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Journal of Clinical Medicine publishes Special Issues to create collections of papers on specific topics, with the aim of building a community of authors and readers to discuss the latest research and develop new ideas and research directions. Special Issues are led by Guest Editors, who are experts on the topic and all Special Issue submissions follow MDPI's standard editorial process. The journal’s Editor-in-Chief and/or designated Editorial Board Member will oversee Guest Editor appointments and Special Issue proposals, checking their content for relevance and ensuring the suitability of the material for the journal. The papers published in a Special Issue will be collected and displayed on a dedicated page of the journal’s website. Further information on MDPI's Special Issue policies and Guest Editor responsibilities can be found here. For any inquiries related to a Special Issue, please contact the Editorial Office.

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The “Orthogeriatric Fracture Syndrome”—Issues and Perspectives

edited by

Johannes Dominik Bastian

submission deadline 25 Nov 2025 | 18 articles | Viewed by 28776 | Submission Open

Keywords: geriatric trauma; fragility fracture; orthogeriatric; co-management; assessment; integrated care; osteoporosis; sarcopenia; frailty; gait disturbance; fall; rehabilitation; prehabilitation; prevention; ehealth; digitalization

(This special issue belongs to the Section Orthopedics)

Perinatal Mental Health Management

edited by

Sigita Lesinskienë

submission deadline 25 Nov 2025 | 5 articles | Viewed by 19718 | Submission Open

Keywords: perinatal mental health; child mental health; problem behavior; cognitive development therapy; hyperactivity

(This special issue belongs to the Section Mental Health)

Neurovascular Diseases: Clinical Advances and Challenges

edited by

Roberto Colasanti

, Silky Chotai, Alessandro Di Rienzo and Joham Choque-Velasquez

submission deadline 25 Nov 2025 | 11 articles | Viewed by 19380 | Submission Open

Keywords: neurovascular diseases; ischemic stroke; hemorrhagic stroke; aneurysms; vascular malformations; diagnostic imaging; minimally invasive approaches; surgical techniques; endovascular interventions; treatment algorithms

(This special issue belongs to the Section Clinical Neurology)

Clinical Pharmacology: Adverse Drug Reactions

edited by

Andrej Belančić

and Ivana Mudnić

submission deadline 25 Nov 2025 | 5 articles | Viewed by 18802 | Submission Open

Keywords: pharmacology; adverse drug reactions; drug interactions; pharmacovigilance; drug safety

(This special issue belongs to the Section Pharmacology)

Ventilation in Critical Care Medicine: 2nd Edition

edited by Gianluca Zani

submission deadline 25 Nov 2025 | 1 articles | Viewed by 13498 | Submission Open

Keywords: invasive ventilation; non-invasive ventilation; acute respiratory failure; best PEEP; respiratory weaning; respiratory mechanics; ventilation and perfusion; personalized ventilation

(This special issue belongs to the Section Intensive Care)

Glomerulonephritis: Current Diagnosis, Treatment and Future Options

edited by Ana I. Ávila and

Montserrat M. Díaz-Encarnación

submission deadline 25 Nov 2025 | 3 articles | Viewed by 12711 | Submission Open

Keywords: glomerulonephritis; diagnosis; management; drug therapies; treatment

(This special issue belongs to the Section Nephrology & Urology)

Challenges in Diagnosis and Treatment of Gynecological Malignancies in Young Adults

edited by

Oraianthi Fiste

, Dimitrios Haidopoulos and

Michalis Liontos

submission deadline 25 Nov 2025 | 4 articles | Viewed by 10952 | Submission Open

Keywords: gynecological cancers; young adults; young women; fertility; personalized care

(This special issue belongs to the Section Obstetrics & Gynecology)

Weaning from Non-Invasive Mechanical Ventilation Approaches (NIV-NHF): Insights on How, When and Where

edited by

Antonio Matías Esquìnas

submission deadline 25 Nov 2025 | 2 articles | Viewed by 9444 | Submission Open

Keywords: non-invasive positive pressure ventilation (NIPPV); nasal high flow oxygen; respiratory failure; intensive care units; pneumology wards; non-invasive mechanical ventilation approaches (NIV nasal high flow)

(This special issue belongs to the Section Intensive Care)

Recent Advances in Spine Tumor Diagnosis and Treatment

edited by Jae Hwan Cho

submission deadline 25 Nov 2025 | 8 articles | Viewed by 8650 | Submission Open

Keywords: spine tumor; spinal metastasis; pathologic fracture; cord compression; separation surgery; radiotherapy; interdisciplinary collaboration; surgeon’ s role; medical oncologist; radiologic oncologist; psychological aspects; pain management; innovative approaches; patient outcomes; diagnostic advancements

