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International Journal of Molecular Sciences publishes Special Issues to create collections of papers on specific topics, with the aim of building a community of authors and readers to discuss the latest research and develop new ideas and research directions. Special Issues are led by Guest Editors, who are experts on the topic and all Special Issue submissions follow MDPI's standard editorial process. The journal’s Editor-in-Chief and/or designated Editorial Board Member will oversee Guest Editor appointments and Special Issue proposals, checking their content for relevance and ensuring the suitability of the material for the journal. The papers published in a Special Issue will be collected and displayed on a dedicated page of the journal’s website. Further information on MDPI's Special Issue policies and Guest Editor responsibilities can be found here. For any inquiries related to a Special Issue, please contact the Editorial Office.

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Multiple Sclerosis: From Molecular Pathology to Novel Therapeutic Approaches

edited by

László Vécsei

and

Masaru Tanaka

submission deadline 20 Jan 2026 | 6 articles | Viewed by 10204 | Submission Open

Keywords: progression-independent relapses (PIRAs); smouldering-associated worsening (SAW); lack of new relapses and of new magnetic resonance imaging activity (NEIDA); slowly expanding lesions (SEL); no evidence of smouldering disease activity (NESDA); neurofilament (NfL); glial fibrillary acidic protein (GFAP); patient-reported outcome (PRO); paramagnetic rim lesions (PRLs); relapse-associated worsening (RAW)

(This special issue belongs to the Section Molecular Neurobiology)

Respiratory Virus Infection

edited by Nikolaos Siafakas

submission deadline 20 Jan 2026 | 6 articles | Viewed by 10080 | Submission Open

Keywords: respiratory virus; diagnosis; surveillance; epidemiology; therapy; vaccination; influenza virus; coronavirus; respiratory syncytial virus; rhinovirus/enterovirus

(This special issue belongs to the Section Molecular Microbiology)

Herpes Simplex Virus: Immunity, Pathogenicity, Immune Escape Mechanisms, and Antiviral Strategies

edited by

Maria Teresa Sciortino

submission deadline 20 Jan 2026 | 2 articles | Viewed by 9357 | Submission Open

Keywords: herpes simplex virus (HSV); latency; immune evasion; tegument proteins; epigenetic mechanisms; viral pathogenesis; antiviral strategies; molecular mechanisms; therapeutic interventions

(This special issue belongs to the Section Molecular Immunology)

Molecular Biomarkers in Cancers: Advances and Challenges, 2nd Edition

edited by

Paramjit S. Tappia

and

Bram Ramjiawan

submission deadline 20 Jan 2026 | 6 articles | Viewed by 9256 | Submission Open

Keywords: cancer; cancer staging; diagnostic tools; novel biomarkers; proteomics; molecular markers; metabolic profiling; prognostic value

(This special issue belongs to the Section Molecular Pathology, Diagnostics, and Therapeutics)

Protein and Protein Interactions

edited by Wu Xu

submission deadline 20 Jan 2026 | 4 articles | Viewed by 8876 | Submission Open

Keywords: protein and protein interactions; ligand and protein interactions; computational method; geometry-based; energy-based; conformational changes; binding site prediction; structural biology; computational biology and bioinformatics

(This special issue belongs to the Section Molecular Biology)

Biochemical and Molecular Aspects of Bioremediation of Soils with Organic Pollutants by Microorganisms

edited by

Mariusz Cycoń

submission deadline 20 Jan 2026 | 5 articles | Viewed by 8861 | Submission Open

Keywords: bioremediation; soil pollution; organic pollutants; microorganisms; microbial communities; gene expression; enzyme degradation; molecular tools; indigenous soil microorganisms; contaminated soils

(This special issue belongs to the Section Molecular Microbiology)

Molecular Research in Bone and Soft Tissue Tumors

edited by

Shinji Miwa

submission deadline 20 Jan 2026 | 4 articles | Viewed by 8788 | Submission Open

Keywords: sarcoma; therapeutic target; metastasis; anticancer agent; immunotherapy

