-inflammatory drugs; biological tear substitutes; nutrients; pulsed light

(This special issue belongs to the Section Ophthalmology)

New Perspectives in Lumbar Spine Surgery: Treatment and Management

edited by

Giuseppe La Rocca

submission deadline 25 Nov 2025 | 4 articles | Viewed by 6313 | Submission Open

Keywords: lumbar surgery; spine surgery; minimally invasive techniques; advanced imaging; surgical innovations; patient outcomes; evidence-based practices; postoperative care; rehabilitation strategies; surgical management

(This special issue belongs to the Section Orthopedics)

Research and Applications in Clinical Pharmacy Based on Pharmacokinetics and Pharmacogenetics

edited by

Marta Miarons

submission deadline 25 Nov 2025 | 3 articles | Viewed by 5825 | Submission Open

Keywords: pharmacokinetics; clinical pharmacy; personalized medicine; drug therapy management; therapeutic drug monitoring

(This special issue belongs to the Section Pharmacology)

Advanced Techniques for the Treatment of Complex Coronary Artery Disease: 2nd Edition

edited by Simone Calcagno

submission deadline 25 Nov 2025 | 3 articles | Viewed by 5626 | Submission Open

Keywords: coronary calcified lesion; IVUS; OCT; intravascular lithotripsy; bifurcation coronary lesions; left main; chronic total occlusions; multivessel disease; STEMI; NSTEMI

(This special issue belongs to the Section Cardiovascular Medicine)

Novel Insights into the Diagnosis and Management of Inflammatory Bowel Disease (IBD)

edited by

Alina Ioana Tantau

submission deadline 25 Nov 2025 | 4 articles | Viewed by 3818 | Submission Open

Keywords: inflammatory bowel disease; non-invasive biomarkers; abdominal ultrasonography; colonoscopy; biologic therapy; small molecules; mucosal healing; brain-gut axis; dysbiosis; colorectal dysplasia

(This special issue belongs to the Section Gastroenterology & Hepatopancreatobiliary Medicine)

Recent Developments and Emerging Trends in Aortic Surgery

edited by Daniele Linardi

submission deadline 25 Nov 2025 | 4 articles | Viewed by 3807 | Submission Open

Keywords: aortic aneurysm; aortic dissection; endovascular repair; minimally invasive approaches; thoracic aorta; abdominal aorta; aortic valve-sparing surgery; aortic stent grafts

(This special issue belongs to the Section Vascular Medicine)

Assessing Strategies and Challenges in Heart Failure: An Update

edited by

Shiro Hoshida

submission deadline 25 Nov 2025 | 2 articles | Viewed by 3557 | Submission Open

Keywords: cardiac MR; coronary microvascular dysfunction; diagnosis; endothelial function; heart failure; myocardial metabolism; prognosis

(This special issue belongs to the Section Cardiology)

Recent Advances in Intracranial Aneurysm Treatment

edited by Victor Volovici

submission deadline 25 Nov 2025 | 2 articles | Viewed by 3372 | Submission Open

Keywords: intracranial aneurysm; cerebrovascular disease; microneurosurgery; endovascular treatment; subarachnoid hemorrhage

(This special issue belongs to the Section Clinical Neurology)

Vascular Surgery: Current Advances and Future Directions

edited by Giovanni Coppi

submission deadline 25 Nov 2025 | 2 articles | Viewed by 2606 | Submission Open

Keywords: stroke; carotid artery stenosis; carotid artery stenting; carotid endarterectomy; occlusion

(This special issue belongs to the Section General Surgery)

Recent Developments and Emerging Trends of Echocardiography in Cardiac Disease

edited by Petri Gudmundsson

submission deadline 25 Nov 2025 | 2 articles | Viewed by 2592 | Submission Open

Keywords: echocardiography development; artificial intelligence (AI) integration; real-time 3D and 4D imaging; portable and handheld devices; contrast-enhanced imaging; tissue characterization; integration with other modalities; quantitative analysis; tele-echocardiography