(This special issue belongs to the Section Clinical Neurology)

Gynecological Cancers—Surgical Management, Prognosis, and Quality of Life: 2nd Edition

edited by

Valentina Elisabetta Bounous

submission deadline 25 Nov 2025 | 5 articles | Viewed by 8562 | Submission Open

Keywords: gynecological cancers; endometrial cancer; ovarian cancer; cervical cancer; vulvar cancer; vaginal cancer; breast cancer; surgery; radiotherapy; systemic treatment; quality of life

(This special issue belongs to the Section Obstetrics & Gynecology)

Endometriosis: Clinical Challenges and Prognosis

edited by

Francisco Artacho-Cordon

submission deadline 25 Nov 2025 | 4 articles | Viewed by 8024 | Submission Open

Keywords: endometriosis; therapy; rehabilitation; psychology; diagnostics; ultrasound imaging; metabolomics; prognosis

(This special issue belongs to the Section Obstetrics & Gynecology)

Cystic Fibrosis: Novel Strategies of Diagnosis and Treatments

edited by

Michal Gur

and

Lea Bentur

submission deadline 25 Nov 2025 | 6 articles | Viewed by 7707 | Submission Open

Keywords: cystic fibrosis; CFTR modulators; stop mutations; gene therapy; mRNA therapy; novel therapies; rare pathogens

(This special issue belongs to the Section Respiratory Medicine)

A Multi-Faceted Approach to Urinary Incontinence and Other Pelvic Floor Dysfunction—from Prevention to Therapy

edited by

Agnieszka Mazur-Bialy

submission deadline 25 Nov 2025 | 3 articles | Viewed by 7519 | Submission Open

Keywords: urinary incontinence; pelvic floor dysfunction; urinary and fecal incontinence; pelvic organs prolapse; pelvic pain; pelvic floor disorders

(This special issue belongs to the Section Nephrology & Urology)

Clinical Diagnosis and Management of Vestibular Disorders

edited by

Sinisa Maslovara

, Mario Habek and

Andro Košec

submission deadline 25 Nov 2025 | 7 articles | Viewed by 7185 | Submission Open

Keywords: vertigo; dizziness; epidemiology; genetics; diagnostics; management

(This special issue belongs to the Section Otolaryngology)

Cardiothoracic Surgery and Enhanced Recovery: Recent Advances and Perspectives

edited by Edris A.F. Mahtab

submission deadline 25 Nov 2025 | 4 articles | Viewed by 7089 | Submission Open

Keywords: coronary artery bypass surgery; valve repair/replacement; minimally invasive cardiac procedures; aortic dissection repair; thoracic aortic aneurysm surgery; lung transplantation; ventricular assist devices; esophagectomy; lung surgery; heart transplantation; use of XR and AI in Enhanced recovery

(This special issue belongs to the Section General Surgery)

Advances in Dry Eye Disease Treatment: 2nd Edition

edited by

Piera Versura

and

Murat Dogru

submission deadline 25 Nov 2025 | 3 articles | Viewed by 6639 | Submission Open

Keywords: dry eye disease; meibomian gland; tear substitutes; corticosteroids; cyclosporin; antibiotics; non-steroid anti-inflammatory drugs; biological tear substitutes; nutrients; pulsed light

(This special issue belongs to the Section Ophthalmology)

Clinical Utility of Optical Coherence Tomography in Ophthalmology: 2nd Edition

edited by

Jose Ignacio Fernandez-Vigo

submission deadline 25 Nov 2025 | 4 articles | Viewed by 6547 | Submission Open

Keywords: optical coherence tomography; ophthalmology; intraoperative OCT; en face OCT; wide-field OCT; retinal diseases; glaucoma; cornea; strabismus; cataract

(This special issue belongs to the Section Ophthalmology)

New Perspectives in Lumbar Spine Surgery: Treatment and Management

edited by

Giuseppe La Rocca

submission deadline 25 Nov 2025 | 4 articles | Viewed by 6018 | Submission Open

Keywords: lumbar surgery; spine surgery; minimally invasive techniques; advanced imaging; surgical innovations; patient outcomes; evidence-based practices; postoperative care; rehabilitation strategies; surgical management

(This special issue belongs to the Section Orthopedics)

Research and Applications in Clinical Pharmacy Based on Pharmacokinetics and Pharmacogenetics

edited by

Marta Miarons

submission deadline 25 Nov 2025 | 3 articles | Viewed by 5572 | Submission Open

Keywords: pharmacokinetics; clinical pharmacy; personalized medicine; drug therapy management; therapeutic drug monitoring