(This special issue belongs to the Section Molecular Oncology)

Diabetes and Its Complications: From Molecular Mechanisms to Novel Therapeutic Approaches—2nd Edition

edited by

Andrea Paola Rojas Gil

submission deadline 20 Jan 2026 | 1 articles | Viewed by 8570 | Submission Open

Keywords: diabetes; diabetes complications; environmental factors; endocrine disruptors; nutrition; sleep; therapy; molecular mechanisms

(This special issue belongs to the Section Molecular Pathology, Diagnostics, and Therapeutics)

Abiotic Stresses in Plants: From Molecules to Environment—2nd Edition

edited by

Martin Bartas

submission deadline 20 Jan 2026 | 6 articles | Viewed by 8509 | Submission Open

Keywords: stress signaling; abiotic stress; oxidative stress; genotoxic stress

(This special issue belongs to the Section Molecular Plant Sciences)

Recent Advances in Electrochemical-Related Materials

edited by Celia García-Hernandez

submission deadline 20 Jan 2026 | 6 articles | Viewed by 8376 | Submission Open

Keywords: novel electrochemical devices; advanced micro- and nanomaterials for electrochemical applications; batteries; fuel and photoelectrochemical cells; electrochemical sensors and biosensors; new advances in supercapacitors; electrochemical electrolyzers; advanced electrochemical materials for environmental applications

(This special issue belongs to the Section Materials Science)

Latest Research on Plant Genomics and Genome Editing, 2nd Edition

edited by

Fabrizio Carbone

submission deadline 20 Jan 2026 | 6 articles | Viewed by 8314 | Submission Open

Keywords: next-generation sequencing; structural and functional genomics; SNPs; miRNA; LncRNA; CRISPR/Cas9; TALEN; genome editing

(This special issue belongs to the Section Molecular Plant Sciences)

Mesenchymal Stem Cell-Based Therapy: Cell Therapy vs. EV Therapy

edited by Masahito Nakazaki

submission deadline 20 Jan 2026 | 2 articles | Viewed by 8289 | Submission Open

Keywords: mesenchymal stromal/stem cells; small extracellular vesicles; large extracellular vesicles; clinical trials; spinal cord injury; cerebrovascular disease

(This special issue belongs to the Section Biochemistry)

Investigating Host-Parasite Interactions for the Discovery of Novel Therapies and Vaccine Targets

edited by

Natalie Nieuwenhuizen

submission deadline 20 Jan 2026 | 6 articles | Viewed by 8202 | Submission Open

Keywords: parasites; host-pathogen interactions; helminths; worms; protozoans; leishmania; malaria; schistosomiasis; trypanosomiasis; ascariasis; anisakiasis; vectors; mosquitoes; ticks; neglected tropical diseases

(This special issue belongs to the Section Molecular Immunology)

Molecular Mechanisms and Therapies for Melanoma

edited by Anna Piotrowska

submission deadline 20 Jan 2026 | 3 articles | Viewed by 8165 | Submission Open

Keywords: melanoma; targeted therapy; BRAF/MEK inhibitors; immunotherapy; anti-PD-1 and anti-CTLA-4 immunotherapy; melanoma microenvironment; cancer-associated fibroblasts (CAFs)/melanoma-associated fibroblasts (MAFs); MAPK (mitogen-activated protein kinase) signaling pathway

(This special issue belongs to the Section Molecular Pathology, Diagnostics, and Therapeutics)

New Insights into the Immunopathology of Infectious Diseases

edited by Marta Camici

submission deadline 20 Jan 2026 | 4 articles | Viewed by 8079 | Submission Open

Keywords: infection immunology; immune dysregulation in infectious diseases; interactions between infective agents and immune responses; modeling of the immune system; new pathways of pathogenesis

(This special issue belongs to the Section Molecular Immunology)

