Glycosylation in Tumor Microenvironment: Roles, Mechanisms and Interventions
A special issue of International Journal of Molecular Sciences (ISSN 1422-0067). This special issue belongs to the section "Molecular Oncology".
Deadline for manuscript submissions: 25 June 2026 | Viewed by 3
Special Issue Editor
Interests: glycosphingolipids; neuronal cell; glioma cell; cancer; glycosylation; gangliosides; inflammation; neurodegeneration
Special Issues, Collections and Topics in MDPI journals
Special Issue Information
Dear Colleagues,
While cancer arises from genetic disorders, a variety of cell–cell and cell–matrix interactions are involved, and cancer cells acquire many malignant properties that advantageously support their transformation, expansion, and eventual metastasis. These interactions are exerted between cancer cells and various normal cells and components, such as fibroblasts, vascular cells, and host immune cells, including macrophages, T and B lymphocytes, NK cells, and cytokines. The tumor microenvironment contains all of these cells and components, forming a dynamic environment, and has emerged as an essential target of cancer therapeutics.
As glycosylation covers the majority of proteins and lipids, it occurs universally and dynamically and plays important roles in all of these processes. Carbohydrates on these molecules are critically involved in modes of interaction between cells and/or between cells and soluble factors, thereby regulating cell signalling, cell behaviours, and, ultimately, the nature of the tumor microenvironment. Elucidating the roles, mechanisms, and interventions related to glycosylation in both tumor cells and normal cells is therefore highly significant for understanding the tumor microenvironment and for developing strategies for cancer treatment.
Prof. Dr. Koichi Furukawa
Guest Editor
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Keywords
- glycoproteins
- glycolipids
- signaling
- cell–cell interaction
- cell membrane
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