(This special issue belongs to the Section Pharmacology)

Advanced Techniques for the Treatment of Complex Coronary Artery Disease: 2nd Edition

edited by Simone Calcagno

submission deadline 25 Nov 2025 | 3 articles | Viewed by 5498 | Submission Open

Keywords: coronary calcified lesion; IVUS; OCT; intravascular lithotripsy; bifurcation coronary lesions; left main; chronic total occlusions; multivessel disease; STEMI; NSTEMI

(This special issue belongs to the Section Cardiovascular Medicine)

Novel Insights into the Diagnosis and Management of Inflammatory Bowel Disease (IBD)

edited by

Alina Ioana Tantau

submission deadline 25 Nov 2025 | 4 articles | Viewed by 3728 | Submission Open

Keywords: inflammatory bowel disease; non-invasive biomarkers; abdominal ultrasonography; colonoscopy; biologic therapy; small molecules; mucosal healing; brain-gut axis; dysbiosis; colorectal dysplasia

(This special issue belongs to the Section Gastroenterology & Hepatopancreatobiliary Medicine)

Recent Developments and Emerging Trends in Aortic Surgery

edited by Daniele Linardi

submission deadline 25 Nov 2025 | 4 articles | Viewed by 3641 | Submission Open

Keywords: aortic aneurysm; aortic dissection; endovascular repair; minimally invasive approaches; thoracic aorta; abdominal aorta; aortic valve-sparing surgery; aortic stent grafts

(This special issue belongs to the Section Vascular Medicine)

Assessing Strategies and Challenges in Heart Failure: An Update

edited by

Shiro Hoshida

submission deadline 25 Nov 2025 | 2 articles | Viewed by 3469 | Submission Open

Keywords: cardiac MR; coronary microvascular dysfunction; diagnosis; endothelial function; heart failure; myocardial metabolism; prognosis

(This special issue belongs to the Section Cardiology)

Recent Advances in Intracranial Aneurysm Treatment

edited by Victor Volovici

submission deadline 25 Nov 2025 | 2 articles | Viewed by 3320 | Submission Open

Keywords: intracranial aneurysm; cerebrovascular disease; microneurosurgery; endovascular treatment; subarachnoid hemorrhage

(This special issue belongs to the Section Clinical Neurology)

Thoracic Surgery: Recent Developments and Future Challenges

edited by

Marco Andolfi

and Lucio Cagini

submission deadline 25 Nov 2025 | 1 articles | Viewed by 2739 | Submission Open

Keywords: VATS; RATS; ERAS; sublobar resection; minimally invasive thoracic surgery; target therapy; nodule localization

(This special issue belongs to the Section Respiratory Medicine)

Recent Developments and Emerging Trends of Echocardiography in Cardiac Disease

edited by Petri Gudmundsson

submission deadline 25 Nov 2025 | 2 articles | Viewed by 2569 | Submission Open

Keywords: echocardiography development; artificial intelligence (AI) integration; real-time 3D and 4D imaging; portable and handheld devices; contrast-enhanced imaging; tissue characterization; integration with other modalities; quantitative analysis; tele-echocardiography

(This special issue belongs to the Section Cardiology)

Vascular Surgery: Current Advances and Future Directions

edited by Giovanni Coppi

submission deadline 25 Nov 2025 | 2 articles | Viewed by 2568 | Submission Open

Keywords: stroke; carotid artery stenosis; carotid artery stenting; carotid endarterectomy; occlusion

(This special issue belongs to the Section General Surgery)

The Rebirth of Ventral Skull Base Surgery through Multiportal Approaches: Endonasal, Transorbital, Transmaxillary and Transoral Routes

edited by Matteo de Notaris and Francesco Corrivetti

submission deadline 25 Nov 2025 | 3 articles | Viewed by 2221 | Submission Open

Keywords: skull base surgery; neuroendoscopy; neuroanatomy; multiportal approaches; technical advancements

(This special issue belongs to the Section Clinical Neurology)

Clinical Highlights in Uveal Melanoma

edited by Tomasz Chorągiewicz and

Joanna Dolar-Szczasny

submission deadline 25 Nov 2025 | 1 articles | Viewed by 2085 | Submission Open

Keywords: choroidal melanoma; uveal melanoma; radiotherapy; enucleation; brachytherapy

(This special issue belongs to the Section Ophthalmology)