(This special issue belongs to the Section Cardiology)

The Rebirth of Ventral Skull Base Surgery through Multiportal Approaches: Endonasal, Transorbital, Transmaxillary and Transoral Routes

edited by Matteo de Notaris and Francesco Corrivetti

submission deadline 25 Nov 2025 | 3 articles | Viewed by 2390 | Submission Open

Keywords: skull base surgery; neuroendoscopy; neuroanatomy; multiportal approaches; technical advancements

(This special issue belongs to the Section Clinical Neurology)

Modern Blood Banking and Transfusion in Clinical Practice: Second Edition

edited by

Pilar Solves

submission deadline 25 Nov 2025 | 2 articles | Viewed by 1877 | Submission Open

Keywords: blood transfusion therapy; patient blood management; restrictive transfusion; cell therapy; platelet transfusion

(This special issue belongs to the Section Hematology)

Clinical Advances in Surgical Treatment for Hepato–Pancreatic–Biliary (HPB) Diseases

edited by

Spiros G. Delis

submission deadline 25 Nov 2025 | 1 articles | Viewed by 1564 | Submission Open

Keywords: pancreas surgery; liver resection; minimal invasive approach; virtual reality; robotic surgery; MDT

(This special issue belongs to the Section Gastroenterology & Hepatopancreatobiliary Medicine)

Treatment and Prognosis of Spinal Surgery

edited by Andy Ton and Shane Shahrestani

submission deadline 25 Nov 2025 | 2 articles | Viewed by 1560 | Submission Open

Keywords: spinal surgery; minimally invasive surgery (MIS); robotic-assisted surgery; patient-reported outcomes (PROs); postoper-ative outcomes; predictive analytics; radiographic predictors; endoscopic; disk arthroplasty; single position surgery

(This special issue belongs to the Section Clinical Neurology)

Hospital-Acquired Infections in the Elderly

edited by Nadya Kagansky and Emily Lubart

submission deadline 25 Nov 2025 | 1 articles | Viewed by 1269 | Submission Open

Keywords: hospital-acquired infections (HAIs); elderly patients; infection control; microbial resistance; epidemiology; risk factors; prevention strategies; treatment options; diagnostic accuracy

(This special issue belongs to the Section Epidemiology & Public Health)

Endometriosis: Current Insights and Treatments

edited by Mercedes Espada Vaquero

submission deadline 25 Nov 2025 | 1 articles | Viewed by 1153 | Submission Open

Keywords: endometriosis; chronic pelvic pain; pelvic floor dysfunction; hormonal treatment; gynecological surgery; diagnosis; hysteroscopy; infertility

(This special issue belongs to the Section Obstetrics & Gynecology)

Emerging Treatment Options in Aortic Valve Disease and Aortic Stenosis

edited by Borut Geršak and Robert Phillip Gallegos

submission deadline 25 Nov 2025 | 1 articles | Viewed by 1039 | Submission Open

Keywords: aortic stenosis; minimally invasive surgery; transcatheter aortic valve replacement; surgical treatment; diagnostic strategies; re-operation/redo AVR; calcified root; valve in valve

(This special issue belongs to the Section Cardiology)

New Insights in Paediatric Endocrinology

edited by

Marco Fiore

submission deadline 25 Nov 2025 | 1 articles | Viewed by 482 | Submission Open

Keywords: endocrinology; pediatrics; hormones; therapy and treatment; adolescents; newborns

(This special issue belongs to the Section Clinical Pediatrics)

Ischemic Stroke: Diagnosis, Treatment, and Management

edited by

Maria Luisa Zedde

and Rosario Pascarella

submission deadline 25 Nov 2025 | Viewed by 457 | Submission Open

Keywords: ischemic stroke; diagnosis; treatment; stroke unit; stroke care; stroke etiology; thrombolysis; EVT; rare causes of stroke; cerebral vein thrombosis

