Melanoma: Molecular Mechanism and Therapy, 2nd Edition
A special issue of International Journal of Molecular Sciences (ISSN 1422-0067). This special issue belongs to the section "Molecular Oncology".
Deadline for manuscript submissions: 31 October 2025 | Viewed by 24
Special Issue Editor
Interests: human malignant melanoma; genomic alterations; gene expression alterations; chromosome copy number alterations; array CGH; FISH
Special Issues, Collections and Topics in MDPI journals
Special Issue Information
Dear Colleagues,
This Special Issue builds on the success of our previous edition, Melanoma: Molecular Mechanisms and Therapy, via continuing to explore the latest advances in understanding and treating one of the most aggressive forms of skin cancer.
Melanoma is characterized by high metastatic potential, presenting a major clinical challenge, especially in advanced stages. While early-stage melanoma has a favorable prognosis—with five-year survival rates exceeding 98%— this rate drops dramatically to approximately 17% in patients with distant metastases. Over the past decade, significant progress has been made in the development of targeted therapies and immunotherapies, which have improved clinical outcomes for patients with advanced and metastatic disease. Despite these innovations, the treatment of melanoma with distant metastases remains a complex clinical challenge. The molecular mechanisms underlying melanoma progression, metastasis, and therapy resistance are complex and not yet fully elucidated. Although therapies targeting key signaling pathways (e.g., BRAF and MEK inhibitors) and immune checkpoints demonstrate initial efficacy, resistance frequently develops, often driven by the molecular heterogeneity and plasticity of melanoma cells. This underscores the need for deeper insights into the pathways governing tumor evolution and therapeutic escape.
This Special Issue aims to highlight recent advances in our understanding of the molecular basis of melanoma development, metastasis, and resistance to therapy. We welcome original research articles, reviews, and short communications that investigate molecular drivers of disease progression, mechanisms of drug resistance, novel therapeutic targets, and biomarkers predictive of treatment response. Submissions that provide mechanistic insights with potential translational relevance are particularly encouraged.
Prof. Dr. Balázs Margit
Guest Editor
Manuscript Submission Information
Manuscripts should be submitted online at www.mdpi.com by registering and logging in to this website. Once you are registered, click here to go to the submission form. Manuscripts can be submitted until the deadline. All submissions that pass pre-check are peer-reviewed. Accepted papers will be published continuously in the journal (as soon as accepted) and will be listed together on the special issue website. Research articles, review articles as well as short communications are invited. For planned papers, a title and short abstract (about 100 words) can be sent to the Editorial Office for announcement on this website.
Submitted manuscripts should not have been published previously, nor be under consideration for publication elsewhere (except conference proceedings papers). All manuscripts are thoroughly refereed through a single-blind peer-review process. A guide for authors and other relevant information for submission of manuscripts is available on the Instructions for Authors page. International Journal of Molecular Sciences is an international peer-reviewed open access semimonthly journal published by MDPI.
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Keywords
- melanoma progression
- melanoma metastasis
- molecular background
- targeted therapies
- immunotherapy
- acquired drug resistance
- prognostic and predictive markers
- therapeutic targets
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