Endometriosis Pathophysiology, Diagnosis and Emerging Therapeutic Strategies

edited by

Mariarosaria Boccellino

submission deadline 20 Jan 2026 | 1 articles | Viewed by 7897 | Submission Open

Keywords: endometriosis; pathophysiology; infertility; biomarkers; pharmacological treatments

(This special issue belongs to the Section Molecular Pathology, Diagnostics, and Therapeutics)

Virus Infection and Infectious Diseases: Unraveling Mechanisms, Innovations and Therapeutic Strategies—Second Edition

edited by Jung-Hyun Lee

submission deadline 20 Jan 2026 | 5 articles | Viewed by 7804 | Submission Open

Keywords: mechanism of virus infection; host immune responses; innovations in diagnostics and surveillance; therapeutic strategies; epidemiology and global health; data science for infectious disease; zoonotic transmission; virus evolution

(This special issue belongs to the Section Molecular Immunology)

Advanced Electrode and Electrolyte Materials: Molecular Scale Design, Synthesis, Mechanisms and Applications

edited by

Christian Julien

submission deadline 20 Jan 2026 | 3 articles | Viewed by 7697 | Submission Open

Keywords: cathode; anode; electrolyte; synthesis; electrochemistry; rechargeable batteries; lithium-ion batteries; all-solid-state lithium metal batteries

(This special issue belongs to the Section Materials Science)

Recent Advances in Adult Stem Cell Research

edited by Dongsu Park

submission deadline 20 Jan 2026 | 4 articles | Viewed by 7590 | Submission Open

Keywords: tissue-resident stem cells; skeletal stem/progenitor cells; hematopoietic stem cells; tendon/ligament stem cells; musculoskeletal tissue regeneration; stem cell microenvironment; stem cell aging

(This special issue belongs to the Section Molecular Biology)

Molecular Mechanism and Pathogenesis of Cardiac Disease

edited by Yu-Hsun Kao

submission deadline 20 Jan 2026 | 3 articles | Viewed by 7588 | Submission Open

Keywords: cardiac diseases; cardiac metabolidm; epigenetics; ER stress; mitochondrial dysfunction; molecular mechanisms; therapeutic targets

(This special issue belongs to the Section Molecular Pathology, Diagnostics, and Therapeutics)

Biomaterials for Drug Delivery and Advanced Therapies

edited by

Annalisa Bianchera

submission deadline 20 Jan 2026 | 3 articles | Viewed by 7577 | Submission Open

Keywords: polymers; biomaterials; drug delivery; scaffold; ATMPs; tissue regeneration

(This special issue belongs to the Section Materials Science)

Molecular and Cellular Mechanisms of Skin Diseases (Second Edition)

edited by

Elisabetta Palazzo

submission deadline 20 Jan 2026 | 4 articles | Viewed by 7575 | Submission Open

Keywords: hyperproliferative skin diseases; psoriasis; keratinocyte carcinoma; actinic keratosis; atopic dermatitis; skin inflammation; inflammation-associated skin diseases; epidermal differentiation; epidermal cell metabolism; 3D models; in vivo models

(This special issue belongs to the Section Molecular Biology)

Recent Developments in Obesity: Metabolism, Pathophysiology and Treatment

edited by

Peteris Tretjakovs

submission deadline 20 Jan 2026 | 1 articles | Viewed by 7080 | Submission Open

Keywords: obesity; adipokines; insulin sensitivity; lipid metabolism; pro-inflammatory cytokines; gut microbiota; GLP-1 receptor agonists; personalized nutrition; lifestyle interventions

(This special issue belongs to the Section Molecular Endocrinology and Metabolism)

The Structures, Syntheses of Natural Products, and Their Biological Effects

edited by

Ran Jia

submission deadline 20 Jan 2026 | 3 articles | Viewed by 7067 | Submission Open

Keywords: structures of natural products; syntheses; biological effects; biomedical applications

(This special issue belongs to the Section Bioactives and Nutraceuticals)

