From Molecule to Mind: Neuropharmacology of Psychoactive Alkaloids and Next-Generation Neuroactives
A special issue of International Journal of Molecular Sciences (ISSN 1422-0067). This special issue belongs to the section "Bioactives and Nutraceuticals".
Deadline for manuscript submissions: 30 April 2026 | Viewed by 14
Special Issue Editor
Special Issue Information
Dear Colleagues,
Psychoactive alkaloids such as caffeine and nicotine have shaped human cognition and behavior for centuries, offering powerful yet imperfect tools for modulating alertness, mood, and performance. Their rapid efficacy, accessibility, and affordability have made them deeply integrated into modern life. Despite their benefits, challenges, including tolerance, desensitization, and addiction, underscore the need for safer, more sustainable neuroactive alternatives. This Special Issue explores the molecular and neuropharmacological underpinnings of classical alkaloids. It examines emerging next-generation bioactive compounds—from botanicals to synthetic analogs—aimed at achieving enhanced efficacy with improved safety profiles. By bridging molecular insights with translational advances, this issue aims to illuminate innovative strategies for neuropharmacological interventions, performance enhancement, and preventive health.
Dr. Kyoko Koshibu
Guest Editor
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Keywords
- psychoactive alkaloids
- neuropharmacology
- bioactive compounds
- performance enhancement
- addiction
- translational research
- cognitive modulation
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