Nobel Prize in Physiology or Medicine — The Science Behind the Prize
Each year, the Nobel Prizes shine a spotlight on discoveries and ideas that have reshaped how we understand the world and ourselves. Rooted in Alfred Nobel’s vision of rewarding contributions “for the greatest benefit to humankind,” the prizes recognize milestones that often began as bold questions, painstaking experiments, or courageous stands. Beyond honoring individual brilliance, they tell a larger story of human progress—how curiosity, creativity, and determination can transform lives, opening new possibilities for health, understanding, and peace.
The Nobel Prize in Physiology or Medicine 2025 has been awarded to Mary E. Brunkow, Fred Ramsdell, and Shimon Sakaguchi for for their discoveries concerning peripheral immune tolerance.
At MDPI, we are proud to have been entrusted over the years with the distribution of works by more than 40 Nobel laureates. Shimon Sakaguchi (Nobel Prize in Physiology or Medicine, University of Osaka, Japan) has published articles in MDPI's Cancers journal just a few years ago.
Article published with MDPI
Hyper-Progressive Disease: The Potential Role and Consequences of T-Regulatory Cells Foiling Anti-PD-1 Cancer Immunotherapy
Authors: Christopher Tay, Yamin Qian and Shimon Sakaguchi
Cancers 2021, 13(1), 48.
Keynote Speakers
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Prof. Dr. Jacek Z. Kubiak |
Dr. Carlos S. Moreno |
Prof. Dr. Claus Jacob |
We hosted a webinar where our experts shared highlights from past laureates and their groundbreaking research in medicine and physiology, while also exploring current trends shaping the field.
You are welcome to watch the recording!
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“Homologous and Heterologous Vaccination Regimens with mRNA and rVSV Platforms Induce Potent Immune Responses Against SFTSV Glycoprotein”
by Tomaz B. Manzoni, Jonna B. Westover, Kendall A. Lundgreen, Philip D. Hicks, Raegan J. Petch, Jordan T. Ort, Drew Weissman, Steven H. Y. Fan, Scott E. Hensley, Norbert Pardi et al.
Viruses 2025, 17(8), 1095; https://doi.org/10.3390/v17081095
“Growth Hormone-Releasing Hormone (GHRH) Antagonist Peptides Combined with PI3K Isoform Inhibitors Enhance Cell Death in Prostate Cancer”
by Carlos Perez-Stable, Alicia de las Pozas, Medhi Wangpaichitr, Wei Sha, Haibo Wang, Renzhi Cai and Andrew V. Schally
Cancers 2025, 17(10), 1643; https://doi.org/10.3390/cancers17101643
“The Aggravating Role of Failing Neuropeptide Networks in the Development of Sporadic Alzheimer’s Disease”
by Miklós Jászberényi, Balázs Thurzó, Arumugam R. Jayakumar and Andrew V. Schally
Int. J. Mol. Sci. 2024, 25(23), 13086; https://doi.org/10.3390/ijms252313086
“Expression of Growth Hormone-Releasing Hormone and Its Receptor Splice Variants in a Cohort of Hungarian Pediatric Patients with Hematological and Oncological Disorders: A Pilot Study”
by Éva Juhász, Zsuzsanna Szabó, Andrew V. Schally, József Király, Petra Fodor, Gábor Kónya, Balázs Dezső, Erzsébet Szabó, Gábor Halmos and Csongor Kiss
Int. J. Mol. Sci. 2024, 25(16), 8831; https://doi.org/10.3390/ijms25168831
“Innate and Adaptive Immune Parameters following mRNA Vaccination in Mice”
by Srinivasa Reddy Bonam, Nicholas C. Hazell, Mano Joseph Mathew, Yuejin Liang, Xuxiang Zhang, Zhi Wei, Mohamad-Gabriel Alameh, Drew Weissman and Haitao Hu
Vaccines 2024, 12(5), 543; https://doi.org/10.3390/vaccines12050543
“Viroids, Satellite RNAs and Prions: Folding of Nucleic Acids and Misfolding of Proteins”
by Gerhard Steger, Detlev Riesner and Stanley B. Prusiner
Viruses 2024, 16(3), 360; https://doi.org/10.3390/v16030360
“The Swiss Brain Health Plan 2023–2033”
by Claudio L. A. Bassetti, Mirjam R. Heldner, Kristina Adorjan, Emiliano Albanese, Gilles Allali, Marcel Arnold, Indrit Bègue, Murielle Bochud, Andrew Chan, Thomas C. Südhof et al.
