Search for Articles:
Title / Keyword
Author / Affiliation / Email
Journal
Article Type
 
 
Advanced Search
 
Section
Special Issue
Volume
Issue
Number
Page
 
8.1
4.9
Journals
IJMS
Special Issues
Virus Infection and Infectious Diseases: Unraveling Mechanisms, Innovations and Therapeutic...
ijms-logo
Submit to Special Issue Submit Abstract to Special Issue Review for IJMS Propose a Special Issue

Journal Menu

► Journal Menu

Journal Browser

► Journal Browser
share announcement

Virus Infection and Infectious Diseases: Unraveling Mechanisms, Innovations and Therapeutic Strategies—Second Edition

A special issue of International Journal of Molecular Sciences (ISSN 1422-0067). This special issue belongs to the section "Molecular Immunology".

Deadline for manuscript submissions: 30 May 2025 | Viewed by 710

Special Issue Editor

Prof. Dr. Jung-Hyun Lee

E-Mail Website
Guest Editor
Department of Life Science, University of Seoul, Seoul 02504, Republic of Korea
Interests: viurs infection; extracellular vesicles; virus-host interactions; immune responses; immune sensors
Special Issues, Collections and Topics in MDPI journals

Special Issue Information

Dear Colleagues,

Viruses constitute an abundant, highly diverse, and economically significant group of pathogens affecting plants, animals, and humans. Despite their minuscule size, viruses initiate extensive pathological changes in or modifications to various host cells to ensure their survival.

This Special Issue welcomes the submission of the latest original research articles, short communications, and reviews concerning recent progress in virus–host interaction research and therapeutic approaches for infectious diseases. This Special Issue aims to furnish a comprehensive platform for the exchange of knowledge and contributions, enriching the evolving landscape in this field.

Prof. Dr. Jung-Hyun Lee
Guest Editor

Manuscript Submission Information

Manuscripts should be submitted online at www.mdpi.com by registering and logging in to this website. Once you are registered, click here to go to the submission form. Manuscripts can be submitted until the deadline. All submissions that pass pre-check are peer-reviewed. Accepted papers will be published continuously in the journal (as soon as accepted) and will be listed together on the special issue website. Research articles, review articles as well as short communications are invited. For planned papers, a title and short abstract (about 100 words) can be sent to the Editorial Office for announcement on this website.

Submitted manuscripts should not have been published previously, nor be under consideration for publication elsewhere (except conference proceedings papers). All manuscripts are thoroughly refereed through a single-blind peer-review process. A guide for authors and other relevant information for submission of manuscripts is available on the Instructions for Authors page. International Journal of Molecular Sciences is an international peer-reviewed open access semimonthly journal published by MDPI.

Please visit the Instructions for Authors page before submitting a manuscript. There is an Article Processing Charge (APC) for publication in this open access journal. For details about the APC please see here. Submitted papers should be well formatted and use good English. Authors may use MDPI's English editing service prior to publication or during author revisions.

Keywords

  • mechanism of virus infection
  • host immune responses
  • innovations in diagnostics and surveillance
  • therapeutic strategies
  • epidemiology and global health
  • data science for infectious disease
  • zoonotic transmission
  • virus evolution

Benefits of Publishing in a Special Issue

  • Ease of navigation: Grouping papers by topic helps scholars navigate broad scope journals more efficiently.
  • Greater discoverability: Special Issues support the reach and impact of scientific research. Articles in Special Issues are more discoverable and cited more frequently.
  • Expansion of research network: Special Issues facilitate connections among authors, fostering scientific collaborations.
  • External promotion: Articles in Special Issues are often promoted through the journal's social media, increasing their visibility.
  • e-Book format: Special Issues with more than 10 articles can be published as dedicated e-books, ensuring wide and rapid dissemination.

Further information on MDPI's Special Issue policies can be found here.