(This special issue belongs to the Section Clinical Neurology)

Recent Advances in Diagnosis and Treatment of Comorbid Disorders in Interstitial Lung Diseases

edited by

Giacomo Sica

and Domenica Francesca Mariniello

submission deadline 25 Nov 2025 | Viewed by 243 | Submission Open

Keywords: interstitial lung disease; ILD; progressive pulmonary fibrosis; artificial intelligence; management

(This special issue belongs to the Section Respiratory Medicine)

Enhancing Safety and Outcomes in Complex Spine Surgery

edited by Ahmed Ramadan Sadek

submission deadline 25 Nov 2025 | Viewed by 235 | Submission Open

Keywords: spinal surgery; spinal deformity; scoliosis; sciatica; back and neck pain

(This special issue belongs to the Section Clinical Neurology)

Minimally Invasive Laparoendoscopic Procedures in Abdominal Emergencies

edited by

Eugen Tãrcoveanu

Costel Bradea

and

Alin Mihai Vasilescu

submission deadline 25 Nov 2025 | Viewed by 194 | Submission Open

Keywords: laparoscopic surgery; robotic surgery; minimally invasive surgery; hepatobiliary surgery; pancreatic surgery; gastrointestinal surgery; general surgery; emergency surgery; trauma; recent advances in laparoscopic surgery; surgical training in laparoscopy; endoscopic surgery; the feasibility and safety of laparoscopic; endoscopic co-operative surgery for the treatment of digestive pathology

(This special issue belongs to the Section General Surgery)

Advances in Ablation Therapy for Atrial Fibrillation: Innovations and Clinical Applications

edited by Ioanna Koniari

submission deadline 25 Nov 2025 | Viewed by 182 | Submission Open

Keywords: atrial fibrillation; ablation; PFA; PVI; non-thermal energy; mapping system

(This special issue belongs to the Section Cardiology)

The Use of Circulating Extracellular Vesicles as a Tool in the Diagnosis, Monitoring and Treatment of Disease

edited by

Antonio Casado-Díaz

submission deadline 25 Nov 2025 | Viewed by 172 | Submission Open

Keywords: circulating extracellular vesicles; regenerative medicine; biomarker; diagnosis; exosomes; liquid biopsy

(This special issue belongs to the Section Clinical Laboratory Medicine)

Treatment and Digital Outcome Assessment in Orthopaedic Trauma

edited by Benedikt Johannes Braun and

Meir Tibi Marmor

submission deadline 25 Nov 2025 | Viewed by 134 | Submission Open

Keywords: orthopaedic trauma; digital outcome assessment; wearable sensors; patient-reported outcomes; machine learning (or artificial intelligence)

(This special issue belongs to the Section Orthopedics)

New Approaches in Open and Minimally Invasive Surgery for Abdominal Oncologic Surgery

edited by

Alessandro Coppola

and Immacolata Iannone

submission deadline 25 Nov 2025 | Viewed by 122 | Submission Open

Keywords: surgical oncology; early diagnosis; minimally invasive surgery; personalized medicine; combined therapy; gastrointestinal cancer; oligometastatic cancer; peritoneal disease

(This special issue belongs to the Section General Surgery)

Clinical Innovation in Endoscopic Sinus and Anterior Skull Base Surgery

edited by

Samiul Muquit

and

Marios Stavrakas

submission deadline 27 Nov 2025 | Viewed by 176 | Submission Open

Keywords: rhinology; endoscopic anterior skull base surgery; anterior skull base surgery; endoscopic sinus surgery; chronic rhinosinusitis (CRS); otolaryngology

(This special issue belongs to the Section Otolaryngology)

Management of Complex Infective Endocarditis

edited by Shekhar Saha, Tulio Caldonazo and Mateo Marin-Cuartas

submission deadline 27 Nov 2025 | Viewed by 114 | Submission Open

Keywords: infective endocarditis; imaging; diagnosis; cardiac surgery; pathogens; antibiotic treatment; risk estimation

