Melanoma: Molecular Mechanism and Therapy, 2nd Edition
A special issue of International Journal of Molecular Sciences (ISSN 1422-0067). This special issue belongs to the section "Molecular Oncology".
Deadline for manuscript submissions: 31 October 2025
Special Issue Editor
Interests: human malignant melanoma; genomic alterations; gene expression alterations; chromosome copy number alterations; array CGH; FISH
Special Issues, Collections and Topics in MDPI journals
Special Issue Information
Dear Colleagues,
This Special Issue builds upon the success of our previous edition, “Melanoma: Molecular Mechanism and Therapy” (https://www.mdpi.com/journal/ijms/special_issues/VLD5RY6AZX), by continuing to explore the latest advances in understanding and treating one of the most aggressive forms of skin cancer.
Melanoma is distinguished by its high metastatic potential and remains a formidable clinical challenge, particularly in its advanced stages. While the five-year survival rate for early-stage melanoma exceeds 98%, this figure plummets to around 17% when distant metastases are present. Over the past decade, several new therapeutic strategies have improved the prognosis of patients with late-stage and metastatic melanoma. Unfortunately, successful treatment of melanoma patients with distant metastases is still a major therapeutic challenge.
The molecular mechanisms underlying metastasis are only partially understood. Although initial responses to targeted therapies (e.g., BRAF/MEK inhibitors) or immunotherapies can be promising, resistance often develops due to the complex and heterogeneous nature of molecular alterations in melanoma. It is imperative to deepen our understanding of the molecular pathways involved in its disease progression and drug resistance.
This Special Issue invites contributions that address the molecular basis of melanoma development, metastasis, therapy resistance, and potential therapeutic targets. We welcome original research articles, reviews, and short communications.
Prof. Dr. Margit Balázs
Guest Editor
Manuscript Submission Information
Manuscripts should be submitted online at www.mdpi.com by registering and logging in to this website. Once you are registered, click here to go to the submission form. Manuscripts can be submitted until the deadline. All submissions that pass pre-check are peer-reviewed. Accepted papers will be published continuously in the journal (as soon as accepted) and will be listed together on the special issue website. Research articles, review articles as well as short communications are invited. For planned papers, a title and short abstract (about 100 words) can be sent to the Editorial Office for announcement on this website.
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Keywords
- melanoma progression
- melanoma metastasis
- molecular background
- targeted therapies
- immunotherapy
- acquired drug resistance
- prognostic and predictive markers
- therapeutic targets
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