Modern Blood Banking and Transfusion in Clinical Practice: Second Edition

edited by

Pilar Solves

submission deadline 25 Nov 2025 | 2 articles | Viewed by 1818 | Submission Open

Keywords: blood transfusion therapy; patient blood management; restrictive transfusion; cell therapy; platelet transfusion

(This special issue belongs to the Section Hematology)

Interstitial Lung Disease Secondary to Autoimmune Disorders: Recent Advances and Novel Perspectives

edited by

Gaetano La Rocca

Gianluca Sambataro

and Francesco Ferro

submission deadline 25 Nov 2025 | 1 articles | Viewed by 1742 | Submission Open

Keywords: interstitial lung disease; lung involvement; connective tissue diseases; rheumatoid arthritis; systemic vasculitis; radiomics; lung ultrasound; biomarkers; pathogenetic immunological pathways; therapeutic targets

(This special issue belongs to the Section Respiratory Medicine)

Treatment and Prognosis of Spinal Surgery

edited by Andy Ton and Shane Shahrestani

submission deadline 25 Nov 2025 | 2 articles | Viewed by 1514 | Submission Open

Keywords: spinal surgery; minimally invasive surgery (MIS); robotic-assisted surgery; patient-reported outcomes (PROs); postoper-ative outcomes; predictive analytics; radiographic predictors; endoscopic; disk arthroplasty; single position surgery

(This special issue belongs to the Section Clinical Neurology)

Clinical Advances in Surgical Treatment for Hepato–Pancreatic–Biliary (HPB) Diseases

edited by

Spiros G. Delis

submission deadline 25 Nov 2025 | 1 articles | Viewed by 1488 | Submission Open

Keywords: pancreas surgery; liver resection; minimal invasive approach; virtual reality; robotic surgery; MDT

(This special issue belongs to the Section Gastroenterology & Hepatopancreatobiliary Medicine)

Advances in the Clinical Management of Perioperative Anesthesia: 2nd Edition

edited by Alessia Mattei, Rita Cataldo and

Alessandro Strumia

submission deadline 25 Nov 2025 | 2 articles | Viewed by 1254 | Submission Open

Keywords: perioperative outcomes (surgical; anesthetic; medical); evidence-based care; perioperative guidelines and consensus statements; preoperative evaluation and risk scores; preoperative testing; surgical optimization and enhanced surgical recovery programs; intensive care unit

(This special issue belongs to the Section Anesthesiology)

Hospital-Acquired Infections in the Elderly

edited by Nadya Kagansky and Emily Lubart

submission deadline 25 Nov 2025 | 1 articles | Viewed by 1244 | Submission Open

Keywords: hospital-acquired infections (HAIs); elderly patients; infection control; microbial resistance; epidemiology; risk factors; prevention strategies; treatment options; diagnostic accuracy

(This special issue belongs to the Section Epidemiology & Public Health)

Current Clinical Advances in Urinary Incontinence

edited by Adolf Lukanovic, David Lukanović and Mija Blaganje

submission deadline 25 Nov 2025 | 1 articles | Viewed by 1166 | Submission Open

Keywords: female urinary incontinence; stress urinary incontinence; overactive bladder; diagnosis; prevention; conservative treatment; minimally invasive treatment; surgery; mid-urethral sling; new approach; energy-based devices

(This special issue belongs to the Section Nephrology & Urology)

Diabetic Foot: Emerging Prevention Strategies and Epidemiology

edited by

Vilma Urbančič-Rovan

submission deadline 25 Nov 2025 | 1 articles | Viewed by 1113 | Submission Open

Keywords: diabetic foot; foot clinics; epidemiology; prevention; screening; amputation; podiatry

(This special issue belongs to the Section Endocrinology & Metabolism)

Approaches and Challenges in Oral Rehabilitation

edited by

Yoko Hasegawa

and Takayuki Kosaka

submission deadline 25 Nov 2025 | 1 articles | Viewed by 1008 | Submission Open

Keywords: oral rehabilitation; oral health; systemic health; dental innovation; neuroplasticity

(This special issue belongs to the Section Dentistry, Oral Surgery and Oral Medicine)

Emerging Treatment Options in Aortic Valve Disease and Aortic Stenosis

edited by Borut Geršak and Robert Phillip Gallegos

submission deadline 25 Nov 2025 | 1 articles | Viewed by 1003 | Submission Open

Keywords: aortic stenosis; minimally invasive surgery; transcatheter aortic valve replacement; surgical treatment; diagnostic strategies; re-operation/redo AVR; calcified root; valve in valve

(This special issue belongs to the Section Cardiology)