Related Special Issue

Published Papers (2 papers)

Download All Papers
Order results
Result details
Show export options expand_more Show export options expand_less
Select all
Export citation of selected articles as:

Research

Jump to: Review

15 pages, 3919 KiB  
Article
Characteristics of the First Domestic Duck-Origin H12N8 Avian Influenza Virus in China
by Conghui Zhao, Jiacheng Huang, Chunping Zhang, Yang Wang, Xiaoxuan Zhang, Sha Liu, Haoxi Qiang, Huanhuan Wang, Hangyu Zheng, Mingzhi Zhuang, Yanni Peng, Fuzai Chen, Xiancheng Zeng, Ji-Long Chen and Shujie Ma
Int. J. Mol. Sci. 2025, 26(6), 2740; https://doi.org/10.3390/ijms26062740 - 18 Mar 2025
Viewed by 454
Abstract
The H12 subtypes of avian influenza viruses (AIVs) are globally prevalent in wild birds, occasionally spilling over into poultry. In this study, we isolated an H12N8 virus from ducks in a live poultry market. Full genomic analysis revealed that the virus bears a [...] Read more.
The H12 subtypes of avian influenza viruses (AIVs) are globally prevalent in wild birds, occasionally spilling over into poultry. In this study, we isolated an H12N8 virus from ducks in a live poultry market. Full genomic analysis revealed that the virus bears a single basic amino acid in the cleavage site of the hemagglutinin gene. Phylogenetic analysis revealed that the eight gene segments of the H12N8 virus belong to the Eurasian lineage and the HA gene was clustered with wild bird-originated H12 viruses, with its NP gene showing the highest nucleotide similarity to 2013-like H7N9 viruses. The H12N8 virus replicated effectively in both mammalian and avian cells without prior adaptation. Moreover, the H12N8 virus could infect and replicate in the upper respiratory tract of BALB/c mice without prior adaptation. The H12N8 virus replicated and transmitted inefficiently in both ducks and chickens and hardly triggered high hemagglutination inhibition (HI) antibody titers in the inoculated and contact animals. These results suggest that the wild bird-origin H12N8 virus has reassorted with viruses circulating in domestic poultry, but it inefficiently replicates and transmits in avian hosts. Our findings demonstrate that H12N8 AIV has emerged in domestic poultry, emphasizing the importance of active surveillance of AIVs in both wild and domestic birds. Full article
(This article belongs to the Special Issue Virus Infection and Infectious Diseases: Unraveling Mechanisms, Innovations and Therapeutic Strategies—Second Edition)
►▼ Show Figures

Figure 1

Review

Jump to: Research

12 pages, 927 KiB  
Review
Research Advances in the Immunomodulatory Functions of CD100/SEMA4D and Their Roles in Viral Infectious Diseases
by Mengxiao Zhao, Liwei Chen, Yuhang Chen, Xuecheng Yang, Xuemei Feng, Dongliang Yang, Xin Zheng and Jia Liu
Int. J. Mol. Sci. 2025, 26(9), 4341; https://doi.org/10.3390/ijms26094341 (registering DOI) - 2 May 2025
Abstract
CD100/SEMA4D, a member of the Semaphorin family, is a transmembrane glycoprotein that regulates neurogenesis, immune modulation, and angiogenesis, with its immunoregulatory roles having attracted considerable attention. It is dynamically expressed on the surface of diverse immune cells—including T cells, B cells, dendritic cells [...] Read more.
CD100/SEMA4D, a member of the Semaphorin family, is a transmembrane glycoprotein that regulates neurogenesis, immune modulation, and angiogenesis, with its immunoregulatory roles having attracted considerable attention. It is dynamically expressed on the surface of diverse immune cells—including T cells, B cells, dendritic cells (DCs), and natural killer (NK) cells—with expression levels modulated by cellular activation states. CD100 exists in two functional forms: membrane-bound CD100 (mCD100) and soluble CD100 (sCD100) generated via proteolytic cleavage. Recent studies have highlighted its critical involvement in viral infectious diseases. This review systematically summarizes the molecular characteristics, expression patterns, and regulatory functions of CD100 on different immune cells, and discusses its role in viral infectious diseases and its clinical application potential. Full article
(This article belongs to the Special Issue Virus Infection and Infectious Diseases: Unraveling Mechanisms, Innovations and Therapeutic Strategies—Second Edition)
►▼ Show Figures

Figure 1

Show export options expand_more Show export options expand_less
Select all
Export citation of selected articles as:
 
Displaying articles 1-2
Back to TopTop