Biomarkers in Cardiovascular Diseases: Diagnosis, Pathology and Treatment

edited by

Marco Valerio Mariani

submission deadline 20 Jan 2026 | 3 articles | Viewed by 7046 | Submission Open

Keywords: heart failure; myocardial remodeling; ischemic heart disease; myocarditis; cardiomyopathies; prevention; diagnosis; therapy

(This special issue belongs to the Section Molecular Pathology, Diagnostics, and Therapeutics)

Molecular Mechanisms of Heart Failure: Insights and Therapeutic Strategies

edited by Emilio Vanoli and Eugenio Caradonna

submission deadline 20 Jan 2026 | 2 articles | Viewed by 6816 | Submission Open

Keywords: heart failure; autonomic nervous system; brain– gut interaction; gut microbiota; neurohumoral treatment; cardiac remodeling; inflammation

(This special issue belongs to the Section Molecular Pathology, Diagnostics, and Therapeutics)

New Research Insights in Cystic Fibrosis and CFTR-Related Diseases

edited by Judith A. Coppinger

submission deadline 20 Jan 2026 | 3 articles | Viewed by 6724 | Submission Open

Keywords: cystic fibrosis; CFTR related diseases; COPD; immune cells; extracellular vesicles; neutrophils; therapeutics; biomarkers

(This special issue belongs to the Section Molecular Pathology, Diagnostics, and Therapeutics)

Plant Molecular Regulatory Networks and Stress Responses

edited by

Xiujun Zhang

submission deadline 20 Jan 2026 | 5 articles | Viewed by 6621 | Submission Open

Keywords: plant stress response; stress response gene; regulatory mechanism; gene regulatory network; transcriptional regulation; post-transcriptional regulation; multi-omics integration; single-cell RNA-seq; spatial genomics; bioinformatics

(This special issue belongs to the Section Molecular Plant Sciences)

Fat and Obesity: Molecular Mechanisms and Pathogenesis

edited by

Seon-Yong Jeong

submission deadline 20 Jan 2026 | 4 articles | Viewed by 6595 | Submission Open

Keywords: obesity; weight gain; adipogenesis; lipolysis; energy balance; hormones; fat oxidation; nutrition; phytomedicine; drug development; cohort studies; genetics and genomics studies

(This special issue belongs to the Section Bioactives and Nutraceuticals)

Molecular Research in Parkinson's Disease

edited by

Yi-Chuan Cheng

submission deadline 20 Jan 2026 | 2 articles | Viewed by 6577 | Submission Open

Keywords: Parkinson's disease; molecular regulation; genetic mutations; epigenetics; protein aggregation; mitochondrial dysfunction; neuroinflammation; biomarkers

(This special issue belongs to the Section Molecular Neurobiology)

Molecular Diagnostics and Treatment Advances in Lung Diseases

edited by Eirini Vasarmidi

submission deadline 20 Jan 2026 | 2 articles | Viewed by 6513 | Submission Open

Keywords: lung diseases; pulmonary; alveolar; diagnosis; treatment; biomarkers; molecular; bronchoalveolar lavage; genetics; pathogenesis

(This special issue belongs to the Section Molecular Pathology, Diagnostics, and Therapeutics)

Molecular Mechanisms and the Link Between Obesity, Diabetes and Inflammation

edited by

Maria Chiara Pelle

and

Arturi Franco

submission deadline 20 Jan 2026 | 4 articles | Viewed by 6384 | Submission Open

Keywords: adipose tissue; biomarkers; diabetes; inflammation; obesity; cytokine; insulin resistance; signaling pathways; metabolic diseases

(This special issue belongs to the Section Molecular Endocrinology and Metabolism)

Neurodegeneration and Neuroinflammatory Processes in Age-Related Diseases

edited by

Barbara Mroczko

submission deadline 20 Jan 2026 | 3 articles | Viewed by 6368 | Submission Open

Keywords: age-related diseases; neurodegenerative diseases; neurodegeneration; neuroinflammation; aging

(This special issue belongs to the Section Molecular Neurobiology)

