Multiple Sclerosis: From Molecular Pathology to Novel Therapeutic Approaches
A special issue of International Journal of Molecular Sciences (ISSN 1422-0067). This special issue belongs to the section "Molecular Neurobiology".
Deadline for manuscript submissions: 30 June 2025 | Viewed by 290
Special Issue Editors
2. Department of Neurology, Albert Szent-Györgyi Medical School, University of Szeged, Semmelweis u. 6, H-6725 Szeged, Hungary
Interests: multiple sclerosis; neurodegeneration; smouldering lesion; molecular pathology; novel therapies; kynurenines
Special Issues, Collections and Topics in MDPI journals
Interests: depression; anxiety; dementia pain; their comorbidities nature; translational research in neurological diseases; psychiatric disorders
Special Issues, Collections and Topics in MDPI journals
Special Issue Information
Dear Colleagues,
Multiple sclerosis (MS) is a chronic disease characterised by inflammation, extensive primary demyelination, and progressive neurodegenerative processes. Long-term disability in MS is largely independent of relapses (progression independent of relapse activity, PIRA) and correlates well with brain atrophy detected by MRI images. Smouldering lesions show a low-grade chronic inflammation characterised by chronic axonal damage and concurrent demyelination and are further characterised by a gradual increase in size towards the normal-appearing white matter (NAWM). During the course of the disease, the proportion of smouldering lesions increases over time and is higher in progressive than in relapsing–remitting disease. These lesions have also been shown to correlate with disability and predict progression in both relapsing–remitting and secondary progressive SM. It is important to revise the current disease classification system, clinical trial designs, and trial endpoints. Furthermore, novel molecular biomarkers (like NfL, GFAP, CHI3L, CXCL13, kynurenines, redox molecules, etc.) help the decision about the optimal treatment of MS patients.
Prof. Dr. László Vécsei
Dr. Masaru Tanaka
Guest Editors
Manuscript Submission Information
Manuscripts should be submitted online at www.mdpi.com by registering and logging in to this website. Once you are registered, click here to go to the submission form. Manuscripts can be submitted until the deadline. All submissions that pass pre-check are peer-reviewed. Accepted papers will be published continuously in the journal (as soon as accepted) and will be listed together on the special issue website. Research articles, review articles as well as short communications are invited. For planned papers, a title and short abstract (about 100 words) can be sent to the Editorial Office for announcement on this website.
Submitted manuscripts should not have been published previously, nor be under consideration for publication elsewhere (except conference proceedings papers). All manuscripts are thoroughly refereed through a single-blind peer-review process. A guide for authors and other relevant information for submission of manuscripts is available on the Instructions for Authors page. International Journal of Molecular Sciences is an international peer-reviewed open access semimonthly journal published by MDPI.
Please visit the Instructions for Authors page before submitting a manuscript. There is an Article Processing Charge (APC) for publication in this open access journal. For details about the APC please see here. Submitted papers should be well formatted and use good English. Authors may use MDPI's English editing service prior to publication or during author revisions.
Keywords
- progression-independent relapses (PIRAs)
- smouldering-associated worsening (SAW)
- lack of new relapses and of new magnetic resonance imaging activity (NEIDA)
- slowly expanding lesions (SEL)
- no evidence of smouldering disease activity (NESDA)
- neurofilament (NfL)
- glial fibrillary acidic protein (GFAP)
- patient-reported outcome (PRO)
- paramagnetic rim lesions (PRLs)
- relapse-associated worsening (RAW)
Benefits of Publishing in a Special Issue
- Ease of navigation: Grouping papers by topic helps scholars navigate broad scope journals more efficiently.
- Greater discoverability: Special Issues support the reach and impact of scientific research. Articles in Special Issues are more discoverable and cited more frequently.
- Expansion of research network: Special Issues facilitate connections among authors, fostering scientific collaborations.
- External promotion: Articles in Special Issues are often promoted through the journal's social media, increasing their visibility.
- e-Book format: Special Issues with more than 10 articles can be published as dedicated e-books, ensuring wide and rapid dissemination.
Further information on MDPI's Special Issue policies can be found here.