Clin. Transl. Neurosci. 2023, 7(4), 38; https://doi.org/10.3390/ctn7040038
“A Survey of Archaeal Restriction–Modification Systems”
by Brian P. Anton and Richard J. Roberts
Microorganisms 2023, 11(10), 2424; https://doi.org/10.3390/microorganisms11102424
“A Trivalent HSV-2 gC2, gD2, gE2 Nucleoside-Modified mRNA-LNP Vaccine Provides Outstanding Protection in Mice against Genital and Non-Genital HSV-1 Infection, Comparable to the Same Antigens Derived from HSV-1”
by Kevin P. Egan, Sita Awasthi, Giulia Tebaldi, Lauren M. Hook, Alexis M. Naughton, Bernard T. Fowler, Mitchell Beattie, Mohamad-Gabriel Alameh, Drew Weissman, Gary H. Cohen et al.
Viruses 2023, 15(7), 1483; https://doi.org/10.3390/v15071483
“Mechanisms of Action of the Host-Targeting Agent Cyclosporin A and Direct-Acting Antiviral Agents against Hepatitis C Virus”
by Dandan Liu, Tanya P. Ndongwe, Juan Ji, Andrew D. Huber, Eleftherios Michailidis, Charles M. Rice, Robert Ralston, Philip R. Tedbury and Stefan G. Sarafianos
Viruses 2023, 15(4), 981; https://doi.org/10.3390/v15040981
“Characterization of Live-Attenuated Powassan Virus Vaccine Candidates Identifies an Efficacious Prime-Boost Strategy for Mitigating Powassan Virus Disease in a Murine Model”
by Andrew M. Cheung, Elaine Z. Yip, Alison W. Ashbrook, Niluka Goonawardane, Corrine Quirk, Charles M. Rice, Margaret R. MacDonald and Hans-Heinrich Hoffmann
Vaccines 2023, 11(3), 612; https://doi.org/10.3390/vaccines11030612
“Soluble Guanylate Cyclase β1 Subunit Represses Human Glioblastoma Growth”
by Haijie Xiao, Haifeng Zhu, Oliver Bögler, Fabiola Zakia Mónica, Alexander Y. Kots, Ferid Murad and Ka Bian
Cancers 2023, 15(5), 1567; https://doi.org/10.3390/cancers15051567
“Siccanin Is a Dual-Target Inhibitor of Plasmodium falciparum Mitochondrial Complex II and Complex III”
by Keisuke Komatsuya, Takaya Sakura, Kazuro Shiomi, Satoshi Ōmura, Kenji Hikosaka, Tomoyoshi Nozaki, Kiyoshi Kita and Daniel Ken Inaoka
Pharmaceuticals 2022, 15(7), 903; https://doi.org/10.3390/ph15070903
“Bovine Meat and Milk Factors (BMMFs): Their Proposed Role in Common Human Cancers and Type 2 Diabetes Mellitus”
by Ethel-Michele de Villiers and Harald zur Hausen
Cancers 2021, 13(21), 5407; https://doi.org/10.3390/cancers13215407
“How an Infection of Sheep Revealed Prion Mechanisms in Alzheimer’s Disease and Other Neurodegenerative Disorders”
by George A. Carlson and Stanley B. Prusiner
Int. J. Mol. Sci. 2021, 22(9), 4861; https://doi.org/10.3390/ijms22094861
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“RNA Vaccines and Therapeutics: Challenges and Opportunities” |
“The Advance of Biomarker-Driven Targeted Therapies in Cancer” |
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“Genetic and Genomic Biomarkers in Cancer Diagnosis, Prognosis, and Treatment Prediction” |
“Emerging Trends in Next-Generation Vaccines to Combat Infectious Diseases” |
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“Innovative Prophylactic and Therapeutics for the Treatment of Coronavirus Infection” |
“MicroRNAs: Regulators of Cellular Fate” |
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