Advances in Drug Discovery and Synthesis: 2nd Edition

edited by

Lidia Ciccone

and

Susanna Nencetti

submission deadline 20 Jan 2026 | 2 articles | Viewed by 6298 | Submission Open

Keywords: medicinal chemistry; drug discovery; design and synthesis of bioactive compounds; molecular modeling; X-ray crystallography; structure– activity relationships; structure-based drug design

(This special issue belongs to the Section Molecular Pharmacology)

Molecular Research Landscape of Pulmonary Arterial Hypertension

edited by Cármen Brás-Silva

submission deadline 20 Jan 2026 | 3 articles | Viewed by 6256 | Submission Open

Keywords: pulmonary arterial hypertension; right ventricle; right heart failure; molecular mechanisms; vascular disease; translational research; therapy

(This special issue belongs to the Section Molecular Biology)

New Insights into Male Infertility and Sperm Biology

edited by

Monica Muratori

submission deadline 20 Jan 2026 | 4 articles | Viewed by 6248 | Submission Open

Keywords: male infertility; sperm DNA fragmentation; sperm oxidative stress; sperm nuclear condensation; assisted reproductive technologies; genomics; epigenomics; transcriptomics; proteomics; metabolomics

(This special issue belongs to the Section Molecular Biology)

Melanin and Other Pigments: Function, Synthesis and Characterization

edited by Koen P. Vercruysse

submission deadline 20 Jan 2026 | 3 articles | Viewed by 6101 | Submission Open

Keywords: melanin; eumelanin; pheomelanin; allomelanin; catechol; indole; phenol

(This special issue belongs to the Section Biochemistry)

Neuroinflammation and Cellular Senescence in Brain Aging and Neurodegeneration: From Molecular Mechanisms to Therapeutic Applications

edited by Jordi Olloquequi and M. Emília Juan

submission deadline 20 Jan 2026 | 2 articles | Viewed by 6040 | Submission Open

Keywords: SASP; glial activation; age-related disorders; neurotherapeutics; molecular signaling

(This special issue belongs to the Section Molecular Neurobiology)

Molecular Insights into Antimicrobial Activity

edited by

Liliana Mititelu Tartau

submission deadline 20 Jan 2026 | 2 articles | Viewed by 5947 | Submission Open

Keywords: antimicrobial activity; antimicrobial agents; antimicrobial peptides; phytochemicals with antimicrobial properties; antimicrobial synergy; pathogen-specific targeting; antimicrobial resistance; biomedical science; nanotechnology in antimicrobials; genomic

(This special issue belongs to the Section Molecular Microbiology)

Chronic Kidney Disease: From Molecular Mechanisms to Therapeutic Approaches

edited by

Ligia Petrica

submission deadline 20 Jan 2026 | 3 articles | Viewed by 5846 | Submission Open

Keywords: genetics; epigenetics; inflammation; metabolomics; oxiative stress

(This special issue belongs to the Section Molecular Biology)

Molecular Immunologic Perspectives on Mycobacterium tuberculosis Infection

edited by

Vishwanath Venketaraman

submission deadline 20 Jan 2026 | 2 articles | Viewed by 5826 | Submission Open

Keywords: M. tb infection; molecular immunology; HIV; AIDS; pathogenesis; host immune responses; adjunctive therapy; immune-enhancing agents; antimycobacterial compounds; host-directed therapies; pathogenesis; modulation of host immune responses

(This special issue belongs to the Section Molecular Immunology)

Tissue Regeneration and Repair in Airway Diseases

edited by Rolf Ziesche

submission deadline 20 Jan 2026 | 2 articles | Viewed by 5459 | Submission Open

Keywords: chronic inﬂammation; structural integrity; regenerative repair; structural disintegration; impact of aging on inﬂammation and repair

(This special issue belongs to the Section Molecular Pathology, Diagnostics, and Therapeutics)