(This special issue belongs to the Section Cardiology)

Advances in the Diagnosis and Management of Age-Related Macular Degeneration: 2nd Edition

edited by Tsutomu Yasukawa

submission deadline 28 Nov 2025 | 10 articles | Viewed by 11463 | Submission Open

Keywords: age-related macular degeneration; angiography; antivascular endothelial growth factor therapy; choroidal neovascularization; geographic atrophy; multimodal imaging; ophthalmology; optical coherence tomography; photodynamic therapy; retinal pigment epithelium

(This special issue belongs to the Section Ophthalmology)

New Trends in Mechanical Ventilation

edited by

Jan P. Mulier

submission deadline 28 Nov 2025 | 2 articles | Viewed by 7395 | Submission Open

Keywords: positive pressure ventilation; negative pressure ventilation; constant flow ventilation; PEEP; lung recruitment; obesity; laparoscopy; ARDS; atelectasis; total lung compliance

(This special issue belongs to the Section Anesthesiology)

Advances in Spine Surgery: Best Practices and Future Directions

edited by Martin N. Stienen and

Stefan Motov

submission deadline 28 Nov 2025 | 6 articles | Viewed by 6869 | Submission Open

Keywords: minimally invasive spine surgery; spinal endoscopy; spinal robotics; spinal navigation; ERAS; machine learning; artificial intelligence; complication management; revision surgery; spinal deformity; innovation; future direction

(This special issue belongs to the Section Clinical Neurology)

Current Practices in Cardiovascular Perfusion and Recovery

edited by

Irbaz Hameed

submission deadline 28 Nov 2025 | 1 articles | Viewed by 2807 | Submission Open

Keywords: organ perfusion; ex vivo perfusion; ischemia– reperfusion injury; organ recovery; transplantation; machine perfusion; organ preservation

(This special issue belongs to the Section Cardiology)

Advancements in Anterior Cruciate Ligament Injury: From Diagnosis to the Return-to-Sports: 2nd Edition

edited by Alexandre Hardy and Nicolas Bouguennec

submission deadline 28 Nov 2025 | 3 articles | Viewed by 2406 | Submission Open

Keywords: anterior cruciate ligament reconstruction (ACLR); timing of ACLR; ramp lesion; meniscal lesion; lateral extra-articular procedure

(This special issue belongs to the Section Sports Medicine)

Clinical Updates in Heart Transplantation

edited by

Giacomo Bianchi

submission deadline 28 Nov 2025 | 2 articles | Viewed by 1549 | Submission Open

Keywords: heart transplantation; ex vivo heart preservation; immunosuppression; xenotransplantation; pre-clinical models; dilated cardiomyopathy; amyloidosis; congenital heart disease

(This special issue belongs to the Section Cardiology)

Innovations in Thoracic Surgery and Disease Management: Integrating Genomics, Technology, and Multidisciplinary Care

edited by

Marco Scarci

and

Savvas Lampridis

submission deadline 28 Nov 2025 | Viewed by 247 | Submission Open

Keywords: thoracic surgery; thoracic disease; genomic medicine; artificial intelligence; advanced imaging; multidisciplinary care; minimally invasive surgery; robotic surgery; precision medicine

(This special issue belongs to the Section Respiratory Medicine)

Novel Treatments for Vestibular Migraine

edited by

Teru Kamogashira

submission deadline 28 Nov 2025 | Viewed by 243 | Submission Open

Keywords: neuromodulation therapy; sympathetic nerve stimulation; CGRP-targeted therapy; dietary interventions; elimination diets; ketogenic diet; low-glycemic index diet; nutritional supplements; pathophysiology of vestibular migraine; clinical adoption of VM therapies

(This special issue belongs to the Section Otolaryngology)

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