Endometriosis: Current Insights and Treatments

edited by Mercedes Espada Vaquero

submission deadline 25 Nov 2025 | 1 articles | Viewed by 942 | Submission Open

Keywords: endometriosis; chronic pelvic pain; pelvic floor dysfunction; hormonal treatment; gynecological surgery; diagnosis; hysteroscopy; infertility

(This special issue belongs to the Section Obstetrics & Gynecology)

Recent Advances in Adverse Pregnancy and Neonatal Outcomes

edited by

Sae-kyung Choi

submission deadline 25 Nov 2025 | 1 articles | Viewed by 937 | Submission Open

Keywords: maternal and fetal; adverse pregnancy; neonatal outcomes; newborns; cesarean section

(This special issue belongs to the Section Obstetrics & Gynecology)

New Insights in Paediatric Endocrinology

edited by

Marco Fiore

submission deadline 25 Nov 2025 | 1 articles | Viewed by 460 | Submission Open

Keywords: endocrinology; pediatrics; hormones; therapy and treatment; adolescents; newborns

(This special issue belongs to the Section Clinical Pediatrics)

Ischemic Stroke: Diagnosis, Treatment, and Management

edited by

Maria Luisa Zedde

and Rosario Pascarella

submission deadline 25 Nov 2025 | Viewed by 427 | Submission Open

Keywords: ischemic stroke; diagnosis; treatment; stroke unit; stroke care; stroke etiology; thrombolysis; EVT; rare causes of stroke; cerebral vein thrombosis

(This special issue belongs to the Section Clinical Neurology)

Recent Advances in Diagnosis and Treatment of Comorbid Disorders in Interstitial Lung Diseases

edited by

Giacomo Sica

and Domenica Francesca Mariniello

submission deadline 25 Nov 2025 | Viewed by 237 | Submission Open

Keywords: interstitial lung disease; ILD; progressive pulmonary fibrosis; artificial intelligence; management

(This special issue belongs to the Section Respiratory Medicine)

Enhancing Safety and Outcomes in Complex Spine Surgery

edited by Ahmed Ramadan Sadek

submission deadline 25 Nov 2025 | Viewed by 230 | Submission Open

Keywords: spinal surgery; spinal deformity; scoliosis; sciatica; back and neck pain

(This special issue belongs to the Section Clinical Neurology)

New Horizons in Aortic Valve Replacement

edited by Abdellaziz Dahou

submission deadline 25 Nov 2025 | Viewed by 188 | Submission Open

Keywords: aortic valve; aortic stenosis; TAVR; SAVR; valve durability; aortic valve replacement; transcatheter aortic valve replacement; surgical aortic valve replacement

(This special issue belongs to the Section Cardiology)

Advances in Ablation Therapy for Atrial Fibrillation: Innovations and Clinical Applications

edited by Ioanna Koniari

submission deadline 25 Nov 2025 | Viewed by 179 | Submission Open

Keywords: atrial fibrillation; ablation; PFA; PVI; non-thermal energy; mapping system

(This special issue belongs to the Section Cardiology)

Ventricular Assist Devices: Clinical Advances in Practice and Future Perspectives

edited by Balakrishnan M. Mahesh

submission deadline 25 Nov 2025 | Viewed by 173 | Submission Open

Keywords: ventricular assist device; mechanical circulatory support; pulsatile pneumatic devices; microaxial intraventricular de-vices; magnetically levitated devices; cardiac transplantation; donor circulatory death; normothermic regional perfusion

(This special issue belongs to the Section Cardiology)

The Use of Circulating Extracellular Vesicles as a Tool in the Diagnosis, Monitoring and Treatment of Disease

edited by

Antonio Casado-Díaz

submission deadline 25 Nov 2025 | Viewed by 164 | Submission Open

Keywords: circulating extracellular vesicles; regenerative medicine; biomarker; diagnosis; exosomes; liquid biopsy

(This special issue belongs to the Section Clinical Laboratory Medicine)

Minimally Invasive Laparoendoscopic Procedures in Abdominal Emergencies

edited by

Eugen Tãrcoveanu

Costel Bradea

and

Alin Mihai Vasilescu

submission deadline 25 Nov 2025 | Viewed by 139 | Submission Open

Keywords: laparoscopic surgery; robotic surgery; minimally invasive surgery; hepatobiliary surgery; pancreatic surgery; gastrointestinal surgery; general surgery; emergency surgery; trauma; recent advances in laparoscopic surgery; surgical training in laparoscopy; endoscopic surgery; the feasibility and safety of laparoscopic; endoscopic co-operative surgery for the treatment of digestive pathology

(This special issue belongs to the Section General Surgery)

Displaying special issue 51-100 on page 2 of 32.

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