New Perspectives in Steroidomics

edited by

Martin Hill

submission deadline 20 Jan 2026 | 3 articles | Viewed by 5346 | Submission Open

Keywords: steroidomics; steroids; pathophysiology; physiology; diagnostics; treatment; prediction; prognosis; LC-MS/MS; GC-MS/MS

(This special issue belongs to the Section Molecular Endocrinology and Metabolism)

Molecular Insights into Lipodystrophy

edited by

Sofía Sánchez-Iglesias

and

David Araújo-Vilar

submission deadline 20 Jan 2026 | 3 articles | Viewed by 5161 | Submission Open

Keywords: lipodystrophy; adipogenesis; animal models; lipid metabolism; therapeutic targets; insulin signaling pathways; adipose tissue

(This special issue belongs to the Section Molecular Pathology, Diagnostics, and Therapeutics)

Hormone Metabolism and Signaling in Human Health and Disease

edited by

Kuo-Hu Chen

submission deadline 20 Jan 2026 | 1 articles | Viewed by 5129 | Submission Open

Keywords: hormone metabolism; signaling pathways; pathophysiology; molecular and cellular biology; diseases originating from hormone disorders; hormonal therapy

(This special issue belongs to the Section Molecular Endocrinology and Metabolism)

Natural Compounds: Structural Diversity, Modifications, and Biological Activities

edited by Tomasz Pospieszny

submission deadline 20 Jan 2026 | 3 articles | Viewed by 5088 | Submission Open

Keywords: bile acids; molecular research; biological activity; natural products; steroids

(This special issue belongs to the Section Bioactives and Nutraceuticals)

New Insights into Satellite DNAs

edited by

Isidoro Feliciello

and

Đurđica Ugarković

submission deadline 20 Jan 2026 | 2 articles | Viewed by 4984 | Submission Open

Keywords: satellite DNA; satellitome; satellite DNA organization; satellite DNA evolution; satellite DNA origin; satellite DNA transcription; satellite DNA function; satellite DNA regulation; satellite RNA; heterochromatin; centromere; telomere; gene regulation; cancer; biomarkers; epigenetics; next-generation sequencing (NGS); nanopore sequencing; PacBio sequencing

(This special issue belongs to the Section Molecular Biology)

Research and Innovations in Green Monomers and Macromolecular Materials

edited by

Joanna Rydz

Marta Musioł

and

Wanda Sikorska

submission deadline 20 Jan 2026 | 3 articles | Viewed by 4928 | Submission Open

Keywords: green monomers and macromolecular material for a sustainable future; current barriers and future needs of green macromolecular materials; latest breakthroughs and approaches in molecular sciences; bio-based and/or biodegradable polymers based on natural; renewable; and synthetic polymers; synthesis; design; characterization; and development of innovative; technologically advanced; adaptable; and multifunctional green polymers in chemistry; biology; and medicine; relationships between structure; properties; functions; and performance of green polymers; sustainability; recycling; and environmental issues of green macromolecular materials; commercial applications: concepts; methodologies; and tools; 3D printing for personalized consumer products

(This special issue belongs to the Section Materials Science)

Advances and Emerging Trends in Marine Natural Products

edited by Rafael Alexandre Faria da Costa Félix and

Carina Félix

submission deadline 20 Jan 2026 | 4 articles | Viewed by 4909 | Submission Open

Keywords: marine natural products; bioprospecting; circular bioeconomy; bioactive compounds; antioxidant; antimicrobial; anti-inflammatory; polymers; peptides; genome mining; enzyme inhibitors; plant priming; green extraction methodologies

(This special issue belongs to the Section Molecular Pharmacology)

Applications of Machine Learning in Bioinformatics and Biomedicine

edited by

Fuyi Li

submission deadline 20 Jan 2026 | 3 articles | Viewed by 4895 | Submission Open

Keywords: bioinformatics; computational biology; machine learning; deep learning; AI for biology

(This special issue belongs to the Section Molecular Informatics)

Displaying special issue 301-350 on page 7 of 65.

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